scholarly journals Potential Drug Interactions and Drug Risk during Pregnancy and Breastfeeding: An Observational Study in a Women's Health Intensive Care Unit

2017 ◽  
Vol 39 (06) ◽  
pp. 258-264 ◽  
Author(s):  
Amanda Ferracini ◽  
Aline Rodrigues ◽  
Marília Visacri ◽  
Rebeca Stahlschmidt ◽  
Nice Silva ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Drug Interactions ◽  
Potential Risk ◽  
Potential Drug ◽  
Cross Sectional ◽  
Drug Risk ◽  
Online Databases ◽  
One Year ◽  
The City

Introduction In the pregnancy-puerperal cycle, women may develop complications that require admission to the Intensive Care Unit (ICU). Thus, special attention to pharmacotherapy is necessary, particularly to potential drug interactions (PDIs) and to the effect of the drugs on the fetus and newborn. Objective The aim of this study was to determine the profile of PDIs and the potential risk of drugs used during pregnancy and breastfeeding among patients admitted to the ICU. Methods We conducted an observational, cross-sectional and prospective study, including pregnant and breastfeeding women admitted to the ICU at the Women's Hospital of a university in the city of Campinas, Brazil, for one year. Online databases were used to identify and classify the PDIs and the potential risk of the drugs used during pregnancy and breastfeeding. Results We evaluated 305 prescriptions of 58 women, 31 pregnant and 27 breastfeeding, and 284 (91%) prescriptions presented PDIs. A total of 175 different combinations of PDIs were identified in the prescriptions, and adverse effects caused by the simultaneous use of drugs were not actually observed in the clinical practice. A total of 26 (1.4%) PDIs were classified as contraindicated. We identified 15 (13.8%) drugs prescribed with risk D, and 2 (1.8%) with risk X for pregnant women, as well as 4 (4.9%) drugs prescribed with high risk for breastfeeding women. Conclusions This study demonstrates that there is a high incidence of PDIs in prescriptions. Most drugs used by pregnant and breastfeeding women at the ICU did not present serious risks to their fetus and newborns, but sometimes drugs with risk D or X are necessary in the course of the treatment.

scholarly journals Factors associated to potential drug interactions in one Intensive Care Unit: a cross-sectional study

2019 ◽  
Vol 23 (3) ◽  
Author(s):  
Ana Laura Biral Cortes ◽  
Zenith Rosa Silvino
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Drug Interactions ◽  
Adverse Drug Events ◽  
Length Of Hospital Stay ◽  
Regular Insulin ◽  
Cross Sectional Study ◽  
Potential Drug ◽  
Cross Sectional ◽  
Factors Associated

ABSTRACT Objective: to identify the factors associated to Potential Drug Interactions with High Alert Medications in the Intensive Care Unit of a Sentinel Hospital. Methods: a cross-sectional, retrospective study using a quantitative approach carried out at a Sentinel Hospital in Rio de Janeiro. The research was based on the analysis of the prescriptions of patients hospitalized in the Intensive Care Unit of the Hospital, in a period of one year, in order to identify the drug interactions related to high alert medications in these prescriptions. Results: Of the 60 prescriptions analyzed, 244 were selected. In these prescriptions, 846 potential drug interactions related to high alert medications and 33 high alert medications were identified. Of the 112 types of potential drug interactions identified, some were more recurrent: tramadol e ondansetron, midazolam and omeprazole, regular insulin and hydrocortisone, fentanyl and midazolam, and regular insulin and noradrenaline. The variables polypharmacy, length of hospital stay, and some specific medications were associated with drug interactions with high alert medications. Conclusion and Implications for practice: It is important to strengthen strategies to reduce adverse drug events. Therefore, the relevance of studies that investigate the origin of these events is highlighted. Drug interactions can represent medication errors. It’s indispensable to work with strategies to better manage the medication system.

Evaluation of Potential Drug–Drug Interactions in Adults in the Intensive Care Unit: A Systematic Review and Meta-Analysis

Drug Safety ◽  
2019 ◽  
Vol 42 (9) ◽  
pp. 1035-1044 ◽  
Author(s):  
Mary Grace Fitzmaurice ◽  
Adrian Wong ◽  
Hannah Akerberg ◽  
Simona Avramovska ◽  
Pamela L. Smithburger ◽  
...  
Keyword(s):  
Systematic Review ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Drug Interactions ◽  
Meta Analysis ◽  
Potential Drug

scholarly journals Identification and Assessment of Potential Drug–Drug Interactions in Intensive Care Unit Patients

2019 ◽  
Vol 23 (4) ◽  
pp. 170-174
Author(s):  
Shivakumar Iyer ◽  
Bhavika Ravindra Wagh ◽  
Deepa Dhananjay Godbole ◽  
Shubham Shivaji Deshmukh ◽  
Prasanna R Deshpande
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Drug Interactions ◽  
Potential Drug

scholarly journals Pressure Ulcers Prevalence and Potential Risk Factors Among Intensive Care Unit Patients in Governmental Hospitals in Palestine: A Cross-sectional Study

2019 ◽  
Vol 12 (1) ◽  
pp. 121-126 ◽  
Author(s):  
Jamal A.S. Qaddumi ◽  
Omar Almahmoud
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Potential Risk ◽  
Pressure Ulcers ◽  
Advisory Panel ◽  
Cross Sectional ◽  
Data Set ◽  
Potential Risk Factors ◽  
The Government

Aim: To determine the prevalence rate and the potential risk factors of pressure ulcers (PUs) among patients in the intensive care unit (ICU) departments of the government hospitals in Palestine. Methods: A quantitative, cross-sectional, descriptive analytical study was carried out in five government hospital intensive care units in four different Palestinian cities between September 27, 2017, and October 27, 2017. The data of 109 out of 115 (94.78%) inpatients were analyzed. The Minimum Data Set (MDS) recommended by the European Pressure Ulcer Advisory Panel (EPUAP) was used to collect inpatients’ information. Results: The result of the analysis showed that the prevalence of pressure ulcers in the ICU departments was 33%, and the prevalence of PUs when excluding stage one was 7.3%. The common stage for pressure ulcers was stage one. It was also determined that the most common risk factors for the development of pressure ulcers were the number of days in the hospital, moisture, and friction. Conclusion: According to the recent studies in the Asian States, the prevalence of pressure ulcers in Palestine is considerably higher than in China and Jordan. However, it is still lower than the prevalence reported in comparable published studies in Western Europe. Increasing the staff’s knowledge about PUs screening and preventive measures is highly recommended in order to decrease the burden of PUs.

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