Low-intensity exercise training maintains adipokines in obese children

2010 ◽  
Vol 01 (01) ◽  
pp. 017-022
Author(s):  
Sunghwun Kang ◽  
Jinhee Woo ◽  
Nam-Hwoeh Yeo ◽  
Duckpil Ok ◽  
Jaeho Yoo ◽  
...  
Keyword(s):  
Body Composition ◽  
Growth Factors ◽  
Growth Factor ◽  
Exercise Training ◽  
Body Fat ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Obese Children ◽  
Low Intensity ◽  
Low Intensity Exercise

AbstractThe aim of the present study is to investigate the effects of a 12 weeks low-intensity exercise training on body composition, adipokines, and growth factors in normal (NG) and obese (OG) children. Maximal oxygen uptake (VO2max); body composition; adipokines consisting of adiponectin, retinol binding protein-4 (RBP4), and interleukin-6 (IL-6); and growth factors including insulin like growth factor-1 (IGF-1) and insulin like growth factor binding protein-3 (IGF-BP3) were measured before and after low-intensity exercise training program. Body composition parameters such as body weight, body mass index, body fat (%) and VO2 max were significantly different between NG and OG. Adiponectin levels in NG were increased after 12 weeks exercise training. In addition, our results showed that the concentrations of adiponectin, RBP4, IGF-1, and IGF-BP3 in OG were higher than those of NG. Adiponectin levels were significantly correlated with body fat (r = −0.545, p = 0.001) and VO2max (r = 0.368, p = 0.032) and RBP4 levels were significantly correlated with body fat (r = 0.371, p = 0.031) in all subjects. Exercise training improved adiponectin levels in NG subjects and maintained the levels of body fat, adipokines (adiponectin, RBP4), and growth factors (IGF-1, IGF-BP3) in OG subjects. The present study revealed that regular low-intensity exercise training is strongly associated with high adiponectin levels in healthy children. However, obese children did not exhibit any changes in the levels of adipokines and maintained body composition and growth factors.

Influence of insulin-like growth factor-binding protein-2 on plasma clearance and transfer of insulin-like growth factors-I and -II from plasma into mammary-derived lymph and milk of goats

1996 ◽  
Vol 150 (1) ◽  
pp. 121-127 ◽  
Author(s):  
C G Prosser ◽  
J Schwander
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Plasma Clearance ◽  
Binding Protein ◽  
Plasma Concentrations ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Lactating Goats ◽  
Igf I ◽  
Insulin Like Growth Factors

Abstract Plasma clearance of insulin-like growth factors-I and -II (IGF-I and -II) and insulin-like growth factor-binding protein-2 (IGFBP-2) from lactating goats (n=4) was determined following a single intravenous injection of the corresponding 125I-labelled human protein. Transfer of these proteins out of the vascular space was monitored by their subsequent appearance in mammary-derived lymph and milk. Clearance of 125I-IGFBP-2 from circulation was 0·37 ± 0·06 ml/min/kg, which is markedly greater than that of 125I-IGF-I or -II (0·11 ± and 0·12 ± 0·01 ml/min/kg respectively). This was also reflected in longer elimination half-lives for IGF-I (353 ± 6 min) and -II (254 ± 8 min) compared with IGFBP-2 (110 ± 9 min). Three hours after injection of the 125I-labelled protein, the plasma:lymph ratio of trichloroacetic acid-precipitable radioactivity was 1·54 ±0·04, 3·3 ±0·6 and 4·1 ±0·4 for IGFBP-2, IGF-I and -II respectively. The form of 125I-IGFBP-2 in lymph was not different from that of plasma. Elevation of plasma concentrations of IGFBP-2 by its intravenous infusion significantly decreased plasma half-life of both IGF-I and -II (251 ± 8 and 198 ±7 min respectively). Although the amount and rate of transfer of IGF into mammary-derived lymph was decreased slightly by IGFBP-2, concentrations eventually obtained were not different from control. However, secretion of IGFs into milk was significantly reduced by IGFBP-2, particularly in the case of IGF-I. These results are consistent with the ability of all three compounds to cross the vascular endothelium intact and of IGFBP-2 to decrease the uptake of IGF by mammary epithelium and subsequent secretion into milk. IGFBP-2 may well have acted to target plasma IGF towards non-mammary tissues, thus explaining the more rapid plasma clearance of IGFs in the presence of elevated IGFBP-2. Journal of Endocrinology (1996) 150, 121–127

