The Measurement of Performance in Probabilistic Diagnosis V. General Recommendations

1981 ◽  
Vol 20 (02) ◽  
pp. 97-100 ◽  
Author(s):  
J. D. F. Habbema ◽  
J. Hilden ◽  
B. Bjerregaard

Guidelines are offered concerning the use of evaluation tools, with emphasis on the simplest and most informative ones amongst those proposed in Parts I—IV of this series. Moreover, the main areas of future research and development, as the authors see them, are pointed out.

Author(s):  
Pankaj Musyuni ◽  
Geeta Aggarwal ◽  
Manju Nagpal ◽  
Ramesh K. Goyal

Background: Protecting intellectual property rights are important and particularly pertinent for inventions which are an outcome of rigorous research and development. While the grant of patents is subject to establishing novelty and inventive step, it further indicates the technological development and helpful for researchers working in the same technical domain. The aim of the present research work is to map the existing work through analysis of patent literature, in the field of Coronaviruses (CoV), particularly COVID-19 (2019-nCoV). CoV is a large family of viruses known to cause illness in human and animals, particularly known for causing respiratory infections as evidenced in earlier times such as in MERS i.e. Middle East Respiratory Syndrome; SRS i.e. Severe Acute Respiratory Syndrome. A recently identified novel-coronavirus has known as COVID-19 which has currently caused pandemic situation across the globe. Objective: To expand analysis of patents related to CoV and 2019-nCoV. Evaluation has been conducted by patenting trends of particular strains of identified CoV diseases by present legal status, main concerned countries via earliest priority years and its assignee types and inventors of identified relevant patents. We analyzed the global patent documents to check the scope of claims along with focuses and trends of the published patent documents for the entire CoV family including 2019- nCoV through the present landscape. Methods: To extract the results, Derwent Innovation database is used by a combination of different key-strings. Approximately 3800 patents were obtained and further scrutinized and analyzed. The present write-up also discusses the recent progress of patent applications in a period of the year 2010 to 2020 (present) along with the recent developments in India for the treatment options for CoV and 2019-nCoV. Results: Present analysis showed that key areas of the inventions have been focused on vaccines and diagnostic kits apart from the composition for treatment of CoV. We also observed that no specific vaccine treatments is available for treatment of 2019-nCov, however, developing novel chemical or biological drugs and kits for early diagnosis, prevention and disease management is the primarily governing topic among the patented inventions. The present study also indicates potential research opportunities for the future, particularly to combat 2019-nCoV. Conclusion: The present paper analyzes the existing patents in the field of Coronaviruses and 2019-nCoV and suggests a way forward for the effective contribution in this upcoming research area. From the trend analysis, it was observed an increase in filing of the overall trend of patent families for a period of 2010 to the current year. This multifaceted analysis of identified patent literature provides an understanding of the focuses on present ongoing research and grey area in terms of the trends of technological innovations in disease management in patients with CoV and 2019-nCoV. Further, the findings and outcome of the present study offer insights for the proposed research and innovation opportunities and provide actionable information in order to facilitate policymakers, academia, research driven institutes and also investors to make better decisions regarding programmed steps for research and development for the diagnosis, treatment and taking preventive measures for CoV and 2019-nCoV. The present article also emphasizes on the need for future development and the role of academia and collaboration with industry for speedy research with a rationale.


2021 ◽  
Vol 7 (1) ◽  
pp. 104
Author(s):  
Wei-Hao Su ◽  
Kai-Ying Chen ◽  
Louis Y. Y. Lu ◽  
Ya-Chi Huang

This study collected literature on augmented reality (AR) from academic and patent databases to plot the historic development trajectory of AR and forecast its future research and development trends. A total of 3193 and 13,629 papers were collected from academic and patent databases, respectively. First, a network was established using references from the academic literature; main path analysis was conducted on this reference network to plot the overall development trajectory. Subsequent cluster and word cloud analyses revealed the following five major groups of AR research topics: AR surgical navigation applications, AR education applications, AR applications in manufacturing, AR applications in architecture, and AR applications in visual tracking. Subsequently, the relationships between the overall development trajectory and the five AR research topics were compared. Next, the title and abstract of AR-related academic and patent papers were subjected to text mining to identify keywords with a high frequency of occurrence. The results can provide a reference for industry, government, and academia when planning future development strategies for the AR field. This research adopted an integrated analysis procedure to plot the trajectory of AR technology development and applications successfully and effectively, predict future patent research and development directions and produce technological forecasts.


Author(s):  
Runmeng Qiao ◽  
Xin Wang ◽  
Guangjiong Qin ◽  
Jialei Liu ◽  
Aocheng Cao ◽  
...  

