scholarly journals Effect of Oral Contraceptives on Factor VIII Clotting Activity and Factor VIII Related Antigen in Known Haemophilia Carriers

1977 ◽  
Author(s):  
Penelope Stableforth ◽  
Katharine M. Dormandy ◽  
Roger M. Hardisty
Keyword(s):  
Statistical Analysis ◽  
Oral Contraceptive ◽  
Factor Viii ◽  
Oral Contraceptives ◽  
Matched Control ◽  
Carrier Detection ◽  
Oral Contraceptive Pills ◽  
Factor Viii Related Antigen ◽  
Contraceptive Pills ◽  
Significant Difference

The factor VIII clotting activity (VIII:C) and factor VIII related antigen (VIIIR:AG) were determined on 3 occasions in 14 known haemophilia carriers, each paired with an age-matched control, both groups being on oral contraceptives (O.C.), and 18 known carriers each paired with an age-matched control, neither group on O.C. The VIII:C/VIIIR:AG ratio was less than 0.7 in 14 out of 14 carriers on O.C. and greater than 0.7 in 13 out of 14 controls on O.C. 16 out of 18 carriers not on O.C. had a ratio less than 0.7 while 16 out of 18 controls not on O.C. had a ratio greater than 0.7. Statistical analysis showed that there was no significant difference in the accuracy of carrier detection in this group of known carriers, whether or not they were on oral contraceptive pills.

Effect of short-term use of oral contraceptive pills on intraocular pressure

2020 ◽  
Vol 35 (3) ◽  
Author(s):  
Tayyaba Gul Malik ◽  
Hina Nadeem ◽  
Eiman Ayesha ◽  
Rabail Alam
Keyword(s):  
Oral Contraceptive ◽  
Childbearing Age ◽  
Short Term ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
Time Period ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Short Time

Objective: To study the effect of short-term use of oral contraceptive pills on intra-ocular pressures of women of childbearing age.   Methods: It was a comparative observational study, conducted at Arif memorial teaching hospital and Allied hospital Faisalabad for a period of six months. Hundred female subjects were divided into two groups of 50 each. Group A, included females, who had been taking oral contraceptive pills (OCP) for more than 6 months and less than 36 months. Group B, included 50 age-matched controls, who had never used OCP. Ophthalmic and systemic history was taken. Careful Slit lamp examination was performed and intraocular pressures (IOP) were measured using Goldman Applanation tonometer. Fundus examination was done to rule out any posterior segment disease. After collection of data, we analyzed and compared the intra ocular pressures between the two groups by using ANOVA in SPSS version 21.   Results: Average duration of using OCP was 14.9 months. There was no significant difference of Cup to Disc ratios between the two groups (p= 0.109). However, significant difference was noted between the IOP of OCP group and controls. (p=0.000). Conclusion: OCP significantly increase IOP even when used for short time period.

scholarly journals The Effect of Oral Contraceptive Pills on The Gene Mutation of Factor V Leiden among Sudanese Women

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Kawthar Abdelgaleil Mohammed Salih ◽  
Hiba Abdelmalik ◽  
Hiba Babiker ◽  
Ahmed Bakheet Abd Alla
Keyword(s):  
Oral Contraceptive ◽  
Gene Mutation ◽  
Oral Contraceptive Pill ◽  
Factor V Leiden ◽  
Factor V ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pill ◽  
Contraceptive Pills ◽  
Significant Difference ◽  
The Impact

Oral contraceptive pills are problems for women, often have many effects, and may cause several diseases. The purpose of this research was to determine the impact of oral contraceptive pills on factor V sufferers. This case-control study conducted in Khartoum Sudan during the period from April to November 2018. The study included 50 women who used oral contraceptive as a case and 50 women who did not use oral contraceptive pills as a control, all of whom were verbally informed of the study and approved for participation. The PCR do for each sample. The results obtained from cases show that the mean age is 30±5.5 and divided into three groups less than 20 with a lower frequency of 4 % (2/50), (20-35) with a higher incidence of 80 % (40/50) and a higher rate of 16 % (8/50) for more than 35 years. Most cases use the oral contraceptive pill for more than one year at a frequency of 60% (30/50) with a mean of 2±0.8. The most frequent oral contraceptive pill use was levonorgestrel 88% (44/50), followed by desogestrel 12% (6/50). The study concludes that there is no significant difference in gene mutation between case and control. There was also an insignificant association between the mutation and demographic data.