scholarly journals Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3

FEBS Letters ◽  
2001 ◽  
Vol 509 (3) ◽  
pp. 395-398 ◽  
Author(s):  
Stephan Storch ◽  
Bernd Kübler ◽  
Stefan Höning ◽  
Michael Ackmann ◽  
Jürgen Zapf ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Binding Properties ◽  
Factor Binding ◽  
Insulin Like Growth Factors

scholarly journals Insulin-like growth factor binding protein-1 as a predictor of glucose-stimulated hyperinsulinemia in prepubertal obese children

1999 ◽  
pp. 231-234 ◽  
Author(s):  
H Saitoh ◽  
T Kamoda ◽  
S Nakahara ◽  
T Hirano ◽  
A Matsui
Keyword(s):  
Growth Factor ◽  
Serum Level ◽  
Binding Protein ◽  
Serum Insulin ◽  
Insulin Response ◽  
Oral Glucose ◽  
Insulin Like Growth Factor ◽  
Fasting Insulin ◽  
Obese Children ◽  
Factor Binding

OBJECTIVE: The present study was undertaken to examine the association of a glucose-stimulated insulin response with the fasting insulin-like growth factor-binding protein (IGFBP)-1 concentration in prepubertal obese children. SUBJECTS AND METHODS: The fasting levels of serum insulin and IGFBP-1 were measured in 17 obese and 16 control children. Furthermore, we performed an oral glucose tolerance test in obese children and examined the association of the area under the curve (AUC) for insulin with the fasting IGFBP-1 level. RESULTS: The mean serum level of IGFBP-1 was significantly lower in obese children (41.0 +/- 4.8 micrograms/l. P < 0.005) than in controls (91.2 +/- 9.9 micrograms/l). Although there was an inverse relationship between the fasting levels of serum insulin and IGFBP-1 in all subjects (r = -0.42, P < 0.05), no significant correlation between these two parameters was observed in the obese group alone. In obese children, the fasting IGFBP-1 level correlated inversely with AUC-insulin (r = -0.70, P < 0.005), whereas there was no significant relationship between the fasting insulin level and AUC-insulin. CONCLUSION: The present study suggests that the serum level of IGFBP-1 may be an early predictor of insulin resistance in prepubertal obesity.

Insulin-Like Growth Factors and Metabolic Syndrome in Obese Children

2017 ◽  
Vol 87 (6) ◽  
pp. 400-404 ◽  
Author(s):  
Elena Inzaghi ◽  
Barbara Baldini Ferroli ◽  
Danilo Fintini ◽  
Armando Grossi ◽  
Valerio Nobili ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Composition ◽  
Insulin Sensitivity ◽  
Growth Factor ◽  
Density Lipoprotein ◽  
Insulin Like Growth Factor ◽  
Obese Children ◽  
Metabolic Role ◽  
Igf I ◽  
Group 2

Background/Aims: Insulin-like growth factor (IGF)-I is related to cardiometabolic risk in adults, whereas the metabolic role of IGF-II is unclear. The aim of this study was to assess IGFs in obese children and correlate them with metabolic syndrome (MetS) components. Methods: This is a retrospective study including 574 obese children (11.34 ± 3.16 years). All subjects underwent complete anthropometry and biochemical assessment. In a subgroup of 136 subjects, body composition was evaluated. IGF-I was measured in 300 obese subjects and IGF-II in 77 obese and 15 lean children. 177 subjects were divided according to the presence of 1 or more MetS criteria: group 1, subjects with 1 MetS criterion; group 2, subjects with 2 components; and group 3, subjects with MetS diagnosis. Results: IGF-I, IGF-II, and IGF-I/insulin-like growth factor-binding protein-3 ratio were not different among subjects with an increasing number of MetS criteria and were not associated with single components of MetS as well as with body composition parameters. In children younger than 10 years, IGF-I directly correlated with high-density lipoprotein cholesterol (p < 0.005) even after controlling for confounders. IGF-II was significantly higher in obese children and correlated with parameters of insulin sensitivity (p < 0.05). Conclusion: IGFs were neither related to MetS nor to body composition parameters in obese children. Further studies are needed to clarify the mechanisms underlying the relationship between IGF-II and insulin sensitivity.

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