scholarly journals Circular RNA CircPPP1CB Suppresses Tumorigenesis by Interacting With the MiR-1307-3p/SMG1 Axis in Human Bladder Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Feifan Wang ◽  
Yan Zhang ◽  
Xuejian Zhou ◽  
Xianwu Chen ◽  
Jiayong Xiang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Epithelial To Mesenchymal Transition ◽  
Human Cancer ◽  
Circular Rna ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Mesenchymal Transition ◽  
Circular Structure

Circular RNA (circRNA) is a newly discovered endogenous non-coding RNA (ncRNA), which is characterized with a closed circular structure. A growing body of evidence has verified the vital roles of circRNAs in human cancer. In this research, we selected circPPP1CB as a study object by circRNA sequencing and quantitative real-time PCR (qRT-PCR) validation in human bladder cancer (BC). CircPPP1CB is downregulated in BC and is negatively correlated with clinical stages and histological grades. Functionally, circPPP1CB modulated cell growth, metastasis, and epithelial-to-mesenchymal transition (EMT) process in vitro and in vivo. Mechanically, we performed various experiments to verify the circPPP1CB/miR-1307-3p/SMG1 regulatory axis. Taken together, our results demonstrated that circPPP1CB participates in tumor growth, metastasis, and EMT process by interacting with the miR-1307-3p/SMG1 axis, and that circPPP1CB might be a novel therapeutic target and diagnostic biomarker in human BC.

1125 SILENCING NOTCH-1 AND NOTCH-3 PROMOTES EPITHELIAL-TO-MESENCHYMAL TRANSITION (EMT) AND SELF-RENEWAL POTENTIAL IN HUMAN BLADDER CANCER

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Wolfgang Jaeger ◽  
Tetsutaro Hayashi ◽  
Shannon Awrey ◽  
Kilian M. Gust ◽  
Thomas Cordonnier ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Epithelial To Mesenchymal Transition ◽  
Human Bladder Cancer ◽  
Notch 1 ◽  
Human Bladder ◽  
Self Renewal ◽  
Mesenchymal Transition ◽  
Notch 3

scholarly journals Repression of engrailed 2 inhibits the proliferation and invasion of human bladder cancer in vitro and in vivo

2015 ◽  
Vol 33 (5) ◽  
pp. 2319-2330 ◽  
Author(s):  
YUNFEI LI ◽  
HAITAO LIU ◽  
CAIYONG LAI ◽  
ZEXUAN SU ◽  
BAOLI HENG ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Proliferation And Invasion

AG-013736, a novel VEGF receptor and PDGF receptor inhibitor with potent activity against human bladder carcinoma in vitro and in vivo.

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 13109-13109 ◽  
Author(s):  
K. Zhu ◽  
M. Pino ◽  
A. O. Siefker-Radtke ◽  
D. Shalinsky ◽  
D. Hu-Lowe ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Growth Factor ◽  
Kinase Inhibitor ◽  
Vegf Receptor ◽  
Pdgf Receptor ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Clinical Drugs

13109 The receptors for vascular endothelial growth factor and platelet-derived growth factor (VEGFR-2 and PDGFR) play essential and complementary roles in angiogenesis, and combined inhibition of these receptors may therefore result in potent antitumor activity in vivo. Here we characterized the effects of a small molecule tyrosine kinase inhibitor AG-013736 (Pfizer) in HUVEC and human bladder cancer cells. Previously, AG-013736 was reported to inhibit VEGFRs with picomolar potency and PDGFRs with nanomolar activity. All of the cell lines examined displayed cell surface VEGFR-2 and PDGFR α and β expression as measured by flow cytometry. Low nanomolar concentrations of AG-013736 blocked the HUVEC cell proliferation with inhibition of VEGF receptor 2 and PDGF receptor phosphorylation. AG-013736 caused regression of established subcutaneous human bladder cancer xenografts, effects that were associated with inhibition of VEGFR-2 and PDGFR β phosphorylation but not EGFR phosphorylation and reduction in tumor microvessel densities (MVDs). Our results demonstrate that AG-013736 has substantial anti-angiogenesis activity in preclinical models of human bladder cancer, which warrants further exploration either alone or with the combination of other pre-clinical drugs in bladder cancer treatment. No significant financial relationships to disclose.

scholarly journals Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer

2005 ◽  
Vol 93 (3) ◽  
pp. 346-354 ◽  
Author(s):  
J J Ord ◽  
E H Streeter ◽  
I S D Roberts ◽  
D Cranston ◽  
A L Harris
Keyword(s):  
Gene Expression ◽  
Bladder Cancer ◽  
Human Bladder Cancer ◽  
Human Bladder
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