scholarly journals Does host socio-spatial behavior lead to a fine-scale spatial genetic structure in its associated parasites?

Parasite ◽  
2019 ◽  
Vol 26 ◽  
pp. 64
Author(s):  
Elodie Portanier ◽  
Mathieu Garel ◽  
Sébastien Devillard ◽  
Jeanne Duhayer ◽  
Marie-Thérèse Poirel ◽  
...  
Keyword(s):  
Life Cycle ◽  
Genetic Structure ◽  
Spatial Genetic Structure ◽  
Small Ruminants ◽  
Spatial Behavior ◽  
Biological Factors ◽  
Parasite Life Cycle ◽  
Host Parasite Interactions ◽  
Host Genetic ◽  
Host Parasite

Gastro-intestinal nematodes, especially Haemonchus contortus, are widespread pathogenic parasites of small ruminants. Studying their spatial genetic structure is as important as studying host genetic structure to fully understand host-parasite interactions and transmission patterns. For parasites having a simple life cycle (e.g., monoxenous parasites), gene flow and spatial genetic structure are expected to strongly rely on the socio-spatial behavior of their hosts. Based on five microsatellite loci, we tested this hypothesis for H. contortus sampled in a wild Mediterranean mouflon population (Ovis gmelini musimon × Ovis sp.) in which species- and environment-related characteristics have been found to generate socio-spatial units. We nevertheless found that their parasites had no spatial genetic structure, suggesting that mouflon behavior was not enough to limit parasite dispersal in this study area and/or that other ecological and biological factors were involved in this process, for example other hosts, the parasite life cycle, or the study area history.

scholarly journals To delay once or twice: the effect of hypobiosis and free-living stages on the stability of host–parasite interactions

2008 ◽  
Vol 5 (25) ◽  
pp. 919-928 ◽  
Author(s):  
Sabrina Gaba ◽  
Sébastien Gourbière
Keyword(s):  
Population Dynamics ◽  
Life Cycle ◽  
Time Delay ◽  
Host Population ◽  
Previous Attempt ◽  
Maximal Effect ◽  
Parasite Life Cycle ◽  
Free Living ◽  
Host Parasite Interactions ◽  
Host Parasite

The life cycle of many endoparasites can be delayed by free-living infective stages and a developmental arrestment in the host referred to as hypobiosis. We investigated the effects of hypobiosis and its interaction with delay in the free-living stages on host–parasite population dynamics by expanding a previous attempt by Dobson & Hudson. When the parasite life cycle does not include free-living stages, hypobiosis destabilizes the host–parasite interactions, irrespective of the assumptions about the regulation of the host population dynamics. Interestingly, the destabilizing effect varies in a nonlinear way with the duration of hypobiosis, the maximal effect being expected for three to five months delay. When the parasite life cycle involves free-living stages, hypobiosis of short or intermediate duration increases the destabilizing effect of the first time delay. However, hypobiosis of a duration of five months or more can stabilize interactions, irrespective of the regulation of the host population dynamics. Overall, we confirmed that hypobiosis is an unusual time delay as it can stabilize a two-way interaction. Contrary to the previous conclusions, such an atypical effect does not require self-regulation of the host population, but instead depends on the existence of free-living stages.

scholarly journals From Metabolite to Metabolome: Metabolomics Applications in Plasmodium Research

2021 ◽  
Vol 11 ◽  
Author(s):  
Xinyu Yu ◽  
Gaoqian Feng ◽  
Qingfeng Zhang ◽  
Jun Cao
Keyword(s):  
Life Cycle ◽  
Life Stages ◽  
Disease Etiology ◽  
Malaria Research ◽  
Metabolic Mapping ◽  
The Past ◽  
Host Parasite Interactions ◽  
Life Cycle Stages ◽  
Parasite Biology ◽  
Host Parasite

Advances in research over the past few decades have greatly improved metabolomics-based approaches in studying parasite biology and disease etiology. This improves the investigation of varied metabolic requirements during life stages or when following transmission to their hosts, and fulfills the demand for improved diagnostics and precise therapeutics. Therefore, this review highlights the progress of metabolomics in malaria research, including metabolic mapping of Plasmodium vertebrate life cycle stages to investigate antimalarials mode of actions and underlying complex host-parasite interactions. Also, we discuss current limitations as well as make several practical suggestions for methodological improvements which could drive metabolomics progress for malaria from a comprehensive perspective.

scholarly journals Energy-harnessing problem solving of primordial life: modeling the emergence of catalytic host-parasite life cycles

2021 ◽  
Author(s):  
Bernard Conrad ◽  
Magnus Pirovino
Keyword(s):  
Life Cycle ◽  
Problem Solving ◽  
Life Forms ◽  
Life Cycles ◽  
Darwinian Evolution ◽  
Volterra Equations ◽  
Genome Replication ◽  
Parasite Life Cycle ◽  
Functional Features ◽  
Host Parasite

