Non-invasive quantification of hepatic fibrosis in the CCl4 mouse model by magnetic resonance relaxometry (MRR): first results

2012 ◽  
Vol 50 (01) ◽  
Author(s):  
K Hochrath ◽  
A Müller ◽  
M Krawczyk ◽  
A Bücker ◽  
F Lammert
Keyword(s):  
Magnetic Resonance ◽  
Mouse Model ◽  
Hepatic Fibrosis ◽  
Non Invasive ◽  
First Results

Determining the Signal Source in Magnetic Resonance Imaging of Myelofibrotic Bone Marrow

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 3140-3140
Author(s):  
Shinobu Matsuura ◽  
Shenia Patterson ◽  
Hector Lucero ◽  
Aaron Grant ◽  
Victoria L. M. Herrera ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Bone Marrow ◽  
Magnetic Resonance ◽  
Mouse Model ◽  
Conflicts Of Interest ◽  
Integrative Approach ◽  
Histological Findings ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Lipid Signal

Abstract Magnetic resonance imaging (MRI) is a promising diagnostic method for evaluation of bone marrow myelofibrosis for offering non-invasive, wider-area coverage over conventional histology. Although the most striking feature in histology of myelofibrotic bone marrow is the proliferation of reticulin fibers, the spectrum of findings involves abnormalities in cell number and composition, vessel proliferation, as well as possible pre-fibrotic abnormalities in matrix such as inflammation/edema. Correlation of MRI observations with such histological findings to accurately define the pathogenic phases of myelofibrosis has been challenging. Here, we present the first MRI analysis of myelofibrosis in a mouse model (Gata-1low mice) in an attempt to correlate MRI signal observations with histological findings. T2-weighted MRI images of femur bone marrow of Gata-1low animals at different ages (12 to 46 weeks) showed high MR signal intensity, absent in age-matched wild-type controls, that is detected as early as 12 weeks of age, before onset of histologically-defined fibrosis in this mouse model. MRI acquisitions employing fat suppression, a technique that suppresses signals from lipids, together with the absence of chemical shift artifacts in the images, excluded the possibility of lipids as the source of the prominent MR signal. To determine the source of this prominent non-lipid signal in Gata-1low bone marrow, cellular composition, vascularization and vascular permeability were tested. Our findings demonstrate a multi-source nature of MRI signals in bone marrow, which evolves from young (12 weeks) to old (40 weeks) Gata-1low bone marrow consistent with the pathologic progression of myelofibrosis. Data support the importance of an integrative approach to further the development of this non-invasive modality for following the dynamics and progression of this multifactorial pathology in humans. Disclosures No relevant conflicts of interest to declare.

scholarly journals Preliminary experience with 3T magnetic resonance elastography imaging of the liver

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Anagha Joshi ◽  
Mridula M. Muthe ◽  
Vikrant Firke ◽  
Harshal Badgujar
Keyword(s):  
Magnetic Resonance ◽  
Hepatic Fibrosis ◽  
Liver Stiffness ◽  
Stage Iv ◽  
Normal Liver ◽  
Magnetic Resonance Elastography ◽  
Invasive Technique ◽  
Non Invasive ◽  
The Waves ◽  
Identification And Quantification

Background: Magnetic resonance elastography (MRE) is a promising non-invasive technique for the identification and quantification of hepatic fibrosis. This manuscript describes our early experience with MRE for the assessment of the presence and staging of liver fibrosis on a 3T magnetic resonance imaging (MRI) system.Objectives: The purpose of this study was to describe the MRE physics, procedure, interpretation and drawbacks, along with a few recommendations as per our experience.Method: Magnetic resonance elastography was performed on 85 patients with a 3T MRI and the images were analysed both qualitatively and quantitatively. Liver stiffness was assessed by drawing freehand geographic regions of interest on the elastograms to cover the maximum portion of the hepatic parenchyma within the 95% confidence maps on each slice. Correlation with histopathology was performed whenever available.Results: Of the 80 patients who met the inclusion criteria, 41 patients displayed a normal liver stiffness measurement (LSM) and 39 patients had a raised LSM. In the patients who had a raised LSM, 14 patients had Stage I–II fibrosis, 8 patients had Stage II–III fibrosis, 6 patients had Stage III–IV fibrosis, 4 patients had Stage IV fibrosis or cirrhosis and 7 patients had non-alcoholic steatohepatitis. The mean thickness of the waves increased with increasing stages of fibrosis. The waves became gradually darker medially in patients with normal LSM as compared to the patients with raised LSM. Histopathology with METAVIR scoring was available in 46 patients, which agreed with the MRE findings in all except two patients.Conclusion: Magnetic resonance elastography is a suitable non-invasive modality for the identification and quantification of hepatic fibrosis.

scholarly journals Non-Invasive Assessment of Hepatic Fibrosis by Elastic Measurement of Liver Using Magnetic Resonance Tagging Images

2018 ◽  
Vol 8 (3) ◽  
pp. 437 ◽  
Author(s):  
Xuejun Zhang ◽  
Xiangrong Zhou ◽  
Takeshi Hara ◽  
Hiroshi Fujita
Keyword(s):  
Magnetic Resonance ◽  
Hepatic Fibrosis ◽  
Non Invasive ◽  
Magnetic Resonance Tagging
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