Diagnostik der Leberfibrose bei nicht-alkoholischer Fettlebererkrankung mittels Composite Score aus einem Eicosanoid, einer Gallensäure und einem Androgen

2018 ◽  
Vol 56 (08) ◽  
pp. e284-e284
Author(s):  
F Stickel ◽  
S Schulze Pellengahr ◽  
S Neuber ◽  
B Kamlage ◽  
A Wagner-Golbs ◽  
...  
Keyword(s):  
Composite Score

Pattern of Near Transfer Effects Following Working Memory Training With a Dual N-Back Task

2017 ◽  
Vol 64 (4) ◽  
pp. 240-252 ◽  
Author(s):  
Anna Soveri ◽  
Eric P. A. Karlsson ◽  
Otto Waris ◽  
Petra Grönholm-Nyman ◽  
Matti Laine
Keyword(s):  
Working Memory ◽  
Controlled Trial ◽  
Composite Score ◽  
Memory Training ◽  
Interference Control ◽  
Transfer Effects ◽  
Near Transfer ◽  
Randomized Controlled ◽  
Transfer Tasks ◽  
Back Task

Abstract. In a randomized controlled trial, we investigated the pattern of near transfer effects of working memory (WM) training with an adaptive auditory-visuospatial dual n-back training task in healthy young adults. The results revealed significant task-specific transfer to an untrained single n-back task, and more general near transfer to a WM updating composite score plus a nearly significant effect on a composite score measuring interference control in WM. No transfer effects were seen on Active or Passive WM composites. The results are discussed in the light of cognitive versus strategy-related overlap between training and transfer tasks.

5.14 Psychometric Properties of a Novel Vineland-II 2-Domain Composite Score to Assess Social Communication and Social Interaction in ASD

2018 ◽  
Vol 57 (10) ◽  
pp. S231-S232
Author(s):  
Robert L. Findling ◽  
Stephanie Le Scouiller ◽  
Lisa Squassante ◽  
Kevin Sanders ◽  
Janice Smith ◽  
...  
Keyword(s):  
Social Interaction ◽  
Psychometric Properties ◽  
Social Communication ◽  
Composite Score

A comparison of functional movement patterns between female low back pain developers and non-pain developers

Work ◽  
2021 ◽  
pp. 1-8
Author(s):  
Fatemeh Khoshroo ◽  
Foad Seidi ◽  
Reza Rajabi ◽  
Abbey Thomas
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Muscle Activation ◽  
Statistical Significance ◽  
Movement Patterns ◽  
Composite Score ◽  
Quality Data ◽  
Low Back ◽  
Functional Movement ◽  
Prolonged Standing

BACKGROUND: Distinctive features of low back pain-developers (LBPDs) as pre-clinical low back pain (LBP) population have been evidenced in three areas of alignment, muscle activation, and movement patterns. To clarify whether the reported altered functional movement patterns in chronic LBP patients result from or result in LBP disorders, LBPDs’ functional movement patterns should be investigated. OBJECTIVES: This study aimed to compare female LBPDs’ functional movement patterns with non-pain developers’ (NPDs). METHODS: Sixty female LBPDs and NPDs were recruited based on the research requirements. The Functional Movement Screen (FMS) was used to investigate movement quality. Data were compared between groups via Mann-Whitney U tests and correlation analyses examined association between pain intensity and onset during prolonged standing and the FMS score. Receiver Operating Characteristic Curves and Chi Squares were conducted to find the best cutoff points. An alpha level of p≤0.05 was used to establish statistical significance. RESULTS: LBPDs scored significantly lower, or rather worse than NPDs in the FMS composite score (12.06±1.33 vs. 16.43±1.59, U = 3, P <  0.001). Moreover, the optimal cutoff scores of≤14 on the FMS, 2 on the push-up, and 1 on the deep squat discriminated between female LBPDs and NPDs. The FMS composite score was correlated negatively with LBP intensity (r (60) = –0.724, p <  0.001) and positively with LBP onset (r (60) = 0.277, p = 0.032) during prolonged standing. Finally, the results indicated that female LBPDs presented with at least one bilateral asymmetry on the FMS had 10 times (95%CI, 2.941–34.008) and with at least two bilateral asymmetries on the FMS had 15.5 times (95%CI, 3.814–63.359) higher odds of developing LBP during prolonged standing than NPDs. CONCLUSIONS: Female LBPDs, who are at higher risk for developing LBP in the future, have significantly lower quality of functional movement patterns compared to NPDs. Moreover, the FMS appears to show promise for predicting individuals who are at risk for LBP development during prolonged standing.