AbstractAll life forms on earth ultimately descended from a primordial population dubbed the last universal common ancestor or LUCA via Darwinian evolution. Extant living systems share two salient functional features, a metabolism extracting and transforming energy required for survival, and an evolvable, informational polymer – the genome – conferring heredity. Genome replication invariably generates essential and ubiquitous genetic parasites. Here we model the energetic, replicative conditions of LUCA-like organisms and their parasites, as well as adaptive problem solving of host-parasite pairs. We show using the Lotka-Volterra equations that three host-parasite pairs – individually a unit of a host and a parasite that is itself parasitized – are sufficient for robust and stable homeostasis, forming a life cycle. This catalytic life cycle efficiently captures, channels and transforms energy, enabling dynamic host survival and adaptation. We propose a Malthusian fitness model for an original quasispecies evolving through a host-parasite life cycle.

scholarly journals Proteomic identification of galectin-11 and 14 ligands fromHaemonchus contortus

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4510
Author(s):  
Dhanasekaran Sakthivel ◽  
Jaclyn Swan ◽  
Sarah Preston ◽  
MD Shakif-Azam ◽  
Pierre Faou ◽  
...  
Keyword(s):  
Immune Responses ◽  
Adult Stage ◽  
Parasitic Infection ◽  
Small Ruminants ◽  
Affinity Column ◽  
Protein Targets ◽  
Zinc Metalloprotease ◽  
Host Parasite Interactions ◽  
Affinity Column Chromatography ◽  
Host Parasite

Haemonchus contortusis the most pathogenic nematode of small ruminants. Infection in sheep and goats results in anaemia that decreases animal productivity and can ultimately cause death. The involvement of ruminant-specific galectin-11 (LGALS-11) and galectin-14 (LGALS-14) has been postulated to play important roles in protective immune responses against parasitic infection; however, their ligands are unknown. In the current study, LGALS-11 and LGALS-14 ligands inH. contortuswere identified from larval (L4) and adult parasitic stages extracts using immobilised LGALS-11 and LGALS-14 affinity column chromatography and mass spectrometry. Both LGALS-11 and LGALS-14 bound more putative protein targets in the adult stage ofH. contortus(43 proteins) when compared to the larval stage (two proteins). Of the 43 proteins identified in the adult stage, 34 and 35 proteins were bound by LGALS-11 and LGALS-14, respectively, with 26 proteins binding to both galectins. Interestingly, hematophagous stage-specific sperm-coating protein and zinc metalloprotease (M13), which are known vaccine candidates, were identified as putative ligands of both LGALS-11 and LGALS-14. The identification of glycoproteins ofH. contortusby LGALS-11 and LGALS-14 provide new insights into host-parasite interactions and the potential for developing new interventions.

scholarly journals Proteomic identification of Galectin-11 and 14 ligands from Haemonchus contortus

2017 ◽  
Author(s):  
Dhanasekaran Sakthivel ◽  
Jaclyn Swan ◽  
Sarah Preston ◽  
MD Shakif-Azam ◽  
Pierre Faou ◽  
...  
Keyword(s):  
Haemonchus Contortus ◽  
Adult Stage ◽  
Parasitic Infection ◽  
Small Ruminants ◽  
Affinity Column ◽  
Protein Targets ◽  
Zinc Metalloprotease ◽  
Host Parasite Interactions ◽  
Affinity Column Chromatography ◽  
Host Parasite

Haemonchus contortus is the most pathogenic nematode of small ruminants. Infection in sheep and goats results in anaemia that decreases animal productivity and can ultimately cause death. The involvement of ruminant-specific galectin-11 (LGALS-11) and galectin-14 (LGALS-14) has been postulated to play important roles in protective immune responses against parasitic infection; however, their ligands are unknown. In the current study, LGALS-11 and LGALS-14 ligands in H. contortus were identified from larval (L4) and adult parasitic stages extracts using immobilised LGALS-11 and LGALS-14 affinity column chromatography and mass spectrometry. Both LGALS-11 and LGALS-14 bound more putative protein targets in the adult stage of H. contortus (43 proteins) when compared to the larval stage (2 proteins). Of the 43 proteins identified in the adult stage, 34 and 35 proteins were bound by LGALS-11 and LGALS-14, respectively, with 26 proteins binding to both galectins. Interestingly, hematophagous stage-specific sperm-coating protein and zinc metalloprotease (M13), which are known vaccine candidates, were identified as putative ligands of both LGALS-11 and LGALS-14. The identification of glycoproteins of H. contortus by LGALS-11 and LGALS-14 provide new insights into host-parasite interactions and the potential for developing new interventions.

scholarly journals Ligula intestinalis (Cestoda: Pseudophyllidea): an ideal fish-metazoan parasite model?

