scholarly journals Impact of Rare Bleeding Disorders during Pregnancy on Maternal and Fetal Outcomes: Review of 29 Pregnancies at a Single Center

2017 ◽  
Vol 39 (01) ◽  
pp. 04-08
Author(s):  
Gokcen Orgul ◽  
Fatih Aktoz ◽  
M. Beksac
Keyword(s):  
Factor Xiii ◽  
Red Blood Cell Transfusion ◽  
Obstetric Outcomes ◽  
Factor X ◽  
Factor Xiii Deficiency ◽  
Factor Deficiency ◽  
Different Types ◽  
The Mean ◽  
The Relationship ◽  
Deficiency Cases

Abstract Objective This study aims to give information about the relationship between different types of factor deficiencies and maternal/obstetric outcomes. Methods We retrospectively reviewed the medical records of eight women with factor deficiency disorders. The demographic and clinical features of the patients after their last pregnancies were registered retrospectively. Results There were 29 pregnancies among the 8 patients. The spontaneous abortion rate was relatively high in two patients with factor XIII deficiency (80% and 57.1%) compared with the other factor deficiency groups. There were 16 births, which included 1 set of twins, and 2 deaths (1 stillbirth and 1 postpartum exitus occurred in the same patient). Intrauterine growth restriction was noted in five cases; four of these occurred in factor X deficiency cases. The mean decrease in hemoglobin level of all patients after birth was 1.7 g/dL (range, 0.2–3.6 g/dL). Red blood cell transfusion was required only in one case of factor XIII deficiency. Conclusions There is currently no consensus on the pregnancy management of women with factor deficiencies because of the limited knowledge due to the rarity of such disorders. Labor should be managed in a dedicated unit with a team consisting of an obstetrician, a hematologist, an anesthesiologist, a midwife, and a pediatrician to minimalize the complications.

scholarly journals New data on an exotic Nippotaenia mogurndae (Cestoda), newly introduced to Europe

2008 ◽  
Vol 45 (2) ◽  
pp. 81-85 ◽  
Author(s):  
L. Košuthová ◽  
J. Koščo ◽  
D. Miklisová ◽  
V. Letková ◽  
P. Košuth ◽  
...  
Keyword(s):  
Standard Length ◽  
Amur Sleeper ◽  
Invasive Fish ◽  
Intensity Of Infection ◽  
Significant Difference ◽  
Nippotaenia Mogurndae ◽  
Different Types ◽  
Size Groups ◽  
The Mean ◽  
The Relationship

AbstractData on prevalence and current distribution of the cestode Nippotaenia mogurndae Yamaguti and Miyata, 1940 (Nippotaeniidea) in Slovakia, are provided. A total of 163 fish from 8 localities of different types in the Tisa River basin were infected with N. mogurndae. The mean intensity of infection was 1.8 with a maximum of 5 tapeworms. The expansion of the distribution of the cestode corresponds well with the spreading of its host, the invasive fish Amur sleeper Perccottus glenii Dybowski, 1877. The Spearmann correlation coefficient was used to test the relationship between the intensity of infection and standard length of the fish (r = 0.36; n = 163; P < 0.05), condition coefficient of the fish (r = 0.22; n = 115; P < 0.05) and season (r = −0.37; n = 355; P < 0.05). A significant correlation was confirmed for each pair of variables. There is a statistically significant difference between the prevalence of the cestode in two functional size groups (t = 3.28; n = 163; P < 0.05). The prevalence of the cestode increased with the standard length of fish. The potential risk of further expansion of N. mogurndae to other countries is discussed.

scholarly journals Long-term developmental follow-up in children with nonsyndromic craniosynostosis

2015 ◽  
Vol 16 (4) ◽  
pp. 445-451 ◽  
Author(s):  
Maggie Bellew ◽  
Paul Chumas
Keyword(s):  
Normal Population ◽  
Time Of Surgery ◽  
Different Types ◽  
Long Term Follow Up ◽  
The Mean ◽  
The Relationship ◽  
Single Suture ◽  
The Average Range