Adolescent Popularity as a Nonlinear, Two-Dimensional Construct: Convergent Results From Three Large Samples

2021 ◽  
pp. 027243162110160
Author(s):  
Peter E. L. Marks ◽  
Ben Babcock ◽  
Yvonne H. M. van den Berg ◽  
Rob Gommans ◽  
Antonius H. N. Cillessen
Keyword(s):  
Early Adolescents ◽  
Composite Score ◽  
Two Dimensional ◽  
Behavioral Correlates ◽  
Large Samples ◽  
Three Samples ◽  
Peer Nominations

The goal of this study was to advance the conceptualization and measurement of adolescent popularity by exploring the commonly used composite score (popularity minus unpopularity). We used standardized peer nominations from 4,414 early adolescents (ages ≈ 12-14 years) from three samples collected in two countries. Popularity and unpopularity were strongly related, but not linearly; scatterplots of the two variables resembled an L-shaped right angle. Subsequent analyses indicated that either including popularity as a curvilinear term or including both popularity and unpopularity as separate terms explained significantly more variance in social and behavioral correlates than linear, bivariate analyses using popularity, unpopularity, or composite popularity. These results suggest that researchers studying adolescent popularity should either separate popularity and unpopularity or treat composite popularity as curvilinear.

scholarly journals Multicentre methodological study to create a publicly available score of hospital financial standing in the USA

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e046500
Author(s):  
Radoslav Zinoviev ◽  
Harlan M Krumholz ◽  
Richard Ciccarone ◽  
Rick Antle ◽  
Howard P Forman
Keyword(s):  
Gold Standard ◽  
Financial Stability ◽  
Credit Rating ◽  
Financial Data ◽  
Composite Score ◽  
Methodological Study ◽  
Bond Ratings ◽  
Hospital Operations ◽  
Initial Dataset ◽  
The Usa

ObjectivesTo create a straightforward scoring procedure based on widely available, inexpensive financial data that provides an assessment of the financial health of a hospital.DesignMethodological study.SettingMulticentre study.ParticipantsAll hospitals and health systems reporting the required financial metrics in the USA in 2017 were included for a total of 1075 participants.InterventionsWe examined a list of 232 hospital financial indicators and used existing models and financial literature to select 30 metrics that sufficiently describe hospital operations. In a set of hospital financial data from 2017, we used principal coordinate analysis to assess collinearity among variables and eliminated redundant variables. We isolated 10 unique variables, each assigned a weight equal to the share of its coefficient in a regression onto Moody’s Credit Rating, our predefined gold standard. The sum of weighted variables is a single composite score named the Yale Hospital Financial Score (YHFS).Primary outcome measuresAbility to reproduce both financial trends from a ‘gold-standard’ metric and known associations with non-fiscal data.ResultsThe validity of the YHFS was evaluated by: (1) cross-validating it with previously excluded data; (2) comparing it to existing models and (3) replicating known associations with non-fiscal data. Ten per cent of the initial dataset had been reserved for validation and was not used in creating the model; the YHFS predicts 96.7% of the variation in this reserved sample, demonstrating reproducibility. The YHFS predicts 90.5% and 88.8% of the variation in Moody’s and Standard and Poor’s bond ratings, respectively, supporting its validity. As expected, larger hospitals had higher YHFS scores whereas a greater share of Medicare discharges correlated with lower YHFS scores.ConclusionsWe created a reliable and publicly available composite score of hospital financial stability.

scholarly journals Fear of Falling and Cognitive Decline in Healthy Aging Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 265-265
Author(s):  
Rebecca Kraut ◽  
Roee Holtzer
Keyword(s):  
Older Adults ◽  
Executive Functions ◽  
Cognitive Decline ◽  
Healthy Aging ◽  
Fear Of Falling ◽  
Composite Score ◽  
Cognitive Measures ◽  
Delayed Recall ◽  
Memory And Attention ◽  
Aging Adults

Abstract Fear of Falling (FOF) is common and associated with poor mobility in aging but whether persistence of FOF endorsement influences cognitive decline has not been reported. Here we determined the effect of FOF, measured dichotomously and after accounting for persistence, on decline in global cognitive function (GCF), memory, and attention/executive functions. Older adults with persistent FOF (n=81; mean age=77.63±6.67 yrs; %female=74.1), transient FOF (n=60; mean age=76.93±6.01 yrs; %female=61.7), and no FOF (n=286; mean age=75.77±6.42 yrs; %female=49.3) were included. FOF was assessed through yes/no responses to “do you have a fear of falling?” at baseline. GCF was assessed using RBANS; memory was assessed using a composite score comprising the immediate and delayed recall index scores from RBANS; attention/executive functions were assessed via a composite score comprising TMT A & B, letter and category fluency tasks, and digit symbol modalities. Cognitive measures were administered annually for up to six years. Linear mixed effects models revealed that persistent FOF was associated with a worse decline in GCF compared to both transient FOF (estimate=0.78, p=.022) and no FOF (estimate=0.75, p=.004). Persistent FOF was also associated with a worse decline in memory compared to those with transient FOF (estimate=0.08, p=.004) and those with no FOF (estimate=0.06, p=.006). Associations between FOF status and decline in attention/executive functions were not significant. These findings demonstrate that persistent FOF is a risk factor for cognitive decline in community-residing older adults.

scholarly journals A Prospective Clinical and Radiological Evaluation at 5 Years After Arthroscopic Matrix-Induced Autologous Chondrocyte Implantation

