Tract-based spatial statistics in adult Tourette patients indicate white matter changes in the anterior limb of the internal capsule

BackgroundLate-life depression has been associated with white matter changes in studies using the regions of interest approach.AimsTo investigate the cross-sectional and longitudinal relationship between white matter integrity and depression in community-dwelling individuals using diffusion tensor imaging with tract-based spatial statistics.MethodThe sample comprised 381 participants aged between 72 and 92 years who were assessed twice within 2 years. Depressive symptoms were measured with the Geriatric Depression Scale. Tract-based spatial statistics were applied to investigate white matter integrity in currently depressed v. non-depressed elderly people and in those with a history of depression v. no history of depression. The relationship between white matter integrity and development of depressive symptoms after 2 years were analysed with logistic regression.ResultsIndividuals with current depression had widespread white matter integrity reduction compared with non-depressed elderly people. Significant fractional anisotropy reductions were found in 45 brain areas with the most notable findings in the frontal lobe, association and projection fibres. A history of depression was not associated with reduced fractional anisotropy. White matter changes in the superior frontal gyrus, posterior thalamic radiation, superior longitudinal fasciculus and in the body of corpus callosum predicted depression at follow-up.ConclusionsReduced white matter integrity is associated with late-life depression and predicts future depressive symptoms whereas a history of depression is not related to white matter changes. Disruption to white matter integrity may be a biomarker to predict late-life depression.

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Axonal loss of white matter in migraine without aura: A tract-based spatial statistics study

Cephalalgia ◽

10.1177/0333102412466964 ◽

2012 ◽

Vol 33 (1) ◽

pp. 34-42 ◽

Cited By ~ 48

Author(s):

Dahua Yu ◽

Kai Yuan ◽

Wei Qin ◽

Ling Zhao ◽

Minghao Dong ◽

...

Keyword(s):

White Matter ◽

Spatial Statistics ◽

Diffusion Tensor ◽

Mean Diffusivity ◽

Internal Capsule ◽

Brain Regions ◽

Axonal Loss ◽

Healthy Controls ◽

Posterior Limb ◽

Tract Based Spatial Statistics

Aim Multiple diffusion tensor imaging (DTI) derived indices may help to deduce the pathophysiological type of white matter (WM) changes and provide more specific biomarkers of WM neuropathology in the whole brain of migraine patients without aura (MWoA). Methods Twenty MWoA and 20 age-, education- and gender-matched healthy volunteers participated in this study. Tract-based spatial statistics (TBSS) was employed to investigate the WM abnormalities in MWoA by integrating multiple indices, including fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD). Results Compared with healthy controls, MWoA showed significantly lower FA, MD and AD in multiple brain regions, whereas no difference in RD was observed. Specifically, the overlap among the lower FA, MD, and AD was found in the genu, body, and splenium part of the corpus callosum (CC), the right anterior limb of the internal capsule (ALIC) and the posterior limb of the internal capsule (PLIC) in MWoA compared with healthy controls. Additionally, some of the above WM findings were significantly correlated with duration and headache frequency in MWoA. Conclusion Given that decreased AD may suggest axonal loss, our findings may reveal axonal loss in MWoA.

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