: The plastic film plays an important role in China's agricultural production. However, the large-scale use of plastic film has also produced a very serious problem of agricultural film pollution. Biodegradable polymers have attracted much attention because of the environmental pollution caused by traditional plastic mulching film. The most typical one is poly (butylene adipate co butylene terephthalate, PBAT). Poly (Butylene Adipate-co-Terephthalate) (PBAT) is a kind of aliphatic–aromatic polyesters with excellent biodegradability and mechanical processing properties. Therefore, it has been rapidly developed and widely used in the industry. However, there are clear requirements for the degradation period of agricultural film. At present, the degradable materials available on the market are difficult to meet the requirements of all crops for their degradation period. In this paper, the basic properties,degradation process and ways to delay the degradation of PBAT are reviewed to improve the degradation period of plastic film prepared by using this kind of material. Among them, the degradation process includes photodegradation, biodegradation and hydrolysis. The ways to delay the degradation include adding chain extender, light stabilizer, anti-hydrolysis agent and antibacterial agent. These can provide a theoretical basis for the research and development of biodegradable film with controllable degradation cycle. The future research and development of biodegradable polymers mainly focus on controllable degradation rate, stable degradation cycle, new materials and reducing research and development costs.


2020 ◽  
pp. 1232-1271
Author(s):  
Stuart Armstrong ◽  
Roman V. Yampolskiy

Superintelligent systems are likely to present serious safety issues, since such entities would have great power to control the future according to their possibly misaligned goals or motivation systems. Oracle AIs (OAI) are confined AIs that can only answer questions and do not act in the world, represent one particular solution to this problem. However even Oracles are not particularly safe: humans are still vulnerable to traps, social engineering, or simply becoming dependent on the OAI. But OAIs are still strictly safer than general AIs, and there are many extra layers of precautions we can add on top of these. This paper begins with the definition of the OAI Confinement Problem. After analysis of existing solutions and their shortcomings, a protocol is proposed aimed at making a more secure confinement environment which might delay negative effects from a potentially unfriendly superintelligence while allowing for future research and development of superintelligent systems.


Author(s):  
Demosthenes Akoumianakis

This chapter attempts to consolidate concepts, ideas and results reported in this volume in an effort to synthesize an agenda and sketch a roadmap for future research and development on virtual community practices facilitated by synergistic combination of social interactive media. In this endeavor, the author revisits the notions of new media, communities and social practice, in the light of the preceding chapters and with the intention to pickup seemingly heterogeneous concepts and sketch the puzzle of social interactive media and virtual community practice. The ultimate target is to make inroads towards a reference model for understanding and framing online social practice under the different regimes constituted by new media and social computing.


Author(s):  
Rafael Moreno-Sanchez

The Semantic Web (SW) and Geospatial Semantic Web (GSW) are considered the next step in the evolution of the Web. For most non-Web specialists, geospatial information professionals, and non-computer-science students these concepts and their impacts on the way we use the Web are not clearly understood. The purpose of this chapter is to provide this broad audience of non-specialists with a basic understanding of: the needs and visions driving the evolution toward the SW and GSW; the principles and technologies involved in their implementation; the state of the art in the efforts to create the GSW; the impacts of the GSW on the way we use the Web to discover, evaluate, and integrate geospatial data and services; and the needs for future research and development to make the GSW a reality. A background on the SW is first presented to serve as a basis for more specific discussions on the GSW.


2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Peter L Gorski ◽  
Emanuel von Zezschwitz ◽  
Luigi Lo Iacono ◽  
Matthew Smith

Abstract We present a systematization of usable security principles, guidelines and patterns to facilitate the transfer of existing knowledge to researchers and practitioners. Based on a literature review, we extracted 23 principles, 11 guidelines and 47 patterns for usable security and identified their interconnection. The results indicate that current research tends to focus on only a subset of important principles. The fact that some principles are not yet addressed by any design patterns suggests that further work on refining these patterns is needed. We developed an online repository, which stores the harmonized principles, guidelines and patterns. The tool enables users to search for relevant guidance and explore it in an interactive and programmatic manner. We argue that both the insights presented in this article and the web-based repository will be highly valuable for students to get a good overview, practitioners to implement usable security and researchers to identify areas of future research.


Author(s):  
Patricia M. Danzon

This article summarizes the literature, and considers the issue of paying for research and development. It reviews research and development costs, regulation, productivity and incentives for innovation. It discusses market demand and pricing, effects of insurance, reimbursement regulation, alternatives to patents, and generics. Further, it reviews trends in promotion, regulation of promotion and its effects. It discusses global issues, including differential pricing and R&D for neglected diseases. The focus is on the US, as the home of the largest number of multinational pharmaceutical and smaller biotech companies. This article notes the important differences in regulatory and reimbursement systems in other countries. Finally it suggests that although there is large and growing literature on the pharmaceutical industry that has produced valuable information, important issues remain for future research.


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