scholarly journals Exercise-induced neurocardiogenic syncope

EP Europace ◽  
2000 ◽  
Vol 2 (1) ◽  
pp. 77-82 ◽  
Author(s):  
D. Kosinski ◽  
B.P. Grubb ◽  
B.J. Karas ◽  
S. Frederick
Keyword(s):  
Heart Disease ◽  
Neurocardiogenic Syncope ◽  
Diagnostic Challenge ◽  
Electrical Heart Disease ◽  
Life Threatening ◽  
Qt Syndrome ◽  
Exercise Induced ◽  
Anomalous Coronary ◽  
Upright Tilt

Abstract The evaluation of syncope occurring during exercise or occurring spontaneously in highly trained individuals presents a unique diagnostic challenge. It is of critical importance to exclude potential life-threatening disorders such as hypertrophic cardiomyopathy, long QT syndrome, right ventricular dysplasia, anomalous coronary artery distribution, valvular heart disease, myocarditis, or exercise-induced arrhythmia. This review is not directed towards identifying, treating, or determining athletic eligibility of individuals with such disorders. Rather, we endeavour to discuss the pathophysiology of exercise-induced neurocardiogenic syncope and to address the role of head upright tilt testing in evaluating syncope in athletic individuals in whom proper evaluation has excluded the presence of ischaemic heart disease or primary structural or electrical heart disease.

‘Lipo-tourism’ gone wrong: blood transfusion-transmitted cytomegalovirus disease

2021 ◽  
Vol 14 (3) ◽  
pp. e236892
Author(s):  
Mark Brahier ◽  
Rhanika Neuda ◽  
William Davis ◽  
Rita Poon
Keyword(s):  
Blood Transfusion ◽  
Medical Tourism ◽  
Wound Dehiscence ◽  
Immunocompetent Patient ◽  
Cytomegalovirus Disease ◽  
Diagnostic Challenge ◽  
Risks And Benefits ◽  
Life Threatening ◽  
Cmv Disease

Medical tourism is the pursuit of more affordable surgeries; however, this comes at the risk of suboptimal standards and potential for life-threatening complications. In this case, we describe the diagnostic challenge of cytomegalovirus (CMV) pneumonia in a 40-year-old woman who experienced wound dehiscence and subsequent blood transfusion-transmitted CMV as complications of liposuction in the Dominican Republic. We explore the role of histopathology in the diagnosis of disseminated CMV, discuss the underlying aetiology of CMV pneumonia in this patient and weigh the risks and benefits of initiating antiviral therapy in an immunocompetent patient with CMV disease.

Role of interventional therapy in patients with coronary heart disease and life-threatening ventricular tachyarrhythmias

1993 ◽  
Vol 14 (suppl E) ◽  
pp. 120-127 ◽  
Author(s):  
H.-J. Trappe ◽  
H. Klein ◽  
P. Wenzlaff ◽  
H.-G. Fieguth ◽  
T. Wahlers ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Interventional Therapy ◽  
Ventricular Tachyarrhythmias ◽  
Life Threatening

Monogenic and oligogenic cardiovascular diseases: genetics of arrhythmias—long QT syndrome

ESC CardioMed ◽  
2018 ◽  
pp. 671-676
Author(s):  
Andrea Mazzanti ◽  
Riccardo Maragna ◽  
Silvia G. Priori
Keyword(s):  
Long Qt Syndrome ◽  
Diagnostic Process ◽  
Long Qt ◽  
Polygenic Inheritance ◽  
Life Threatening ◽  
Ion Channel Proteins ◽  
Qt Syndrome ◽  
Adrenergic Activation ◽  
Choice Of Therapy

Long QT syndrome(s) (LQTS) includes a group of inherited arrhythmogenic disorders characterized by a prolonged cardiac repolarization that predisposes to the development of life-threatening arrhythmias, typically in conditions of adrenergic activation (exercise, emotions). LQTS can show both autosomal dominant and autosomal recessive transmission with variable penetrance. Several genes have been causally linked to the disease phenotype, all coding for ion channel proteins and their regulatory partners that control cardiac action potentials duration. To date, 17 genes have been identified. Still, the first three genotypes discovered in the early nineties (LQT1, LQT2, and LQT3) account for the large majority of mutation-positive cases (approximately 80–90%). Genotype-negative LQTS subjects still represent an area of investigation: large duplications and deletions, undetectable to standard screening methodologies and, more recently, polygenic inheritance and the role of modifiers are emerging as possible players for (apparently) genotype-negative LQTSx1. Knowing the genotype of a LQTS patient can provide a relevant contribution for the clinical management by supporting the diagnostic process, the risk stratification, and the choice of therapy.

