Clinical implications of disturbances of uterine vascular morphology and function

2000 ◽  
Vol 14 (6) ◽  
pp. 937-951 ◽  
Author(s):  
Martha Hickey ◽  
Ian S Fraser
Keyword(s):  
Clinical Implications ◽  
Vascular Morphology ◽  
And Function

scholarly journals NG2 expression regulates vascular morphology and function in human brain tumours

NeuroImage ◽  
2006 ◽  
Vol 29 (3) ◽  
pp. 965-976 ◽  
Author(s):  
C. Brekke ◽  
A. Lundervold ◽  
P.Ø. Enger ◽  
C. Brekken ◽  
E. Stålsett ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Tumours ◽  
Vascular Morphology ◽  
Human Brain Tumours ◽  
And Function

scholarly journals Elastic fibers in orthopedics: Form and function in tendons and ligaments, clinical implications, and future directions

2020 ◽  
Vol 38 (11) ◽  
pp. 2305-2317 ◽  
Author(s):  
Jeffrey Ryan Hill ◽  
Jeremy D. Eekhoff ◽  
Robert H. Brophy ◽  
Spencer P. Lake
Keyword(s):  
Elastic Fibers ◽  
Clinical Implications ◽  
Future Directions ◽  
Form And Function ◽  
And Function

scholarly journals Computed Tomographic Measures of Pulmonary Vascular Morphology in Smokers and Their Clinical Implications

2013 ◽  
Vol 188 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Raúl San José Estépar ◽  
Gregory L. Kinney ◽  
Jennifer L. Black-Shinn ◽  
Russell P. Bowler ◽  
Gordon L. Kindlmann ◽  
...  
Keyword(s):  
Clinical Implications ◽  
Computed Tomographic ◽  
Vascular Morphology

Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice

2007 ◽  
Vol 292 (1) ◽  
pp. R440-R446 ◽  
Author(s):  
John N. Lorenz ◽  
Lois J. Arend ◽  
Rachel Robitz ◽  
Richard J. Paul ◽  
A. John MacLennan
Keyword(s):  
Knockout Mice ◽  
Vascular Function ◽  
Vascular Dysfunction ◽  
Vascular Morphology ◽  
Relative Contribution ◽  
Sphingosine 1 Phosphate ◽  
In Vivo Analysis ◽  
And Function ◽  
Isometric Forces

There is growing evidence that sphingosine 1-phosphate (S1P) plays an important role in regulating the development, morphology, and function of the cardiovascular system. There is little data, however, regarding the relative contribution of endogenous S1P and its cognate receptors (referred to as S1P1–5) to cardiovascular homeostasis. We used S1P2 receptor knockout mice (S1P2−/−) to evaluate the role of S1P2 in heart and vascular function. There were no significant differences in blood pressure between wild-type and S1P2−/− mice, measured in awake mice. Cardiac function, evaluated in situ by using a Millar catheter, was also not different in S1P2−/− mice under baseline or stimulated conditions. In vivo analysis of vascular function by flowmetry revealed decreases in mesenteric and renal resistance in S1P2−/− mice, especially during vasoconstriction with phenylephrine. In intact aortic rings, the concentration-force relations for both KCl and phenylephrine were right shifted in S1P2−/− mice, whereas the maximal isometric forces were not different. By contrast, in deendothelialized rings the concentration-force relations were not different but the maximal force was significantly greater in S1P2−/− aorta. Histologically, there were no apparent differences in vascular morphology. These data suggest that the S1P2 receptor plays an important role in the function of the vasculature and is an important mediator of normal hemodynamics. This is mediated, at least in part, through an effect on the endothelium, but direct effects on vascular smooth muscle cannot be ruled out and require further investigation.

scholarly journals Current understanding of thalamic structure and function in migraine

Cephalalgia ◽  
2018 ◽  
Vol 39 (13) ◽  
pp. 1675-1682 ◽  
Author(s):  
Samaira Younis ◽  
Anders Hougaard ◽  
Rodrigo Noseda ◽  
Messoud Ashina
Keyword(s):  
Drug Target ◽  
Critical Role ◽  
Structure And Function ◽  
Pain Modulation ◽  
Clinical Implications ◽  
Important Position ◽  
Cortical Regions ◽  
And Function ◽  
Thalamic Structure

