scholarly journals Perinatal outcomes of multiple births conceived through in vitro fertilization compared with spontaneous multiple births

2018 ◽  
Vol 51 ◽  
pp. 02008
Author(s):  
Irisa Zile ◽  
Inga Jefremova ◽  
Iveta Gavare
Keyword(s):  
In Vitro Fertilization ◽  
Congenital Anomalies ◽  
Perinatal Outcomes ◽  
Perinatal Period ◽  
Population Based ◽  
Multiple Births ◽  
Control Group ◽  
Multiple Pregnancies ◽  
Vitro Fertilization

Pregnancies that occur after assisted reproduction procedures constitute high-risk pregnancies. There is a lack of sufficient epidemio-logically based data on this issue in Latvia. The aim of this study was to compare the maternal and perinatal outcomes of multiple pregnancies conceived by in vitro fertilization (IVF) in comparison with spontaneous multiple pregnancies. This retrospective cohort study (2007–2014) analysed data from population-based Medical Birth Register (MBR). There is a statistically significant increase of multiple births from IVF pregnancies – an average 2% per year (p< 0.01). Newborns of IVF multiple births have higher odds of low birth weight (OR = 1.2) and congenital anomalies (OR = 1.6). Maternity characteristics showed that mothers in the IVF group were significantly older than those in the control group (≥35 years) (OR = 2.1) and primipara births (OR = 4.1). Multiple births conceived by IVF have similar outcomes as spontaneously conceived multiples in the perinatal period, although the rates of congenital anomalies after IVF are just slightly higher than in control group.

scholarly journals Multiple births and maternal mental health from pregnancy to 5 years after birth: A longitudinal population-based cohort study

2014 ◽  
Vol 24 (1-2) ◽  
Author(s):  
Eivind Ystrom ◽  
Ted Reichborn-Kjennerud ◽  
Kristian Tambs ◽  
Per Magnus ◽  
Anne Mari Torgersen ◽  
...  
Keyword(s):  
Mental Health ◽  
Cohort Study ◽  
In Vitro Fertilization ◽  
Maternal Mental Health ◽  
Population Based ◽  
Multiple Births ◽  
Multiple Birth ◽  
Vitro Fertilization ◽  
Risk For Depression

<p><em>Background:</em> There is a lack of population-based studies on multiple births and maternal mental health. Having a high-risk pregnancy by bearing two or more children is a stressful life event, and the challenges of parenting two or more children probably also lead to a high level of parental stress. There are a few results on multiple births and maternal mental health from studies on in vitro fertilization samples. The only previous cohort study on multiple birth and maternal mental health included a single measure of depressive symptoms at 9 months postpartum. We aim to estimate the relative risk for depression and anxiety after multiple birth in a population-based prospective cohort study while adjusting for factors prior and subsequent to fertilization.</p><p><em>Methods</em>: We used data from 87,807 pregnancies included in the Norwegian Mother and Child Cohort study. Information on multiple birth was retrieved from the Norwegian Medical Birth Registry, and maternal mental health was assessed at 17th and 30th week of gestation and 0.5, 1.5, 3, and 5 years postpartum. There were 1,842 plural births included in the study (i.e. 1,821 twin births and 21 higher order births). We predicted maternal mental health at each time point, subsequently adjusting for 1) factors prior to fertilization (e.g. maternal age and in vitro fertilization); 2) factors during pregnancy (e.g. hypertensive states); 3) factors at delivery (e.g. cesarean section); 4) child-related postnatal complications (e.g. intracranial hemorrhage); and 5) concurrent depression or anxiety after pregnancy.</p><p><em>Results</em>: Adjusted for antecedents of plural birth, mothers expecting a plural birth had a normal risk for anxiety (RR=1.05; 95% CI 0.92-1.20) and depression (RR=1.02; 95% CI 0.89-1.16) at 17th week of gestation. However, plural birth was associated with maternal depression at 1.5, 3, and 5 years postpartum and maternal anxiety at 3 years postpartum. The trend was for the association to increase across time, and mothers of multiplets had a significant higher risk for depression at 5 years (RR=1.77; 95% CI 1.33-2.35). Fully adjusted the RR for depression was 1.51 (95% CI 1.10-2.08). By adjusting depression for concurrent anxiety, and vice versa we found the effect of multiple pregnancy to be specific to depression and not anxiety.</p><p><em>Conclusions:</em> Mothers expecting multiplets have normal mental health during pregnancy. After birth there is an increasing risk for depression up to 5 years of age. Our findings indicate that more is simply more, and mothers of multiplets have need for additional support several years postpartum</p>

scholarly journals Effects of in vitro fertilization and maternal characteristics on perinatal outcomes: a population-based study using siblings

