P2Y12 Polymorphisms and the Risk of Adverse Clinical Events in Patients Treated with Clopidogrel: A Meta-Analysis

Abstract Background and study aim Some studies have reported an association between P2Y12 gene polymorphisms and clopidogrel adverse outcomes with inconsistent results. We aimed to explore the relationship between P2Y12 polymorphisms and the risk of adverse clinical events in patients treated with clopidogrel through a meta-analysis. Methods A systematic search of PubMed, Web of Science and the Cochrane Library was conducted. Retrieved articles were comprehensively reviewed and eligible studies were included, and the relevant data was extracted for this meta-analysis. All statistical tests were performed by the Review Manager 5.3 software. Results A total of 14 studies involving 8,698 patients were included. In the Han Chinese population, ischemic events were associated with P2Y12 T744C polymorphism in the CC vs TT+CT genetic model (OR=3.32, 95%CI=1.62-6.82, P=0.001), and the events were associated with P2Y12 C34T polymorphism in the TT+TC vs CC genetic model (OR=1.70, 95%CI=1.22-2.36, P=0.002). However, ischemic events were not related to P2Y12 G52T polymorphism (TT+TG vs GG: OR=1.13, 95%CI=0.76-1.68, P=0.56; TT vs GG+TG: OR=2.02, 95%CI=0.65-6.28, P=0.22). The associations between the P2Y12 polymorphism and ischemic events were not significant in T744C, G52T and C34T genotype for another subgroup of the Caucasian population (P>0.05). Only two studies referring to bleeding events were included in this analysis of C34T polymorphism, and no significant association was found (TT+TC vs CC: OR=1.07, 95%CI=0.37-3.15, P=0.90). Conclusions In the Caucasian population, P2Y12 gene polymorphisms are not associated with clinical events. However, in the Chinese Han population, P2Y12 T744C and C34T polymorphisms are significantly associated with adverse clinical events.

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Ethnicity-stratified analysis of the association between XRCC3 Thr241Met polymorphism and leukemia: an updated meta-analysis

BMC Medical Genomics ◽

10.1186/s12920-021-01076-w ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Zhengjun Xie ◽

Wei Peng ◽

Qiuhua Li ◽

Wei Cheng ◽

Xin Zhao

Keyword(s):

Genetic Model ◽

Meta Analysis ◽

Search Time ◽

Caucasian Population ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Xrcc3 Thr241met ◽

The Cochrane Library ◽

Stratified Analysis

Abstract Background Presently, whether X-ray repair cross complementing group 3 (XRCC3) Thr241Met polymorphism is correlated to leukemia risk remains controversial. Because of this reason, the objective of current study is to explore whether XRCC3 Thr241Met polymorphism confers risk to leukemia. Methods Two independent authors systematically and comprehensively searched Pubmed, Embase, the Cochrane library, Google academic, China National Knowledge Infrastructure (CNKI). Search time is from database foundation to March 2021. Results Overall, significant associations between leukemia risk and XRCC3 Thr241Met polymorphism were found in Caucasian population by allele contrast (T vs. C: OR 1.20, 95% CI 1.02–1.40), homozygote comparison (TT vs. CC: OR 1.35, 95% CI 1.05–1.73), and recessive genetic model (TT vs. TC/CC: OR 1.31, 95% CI 1.04–1.64). Conclusions The present meta-analysis suggests that the XRCC3 Thr241Met polymorphism may be a risk factor for leukemia in Caucasian population.

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Associations between LPL gene polymorphisms and coronary artery disease: evidence based on an updated and cumulative meta-analysis

Bioscience Reports ◽

10.1042/bsr20171642 ◽

2018 ◽

Vol 38 (2) ◽

Cited By ~ 3

Author(s):