Objective To review and discuss the literature on the role of thalamic structure and function in migraine. Discussion The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal functional connectivity between the thalamus and various cortical regions pointing towards an altered pain processing in migraine. Pharmacological nociceptive modulation suggests that the thalamus is a potential drug target. Conclusion A critical role for the thalamus in migraine-related allodynia and photophobia is well established. Additionally, the thalamus is most likely involved in the dysfunctional pain modulation and processing in migraine, but further research is needed to clarify the exact clinical implications of these findings.

Update on the Structure and Function of the Skin Barrier: Atopic Dermatitis as an Exemplar of Clinical Implications

2013 ◽  
Vol 32 (2S) ◽  
pp. S21-S24 ◽  
Author(s):  
Peter Elias ◽  
Lawrence Eichenfield ◽  
Joseph Fowler ◽  
Paul Horowitz ◽  
Renee McLeod
Keyword(s):  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Structure And Function ◽  
Clinical Implications ◽  
And Function

Branching tree model with fractal vascular resistance explains fractal perfusion heterogeneity

2003 ◽  
Vol 284 (5) ◽  
pp. H1848-H1857 ◽  
Author(s):  
M. Marxen ◽  
R. M. Henkelman
Keyword(s):  
Experimental Data ◽  
Imaging Techniques ◽  
Model Parameters ◽  
Tree Model ◽  
Vascular Morphology ◽  
Fractal Parameters ◽  
Free Model ◽  
Branch Vessel ◽  
Vessel Resistance ◽  
And Function

Perfusion heterogeneities in organs such as the heart obey a power law as a function of scale, a behavior termed “fractal.” An explanation of why vascular systems produce such a specific perfusion pattern is still lacking. An intuitive branching tree model is presented that reveals how this behavior can be generated as a consequence of scale-independent branching asymmetry and fractal vessel resistance. Comparison of computer simulations to experimental data from the sheep heart shows that the values of the two free model parameters are realistic. Branching asymmetry within the model is defined by the relative tissue volume being fed by each branch. Vessel ordering for fractal analysis of morphology based on fed or drained tissue volumes is preferable to the commonly used Strahler system, which is shown to depend on branching asymmetry. Recently, noninvasive imaging techniques such as PET and MRI have been used to measure perfusion heterogeneity. The model allows a physiological interpretation of the measured fractal parameters, which could in turn be used to characterize vascular morphology and function.

BAG-1 in carcinogenesis

2004 ◽  
Vol 6 (7) ◽  
pp. 1-15 ◽  
Author(s):  
Adam Sharp ◽  
Simon J. Crabb ◽  
Ramsey I. Cutress ◽  
Matthew Brimmell ◽  
Xiu-hong Wang ◽  
...  
Keyword(s):  
Human Cancer ◽  
Predictive Marker ◽  
Nuclear Hormone Receptor ◽  
Response To Therapy ◽  
Clinical Implications ◽  
Multifunctional Protein ◽  
Cellular Processes ◽  
Wide Range ◽  
Cancer Types ◽  
And Function

BAG-1 is a multifunctional protein that exists as several differentially localised and functionally distinct isoforms. BAG-1 isoforms interact with a diverse array of molecular targets and regulate a wide range of cellular processes, including proliferation, survival, transcription, apoptosis, metastasis and motility. The BAG domain of BAG-1 interacts with chaperone molecules and this is considered important for many BAG-1 functions. The ability of BAG-1 to regulate such a wide variety of cellular processes suggests it might play an important role in many cancer types. For example, regulation of nuclear hormone receptor function and susceptibility to apoptosis might have a major impact on cancer development, progression and response to therapy. There is also increasing evidence that BAG-1 expression is altered in a variety of human malignancies relative to normal cells, and with further understanding of BAG-1 function it might become a powerful prognostic/predictive marker in human cancer. This review describes the structure and function of BAG-1 isoforms and the potential clinical implications of their expression in tumour cells.

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