2016 ◽  
Vol 105 (3) ◽  
pp. 590-598.e2 ◽  
Author(s):  
Jorien Seggers ◽  
Martina Pontesilli ◽  
Anita C.J. Ravelli ◽  
Rebecca C. Painter ◽  
Mijna Hadders-Algra ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Perinatal Outcomes ◽  
Population Based ◽  
Population Based Study ◽  
Vitro Fertilization ◽  
Maternal Characteristics

scholarly journals Effects of fetal reduction in multi-fetal pregnancy on perinatal outcomes

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Neda Razaz ◽  
Tehila Avitan ◽  
Tracy Pressey ◽  
K.S. Joseph
Keyword(s):  
In Vitro Fertilization ◽  
Preterm Delivery ◽  
Perinatal Outcomes ◽  
Neonatal Morbidity ◽  
Population Based ◽  
Singleton Pregnancy ◽  
Reduction Procedure ◽  
Vitro Fertilization ◽  
Fetal Reduction

ABSTRACTBackgroundThere is currently insufficient evidence regarding the prognosis of multi-fetal pregnancies reduced to twins or singletons. We compared the perinatal outcomes of deliveries following fetal reduction with the perinatal outcomes of deliveries without fetal reduction. MethodsWe carried out a retrospective cohort study of all births in British Columbia between 2009 and 2013, using information from a population-based database. Comparisons were made between all women who had a fetal reduction to a twin or a singleton pregnancy with those who did not undergo a fetal reduction procedure. The outcomes of interest were preterm delivery and composite severe neonatal morbidity or perinatal mortality. Generalized estimating equations adjusting for maternal age, parity, pre-pregnancy weight, use of in vitro fertilization and baby’s sex were used to estimate odds ratios (OR) and 95% confidence intervals (CI). ResultsAmong 207,273 deliveries, 139 (0.07%) had a fetal reduction. Of these, 89 women delivered twins and 50 delivered singletons. Women who had a fetal reduction were more likely to have conceived with in vitro fertilization (77.6%) compared with those who did not (3.31%). Twins delivered after fetal reduction had lower rates of neonatal morbidity/mortality (OR 0.19, 95% CI 0.08-0.42) compared with unreduced triplets but rates similar to those of twins without a reduction procedure (OR 1.44, 95% CI 0.81-2.58). Singletons delivered after fetal reduction had non-significantly lower rates of neonatal morbidity/mortality than unreduced twins (OR 0.75, 95% CI 0.36-1.57) but significantly higher rates of neonatal morbidity/mortality (OR 3.98, 95% CI 1.91-8.30), preterm delivery and being small for gestational age than singleton pregnancies without a reduction procedure. ConclusionPerinatal outcomes of twins delivered after fetal reduction are better than those of unreduced triplets and similar to those of unreduced twins.

Levels interleukine-4 and interleukin-17 (IL-4, IL-17) of blood in patients with habitual recurrent pregnancy loss, which occurred in a loop in vitro fertilization

2016 ◽  
pp. 137-139
Author(s):  
K.P. Golovatyuk ◽  
Keyword(s):  
In Vitro Fertilization ◽  
Conditioned Medium ◽  
Mononuclear Cells ◽  
Recurrent Miscarriage ◽  
Interleukin 4 ◽  
Control Group ◽  
Interleukin 17 ◽  
Vitro Fertilization ◽  
Blood Mononuclear Cells

The objective: was to investigate the levels of cytokines IL-4 and IL-17 in serum and conditioned medium cultures of blood mononuclear cells (MNC) and evaluation association between their products and miscarriage, which occurred in IVF cycles. Patients and methods. We observed 240 patients with recurrent miscarriage, came in IVF cycles, and 100 apparently healthy fertile women in the control group. The concentrations of IL-4 and IL-17 in serum and conditioned medium of MNC cultures were determined. Results. The levels of IL-4 in the serum and conditioned medium in spontaneous and stimulated mitogen secretion was not significantly different from those in the control group, whereas IL-17 levels were higher than those in the control group serum, in conditioned media of stimulated and non-stimulated MNCs. Conclusion. Disregulation of activity of circulating blood mononuclear cells in women with recurrent miscarriage that followed IVF, is accompanied by increased secretion of IL-17 and almost constant production of IL-4 on the back of high stimulation index of production of these cytokines. Key words: in vitro fertilization, miscarriage, interleukin-4, interleukin-17, serum stimulated and non-stimulated mononuclear blood.