Wen-Qi Ma ◽

Ying Wang ◽

Xi-Qiong Han ◽

Yi Zhu ◽

Nai-Feng Liu

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Gene Polymorphisms ◽

Genetic Model ◽

Meta Analysis ◽

Cochrane Library ◽

Increased Risk ◽

Lpl Gene ◽

Artery Disease ◽

Cad Risk

Lipoprotein lipase (LPL) is widely linked to lipid and lipoprotein metabolism, but its effects on coronary artery disease (CAD) are not clearly elucidated. The aim of the present study was to clarify the association between LPL gene polymorphisms and CAD susceptibility. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated to estimate the strength of the relationship between LPL gene polymorphisms and CAD risk. Comprehensive electronic databases, including PubMed, EMBASE, Web of Science, and the Cochrane Library, were systematically searched. A total of 45 records containing 80 eligible studies were analyzed. The results indicated an increased risk between the LPL D9N polymorphism and susceptibility to CAD in the dominant genetic model (AA + GA vs. GG: OR = 1.46, 95% CI = 1.14–1.87), whereas the LPL HindIII polymorphism showed a protective effect against CAD under all tested models (GG + GT vs. TT: OR = 0.85, 95% CI = 0.75–0.97; GG vs. TT + TG: OR = 0.62, 95% CI = 0.47–0.83; G vs. T: OR = 0.81, 95% CI = 0.71–0.92). No significant association was identified for the LPL N291S and PvuII polymorphisms. Stratification analysis by ethnicity suggested a significant correlation between the LPL S447X polymorphism and CAD susceptibility in Caucasians under the dominant and allele genetic models. In summary, our meta-analysis indicated that the LPL D9N polymorphism was associated with an increased risk of CAD, whereas the S447X and HindIII polymorphisms showed protective effects. There was no association observed between the N291S and PvuII polymorphisms and CAD risk.

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Vitamin D receptor (VDR) gene FokI, BsmI, ApaI and TaqI polymorphisms and osteoporosis risk: a meta-analysis

10.1101/19009746 ◽

2019 ◽

Cited By ~ 1

Author(s):

Upendra Yadav ◽

Pradeep Kumar ◽

Vandana Rai

Keyword(s):

Gene Polymorphisms ◽

Genetic Model ◽

Meta Analysis ◽

Recessive Model ◽

Caucasian Population ◽

Vdr Gene ◽

Software Studies ◽

Ethnic Populations ◽

Vdr Gene Polymorphisms ◽

Different Populations

AbstractOsteoporosis is a bone disease characterized by low bone density. The prevalence of osteoporosis varies between different populations and ethnic groups. Numerous studies have investigated the relationship between VDR gene polymorphisms and osteoporosis across ethnic populations. Present meta-analysis aims to comprehensively evaluate the influence of common FokI, BsmI, ApaI and TaqI VDR gene polymorphisms and osteoporosis. PubMed, Google Scholar, Springer Link and Elsevier databases were searched for eligible studies and all statistical calculations were performed by Open Meta-Analyst software. Studies investigated BsmI (65 studies; 6,880 case/ 8,049 control), ApaI (31 studies; 3,763 case/ 3,934 control), FokI (18 studies; 1,895 case/ 1,722 control), and TaqI (26 studies; 2,458 case/ 2,895 control) polymorphisms were included in the present meta-analysis. Results of meta-analysis revealed significant association between dominant model of FokI (ORff+Ff vs. FF= 1.19, 95% CI= 1.04-1.36, p= 0.01, I2= 39.36%) in overall analysis and recessive model of Caucasian population of TaqI polymorphism (ORTT+Tt vs. tt= 1.35, 95% CI= 1.11-1.63, p= 0.002, I2= 50.07%). While no such effect is found in any other genetic model in any other gene polymorphisms of the overall analyses or sub-group analyses. In conclusion, we found the FokI polymorphism is associated with osteoporosis in overall analysis, also the TaqI polymorphism is a risk factor for the Caucasian population.

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Association of rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms with psoriasis susceptibility: A meta-analysis of case-control studies

10.21203/rs.2.16320/v3 ◽

2020 ◽

Author(s):

Hai-bo Gong ◽

Shu-tao Gao ◽

Xiong-ming Pu ◽

Xiao-jing Kang ◽

Xiu-juan Wu

Keyword(s):

Gene Polymorphisms ◽

Genetic Model ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Case Control ◽

Cochrane Library ◽

Case Control Studies ◽

China National Knowledge Infrastructure ◽

Effect Model

Abstract Background: To date, the fundamental pathophysiology underlying the occurrence and progression of psoriasis are still unanswered questions. Genome-wide association surveys have revealed that TNFAIP3 and TNIP1 were key biomarkers for psoriasis. Here, we intended to conduct a survey on the association between TNFAIP3 and TNIP1 gene polymorphisms and psoriasis risk.Methods: A comprehensive search of four online databases—China National Knowledge Infrastructure (CNKI), PubMed, Embase, and Cochrane Library was undertaken up to August 25, 2019. We chose allele genetic model to deal with the original data. Newcastle–Ottawa scale (NOS) was used to evaluate the risk bias of each study. The RevMan 5.3 software was used to calculate the combined odds ratio and 95% confidence interval.Results: In total, we included 13 case-control studies consist of 13,908 psoriasis patients and 20,051 controls in this work. Our results demonstrated that rs610604 in TNFAIP3 polymorphism was significantly associated with psoriasis risk using random-effect model (G vs. T, OR = 1.19, 95 % CI: 1.09–1.31, P = 0.0002), and a significant association between rs17728338 in TNIP1 polymorphism and psoriasis vulnerability using fixed-effect model (A vs. G, OR = 1.69, 95% CI:1.58–1.80, P < 0.00001).Conclusions: Our findings indicated that rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms were associated with psoriasis susceptibility.

