In a placebo-controlled study ß-Ecdysone (ECD) prevented the development of the metabolic syndrome

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
D Seidlova-Wuttke ◽  
W Wuttke
Keyword(s):  
Metabolic Syndrome ◽  
Controlled Study ◽  
The Metabolic Syndrome

scholarly journals Testosterone and the Heart

2019 ◽  
Vol 14 (2) ◽  
pp. 103-110 ◽  
Author(s):  
Michael Kirby ◽  
Geoffrey Hackett ◽  
Sudarshan Ramachandran
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Coronary Artery ◽  
Total Mortality ◽  
Controlled Study ◽  
Pde5 Inhibitors ◽  
Night Time ◽  
Beneficial Effects ◽  
The Metabolic Syndrome ◽  
Meta Analyses

The development of a subnormal level of testosterone (T) is not universal in ageing men, with 75% of men retaining normal levels. However, a substantial number of men do develop T deficiency (TD), with many of them carrying a portfolio of cardiovascular (CV) risk factors, including type 2 diabetes (T2D) and the metabolic syndrome. TD increases the risk of CV disease (CVD) and the risk of developing T2D and the metabolic syndrome. The key symptoms suggesting low T are sexual in nature, including erectile dysfunction (ED), loss of night-time erections and reduced libido. Many men with heart disease, if asked, admit to ED being present; a problem that is often compounded by drugs used to treat CVD. A large number of studies and meta-analyses have provided evidence of the link between TD and an increase in CVD and total mortality. Patients with chronic heart failure (CHF) who have TD have a poor prognosis and this is associated with more frequent admissions and increased mortality compared with those who do not have TD. Conversely, in men with symptoms and documented TD, T therapy has been shown to have beneficial effects, namely improvement in exercise capacity in patients with CHF, improvement of myocardial ischaemia and coronary artery disease. Reductions in BMI and waist circumference, and improvements in glycaemic control and lipid profiles, are observed in T-deficient men receiving T therapy. These effects might be expected to translate into benefits and there are more than 100 studies showing CV benefit or improved CV risk factors with T therapy. There are flawed retrospective and prescribing data studies that have suggested increased mortality in treated men, which has led to regulatory warnings, and one placebo-controlled study demonstrating an increase in coronary artery non-calcified and total plaque volumes in men treated with T, which is open for debate. Men with ED and TD who fail to respond to phosphodiesterase type 5 (PDE5) inhibitors can be salvaged by treating the TD. There are data to suggest that T and PDE5 inhibitors may act synergistically to reduce CV risk.

scholarly journals Effect of Bariatric Surgery on the Metabolic Syndrome: A Population-Based, Long-term Controlled Study

2008 ◽  
Vol 83 (8) ◽  
pp. 897-906 ◽  
Author(s):  
John A. Batsis ◽  
Abel Romero-Corral ◽  
Maria L. Collazo-Clavell ◽  
Michael G. Sarr ◽  
Virend K. Somers ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Metabolic Syndrome ◽  
Population Based ◽  
Controlled Study ◽  
The Metabolic Syndrome

scholarly journals Effects of a high walnut and high cashew nut diet on selected markers of the metabolic syndrome: a controlled feeding trial

2007 ◽  
Vol 97 (6) ◽  
pp. 1144-1153 ◽  
Author(s):  
Janine Mukuddem-Petersen ◽  
Welma Stonehouse (Oosthuizen) ◽  
Johann C. Jerling ◽  
Susanna M. Hanekom ◽  
Zelda White
Keyword(s):  
Metabolic Syndrome ◽  
Ldl Cholesterol ◽  
Control Diet ◽  
Hdl Cholesterol ◽  
Controlled Study ◽  
Control Group ◽  
North West ◽  
Cashew Nut ◽  
The Metabolic Syndrome ◽  
Serum Fructosamine

We investigated the effects of a high walnut diet and a high unsalted cashew nut diet on selected markers of the metabolic syndrome. In a randomized, parallel, controlled study design, sixty-four subjects having the metabolic syndrome (twenty-nine men, thirty-five women) with a mean age of 45 (sd 10) years and who met the selection criteria were all fed a 3-week run-in control diet. Hereafter, participants were grouped according to gender and age and then randomized into three groups receiving a controlled feeding diet including walnuts, or unsalted cashew nuts or no nuts for 8 weeks. Subjects were required to have lunch at the metabolic ward of the Nutrition Department of the North-West University (Potchefstroom Campus). Both the walnut and the unsalted cashew nut intervention diets had no significant effect on the HDL-cholesterol, TAG, total cholesterol, LDL-cholesterol, serum fructosamine, serum high-sensitivity C-reactive protein, blood pressure and serum uric acid concentrations when compared to the control diet. Low baseline LDL-cholesterol concentrations in the cashew nut group may have masked a possible nut-related benefit. Plasma glucose concentrations increased significantly (P = 0·04) in the cashew nut group compared to the control group. By contrast, serum fructosamine was unchanged in the cashew nut group while the control group had significantly increased (P = 0·04) concentrations of this short-term marker of glycaemic control. Subjects displayed no improvement in the markers of the metabolic syndrome after following a walnut diet or a cashew nut diet compared to a control diet while maintaining body weight.