Peculiarities of pregnancy and delivery course in women after the application of assisted reproductive technologies against obesity (Based on the retrospective analysis)

2018 ◽  
pp. 122-126
Author(s):  
I.A. Zhabchenko ◽  
◽  
O.R. Sudmak ◽  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnant Women ◽  
Retrospective Analysis ◽  
Perinatal Outcomes ◽  
Reproductive Technologies ◽  
Ischemic Lesion ◽  
Vitro Fertilization ◽  
Pregnancy And Delivery

The objective: to study the structure and frequency of complications of pregnancy, deliveries and perinatal outcomes in three groups of women: women with infertility and obesity, treated by application of in vitro fertilization (hereinafter IVF), pregnant women after IVF application with normal body weight, and pregnant women on the background of obesity which did not have an infertility in past history. Materials and methods. A retrospective analysis of 221 case histories of pregnancies and labors in women who were treated and gave birth in the Pregnancy and delivery pathology Department of SI «Institute of Pediatrics, Obstetrics and Gynecology named after Acad. O. M. Lukyanova of NAMS of Ukraine» for 2012 – 2016 years was carried out. Results. The overwhelming majority of pregnant women after IVF on the background of obesity are primaparas, who have a complicated obstetric history, hormonal changes in the form of progesterone deficiency predominantly and chronic inflammatory processes. Pregnancy with a combination of infertility, treated by the means of IVF application, and obesity, in most cases is accompanied by a long-term threat of termination of pregnancy (48.8%), threatening preterm deliveries (56%), placental dysfunction (41.5%), premature rupture of the amniotic membranes (41.5%), other problems during pregnancy, at the same time, every second woman (58.5%) had a combination of several complications, and required a long-term and repeated inpatient treatment (53.7%). The specific gravity of surgical delivery was 90%, and 16.2% of such deliveries were complicated by pathological blood loss. The number of preterm deliveries was 17.1%, with perinatal losses up to 11.3‰. Among full-term newborns 21.3% of newborns had malnutrition of the I degree and 17% of them had hypoxic-ischemic lesion of CNS. Conclusion. The course of pregnancy, delivery and the postpartum period in the studied contingent of women has a significant frequency of complications, mainly the coinciding ones, which affects on the consequences of perinatal outcomes and requires further study of this problem and the development of differentiated algorithms for antenatal observation. Key words: pregnancy, obesity, in vitro fertilization, complications, delivery, newborn.

Fertility Treatments and the Risk of Preterm Birth Among Women with Subfertility: A Linked-Data Retrospective Cohort Study

2021 ◽  
Author(s):  
Jessica N Sanders ◽  
Sara E Simonsen ◽  
Christina A Porucznik ◽  
Ahmad O Hammoud ◽  
Ken Smith ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Birth ◽  
In Vitro Fertilization ◽  
Retrospective Cohort ◽  
Fetal Death ◽  
Perinatal Outcomes ◽  
Birth Certificates ◽  
Vitro Fertilization ◽  
Fertility Treatments

Abstract Background: In vitro fertilization (IVF) births contribute to a considerable proportion of preterm birth (PTB) each year. However, there is no formal surveillance of adverse perinatal outcomes for less invasive fertility treatments. The study objective was to determine the effect of fertility treatment (in vitro fertilization, intrauterine insemination, usually with ovulation drugs (IUI), or ovulation drugs alone) on preterm birth, compared to no treatment in subfertile women.Methods: The Fertility Experiences Study (FES) is a retrospective cohort study conducted at the University of Utah between April 2010 and September 2012. Women with a history of primary subfertility self-reported treatment data via survey and interviews. Participant data were linked to birth certificates and fetal death records to asses for perinatal outcomes, particularly preterm birth.Results: A total 487 birth certificates and 3 fetal death records were linked as first births for study participants who completed questionnaires. Among linked births, 19% had a PTB. After adjustment for maternal age, paternal age, maternal education, annual income, religious affiliation, female or male fertility diagnosis, and duration of subfertility, the odds ratios and 95% confidence intervals (CI) for PTB were 2.17 (CI: 0.99, 4.75) for births conceived using ovulation drugs, 3.17 (CI: 1.4, 7.19) for neonates conceived using IUI and 4.24 (CI: 2.05, 8.77) for neonates conceived by IVF, compared to women with subfertility who used no treatment during the month of conception. A reported diagnosis of female factor infertility increased the adjusted odds of having a PTB 2.99 (CI: 1.5, 5.97). Duration of pregnancy attempt was not independently associated with PTB. In restricting analyses to singleton gestation, odds ratios remained elevated but were not significant for any type of treatment.Conclusion: IVF, IUI, and ovulation drugs were all associated with a higher incidence of preterm birth and low birth weight, predominantly related to multiple gestation births.

Population-Based Study of Cesarean Section After In Vitro Fertilization in Australia

Birth ◽  
2010 ◽  
Vol 37 (3) ◽  
pp. 184-191 ◽  
Author(s):  
Elizabeth A. Sullivan ◽  
Michael G. Chapman ◽  
Yueping A. Wang ◽  
G. David Adamson
Keyword(s):  
In Vitro Fertilization ◽  
Cesarean Section ◽  
Population Based ◽  
Population Based Study ◽  
Vitro Fertilization
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