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Sarcopenia predicts adverse outcomes in an elderly population with coronary artery disease: a systematic review and meta-analysis

BMC Geriatrics ◽

10.1186/s12877-021-02438-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Qiqi Xue ◽

Jie Wu ◽

Yan Ren ◽

Jiaan Hu ◽

Ke Yang ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Meta Analysis ◽

Psoas Muscle ◽

Coronary Intervention ◽

Adverse Outcomes ◽

Cochrane Library ◽

Muscle Area ◽

Area Index ◽

Artery Disease

Abstract Background The development of sarcopenia is attributed to normal aging and factors like type 2 diabetes, obesity, inactivity, reduced testosterone levels, and malnutrition, which are factors of poor prognosis in patients with coronary artery disease (CAD). This study aimed to perform a meta-analysis to assess whether preoperative sarcopenia can be used to predict the outcomes after cardiac surgery in elderly patients with CAD. Methods PubMed, Embase, the Cochrane library, and Web of Science were searched for available papers published up to December 2020. The primary outcome was major adverse cardiovascular outcomes (MACE). The secondary outcomes were mortality and heart failure (HF)-related hospitalization. The random-effects model was used. Hazard ratios (HRs) with 95% confidence intervals (95%CIs) were estimated. Results Ten studies were included, with 3707 patients followed for 6 months to 4.5 ± 2.3 years. The sarcopenia population had a higher rate of MACE compared to the non-sarcopenia population (HR = 2.27, 95%CI: 1.58–3.27, P < 0.001; I2 = 60.0%, Pheterogeneity = 0.02). The association between sarcopenia and MACE was significant when using the psoas muscle area index (PMI) to define sarcopenia (HR = 2.86, 95%CI: 1.84–4.46, P < 0.001; I2 = 0%, Pheterogeneity = 0.604). Sarcopenia was not associated with higher late mortality (HR = 2.15, 95%CI: 0.89–5.22, P = 0.090; I2 = 91.0%, Pheterogeneity < 0.001), all-cause mortality (HR = 1.35, 95%CI: 0.14–12.84, P = 0.792; I2 = 90.5%, Pheterogeneity = 0.001), and death, HF-related hospitalization (HR = 1.37, 95%CI: 0.59–3.16, P = 0.459; I2 = 62.0%, Pheterogeneity = 0.105). The sensitivity analysis revealed no outlying study in the analysis of the association between sarcopenia and MACE after coronary intervention. Conclusion Sarcopenia is associated with poor MACE outcomes in patients with CAD. The results could help determine subpopulations of patients needing special monitoring after CAD surgery. The present study included several kinds of participants; although non-heterogeneity was found, interpretation should be cautious.

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YOGA IN CHRONIC NECK PAIN: AN EFFECTIVE COMPLEMENTARY THERAPEUTIC OPTION - A META - ANALYSIS

Pakistan Journal of Rehabilitation ◽

10.36283/pjr.zu.7.2/003 ◽

2018 ◽

Vol 7 (2) ◽

pp. 3-12

Author(s):

Jaza Rizvi ◽

Batool Hassan ◽

Sadia Shafaq

Keyword(s):

Neck Pain ◽

Therapeutic Option ◽

Meta Analysis ◽

Chronic Neck Pain ◽

Well Being ◽

Risk Of Bias ◽

Adverse Outcomes ◽

Cochrane Library ◽

P Value ◽

Complementary Method

BACKGROUND Neck pain is recognized as the fourth leading cause of disability worldwide. The severity of neck pain may lead to adverse outcomes related to individual’s health and well-being that augment the risk of disability and may severely interfere in activities of daily living (ADL’s) and participation in the society. AIM The aim of the quantitative analysis is to determine the effectiveness of yoga in relieving chronic neck pain and disability. METHODS Databases such as Google scholar, MEDLINE, PEDro, the Cochrane Library and Pub Med were explored from October-November for randomized controlled trials which assessed neck pain and related disability among chronic neck pain individuals. RESULTS Total six studies consisted of 298 participants with chronic neck pain. In risk of bias assessment, all six studies reported low risk of allocation and reporting bias, while one or two study disclosed high or unknown risk of bias in several domains. Moderate to large effect of -0.857 SMD at 95% CI suggest evidence in favor of the effectiveness of yoga; (Q 30.32, df 5, I2 83.51%) on a significant P-value of <0.0001. CONCLUSION The analysis of studies provided robust evidence with pool effect of -0.857 SMD at 95% CI (p<0.0001) concluded that yoga is an effectual and complementary method for the management of chronic or non-specific neck pain. KEYWORDS Yoga, Neck Pain, Cervical, Therapeutic, Prevention, Meditation

