Failure of Monoiodoacetate to Induce Lameness in Dogs

1994 ◽  
Vol 07 (02) ◽  
pp. 91-93 ◽  
Author(s):  
D. Stobie ◽  
Nancy Greer ◽  
A. J. Lipowitz
Keyword(s):  
Physical Examination ◽  
Gait Analysis ◽  
Guinea Pigs ◽  
Clinical Signs ◽  
Degenerative Joint Disease ◽  
Chronic Arthritis ◽  
Force Platform ◽  
Joint Disease ◽  
Limb Function ◽  
Different Doses

SummaryIntra-articular sodium monoiodoace-tate (MIA) has been shown to consistently induce a reproducible model of chronic arthritis in rats, chickens, guinea pigs, rabbits and horses. The purpose of this study was to determine if intra-articular injections of MIA would produce clinical signs of degenerative joint disease in dogs.Two different doses of MIA were injected into the stifle joints of normal dogs. Changes in limb function were evaluated by physical examination and force platform gait analysis. The dogs were evaluated weekly for three weeks, after which the MIA injections were repeated. They were again evaluated weekly for an additional two weeks.Significant changes in limb function were not found during any portion of the study as determined by physical examination of the injected joints and force platform gait analysis. Intra-articular MIA, at the doses used in this study, did not induce lameness nor clinical signs of degenerative joint disease.This study evaluated the potential of intra-articular injections of sodium monoiodoacetate (MIA) to produce degenerative joint disease in dogs. Changes in the injected joints and limb function were evaluated by physical examination and force platform gait analysis. Intraarticular MIA at the doses used in this study did not induce lameness nor clinical signs of degenerative joint disease in dogs.

scholarly journals Degenerative joint disease in cattle and buffaloes in the Amazon region: a retrospective study

2014 ◽  
Vol 34 (9) ◽  
pp. 845-850 ◽  
Author(s):  
José Diomedes Barbosa ◽  
Danillo Henrique S. Lima ◽  
Alessandra S. Belo-Reis ◽  
Cleyton P. Pinheiro ◽  
Melina G.S. Sousa ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Bone Tissue ◽  
Phosphorus Deficiency ◽  
Clinical Signs ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Predisposing Factor ◽  
Hind Limbs ◽  
Postural Changes ◽  
Progressive Weight Loss

A retrospective study of the epidemiological and clinic-pathological aspects of cattle and buffaloes with degenerative joint disease (DJD) was conducted in the state of Pará, Brazil. From 1999 to 2014, eleven cattle and 24 buffaloes were evaluated. All the treated animals with suspected DJD underwent a clinical examination of the musculoskeletal system. In seven cattle and eight buffaloes with clinical signs of the disease postmortem examination was performed. The common clinical signs observed in both species were chronic lameness, stiff gait, postural changes, audible crackles in the affected limb, prolonged recumbency, difficulty in getting up and progressive weight loss. The lesions observed at necropsy were: irregular articular surfaces, erosion of the articular cartilage and the underlying bone tissue, and proliferation of the periarticular bone tissue with formation of osteophytes. The most affected joints in cattle and buffaloes wereof the hind limb. In buffaloes, the main predisposing factor to the onset of DJD was phosphorus deficiency. In cattle, defects of the anatomical conformation of the hind limbs, chronic trauma due to the activities performed, such as semen collection, and advanced age possibly contributed to the emergence of the disease.

scholarly journals The pathophysiology and medical management of canine osteoarthritis : continuing education

1997 ◽  
Vol 68 (1) ◽  
Author(s):  
T. Vaughan-Scott ◽  
J.H. Taylor
Keyword(s):  
Continuing Education ◽  
Clinical Signs ◽  
Cartilage Degeneration ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Joint Cartilage ◽  
Pharmacological Management ◽  
Gradual Onset ◽  
Joint Surfaces ◽  
Canine Osteoarthritis

Osteoarthritis or degenerative joint disease is a condition characterised by degeneration of articular cartilage often associated with the formation of new bone at joint surfaces or margins. Commonly encountered in dogs, osteoarthritis may have a gradual onset, but may also occur acutely. Osteoarthritis can be a primary disease of joint cartilage, but is more often secondary to abnormal stresses on joints. This article describes the pathogenesis and progression of cartilage degeneration as well as the dietary, lifestyle and pharmacological management of osteoarthritis. Recent pharmacological developments allow the clinician not only to control clinical signs of the disease, but also to slow the progression of cartilage degeneration.

