Fibrinolysis After Multiple Trauma In Man. Clinical And Methodological Aspects

1981 ◽  
Author(s):  
A-C Teger-Nilsson ◽  
E Gyzander ◽  
A Medegård ◽  
B Risberq ◽  
B Wiman
Keyword(s):  
Traffic Accidents ◽  
Soft Tissues ◽  
Bone Fractures ◽  
Degradation Products ◽  
Clinical Situation ◽  
Fibrinolytic System ◽  
Phase Reaction ◽  
Chromogenic Substrate ◽  
Immunological Method ◽  
Activity Measurements

Fifteen patients with at least two bone fractures and damages of soft tissues, mainly after traffic accidents, were investigated for changes in the fibrinolytic system. Seventeen healthy students were controls. The patients were conventionally treated in an intensive care unit. Blood samples, in all 140, were taken on the day of admission and then daily for about one week. The blood was analysed for plasminogen with electroimmunoassay and with chromogenic substrate after streptokinase activation, for α 2-antiplasmin with electroimmunoassay and two types of activity measurements (chromogenic substrate), for α 2-antiplasmin - plasmin complexes with RIA technique, and for α 2-macroglobulin with electroimmunoassay and activity measurements. In addition fibrinogen, fibrinogen-fibrin degradation products and fibrinolytic activity on fibrin plates were estimated.Plasminogen was somewhat low the first days after trauma lowest 69 % ± 22 % (M ± SD), day 3]. It then slowly increased towards the end of the investigation (highest 123% ± 21%). The last days of investigation the immunological method also gave higher values than the activity method, α 2 Antiplasmin was low directly after the trauma (lowest 67% ± 18%, day 1 ) and increased gradually (highest 115% ± 19%, day 6 ). The first days after trauma immunological method gave higher values than the activity methods, α 2 Antiplasmin - plasmin complexes varied, but showed occasionally high values in particular the first day. α 2 -Macroglobulin decreased only slightly on day 5-6, when it also showed a difference between the immunological and activity methods.It is concluded that the fibrinolytic system is activated immediately after a trauma. Later there is an increase of plasminogen, α 2 antiplasmin and fibrinogen, probably due to an acute phase reaction. Some reasons for the methodological discrepancies are discussed. Serial analysis of α 2-antiplasmin activity seems to be a relevant method for evaluation of fibrinolysis in a complex clinical situation.

Plasma Thrombin Assay using a Chromogenic Substrate in Disseminated Intravascular Coagulation due to Snake Bite Envenomation

1979 ◽  
Vol 41 (03) ◽  
pp. 544-552 ◽  
Author(s):  
R P Herrmann ◽  
P E Bailey
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Degradation Products ◽  
Snake Bite ◽  
Chromogenic Substrate ◽  
Coagulation Parameters ◽  
Fibrinogen Degradation Products ◽  
Intravascular Coagulation

SummaryUsing the chromogenic substrate, Tos-Gly-Pro-Arg-pNA-HCL (Chromozym TH, Boehringer Mannheim) plasma thrombin was estimated in six cases of envenomation by Australian elapid snakes. All patients manifested findings chracteristic of defibrination due to envenomation by these snakes. Fibrin-fibrinogen degradation products were grossly elevated, as was plasma thrombin in all cases.Following treatment with antivenene, all abnormal coagulation parameters returned rapidly towards normal by 24 hours and plasma thrombin disappeared.

Mandibular Bone Fractures in elderly patients with reference to etiology of trauma

2021 ◽  
Vol 15 (8) ◽  
pp. 1920-1922
Author(s):  
Nabeela Riaz ◽  
Samreen Younas ◽  
Ijaz Ur Rehman ◽  
Ahmad Abdul Haseeb ◽  
Saba Hanif ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Traffic Accidents ◽  
Road Traffic ◽  
Bone Fractures ◽  
Financial Burden ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Mandibular Fractures ◽  
Mandibular Bone ◽  
Mandibular Injuries

Aim: to explore the mandibular bone fractures in elderly patients with reference to etiology of trauma. Methodology: This was a descriptive study conducted in the department of Oral and Maxillofacial Surgery KEMU/ Mayo Hospital Lahore. Elderly patients (age 60-100years) with mandibular bone fractures. Results: Aetiology of trauma leading to mandibular fractures was as follows; there were 79(65.83%) cases of RTA, 32(26.66%) falls, 4(3.33%) assaults and there were only 3(2.5%) cases of industrial injury. Conclusion: To conclude, this study depicts that road traffic accidents were the predominant cause of injury in the studied age group. Elderly patients need more care and attention, especially after traumatic incidents and lead to financial burden in hospitals Keywords: Maxillofacial trauma, Elderly population, Mandibular injuries, Elderly fractures

scholarly journals Wildlife Ungulate Rescue and Emergency Services in the Pisa Area (Tuscany, Italy): Evaluation of a 9-Years Period (2010–2018)