OBJECT The aim of this study was to determine the distribution of Full Scale IQ (FSIQ) by type of craniosynostosis and to verify the finding that at long-term follow-up, verbal IQ (VIQ) is significantly higher than performance IQ (PIQ) in patients with single-suture sagittal synostosis (SS) despite falling within the “average” range for intelligence. Whether this also occurs in other types of craniosynostosis and whether surgery and sex are relevant were also determined. The relationship between age at time of surgery and later IQ was ascertained. METHODS The data for 91 children with craniosynostosis (47 sagittal, 15 unicoronal, 13 metopic, 9 multisuture, and 7 bicoronal) were collected at their routine, 10 years of age IQ assessment (mean age 123.8 months). The patients included 61 males and 30 females; 62 patients had undergone surgery and 29 had not. RESULTS The mean FSIQ for all types of craniosynostosis combined (96.2) fell within the average range for the general population. Some variation was evident across the different types of craniosynostosis: the SS group showed the highest FSIQs and a “normal” distribution of bandings; the other types had a higher proportion of FSIQs in the lower bandings. The data confirmed the finding that VIQ is greater than PIQ despite falling within the average range for intelligence, with a difference of 5.0 for all types of craniosynostosis combined (p = 0.001), 7.6 for the SS group (p = 0.001), and 6.9 for the unicoronal group (p = 0.029). This VIQ > PIQ effect was not found with multisuture craniosynostosis. The VIQ > PIQ discrepancy occurred regardless of whether the patient had undergone surgery and occurred more often in males than females. In the SS group and the bicoronal group, FSIQ (p = 0.036 and p = 0.046, respectively) and PIQ (p = 0.012 and p = 0.017, respectively), though not VIQ, were higher when surgery had been performed early. CONCLUSIONS The study confirms that at long-term follow-up, although children with nonsyndromic craniosynostosis fall within the normal range for intelligence, there is a VIQ > PIQ discrepancy above what would be expected in the normal population, which may be indicative of more subtle difficulties in achievement. This discrepancy is affected by type of craniosynostosis, sex, and age at time of surgery.

Looking into care: The reliability and feasibility of a Taxonomy of Care for Youth

2016 ◽  
Vol 17 (1) ◽  
pp. 21-33 ◽  
Author(s):  
KE Evenboer ◽  
AMN Huyghen ◽  
J Tuinstra ◽  
SA Reijneveld ◽  
EJ Knorth
Keyword(s):  
Mental Health ◽  
Health Care ◽  
Youth Care ◽  
Emotional And Behavioural Problems ◽  
Rater Reliability ◽  
Child And Youth Care ◽  
Primary Health ◽  
Different Types ◽  
The Mean ◽  
The Relationship

Summary Classifying the care provided to children with emotional and behavioural problems can provide empirical insights into the relationship between child characteristics, the care offered and outcomes after leaving care. The Taxonomy of Care for Youth (TOCFY) has recently been shown to validly classify this care in six domains covering all aspects of care. The aim of this study was to assess the inter-rater reliability and feasibility of TOCFY. Two raters independently classified the care provided to 200 children (50 per organisation) from organisations in primary health care, child and youth care, and mental health care (two organisations), based on their care records. We assessed inter-rater reliability and the degree to which TOCFY categories could be applied anyhow, that is its feasibility. Findings Mean agreement was 89.8% between raters; excluding the cases scored as ‘unknown’, the mean agreement was 82.2%. TOCFY-categories could be applied for over 90% regarding each of the six domains. Applications TOCFY is a valid, reliable and feasible instrument to classify care within different types of care organisations. Give these promising findings, application and further evaluation of TOCFY is recommended.

Microbiological Sampling of Meat Cuts and Manufacturing Beef by Excision or Swabbing†

2001 ◽  
Vol 64 (3) ◽  
pp. 325-334 ◽  
Author(s):  
C. O. GILL ◽  
M. BADONI ◽  
J. C. McGINNIS
Keyword(s):  
Escherichia Coli ◽  
Meat Product ◽  
Sampling Technique ◽  
Cotton Wool ◽  
Raw Meat ◽  
E Coli ◽  
Different Types ◽  
The Mean ◽  
Pork Loin ◽  
The Relationship

Groups of 25 beef or pork loin primal cuts or of pieces of stored or not stored manufacturing beef were sampled by excision and by swabbing with cotton wool, sponge, and gauze. Total aerobic counts, coliforms, and Escherichia coli from each sample were enumerated. Values for the mean log10, log10 mean, and/or the log10 total numbers recovered were calculated for each set of 25 bacterial counts. Those statistics indicated that, for product sampled without storage, swabbing with cotton wool or sponge recovered about 30%, and swabbing with gauze recovered about 10% of the bacteria recovered by excision sampling; but that for product sampled after storage, swabbing with cotton wool or sponge recovered about 50% and swabbing with gauze recovered about 15% of the bacteria recovered by excision sampling. However, the incidences of samples positive for coliforms and E. coli were less for stored than for nonstored product with all methods of sampling. The findings indicate that the conditions of meat surfaces, the handling of product, and the state of the microflora might all affect the numbers of bacteria recovered by any sampling technique. Thus, the relationship between the numbers recovered by excision or any selected swabbing technique may differ for different types of noncomminuted, raw meat product.