scholarly journals Effect of Short-term Use of Oral Contraceptive Pills on Intraocular Pressure

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Tayyaba Gul Malik, Hina Nadeem Eiman Ayesha Rabail Alam
Keyword(s):  
Oral Contraceptive ◽  
Childbearing Age ◽  
Short Term ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
Time Period ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Short Time

Purpose: To study the effect of short-term use of oral contraceptive pills on intra-ocular pressures of women of childbearing age. Study Design: Observational case control study. Place and Duration of Study: The study was conducted at Arif memorial teaching hospital and Allied hospital Faisalabad from October 2017 to March 2018. Material and Methods: There were 100 female subjects, who were divided into two groups of 50 each. Group A, included females, who had been taking oral contraceptive pills (OCP) for more than 6 months and less than 36 months. Group B, included 50 age-matched controls, who had never used OCP. Ophthalmic and systemic history was taken. Careful Slit lamp examination was performed and intraocular pressures (IOP) were measured using Goldman Applanation tonometer. Fundus examination was done to rule out any posterior segment disease. We compared the intra ocular pressures between the two groups by using Student t test. Results: Average age was 29.16 in group A and 27.74 years in group B. Average duration of using OCP was 14.9 months. Mean IOP in right eye was 13.08 � 1.41 mm of Hg and 13.34 � 1.27 mm of Hg in left eye in Group A. While, mean IOP in right eye was 11.72 � 1.35 mm of Hg and in left eye was 11.92 � 1.3 mm of Hg in controls. Significant difference was noted between the IOP of OCP group and controls. (p = 0.000). Conclusion: OCP significantly increases IOP even when used for short time period. Key words: Oral contraceptive pills, Intra-ocular pressure, Glaucoma.

scholarly journals Unilateral Erythema Nodosum following Norethindrone Acetate, Ethinyl Estradiol, and Ferrous Fumarate Combination Therapy

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Michelle S. Min ◽  
Rob Fischer ◽  
John B. Fournier
Keyword(s):  
Oral Contraceptive ◽  
Combination Therapy ◽  
Oral Contraceptives ◽  
Erythema Nodosum ◽  
Ethinyl Estradiol ◽  
Oral Contraceptive Pills ◽  
Ferrous Fumarate ◽  
Contraceptive Pills ◽  
Secondary Causes ◽  
Norethindrone Acetate

Erythema nodosum is a septal panniculitis that typically presents as symmetric, tender nodules on the anterior aspects of bilateral lower extremities. Nearly half of cases are due to secondary causes, with oral contraceptive pills being the leading pharmaceutical cause. However, to our knowledge, there has yet to be a published association with norethindrone acetate, ethinyl estradiol, and ferrous fumarate. We report our experience with a 30-year-old woman who developed unilateral tender nodules within a month of starting 1 mg norethindrone acetate and 20 mcg ethinyl estradiol daily. Of note, she had previously taken oral contraceptives with the same estrogen agent but different progesterone, without problems. We conclude that systemically triggered erythema nodosum can present with lesions localized to one extremity. When a patient presents with tender, firm nodules, clinicians should consider the possibility of erythema nodosum and its triggers, such as oral contraceptives. Additionally, should a patient on hormonal therapy develop erythema nodosum, changing the progesterone agent may allow the patient to continue similar therapy without developing symptoms.

scholarly journals Associated Risk Between Use of Oral Contraceptive Pills and Three Types of Breast Cancer: ER+, ER-, and TN