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Association of miR-146a polymorphism rs2910164 and type 2 diabetes risk: a meta-analysis

Journal of International Medical Research ◽

10.1177/0300060520931313 ◽

2020 ◽

Vol 48 (8) ◽

pp. 030006052093131

Author(s):

Liqing Cheng ◽

Min Zhou ◽

Dongmei Zhang ◽

Bing Chen

Keyword(s):

Type 2 Diabetes ◽

Gene Polymorphisms ◽

Disease Duration ◽

Genetic Model ◽

Meta Analysis ◽

Confounding Factors ◽

Dominant Model ◽

Subgroup Analyses

Objective Circulating miR-146a is aberrantly expressed in patients with type 2 diabetes (T2D), probably resulting from gene polymorphisms. However, the role of polymorphism rs2910164 in T2D pathogenesis remains controversial. Thus, we designed a meta-analysis to investigate the association between rs2910164 and T2D. Methods PubMed and Embase were searched for eligible papers in English published through September 2, 2019. Random or fixed effect models were used to determine risk estimates according to heterogeneities. Results Four studies, involving 2,069 patients and 1,950 controls, were included. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to pool the effect size. The pooled ORs and 95% CIs were 1.501 (0.887–2.541), 1.102 (0.931–1.304), 1.276 (0.900–1.811), 1.204 (0.878–1.652), 1.238 (0.880–1.740), and 1.350 (0.904–2.016) under the homozygote, heterozygote (CG vs. GG and CC vs. CG), dominant, allele, and recessive models, respectively. Heterogeneity was detected in most genetic models, with subgroup analyses performed by ethnicity, genotyping method, and disease duration. The co-dominant model was determined to be the most appropriate genetic model. Conclusions Our findings suggested that polymorphism rs2910164 is not correlated with T2D susceptibility. However, the results should be interpreted with caution because of confounding factors.

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Impact of antenatal care on neonatal mortality among neonates in Ethiopia: a systematic review and meta-analysis

Archives of Public Health ◽

10.1186/s13690-020-00499-8 ◽

2020 ◽

Vol 78 (1) ◽

Author(s):

Tadesse Tolossa ◽

Ginenus Fekadu ◽

Belayneh Mengist ◽

Diriba Mulisa ◽

Getahun Fetensa ◽

...

Keyword(s):

Systematic Review ◽

Antenatal Care ◽

Neonatal Mortality ◽

Neonatal Death ◽

Statistical Tests ◽

Meta Analysis ◽

Sub Saharan Africa ◽

Cochrane Library ◽

The Impact

Abstract Background As compared to other regions of the world, Sub Saharan Africa (SSA) is the region with the highest neonatal mortality and is the region showing the least progress in the reduction of newborn death. Despite better progress made in reducing neonatal mortality, Ethiopia contributes the highest rate of neonatal death in Africa. In Ethiopia, findings from few studies were inconsistent and there is a need to systematically pool existing data to determine the impact of antenatal care on neonatal mortality among mother-neonate pairs in Ethiopia. Methods Published articles from various electronic databases such as Medline, Hinari, Pub Med, Cochrane library, the Web of Science, and Google Scholar were accessed. Also, unpublished studies from library catalogs were identified. All observational studies that were conducted on the association between antenatal care follow-up and neonatal mortality among neonates in Ethiopia were included. Data were extracted on the Microsoft Excel spreadsheet and analyzed using STATA 14.1 version. A random-effects model was used to estimate the pooled estimate with a 95% confidence interval (CI). Forest plots were used to visualize the presence of heterogeneity and estimate the pooled impact on antenatal care on neonatal mortality. The presence of publication bias was assessed by funnel plots and Egger’s statistical tests. Results Initially, a total of 345 studies were accessed. Finally, 28 full-text studies were reviewed and fourteen studies fulfilled inclusion criteria and included in the final meta-analysis. The overall pooled estimate indicates the odds of neonatal death among neonates from women with antenatal care were 65% lower than those neonates from women who had no antenatal care follow-up (OR: 0.35, 95% CI: 0.24, 0.51). Conclusions In this systematic review and meta-analysis, lack of ANC follow-up increase the probability of neonatal mortality as compared to having ANC follow-up. Thus, we will recommend for more coverages of appropriate antenatal care where risk groups can best be identified and managed.