Triple pelvic osteotomy: effect on limb function and progression of degenerative joint disease

1998 ◽  
Vol 34 (3) ◽  
pp. 260-264 ◽  
Author(s):  
AL Johnson ◽  
CW Smith ◽  
GJ Pijanowski ◽  
LL Hungerford
Keyword(s):  
Force Plate ◽  
Pelvic Osteotomy ◽  
Degenerative Joint Disease ◽  
Observation Time ◽  
Peak Force ◽  
Joint Disease ◽  
Radiographic Evidence ◽  
Limb Function ◽  
Plate Analysis ◽  
Over Time

The objective of this study was to evaluate prospectively the outcome of 21 clinical patients treated with triple pelvic osteotomies during the year following surgery. Specific aims included documenting the time of and extent of improved limb function as measured by force plate analysis, evaluating the progression of degenerative joint disease (DJD) in the treated and untreated coxofemoral joints, and determining whether or not triple pelvic osteotomy resulted in degenerative joint changes in the ipsilateral stifle and hock. Twelve dogs were treated unilaterally and nine dogs were treated bilaterally with triple pelvic osteotomies. There were no differences in mean anteversion angles, angles of inclination, or preoperative DJD between treated hips and untreated hips. Degenerative joint disease progressed significantly in all hips regardless of treatment. Two cases developed hyperextension of their hocks after the triple pelvic osteotomies. However, no radiographic evidence of DJD was observed for any of the stifles or hocks at any observation time. A significant increase in vertical peak force (VPF) scores was noted for treated legs by two-to-three months after surgery, which continued over time. Untreated legs did not show a significant change in VPF scores over time. No differences were found in progression to higher scores when unilaterally treated legs, first-side treated legs, and second-side treated legs were compared.

GAIT ANALYSIS: A PILOT STUDY—A POSSIBLE MODE OF ASSESSMENT OF LOWER LIMB FUNCTION IN JUVENILE CHRONIC ARTHRITIS

Rheumatology ◽  
1981 ◽  
Vol 20 (1) ◽  
pp. 31-37 ◽  
Author(s):  
SHARON WITEMEYER ◽  
BARBARA M. ANSELL ◽  
ANN ASHBURN ◽  
JAMES WALL ◽  
LESLIE KLENERMAN
Keyword(s):  
Pilot Study ◽  
Gait Analysis ◽  
Lower Limb ◽  
Juvenile Chronic Arthritis ◽  
Chronic Arthritis ◽  
Limb Function ◽  
Lower Limb Function

The Therapeutic Efficacy of Carprofen (Rimadyl-V™) in 209 Clinical Cases of Canine Degenerative Joint Disease

1992 ◽  
Vol 05 (04) ◽  
pp. 140-144 ◽  
Author(s):  
R. B. Parker ◽  
B. S. Beale ◽  
R. L. Friedman ◽  
R. H. Holtsinger
Keyword(s):  
Therapeutic Efficacy ◽  
Clinical Signs ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Double Blind ◽  
Inflammatory Drug ◽  
Logistic Analysis ◽  
The Usa ◽  
Geographic Regions ◽  
Anti Inflammatory

SummaryCarprofen (D,L-6-chlor-alphamethylcarbazole-2-acetic acid) is a nonsteroidal anti-inflammatory drug with demonstrated therapeutic activity in the relief of clinical signs of degenerative joint disease in laboratory animal models and in human trials. The double-blind clinical study, reported herein, compared the therapeutic efficacy of carprofen with that of a placebo, in the acute relief of clinical canine degenerative joint disease. Twohundred and nine cases were collected from 10 studies in three geographic regions of the USA. The results of logistic analysis showed that dogs treated with carprofen were 24.8 times more likely to receive a positive evaluation by the veterinarian than those treated with a placebo (p <0.01). The odds of showing improvement, when evaluated by the owners, were 13.4 times greater than placebo (p <0.01). The evaluation from the veterinarian and the owner had excellent agreement (Kappa = 0.997) for dogs treated with carprofen and good agreement (Kappa = 0.667) for those treated with the placebo. Regional differences in response rate were not found in these studies. This trial demonstrated that carprofen is efficacious, across geographic regions, in the acute relief of clinical signs associated with canine degenerative joint disease.Carprofen is a new anti-inflammatory drug (NSAID) with analgesic potency. Side effects reported are few. Dogs with degenerative joint disease (DSD) treated with carprofen were 24.8 times more likely to respond favourably than placebo-treated dogs (p <0.01). This study concluded that carprofen is an effective NSAID in relieving the clinical signs of DSD in dogs.

scholarly journals Glucosamine and chondroitin sulfate in the repair of osteochondral defects in dogs - clinical-radiographic analysis

Revista CERES ◽  
2012 ◽  
Vol 59 (5) ◽  
pp. 587-596 ◽  
Author(s):  
Renato Barros Eleotério ◽  
Andréa Pacheco Batista Borges ◽  
Kelly Cristine de Sousa Pontes ◽  
Natália Alves Fernandes ◽  
Priscila Ferreira Soares ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Femoral Condyle ◽  
Clinical Signs ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Control Group ◽  
Radiographic Analysis ◽  
Osteochondral Defects ◽  
Radiographic Findings ◽  
And Control

