scholarly journals Human bladder cancer invasion model using rat bladder in vitro and its use to test mechanisms and therapeutic inhibitors of invasion

2001 ◽  
Vol 84 (4) ◽  
pp. 558-564 ◽  
Author(s):  
C Fujiyama ◽  
A Jones ◽  
S Fuggle ◽  
R Bicknell ◽  
D Cranston ◽  
...  
2002 ◽  
pp. 1482-1486 ◽  
Author(s):  
ADAM JONES ◽  
CHISATO FUJIYAMA ◽  
KEVIN TURNER ◽  
DAVID CRANSTON ◽  
KAYE WILLIAMS ◽  
...  

2002 ◽  
Vol 167 (3) ◽  
pp. 1482-1486 ◽  
Author(s):  
ADAM JONES ◽  
CHISATO FUJIYAMA ◽  
KEVIN TURNER ◽  
DAVID CRANSTON ◽  
KAYE WILLIAMS ◽  
...  

Author(s):  
Feifan Wang ◽  
Yan Zhang ◽  
Xuejian Zhou ◽  
Xianwu Chen ◽  
Jiayong Xiang ◽  
...  

Circular RNA (circRNA) is a newly discovered endogenous non-coding RNA (ncRNA), which is characterized with a closed circular structure. A growing body of evidence has verified the vital roles of circRNAs in human cancer. In this research, we selected circPPP1CB as a study object by circRNA sequencing and quantitative real-time PCR (qRT-PCR) validation in human bladder cancer (BC). CircPPP1CB is downregulated in BC and is negatively correlated with clinical stages and histological grades. Functionally, circPPP1CB modulated cell growth, metastasis, and epithelial-to-mesenchymal transition (EMT) process in vitro and in vivo. Mechanically, we performed various experiments to verify the circPPP1CB/miR-1307-3p/SMG1 regulatory axis. Taken together, our results demonstrated that circPPP1CB participates in tumor growth, metastasis, and EMT process by interacting with the miR-1307-3p/SMG1 axis, and that circPPP1CB might be a novel therapeutic target and diagnostic biomarker in human BC.


2000 ◽  
Vol 72 (2) ◽  
pp. 226 ◽  
Author(s):  
René C. Krieg ◽  
Sonja Fickweiler ◽  
Otto S. Wolfbeis ◽  
Ruth Knuechel

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