Parasitology ◽  
2010 ◽  
Vol 137 (3) ◽  
pp. 425-438 ◽  
Author(s):  
D. HOOLE ◽  
V. CARTER ◽  
S. DUFOUR
Keyword(s):  
Ecological Studies ◽  
Biological Factors ◽  
Ligula Intestinalis ◽  
Metazoan Parasite ◽  
Host Parasite Interactions ◽  
Parasite Ecology ◽  
Host Parasite ◽  
Scientific Tool

SUMMARYSince its use as a model to study metazoan parasite culture and in vitro development, the plerocercoid of the tapeworm, Ligula intestinalis, has served as a useful scientific tool to study a range of biological factors, particularly within its fish intermediate host. From the extensive long-term ecological studies on the interactions between the parasite and cyprinid hosts, to the recent advances made using molecular technology on parasite diversity and speciation, studies on the parasite have, over the last 60 years, led to significant advances in knowledge on host-parasite interactions. The parasite has served as a useful model to study pollution, immunology and parasite ecology and genetics, as well has being the archetypal endocrine disruptor.

scholarly journals Overview of Poultry Eimeria Life Cycle and Host-Parasite Interactions

2020 ◽  
Vol 7 ◽  
Author(s):  
Sara López-Osorio ◽  
Jenny J. Chaparro-Gutiérrez ◽  
Luis M. Gómez-Osorio
Keyword(s):  
Life Cycle ◽  
Host Parasite Interactions ◽  
Host Parasite

Within-host dynamics of a microsporidium with horizontal and vertical transmission:Octosporea bayeriinDaphnia magna

Parasitology ◽  
2004 ◽  
Vol 128 (1) ◽  
pp. 31-38 ◽  
Author(s):  
D. B. VIZOSO ◽  
D. EBERT
Keyword(s):  
Life Cycle ◽  
Fresh Water ◽  
Growth Dynamics ◽  
Parasite Growth ◽  
Spore Density ◽  
Parasite Life Cycle ◽  
Parasite Fitness ◽  
Host Growth ◽  
New Hosts ◽  
Host Parasite

The fresh-water crustaceanDaphnia magnamay acquire an infection with the microsporidiumOctosporea bayerieither by ingesting spores from the water (horizontally), or directly from its mother (vertically). Due to differences in the time and mechanisms of transmission, horizontal and vertical infections may lead to differences in the growth of the parasite within the host. This may influence parasite virulence, transmission to new hosts, and, consequently, epidemiology and evolution. Here we describe the within-host dynamics of 3 spore-types ofO.bayerifrom infections that were acquired either horizontally or vertically. In all treatments the number of spores increased exponentially until spore density reached a plateau, suggesting density-dependent within-host growth. The spore types seen differ in their growth dynamics, suggesting different roles in the parasite life-cycle. Horizontally-infected hosts harboured significantly fewer spores than vertically-infected hosts. Further, host survival was affected by infection route, with mortality being higher in horizontal infections than in vertical infections. Our results suggest that different routes of infection have an immediate effect on within-host parasite growth and thus on parasite fitness and epidemiology.

scholarly journals Proteomic identification of Galectin-11 and 14 ligands from Haemonchus contortus

2017 ◽  
Author(s):  
Dhanasekaran Sakthivel ◽  
Jaclyn Swan ◽  
Sarah Preston ◽  
MD Shakif-Azam ◽  
Pierre Faou ◽  
...  
Keyword(s):  
Haemonchus Contortus ◽  
Adult Stage ◽  
Parasitic Infection ◽  
Small Ruminants ◽  
Affinity Column ◽  
Protein Targets ◽  
Zinc Metalloprotease ◽  
Host Parasite Interactions ◽  
Affinity Column Chromatography ◽  
Host Parasite

Haemonchus contortus is the most pathogenic nematode of small ruminants. Infection in sheep and goats results in anaemia that decreases animal productivity and can ultimately cause death. The involvement of ruminant-specific galectin-11 (LGALS-11) and galectin-14 (LGALS-14) has been postulated to play important roles in protective immune responses against parasitic infection; however, their ligands are unknown. In the current study, LGALS-11 and LGALS-14 ligands in H. contortus were identified from larval (L4) and adult parasitic stages extracts using immobilised LGALS-11 and LGALS-14 affinity column chromatography and mass spectrometry. Both LGALS-11 and LGALS-14 bound more putative protein targets in the adult stage of H. contortus (43 proteins) when compared to the larval stage (2 proteins). Of the 43 proteins identified in the adult stage, 34 and 35 proteins were bound by LGALS-11 and LGALS-14, respectively, with 26 proteins binding to both galectins. Interestingly, hematophagous stage-specific sperm-coating protein and zinc metalloprotease (M13), which are known vaccine candidates, were identified as putative ligands of both LGALS-11 and LGALS-14. The identification of glycoproteins of H. contortus by LGALS-11 and LGALS-14 provide new insights into host-parasite interactions and the potential for developing new interventions.

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