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Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-019-1495-0 ◽

2019 ◽

Vol 14 (1) ◽

Cited By ~ 1

Author(s):

Feifan Lu ◽

Pei Liu ◽

Qidong Zhang ◽

Weiguo Wang ◽

Wanshou Guo

Keyword(s):

Knee Osteoarthritis ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Case Control ◽

Joint Disease ◽

Cochrane Library ◽

Case Control Studies ◽

Knee Oa ◽

Statistical Heterogeneity ◽

Bone Changes

Abstract Background Knee osteoarthritis is a joint disease which is characterized by degeneration of articular cartilage and subsequent subchondral bone changes. Polymorphisms of IL-17A/F gene were the recognized candidate genes associated with knee osteoarthritis risk although the results were conflicting. The aim of this study was to determine whether IL-17A(rs2275913) and IL-17F(rs763780) polymorphisms confer susceptibility to knee osteoarthritis. Method Literature search was performed in PubMed, Medline, Cochrane Library, Web of science, Embase, and Google Scholar (last search was updated on June 20, 2019), and assessing this association was performed by calculating odds ratios with 95% confidence intervals. Statistical heterogeneity was quantitatively evaluated by using the Q statistic with its p value and I2 statistic. Result Six case-control based studies were included involving IL-17A(rs2275913) (2134 cases and 2306 controls) and IL-17F(rs763780) (2134 cases and 2426 controls). The overall analysis suggested that the A allele of the rs2275913 polymorphism, and the C allele of the rs763780 polymorphism in the IL-17 gene may increase the risk of OA. However, subgroup analysis revealed that no association between IL-17A(rs2275913) gene and knee OA risk was found in Caucasian population. Conclusions This meta-analysis revealed that the IL-17A(rs2275913) gene polymorphisms may increase the risk of knee OA in Asians, and the IL-17F(rs763780) gene polymorphisms may increase the risk of knee OA both in Asians and Caucasians. However, because of the limitations of the present study, additional larger studies are needed to confirm our findings in the future.

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Effectiveness and safety of early combined utilization of budesonide and surfactant by airway for Bronchopulmonary dysplasia prevention in premature infants with RDS: A meta-analysis

10.22541/au.162551700.02820122/v1 ◽

2021 ◽

Author(s):

Wei Tang ◽

Dongmei Shi ◽

Tao Ai ◽

Lei Zhang ◽

Yijie Huang ◽

...

Keyword(s):

Premature Infants ◽

Meta Analysis ◽

Intratracheal Instillation ◽

Test Group ◽

Assisted Ventilation ◽

Adverse Outcomes ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Delivery Methods ◽

Hospital Stays

Objective: To address the effectiveness and safety of early airway utilization of budesonide and surfactant for BPD prevention in premature infants with RDS. Methods: PubMed, Web of Science, EMBASE, Cochrane Library, Wanfang, CQ VIP and China National Knowledge Infrastructure databases were searched from the inception to May 2021. Stata 16.0 software was used for statistical analysis. Results: This meta-analysis suggested that early combined utilization of budesonide and surfactant by airway tended to have a superiority on BPD incidence (RR=0.63;95%CI:0.54～0.73, P<0.001), mortality (RR=0.63;95%CI:0.43～0.94, P=0.022) and the composite outcome of BPD or mortality (RR=0.59;95%CI:0.49～0.70, P<0.001), the reuse incidence of surfactant (RR=0.54; 95%CI:0.45～0.65, P<0.001), the duration of assisted ventilation (SMD=-1.14;95%CI: -1.58 ～ -0.70, P<0.001), invasive ventilation (SMD=-1.33;95%CI: -1.76～-0.90, P<0.001), and hospital stays (SMD=-1.20;95%CI: -1.88～-0.51, P=0.001) in preterm infants with RDS. And these benefits were not associated with increased adverse outcomes. Furthermore, a decreased incidence of PDA (RR=0.80; 95%CI:0.64～0.99, P=0.041) was found in test group. Subgroup analysis based on budesonide delivery methods (inhalation or intratracheal instillation) indicated that the decrease of mortality (RR=0.62;95%CI:0.41～0.95, P=0.026), duration of assisted ventilation (SMD=-0.95;95%CI: -1.30～-0.61, P<0.001) and hospital stays (SMD=-1.38;95%CI: -2.33～-0.43, P=0.004) were mainly in budesonide intratracheal instillation subgroup. Conclusions: This meta-analysis suggested that early combined utilization of budesonide and surfactant by airway might be an effective and safe clinical practice for BPD prevention in premature infants with RDS, especially when budesonide was delivered by intratracheal instillation.

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