2020 ◽  
Vol 3 ◽  
Author(s):  
Roshni Rangaswamy
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Oral Contraceptive ◽  
Oral Contraceptives ◽  
Great Length ◽  
Breast Cancers ◽  
Hormone Production ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
Estrogen Receptor Positive

Around 9.5 million women between the ages of 15 and 44 use some form of oral contraceptives. Oral contraceptive pills typically consist of progestin and estrogens, synthetic versions of the hormones that a female-bodied person naturally produces and are used by many people for a various number of reasons; such reasons include regulating acne, controlling hormone production, and preventing pregnancy. One in eight women in the US is diagnosed with breast cancer over the course of her lifetime, and many of these cancers have hormone-related causes. However, there are three types of breast cancer specifically linked to the hormones that are found in oral contraceptive pills: estrogen receptor-positive, estrogen receptor-negative, and triple-negative. While the potential of oral contraceptive-related causes for these breast cancers have been studied at great length, researchers are often unable to confirm their finding of an associated risk between synthetic hormones in oral contraceptives and certain types of breast cancer. Many studies agree that this associated risk exists, but stress the need for more involved research with more detailed and specific objectives. This literature review will provide insight into limitations of current research on the associated risk between oral contraceptives and breast cancer in order to fill research gaps and evaluate the certainty of current findings.

scholarly journals Oral Contraceptive Pills Are Not a Risk Factor for Deep Vein Thrombosis or Pulmonary Embolism After Arthroscopic Shoulder Surgery

2019 ◽  
Vol 7 (1) ◽  
pp. 232596711882297 ◽  
Author(s):  
Austin V. Stone ◽  
Avinesh Agarwalla ◽  
Anirudh K. Gowd ◽  
Cale A. Jacobs ◽  
Jeffrey A. Macalena ◽  
...  
Keyword(s):  
Oral Contraceptive ◽  
Shoulder Surgery ◽  
Vascular Thrombosis ◽  
Oral Contraceptive Pills ◽  
Matched Group ◽  
Female Patients ◽  
Contraceptive Pills ◽  
Increased Risk ◽  
Significant Difference ◽  
Arthroscopic Shoulder Surgery

Background: Worldwide, more than 100 million women between the ages of 15 and 49 years take oral contraceptive pills (OCPs). OCP use increases the risk of venous thromboembolism (VTE) through its primary drug, ethinylestradiol, which slows liver metabolism, promotes tissue retention, and ultimately favors fibrinolysis inhibition and thrombosis. Purpose: To evaluate the effects of OCP use on VTE after arthroscopic shoulder surgery. Study Design: Cohort study; Level of evidence, 3. Methods: A large national payer database (PearlDiver) was queried for patients undergoing arthroscopic shoulder surgery. The incidence of VTE was evaluated in female patients taking OCPs and those not taking OCPs. A matched group was subsequently created to evaluate the incidence of VTE in similar patients with and without OCP use. Results: A total of 57,727 patients underwent arthroscopic shoulder surgery from 2007 to 2016, and 26,365 patients (45.7%) were female. At the time of surgery, 924 female patients (3.5%) were taking OCPs. The incidence of vascular thrombosis was 0.57% (n = 328) after arthroscopic shoulder surgery, and there was no significant difference in the rate of vascular thrombosis in male or female patients (0.57% vs 0.57%, respectively; P > .99). The incidence of VTE in female patients taking and not taking OCPs was 0.22% and 0.57%, respectively ( P = .2). In a matched-group analysis, no significant difference existed in VTE incidence between patients with versus without OCP use (0.22% vs 0.56%, respectively; P = .2). On multivariate analysis, hypertension (odds ratio [OR], 2.00; P < .001) and obesity (OR, 1.43; P = .002) were risk factors for VTE. Conclusion: OCP use at the time of arthroscopic shoulder surgery is not associated with an increased risk of VTE. Obesity and hypertension are associated with a greater risk for thrombolic events, although the risk remains very low. Our findings suggest that patients taking OCPs should be managed according to the surgeon’s standard prophylaxis protocol for arthroscopic shoulder surgery.