2016 ◽  
Vol 45 (1) ◽  
pp. 59-69 ◽  
Author(s):  
Jay R. Ebert ◽  
Michael Fallon ◽  
David J. Wood ◽  
Gregory C. Janes
Keyword(s):  
Autologous Chondrocyte Implantation ◽  
Knee Extension ◽  
Composite Score ◽  
Physical Component Score ◽  
Knee Extension Strength ◽  
Sf 36 ◽  
Peak Knee ◽  
Chondrocyte Implantation ◽  
Minute Walk ◽  
Autologous Chondrocyte

Background: While midterm outcomes after matrix-induced autologous chondrocyte implantation (MACI) are encouraging, the procedure permits an arthroscopic approach that may reduce the morbidity of arthrotomy and permit accelerated rehabilitation. Hypothesis: A significant improvement in clinical and radiological outcomes after arthroscopic MACI will exist through to 5 years after surgery. Study Design: Case series; Level of evidence, 4. Methods: We prospectively evaluated the first 31 patients (15 male, 16 female) who underwent MACI via arthroscopic surgery to address symptomatic tibiofemoral chondral lesions. MACI was followed by a structured rehabilitation program in all patients. Clinical scores were administered preoperatively and at 3 and 6 months as well as 1, 2, and 5 years after surgery. These included the Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm knee scale (LKS), Tegner activity scale (TAS), visual analog scale for pain, Short Form–36 Health Survey (SF-36), active knee motion, and 6-minute walk test. Isokinetic dynamometry was used to assess peak knee extension and flexion strength and limb symmetry indices (LSIs) between the operated and nonoperated limbs. High-resolution magnetic resonance imaging (MRI) was performed at 3 months and at 1, 2, and 5 years postoperatively to evaluate graft repair as well as calculate the MRI composite score. Results: There was a significant improvement ( P < .05) in all KOOS subscale scores, LKS and TAS scores, the SF-36 physical component score, pain frequency and severity, active knee flexion and extension, and 6-minute walk distance. Isokinetic knee extension strength significantly improved, and all knee extension and flexion LSIs were above 90% (apart from peak knee extension strength at 1 year). At 5 years, 93% of patients were satisfied with MACI to relieve their pain, 90% were satisfied with improving their ability to undertake daily activities, and 80% were satisfied with the improvement in participating in sport. Graft infill ( P = .033) and the MRI composite score ( P = .028) significantly improved over time, with 90% of patients demonstrating good to excellent tissue infill at 5 years. There were 2 graft failures at 5 years after surgery. Conclusion: The arthroscopically performed MACI technique demonstrated good clinical and radiological outcomes up to 5 years, with high levels of patient satisfaction.

Task-specific movement training improves kinematics and pain during the Y-balance test and hip muscle strength in females with patellofemoral pain

2021 ◽  
pp. jisakos-2020-000551
Author(s):  
Elanna K Arhos ◽  
Catherine E Lang ◽  
Karen Steger-May ◽  
Linda R Van Dillen ◽  
Barbara Yemm ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Knee Kinematics ◽  
Patellofemoral Pain ◽  
Composite Score ◽  
Secondary Outcome ◽  
Balance Test ◽  
Control Phase ◽  
Intervention Phase ◽  
Movement Training ◽  
Hip Muscle

ObjectivesTask-specific movement training is a proposed intervention for patellofemoral pain aimed to optimise movement during daily tasks. Focused, progressive task practice emphasising optimal limb alignment may yield improvements in performance-based function and hip muscle strength, and transfer learnt movement patterns to untrained tasks. The purpose of this study was to determine if task-specific movement training improves performance-based function (composite score, movement, pain during movement) in an untrained task. Our secondary purpose was to test whether hip muscle strength improved following the movement training intervention.MethodsThis study was a secondary analysis of a prospective, non-randomised, within-group, double-baseline study. Twenty-three females with patellofemoral pain underwent task-specific movement training two times/week for 6 weeks. Outcomes were collected at three time points: enrolment (baseline), 6 weeks (preintervention) and 12 weeks (postintervention). A repeated measures analysis of variance tested whether the change during the intervention phase was greater than the change during the control phase. Y-balance composite score, hip and knee kinematics and pain during the Y-balance test were primary outcome measures; strength of the hip lateral rotator, abductor and extensor muscles was a secondary outcome measure.ResultsThe change in composite score for the Y-balance test was not statistically significantly different between the intervention and control phases (p=0.16). The change during the intervention phase exceeded the change during the control phase for hip and knee kinematics and pain during the Y-balance test, with all variables improving (p<0.0001). The change during the intervention phase was greater than the control phase for hip muscle strength, with all variables improving (p<0.04).ConclusionAlthough the Y-balance test composite score did not improve, performance-based function during an untrained task, measured by movement and pain during the test, improved following task-specific movement training. Hip muscle strength improved, despite no focused muscle strengthening.Level of evidenceLevel II.

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