Heart Disease Induced by AAS Abuse, Using Experimental Mice/Rats Models and the Role of Exercise-Induced Cardiotoxicity

2011 ◽  
Vol 11 (5) ◽  
pp. 409-424 ◽  
Author(s):  
I. Riezzo ◽  
D. De Carlo ◽  
M. Neri ◽  
A. Nieddu ◽  
E. Turillazzi ◽  
...  
Keyword(s):  
Heart Disease ◽  
Exercise Induced

Exercise-Induced Fibrinolysis – Fact or Fiction?

1982 ◽  
Vol 48 (02) ◽  
pp. 201-203 ◽  
Author(s):  
N A Marsh ◽  
P J Gaffney
Keyword(s):  
Plasminogen Activator ◽  
Degradation Products ◽  
Coagulation Factors ◽  
Vascular Wall ◽  
Strenuous Exercise ◽  
Fibrin Degradation Products ◽  
Real Increase ◽  
Exercise Induced ◽  
Male Subjects

SummaryThe effect of strenuous exercise on the fibrinolytic and coagulation mechanisms was examined in six healthy male subjects. Five min bicycle exercise at a work-rate of 800 to 1200 kpm. min−1 produced an abrupt increase in plasma plasminogen activator levels which disappeared after 90 min. However, there was no change in early or late fibrin degradation products nor was there a change in fibrinopeptide A levels or βthromboglobulin levels after exercise although activated partial thromboplastin times were significantly shortened. It is concluded that strenuous exercise does not produce any real increase in fibrinogen-fibrin conversion nor any real increase in the breakdown of these proteins. The role of exercise-induced release of plasminogen activator remains unclear, but probably helps to maintain plasma levels in a discontinuous manner concurrently with the continuous low-level secretion from the vascular wall. The shortening of partial thromboplastin time may be due to the raised levels of plasminogen activator changing the activation state of other coagulation factors.

Role of the sympathoadrenal system in exercise-induced inhibition of insulin secretion. Effects of islet transplantation

Diabetes ◽  
1995 ◽  
Vol 44 (5) ◽  
pp. 565-571 ◽  
Author(s):  
H. Houwing ◽  
K. M. Frankel ◽  
J. H. Strubbe ◽  
P. T. van Suylichem ◽  
A. B. Steffens
Keyword(s):  
Insulin Secretion ◽  
Islet Transplantation ◽  
Sympathoadrenal System ◽  
Exercise Induced

SARS-COV2 virus and Coronavirus disease (COVID-19)

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 977-982
Author(s):  
Mohamed J. Saadh ◽  
Bashar Haj Rashid M ◽  
Roa’a Matar ◽  
Sajeda Riyad Aldibs ◽  
Hala Sbaih ◽  
...  
Keyword(s):  
Close Contact ◽  
Antiviral Agents ◽  
Health Concern ◽  
The Novel ◽  
Global Public Health ◽  
Fatal Disease ◽  
Mild Disease ◽  
Life Threatening ◽  
Novel Coronavirus

SARS-COV2 virus causes Coronavirus disease (COVID-19) and represents the causative agent of a potentially fatal disease that is of great global public health concern. The novel coronavirus (2019) was discovered in 2019 in Wuhan, the market of the wet animal, China with viral pneumonia cases and is life-threatening. Today, WHO announces COVID-19 outbreak as a pandemic. COVID-19 is likely to be zoonotic. It is transmitted from bats as intermediary animals to human. Also, the virus is transmitted from human to human who is in close contact with others. The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. Treatment is nearly supportive; the role of antiviral agents is yet to be established. The SARS-COV2 virus spreads faster than its two ancestors, the SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), but has lower fatality. In this article, we aimed to summarize the transmission, symptoms, pathogenesis, diagnosis, treatment, and vaccine to control the spread of this fatal disease.

Modern ideas about the role of hyperuricemia in the pathogenesis of coronary heart disease

2018 ◽  
Vol 2 (1) ◽  
pp. 47-54
Author(s):  
Eleonora TASHKENBAEVA ◽  
◽  
Dilshod TOGAEV ◽  
Farzona KADIROVA ◽  
Shukhrat ZIYADULLAEV ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease
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