scholarly journals Effect of grape seed extract on postprandial oxidative status and metabolic responses in men and women with the metabolic syndrome - randomized, cross-over, placebo-controlled study

2013 ◽  
Vol 2 (12) ◽  
pp. 508 ◽  
Author(s):  
Indika Edirisinghe ◽  
Jody Randolph ◽  
Mandeep Cheema ◽  
Ravi Tadapaneni ◽  
Eunyoung Park ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Inflammatory Markers ◽  
Oxidized Ldl ◽  
Area Under The Curve ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Controlled Study ◽  
The Metabolic Syndrome

Objective: This investigation was undertaken to determine whether a grape seed extract (GSE) that is rich in mono-, oligo- and poly- meric polyphenols would modify postprandial oxidative stress and inflammation in individuals with the metabolic syndrome (MetS).Background: MetS is known to be associated with impaired glucose tolerance and poor glycemic control. Consumption of a meal high in readily available carbohydrates and fat causes postprandial increases in glycemia and lipidemia and markers of oxidative stress, inflammation and insulin resistance.Materials/methods: After an overnight fast, twelve subjects with MetS (5 men and 7 women) consumed a breakfast meal high in fat and carbohydrate in a cross-over design. A GSE (300 mg) or placebo capsule was administrated 1 hr before the meal (-1 hr). Changes in plasma insulin, glucose, oxidative stress and inflammatory markers were measured hourly for 6 hr. Results: Plasma hydrophilic oxygen radical absorbance capacity (ORAC) measured as the positive incremental area under the curve (-1 to 5 hr) was significantly increased when the meal was preceded by GSE compared with placebo (P<0.05). Meal-induced increases in oxidized LDL were attenuated with GSE (P<0.05). Plasma glucose concentrations (area under the curve from -1 to 5 hr) were also significantly lower when the meal was preceded by GSE (P<0.05) while the insulin concentrations remained unchanged (P>0.05). No changes in inflammatory markers were evident. Conclusion: These data suggest that GSE enhances postprandial plasma antioxidant status and reduces the glycemic response to a meal, high in fat and carbohydrate in subjects with the MetS. Key words: Polyphenols, Oxidative stress, Inflammation, ORAC, Oxidized LDL

Effects of ezetimibe on visceral fat in the metabolic syndrome: a randomised controlled study

2012 ◽  
Vol 42 (12) ◽  
pp. 1287-1294 ◽  
Author(s):  
Hiroyuki Takase ◽  
Yasuaki Dohi ◽  
Tateo Okado ◽  
Tomomi Hashimoto ◽  
Yoshie Goto ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Visceral Fat ◽  
Controlled Study ◽  
The Metabolic Syndrome ◽  
Randomised Controlled Study ◽  
Randomised Controlled

scholarly journals Chromium and polyphenols from cinnamon improve insulin sensitivity

2008 ◽  
Vol 67 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Richard A. Anderson
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Aqueous Extract ◽  
Insulin Signalling ◽  
Fasting Blood Glucose ◽  
Controlled Study ◽  
Improve Insulin Sensitivity ◽  
The Metabolic Syndrome

Naturally-occurring compounds that have been shown to improve insulin sensitivity include Cr and polyphenols found in cinnamon (Cinnamomon cassia). These compounds also have similar effects on insulin signalling and glucose control. The signs of Cr deficiency are similar to those for the metabolic syndrome and supplemental Cr has been shown to improve all these signs in human subjects. In a double-blind placebo-controlled study it has been demonstrated that glucose, insulin, cholesterol and HbA1c are all improved in patients with type 2 diabetes following Cr supplementation. It has also been shown that cinnamon polyphenols improve insulin sensitivity in in vitro, animal and human studies. Cinnamon reduces mean fasting serum glucose (18–29%), TAG (23–30%), total cholesterol (12–26%) and LDL-cholesterol (7–27%) in subjects with type 2 diabetes after 40 d of daily consumption of 1–6 g cinnamon. Subjects with the metabolic syndrome who consume an aqueous extract of cinnamon have been shown to have improved fasting blood glucose, systolic blood pressure, percentage body fat and increased lean body mass compared with the placebo group. Studies utilizing an aqueous extract of cinnamon, high in type A polyphenols, have also demonstrated improvements in fasting glucose, glucose tolerance and insulin sensitivity in women with insulin resistance associated with the polycystic ovary syndrome. For both supplemental Cr and cinnamon not all studies have reported beneficial effects and the responses are related to the duration of the study, form of Cr or cinnamon used and the extent of obesity and glucose intolerance of the subjects.

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