2020 ◽  
Vol 7 ◽  
Author(s):  
Maria Irene Pacini ◽  
Francesca Bonelli ◽  
Angela Briganti ◽  
Simonetta Citi ◽  
Stefania Perrucci ◽  
...  
Keyword(s):  
Diagnostic Imaging ◽  
Emergency Management ◽  
Clinical Data ◽  
Traffic Accidents ◽  
Biochemical Analysis ◽  
Soft Tissues ◽  
Emergency Services ◽  
Imaging Diagnosis ◽  
Traumatic Injuries ◽  
Car Accidents

Background: We analyzed the clinical data of wildlife ungulates admitted for emergency care to the Veterinary Teaching Hospital (VTH), Department of Veterinary Medicine, University of Pisa over a 9-years period.Methods: Clinical data of all the wildlife ungulates admitted to the VTH were recorded. Blood samples were also taken from the animals for hematological and biochemical analysis. An assessment of ecto- and endoparasites was carried out, diagnostic imaging assessment was performed, and the outcomes were recorded.Results: Data concerning clinical parameters, blood work, parasitological analysis, and diagnostic imaging diagnosis were expressed as prevalence.Conclusion: The rescue and emergency treatments were related mostly to traumas caused by car accidents, followed by other causes. The traumatic injuries were mostly severe, characterized by multiple lesions involving hard and soft tissues. In this study, traffic accidents were the main cause of wildlife rescue and emergency management. This is probably due to the increased population of ungulates over the years, along with the considerable anthropization of the Pisa area.

scholarly journals Clinical Performance of a New Biomimetic Double Network Material

2013 ◽  
Vol 7 (1) ◽  
pp. 118-122 ◽  
Author(s):  
Christine Dirxen ◽  
Uwe Blunck ◽  
Saskia Preissner
Keyword(s):  
Soft Tissues ◽  
Clinical Performance ◽  
Young Patients ◽  
Tooth Wear ◽  
Clinical Situation ◽  
Dental Erosion ◽  
Thin Layers ◽  
Invasive Treatment ◽  
Tooth Structure ◽  
Non Invasive

Background:The development of ceramics during the last years was overwhelming. However, the focus was laid on the hardness and the strength of the restorative materials, resulting in high antagonistic tooth wear. This is critical for patients with bruxism.Objectives:The purpose of this study was to evaluate the clinical performance of the new double hybrid material for non-invasive treatment approaches.Material and Methods:The new approach of the material tested, was to modify ceramics to create a biomimetic material that has similar physical properties like dentin and enamel and is still as strong as conventional ceramics.Results:The produced crowns had a thickness ranging from 0.5 to 1.5 mm. To evaluate the clinical performance and durability of the crowns, the patient was examined half a year later. The crowns were still intact and soft tissues appeared healthy and this was achieved without any loss of tooth structure.Conclusions:The material can be milled to thin layers, but is still strong enough to prevent cracks which are stopped by the interpenetrating polymer within the network. Depending on the clinical situation, minimally- up to non-invasive restorations can be milled.Clinical Relevance:Dentistry aims in preservation of tooth structure. Patients suffering from loss of tooth structure (dental erosion, Amelogenesis imperfecta) or even young patients could benefit from minimally-invasive crowns. Due to a Vickers hardness between dentin and enamel, antagonistic tooth wear is very low. This might be interesting for treating patients with bruxism.

Fibrinolytic system, fibrinogen degradation products and soluble fibrin monomer complexes of renal venous and aortal blood

1969 ◽  
Vol 25 (9) ◽  
pp. 996-997
Author(s):  
A. Nowak ◽  
S. Niewiarowski ◽  
Z. Czekala ◽  
K. Worowski ◽  
J. Dosiak ◽  
...  
Keyword(s):  
Degradation Products ◽  
Fibrinolytic System ◽  
Fibrinogen Degradation Products ◽  
Soluble Fibrin ◽  
Fibrin Monomer

Assessment of Plasma Fibrinolytic System with Use of Chromogenic Substrate

1978 ◽  
Vol 7 (2-3) ◽  
pp. 150-154 ◽  
Author(s):  
Z.S. Latallo ◽  
E. Teisseyre ◽  
S. Lopaciuk
Keyword(s):  
Fibrinolytic System ◽  
Chromogenic Substrate

Fibrinolytic Activity in Patients with Acute Tonsillitis

1979 ◽  
Vol 88 (3) ◽  
pp. 366-367 ◽  
Author(s):  
T. Kosugi ◽  
O. Matsuo ◽  
M. Hamaya ◽  
H. Mihara
Keyword(s):  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Healthy Adults ◽  
Fibrinolytic System ◽  
Acute Tonsillitis ◽  
Fibrin Degradation Products ◽  
Fibrinogen Content

Three parameters in blood fibrinolysis, viz, the levels of fibrinogen, plasminogen, and fibrinogen and/or fibrin degradation products (FDP), were measured in patients with acute tonsillitis and the results were compared with those for healthy adults. The fibrinogen content in acute tonsillitis increased significantly ( P <.001), that of plasminogen decreased significantly ( P <.005), while FDP showed a higher value ( P <.01). The significance of the fibrinolytic system in acute tonsillitis is discussed.