Factor XIII Deficiency: Report of Two Cases

2010 ◽  
Vol 35 (1) ◽  
pp. 101-104
Author(s):  
P Poornima ◽  
K Shashibhushan ◽  
K Bharath ◽  
V Subba Reddy
Keyword(s):  
Early Diagnosis ◽  
Replacement Therapy ◽  
Blood Group ◽  
Surgical Management ◽  
Intracranial Hemorrhage ◽  
Factor Xiii ◽  
Bleeding Disorder ◽  
Clotting Factor ◽  
Factor Xiii Deficiency ◽  
Factor Deficiency

Factor XIII deficiency is one of the rare clotting factor deficiencies. Although rare, it is an important disorder because of seriousness of its bleeding manifestations, in particular the incidence of intracranial hemorrhage is higher than any other bleeding disorder. Hence an early diagnosis is extremely important where bleeding manifestations can be prevented by prophylactic factor XIII replacement given at every 4-6 week interval. Case1 presents the management of a factor deficiency associated with a very rare blood group AB+ve, while the case 2 reports the successful surgical management with a replacement therapy.

scholarly journals Is There a Common Summary Statistical Process for Representing the Mean and Variance? A Study Using Illustrations of Familiar Items

i-Perception ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 204166951774729 ◽  
Author(s):  
Yi Yang ◽  
Midori Tokita ◽  
Akira Ishiguchi
Keyword(s):  
Common Mechanism ◽  
Summary Statistics ◽  
Summary Statistic ◽  
Statistical Process ◽  
Subject Design ◽  
Different Types ◽  
Mean And Variance ◽  
The Mean ◽  
The Relationship ◽  
Statistical Summary

A number of studies revealed that our visual system can extract different types of summary statistics, such as the mean and variance, from sets of items. Although the extraction of such summary statistics has been studied well in isolation, the relationship between these statistics remains unclear. In this study, we explored this issue using an individual differences approach. Observers viewed illustrations of strawberries and lollypops varying in size or orientation and performed four tasks in a within-subject design, namely mean and variance discrimination tasks with size and orientation domains. We found that the performances in the mean and variance discrimination tasks were not correlated with each other and demonstrated that extractions of the mean and variance are mediated by different representation mechanisms. In addition, we tested the relationship between performances in size and orientation domains for each summary statistic (i.e. mean and variance) and examined whether each summary statistic has distinct processes across perceptual domains. The results illustrated that statistical summary representations of size and orientation may share a common mechanism for representing the mean and possibly for representing variance. Introspections for each observer performing the tasks were also examined and discussed.

scholarly journals ACCURACY VERSUS SPEED IN FLUCTUATION-ENHANCED SENSING

2012 ◽  
Vol 11 (02) ◽  
pp. 1250010 ◽  
Author(s):  
P. MAKRA ◽  
Z. TOPALIAN ◽  
C. G. GRANQVIST ◽  
L. B. KISH ◽  
C. KWAN
Keyword(s):  
Time Window ◽  
Measurement Data ◽  
Statistical Error ◽  
Window Size ◽  
Practical Case ◽  
Activation Temperature ◽  
Stochastic Signal ◽  
Different Types ◽  
The Mean ◽  
The Relationship

Fluctuation-enhanced sensing (FES) comprises the analysis of the stochastic component of the sensor signal and the utilization of the microscopic dynamics of the interaction between the agent and the sensor. We study the relationship between the measurement time window and the statistical error of the measurement data in the simplest case, when the output is the mean-square value of the stochastic signal. This situation is relevant at any practical case when the time window is finite, for example, when a sampling of the output of a fluctuation-enhanced array takes place; or a single sensor's activation (temperature, etc.) is stepped up; or a single sensor's output is monitored by sampling subsequently in different frequency windows. Our study provides a lower limit of the relative error versus data window size with different types of power density spectra: white noise, 1/f(flicker, pink) noise, and 1/f2 (red) noise spectra.