Among the proposed treatments to repair lesions of degenerative joint disease (DJD), chondroprotective nutraceuticals composed by glucosamine and chondroitin sulfate are a non-invasive theraphy with properties that favors the health of the cartilage. Although used in human, it is also available for veterinary use with administration in the form of nutritional supplement independent of prescription, since they have registry only in the Inspection Service, which does not require safety and efficacy testing. The lack of such tests to prove efficacy and safety of veterinary medicines required by the Ministry of Agriculture and the lack of scientific studies proving its benefits raises doubts about the efficiency of the concentrations of such active substances. In this context, the objective of this study was to evaluate the efficacy of a veterinary chondroprotective nutraceutical based on chondroitin sulfate and glucosamine in the repair of osteochondral defects in lateral femoral condyle of 48 dogs, through clinical and radiographic analysis. The animals were divided into treatment group (TG) and control group (CG), so that only the TG received the nutraceutical every 24 hours at the rate recommended by the manufacturer. The results of the four treatment times (15, 30, 60 and 90 days) showed that the chondroprotective nutraceutical, in the rate, formulation and administration at the times used, did not improve clinical signs and radiologically did not influence in the repair process of the defects, since the treated and control groups showed similar radiographic findings at the end of the treatments.

A retrospective study of canine hip dysplasia in 116 military working dogs. Part II: Clinical signs and performance data

1996 ◽  
Vol 32 (5) ◽  
pp. 423-430 ◽  
Author(s):  
CM Banfield ◽  
JE Bartels ◽  
JA Hudson ◽  
JC Wright ◽  
RD Montgomery ◽  
...  
Keyword(s):  
Hip Dysplasia ◽  
Clinical Signs ◽  
Clinical History ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Significant Difference ◽  
Working Dogs ◽  
And Performance ◽  
Student’S T ◽  
Military Working Dogs

The progression of hip dysplasia was investigated in 116 military working dogs. Medical records were reviewed for any clinical history of hind-limb lameness. Pelvic radiographs were studied for evidence and degree of hip dysplasia, degenerative joint disease, or both. The number of months each dog worked was determined. Each dog's age at termination from service and cause of death (or euthanasia) were recorded. The mean months of work for normal and dysplastic dogs were evaluated using the Student's t-test. No significant difference was found in the total number of months worked between normal and dysplastic dogs (p greater than 0.05).

Metatarsophalangeal arthrodesis in three dogs

1998 ◽  
Vol 34 (2) ◽  
pp. 158-163 ◽  
Author(s):  
MC Rochat ◽  
FA Mann
Keyword(s):  
Internal Fixation ◽  
Cancellous Bone ◽  
Bone Grafts ◽  
Degenerative Joint Disease ◽  
Bone Plates ◽  
Joint Disease ◽  
Limb Function ◽  
Immune Mediated ◽  
K Wires ◽  
End Stage

Metatarsophalangeal (MTP) arthrodesis was done in each of three dogs with end-stage degenerative joint disease resulting from trauma and osteomyelitis (n = 2) and immune-mediated disease (n = 1). In two cases, MTP arthrodesis proved to be a useful method of eliminating pain and salvaging limb function. In one case, concurrent injuries and obesity prevented full return to function. Arthrodesis was accomplished with autogenous cancellous bone grafts and bone plates (n = 2) and with transarticular K-wires (n = 1). External coaptation was a necessary adjunct to internal fixation in all cases.

A case of dorso-medial luxation of the radial carpal bone in a dog

2008 ◽  
Vol 21 (02) ◽  
pp. 171-176 ◽  
Author(s):  
C. Delbeke ◽  
E. Asimus ◽  
P. Meynaud-Collard ◽  
D. Mathon ◽  
A. Zahra ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Closed Reduction ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Carpal Bone ◽  
Collateral Ligament ◽  
Limb Function ◽  
Radial Collateral Ligament ◽  
Clinical Cases

SummaryLuxation of the radial carpal bone is an uncommon injury in the dog and cat. Previous clinical cases have reported palmaro-medial luxation with injury to the short radial collateral ligament. In this study a case of dorsomedial luxation of the radial carpal bone in a 10-yearold female Gordon Setter is described. A closed reduction of the luxation was performed and a conservative treatment was carried out. Thirteen months after the reduction, the dog had a satisfactory limb function, despite the presence of degenerative joint disease of the carpus. A pathogenic hypothesis for this dorso-medial luxation of the radial carpal bone is proposed reproducing the luxation on canine cadavers.

Sign in / Sign up

Export Citation Format

Share Document