On the Significance of Antithrombin-III, α2-Macroglobulin, α2-Antiplasmin, Histidine-Rich Glycoprotein, and Protein C in Patients with Acute Myocardial Infarction and Deep Vein Thrombosis

1985 ◽  
Vol 54 (02) ◽  
pp. 503-505 ◽  
Author(s):  
Jørgen Gram ◽  
Jørgen Jespersen
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Deep Vein Thrombosis ◽  
Longitudinal Study ◽  
Protein C ◽  
Antithrombin Iii ◽  
Clinical Signs ◽  
Vein Thrombosis ◽  
Α2 Macroglobulin ◽  
Deep Vein

SummaryIn a longitudinal study the plasma levels of antithrombin-III, α2-macroglobulin, α2-antiplasmin, histidine-rich glycoprotein, and protein C were followed in two groups of patients with acute myocardial infarction (AMI), one with and one without deep vein thrombosis (DVT). None of the sequentially studied periods revealed significant differences between the two groups of patients. However, small but consistently higher levels of histidine-rich glycoprotein in patients with DVT suggested the existence among patients submitted for myocardial infarction of a subgroup with increased thrombophilic potential. It was concluded that the inhibitors studied are of little value as possible indicators of the presence of DVT at early stages of the disease when clinical signs are absent and when antithrombotic prophylaxis should preferably be initiated.

Patients with APC Resistance Compared with Those with Other Clotting Inhibitor Deficiencies Show Later Onset of Venous Thrombosis During Oral Contraception

1995 ◽  
Vol 1 (4) ◽  
pp. 274-276 ◽  
Author(s):  
Antonio Girolami ◽  
Paolo Simioni ◽  
Sandra Zanardi ◽  
Luigi Scarano ◽  
Bruno Girolami
Keyword(s):  
Deep Vein Thrombosis ◽  
Protein C ◽  
Antithrombin Iii ◽  
Activated Protein C ◽  
Protein S ◽  
Oral Contraception ◽  
Vein Thrombosis ◽  
Apc Resistance ◽  
At Iii ◽  
Deep Vein

The prevalence of deep vein thrombosis in female patients with antithrombin III (AT III), protein C, or protein S deficiency who are on oral contraception has been compared with that of patients with activated protein C (APC) resistance. In the latter case the prevalence was lower (36.4%) than in the AT III deficiency group (71.4%) but similar to that seen in the protein C and protein S group (25%).' Furthermore, venous thrombosis occurred with APC resistance much later than with AT III, protein C, or protein S defects. The time lag between onset of oral contraception and thrombosis (~16 cycles) was not statistically different from that seen in a group of women who were known to have no antithrombin III, protein C, or protein S defects. It appears that as far as the interaction with oral contraception is concerned APC resistance is a much less severe condition compared with other clotting inhibitor defects. Key Words: Oral contraceptive—Activated protein C resistance—Deep vein thrombosis.

Venous Function of the Leg in Patients with Acute Myocardial Infarction

1989 ◽  
Vol 4 (2) ◽  
pp. 83-89 ◽  
Author(s):  
Asbjörn Kierkegaard ◽  
Lars Norgren ◽  
Ulf Thilen
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Deep Vein Thrombosis ◽  
Severe Disease ◽  
Venous Outflow ◽  
Vein Thrombosis ◽  
Venous Volume ◽  
Venous Function ◽  
Deep Vein ◽  
Anterior Infarction

Venous volume and venous outflow of the calf were studied with strain gauge plethysmography in 50 unselected patients with an acute myocardial infarction. These parameters increased during the first days if the course of the infarction was uncomplicated. In complicated myocardial infarction however, no such increase was registered. In patients without complications, venous volume and venous outflow were higher in those who were mobilized compared to inactive ones, and patients with an anterior infarction had higher values than those with other locations of their myocardial infarction. Deterioration of venous function apparently is associated with more severe disease, and may predispose to a further complication, deep vein thrombosis.

A Case of Hereditary Antithrombin III Deficiency Manifested by Myocardial Infarction and Deep Vein Thrombosis

2002 ◽  
Vol 32 (6) ◽  
pp. 521 ◽  
Author(s):  
Ki Young Kim ◽  
Keon Woong Moon ◽  
Doo Soo Jeon ◽  
Joo Youn Choi ◽  
Dae Hyung Jeon ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Deep Vein Thrombosis ◽  
Antithrombin Iii ◽  
Vein Thrombosis ◽  
Antithrombin Iii Deficiency ◽  
Deep Vein

A Sequential Study of Plasma Histidine-Rich Glycoprotein and Plasminogen in Patients with Acute Myocardial Infarction and Deep Vein Thrombosis

1984 ◽  
Vol 51 (01) ◽  
pp. 099-102 ◽  
Author(s):  
Jørgen Jespersen ◽  
Jørgen Gram ◽  
Elsa Bach
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Deep Vein Thrombosis ◽  
Prospective Study ◽  
Acute Phase Reactant ◽  
Vein Thrombosis ◽  
Phase Reactant ◽  
A Prospective Study ◽  
Deep Vein ◽  
Made In