Multi-Center Calibration of the Second Reference Material for Thromboplastin, Rabbit, Plain, Coded CRM 149R

1991 ◽  
Vol 65 (03) ◽  
pp. 263-267 ◽  
Author(s):  
A M H P van den Besselaar ◽  
R M Bertina
Keyword(s):  
Reference Material ◽  
Standard Error ◽  
Standard Errors ◽  
Sensitivity Index ◽  
Long Term Stability ◽  
Significant Bias ◽  
The Mean ◽  
The Relationship ◽  
International Sensitivity Index

SummaryIn a collaborative trial of eleven laboratories which was performed mainly within the framework of the European Community Bureau of Reference (BCR), a second reference material for thromboplastin, rabbit, plain, was calibrated against its predecessor RBT/79. This second reference material (coded CRM 149R) has a mean International Sensitivity Index (ISI) of 1.343 with a standard error of the mean of 0.035. The standard error of the ISI was determined by combination of the standard errors of the ISI of RBT/79 and the slope of the calibration line in this trial.The BCR reference material for thromboplastin, human, plain (coded BCT/099) was also included in this trial for assessment of the long-term stability of the relationship with RBT/79. The results indicated that this relationship has not changed over a period of 8 years. The interlaboratory variation of the slope of the relationship between CRM 149R and RBT/79 was significantly lower than the variation of the slope of the relationship between BCT/099 and RBT/79. In addition to the manual technique, a semi-automatic coagulometer according to Schnitger & Gross was used to determine prothrombin times with CRM 149R. The mean ISI of CRM 149R was not affected by replacement of the manual technique by this particular coagulometer.Two lyophilized plasmas were included in this trial. The mean slope of relationship between RBT/79 and CRM 149R based on the two lyophilized plasmas was the same as the corresponding slope based on fresh plasmas. Tlowever, the mean slope of relationship between RBT/79 and BCT/099 based on the two lyophilized plasmas was 4.9% higher than the mean slope based on fresh plasmas. Thus, the use of these lyophilized plasmas induced a small but significant bias in the slope of relationship between these thromboplastins of different species.

New Families with Hereditary Hemorrhagic Trait due to Deficiency of Fibrin Stabilizing Factor (F. XIII)

1968 ◽  
Vol 20 (03/04) ◽  
pp. 534-541 ◽  
Author(s):  
O Egeberg
Keyword(s):  
Factor Xiii ◽  
Family Members ◽  
Recessive Inheritance ◽  
Factor Xiii Deficiency ◽  
History Of ◽  
Congenital Factor

SummarySevere hemorrhagic disorder due to congenital factor XIII deficiency is described in two unrelated Norwegian girls.Plasma cephalin time was for both patients extraordinarily short during episodes of bleeding and hematomas. No such hyperactivity reaction was demonstrable in unaffected condition some months later.Estimations of blood factor XIII levels revealed a partial defect in the parents of both children, and also in some other family members, consistent with an autosomal incompletely recessive inheritance of the defect. Some of the presumptive heterozygotes had a history of light bleeding phenomenons; whether this was related to their partial lack of factor XIII is so far uncertain.

Pharmacokinetics and Tolerability of Factor XIII Concentrates Prepared from Human Placenta or Plasma: a Crossover Randomised Study

1995 ◽  
Vol 74 (02) ◽  
pp. 622-625 ◽  
Author(s):  
H H Brackmann ◽  
R Egbring ◽  
A Ferster ◽  
P Fondu ◽  
J M Girardel ◽  
...  
Keyword(s):  
Factor Xiii ◽  
Bleeding Events ◽  
Serious Adverse Events ◽  
Double Blind ◽  
Randomised Study ◽  
The Mean ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study ◽  
Fxiii Activity ◽  
Observation Period

SummaryThe pharmacokinetics and tolerability of factor XIII (FXIII) from plasma were compared with those of FXIII from placenta in a randomised, double-blind, crossover study involving 13 patients with congenital FXIII deficiency. Both FXIII activity and FXIII antigen were monitored. No difference was seen in the mean half-lives of the two preparations (9.3 days and 9.1 days for plasma and placenta FXIII activity, respectively). Response was similar for both preparations, but was slightly greater for FXIII from plasma.Similar results were found for recovery (65% vs 60%). The area under the data completed by extrapolation was significantly higher for FXIII from plasma. No differences between preparations in terms of efficacy or tolerability were observed. It can be concluded that treatment with FXIII concentrate from plasma is as efficient as with FXIII concentrate from placenta in terms of recovery and half-life. Both preparations were equivalent in terms of safety during the observation period. With the administration of monthly injections of approximately 30 U/kg serious bleeding events were prevented and no other serious adverse events occurred.

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