BOSENTAN, A NON-SPECIFIC ENDOTHELIN ANTAGONIST, STIMULATES FRACTURE HEALING

2007 ◽  
Vol 19 (01) ◽  
pp. 37-46 ◽  
Author(s):  
Hasan H. Muratli ◽  
Feza Korkusuz ◽  
Petek Korkusuz ◽  
Ali Bicimoglu ◽  
Z. Sevim Ercan
Keyword(s):  
Fracture Healing ◽  
Bone Fractures ◽  
Fracture Site ◽  
Controlled Study ◽  
Prostaglandin E ◽  
Matrix Mineralization ◽  
Hind Limbs ◽  
Diaphyseal Bone ◽  
Activity Measurements ◽  
Intramedullary Rod

It is assumed that bosentan, a non-selective ET-1 receptor antagonist, will enhance fracture healing. The aim of this prospective randomized controlled study was to investigate the effects of transcutaneous bosentan administration into diaphyseal bone fractures using radiology, histology, prostaglandin E2 (PGE2) and leukotrien C 4 (LTC4) activity measurements. A closed diaphyseal fracture was created in the hind limbs following intramedullary rod fixation of Guinea pigs. Bosentan was administred by repetitive weekly 0.1 μg transcutaneous injections into the fracture site. The effects of bosentan were evaluated by radiology and histology on weeks 1, 2 and 4, whereas prostaglandin E2 (PGE2)-like and leukotrien C 4 (LTC4)-like activity was assessed on weeks 1 and 2. The radiological degree of union (p = 0.001) at the fracture site and cortex-callus ratio (p = 0.02) was significantly better in the bosentan administered site at week 1 when compared to the control. Histology presented an initial stimulation of bone formation on weeks 1 and 2 in the experimental group. PGE2-like activity was significantly higher (p = 0.002) on week 1 and 2 in the bosentan-administered side. LTC4-like activity remained constant on week one and decreased on week two. Transcutaneous repetitive bosentan administration into the fracture site initially stimulated periosteal bone healing that resulted with extracellular matrix mineralization. The inflammatory mediators PGE2/LTC4 played a significant role in this process.

scholarly journals Evaluation of the daytime tropospheric loss of 2-methylbutanal

2021 ◽  
Author(s):  
María Asensio ◽  
María Antiñolo ◽  
Sergio Blázquez ◽  
José Albaladejo ◽  
Elena Jiménez
Keyword(s):  
Mass Spectrometry ◽  
Gas Phase ◽  
Degradation Products ◽  
Rate Coefficients ◽  
Oh Radicals ◽  
Phase Reaction ◽  
Gaseous Products ◽  
Flight Mass Spectrometry ◽  
Atmospheric Degradation ◽  
The Impact

Abstract. Saturated aldehydes, e.g. 2-methylbutanal (2MB, CH3CH2CH(CH3)C(O)H), are emitted into the atmosphere by several biogenic sources. The first step in the daytime atmospheric degradation of 2MB involves gas-phase reactions initiated by hydroxyl (OH) radicals, chlorine (Cl) atoms and/or sunlight. In this work, we report the rate coefficients for the gas-phase reaction of 2MB with OH (kOH) and Cl (kCl) together with the photolysis rate coefficient (J) in the ultraviolet solar actinic region in Valencia (Spain) at different times of the day. The temperature dependence of kOH was described in the 263–353 K range by the following Arrhenius expression: kOH(T)=(8.88±0.41)×10-12 exp[(331±14)/T] cm3 molecule-1 s-1. At 298 K, the reported kOH and kCl are (2.68±0.07)×10-11 cm3 molecule-1 s-1 and (2.16±0.16)×10-11 cm3 molecule-1 s-1. Identification and quantification of the gaseous products of the Cl-reaction and those from the photodissociation of 2MB were carried out in a smog chamber by different techniques (Fourier transform infrared spectroscopy, proton transfer time-of-flight mass spectrometry, and gas chromatography coupled to mass spectrometry). The formation and size distribution of secondary organic aerosols formed in the Cl-reaction was monitored by a fast mobility particle sizer spectrometer. A discussion on the relative importance of the first step in the daytime atmospheric degradation of 2MB is presented together with the impact of the degradation products in marine atmospheres.

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