SummaryIn a prospective study of deep vein thrombosis (DVT), detected by the Tc-plasmin test, in 34 patients with acute myocardial infarction sequential determinations were made in plasma by immunologic methods of histidine-rich glycoprotein (HRG) and total plasminogen and the concentrations of free plasminogen calculated. Mean plasma HRG concentrations were consistently higher in the group of patients, in which Tc-plasmin scanning had revealed the existence of DVT. The effect of HRG caused the level of free plasminogen to be only 50–60% of the level of total plasminogen. Fluctuations of HRG caused only minor changes in free plasminogen concentrations. Our data suggest that HRG acts as a weak, negative acute phase reactant.

scholarly journals Clinical case of a paradoxical embolism that caused an acute myocardial infarction after deep vein thrombosis

2020 ◽  
pp. 161-168
Author(s):  
Yu. V. Larchikova ◽  
A. D. Ehrlikh ◽  
I. N. Smetanina ◽  
N. Yu. Zheltov
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Deep Vein Thrombosis ◽  
Clinical Case ◽  
Clinical Situation ◽  
Paradoxical Embolism ◽  
Medical Decisions ◽  
Vein Thrombosis ◽  
The Right ◽  
Deep Vein

Paradoxical thromboembolism due to the presence of an patent foramen ovale (PFO) is a rather rare phenomenon, especially when an embolism results in acute myocardial infarction (MI). The presented clinical case of the paradoxical embolism is interesting for several reasons: firstly, the patient's primary disease was deep vein thrombosis (DVT) and pulmonary artery thromboembolism (PATE); secondly, apparently, it was due to PATE and the subsequent overload of the right side of the heart that thelatent embolism became apparent; thirdly, the paradoxical embolism was apparently caused by the fragments of alarge thrombus stuck in PFO, fourthly, the current clinical situation was ambiguous with respect to medical decisions, primarily concerning antithrombotic therapy.

D-Dimers, Thrombin Antithrombin III Complexes and Prothrombin Fragments 1 + 2: Diagnostic value in Clinically Suspected Deep Vein Thrombosis

1991 ◽  
Vol 65 (01) ◽  
pp. 028-032 ◽  
Author(s):  
B Boneu ◽  
G Bes ◽  
H Pelzer ◽  
P Sié ◽  
H Boccalon
Keyword(s):  
Deep Vein Thrombosis ◽  
Antithrombin Iii ◽  
High Sensitivity ◽  
Diagnostic Value ◽  
Predictive Values ◽  
Vein Thrombosis ◽  
High Negative Predictive Value ◽  
Deep Vein ◽  
D Dimer ◽  
Mercury Strain Gauge

SummaryThis study was performed to determine the accuracy of D-Dimer fibrin derivatives, thrombin-antithrombin III (TAT) complexes and prothrombin fragments 1 + 2 (F 1 + 2) determinations for the diagnosis of deep vein thrombosis (DVT). One hundred and sixteen consecutive patients referred to the angiology unit of our hospital for a clinically suspected DVT were investigated. They were submitted to mercury strain gauge plethysmography and to ultrasonic duplex scanning examination; in cases of inconclusive results or of proximal DVT (n = 35), an ascending phlebography was performed. After these investigations were completed, the diagnosis of DVT was confirmed in 34 and excluded in 82. One half of the patients were already under anticoagulant therapy at the time of investigation. The 3 biological markers were assayed using commercially available ELISA techniques and the D-Dimer was also assayed with a fast latex method. The normal distribution of these markers was established in 40 healthy blood donors. The most accurate assay for the diagnosis of DVT was the D-Dimer ELISA which had both a high sensitivity (94%) and a high negative predictive value (95%). The D-Dirner latex, TAT complexes and F 1 + 2 were far less sensitive and provided negative predictive values which ranged between 78 and 85%. In spite of positive and significant correlations between the levels of ihe 3 markers, their association did not improve their overall accuracy for detecting D\/L Therefore, with the exception of the D-Dimer ELISA, these markers were of little value for the diagnosis of DVT in this specific population.

Predictive Value of Decreasing Antithrombin III in Deep-Vein Thrombosis

1980 ◽  
Vol 44 (03) ◽  
pp. 135-137 ◽  
Author(s):  
Thorkild Lund Andreasen
Keyword(s):  
Deep Vein Thrombosis ◽  
Predictive Value ◽  
Coronary Care Unit ◽  
Antithrombin Iii ◽  
Predictive Values ◽  
Vein Thrombosis ◽  
At Iii ◽  
Coronary Care ◽  
Time Of Admission ◽  
Deep Vein

SummaryAntithrombin III (At-III) was measured at the time of admission and two days later in 131 patients laid up in a coronary care unit. The patients were examined for deep-vein thrombosis (DVT) clinically and by means of 125I-fibrinogen scanning. 19 patients developed DVT. In 11 subjects with and 25 without DVT At-III decreased more than 10%. And in 7 with and 17 without DVT At-III decreased more than 15%. One person with DVT had subnormal At-III. By using decrease of At-III or subnormal initial At-III to predict DVT the following predictive value (PV) were found. Decrease ≤ 10%, PV pos.= 0.32 and PV neg. = 0.93. Decrease ≤ 15%, PV pos. = 0.32 and PV neg. = 0.90. The positive predictive values obtained were too low to let decreasing At-III give occasion for prophylactic anticoagulant treatment.

Sign in / Sign up

Export Citation Format

Share Document