The Association between Current Low-Dose Oral Contraceptive Pills and Periodontal Health: A Matched-Case-Control Study

2010 ◽  
Vol 11 (3) ◽  
pp. 33-40 ◽  
Author(s):  
Amir Moeintaghavi ◽  
Ahmad Haerian-ardakani ◽  
Mahammadreza Reza Talebi-Ardakani ◽  
Keyvan Sohrabi ◽  
Shahin Bahmani ◽  
...  
Keyword(s):  
Oral Contraceptive ◽  
Birth Control ◽  
Oral Contraceptives ◽  
Oral Contraceptive Pill ◽  
Plaque Index ◽  
Periodontal Health ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pill ◽  
Young Females ◽  
Contraceptive Pills

Abstract Aim This study assessed the influence of current oral contraceptive pills on periodontal health in young females. Methods and Materials Seventy women ranging in age from 17 to 35 years (mean 24 years) had a comprehensive periodontal examination. Their current and previous oral contraceptive pill use was assessed by a questionnaire. A periodontal assessment was performed that included recording the following: plaque index, gingival index, probing depth, and attachment level at six sites per tooth. The periodontal health of women taking birth control pills for at least two years was compared to that of women not taking an oral contraceptive. The control and test groups were matched for socioeconomic status, age, oral habits, occupation, and educational levels. Results Although there was no difference in plaque index levels between the two groups, current oral contraceptive pill users had higher levels of gingival inflammation and bleeding on probing. However, no significant differences were found regarding mean probing depths and attachment loss between the two groups. Conclusion Women who were on oral contraceptive pills had more extensive gingivitis and gingival bleeding than their matched controls not taking them. Clinical Significance As birth control policies are advocated by most countries, and because oral contraceptives are the most widely used method for birth control, a need exists to assess the effects of oral contraceptives on the periodontal health of young women. Although additional studies are needed to better understand the mechanism of OC-induced gingivitis, female patients should be informed of the oral and periodontal side effects of OCs and the need for meticulous home care and compliance with periodontal maintenance.

Randomized clinical trial evaluating metformin versus oral contraceptive pills in the treatment of adolescents with polycystic ovarian syndrome

2015 ◽  
Vol 28 (7-8) ◽  
Author(s):  
Hiba Al-Zubeidi ◽  
Karen O. Klein
Keyword(s):  
Insulin Resistance ◽  
Oral Contraceptive ◽  
Polycystic Ovarian Syndrome ◽  
Free Testosterone ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
Significant Difference ◽  
Irregular Menses ◽  
Positive Effect ◽  
Ovarian Syndrome

AbstractPolycystic ovarian syndrome (PCOS) is characterized by irregular menses, elevated androgens, and insulin resistance. Little information is published about the treatment of adolescent PCOS.The aim of this study was to evaluate metformin versus oral contraceptive pills (OCP) in treating adolescent PCOS. Twenty-two girls were randomized to either treatment for 6 months. The outcomes variables included body mass index (BMI) and free testosterone (FT).BMI decreased in all patients (metformin p=0.004, OCP p=0.045). FT decreased significantly only with OCP. Insulin resistance measures decreased in all patients but did not reach significance. The only significant difference in any of the variables between the two groups was number of menses. BMI and FT remained less than baseline for 3 months off treatment.Metformin and OCP have a positive effect on BMI, which persists after treatment is discontinued. FT decreased with both treatments, but only reached significance with OCP.

scholarly journals Effect of Oral Contraceptive Pill Pretreatment on Pregnancy Rates in Patients Stimulated with GnRH Antagonists and rFSH for ICSI

2020 ◽  
Vol 5 (04) ◽  
Author(s):  
Dr. Soni Ashish Kumar ◽  
Dr. Reddy Sanjeeva N
Keyword(s):  
Oral Contraceptive ◽  
Oral Contraceptives ◽  
Gnrh Antagonist ◽  
Treated Group ◽  
Pregnancy Rates ◽  
Gnrh Antagonists ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
Cycle Scheduling ◽  
Antagonist Protocol

Background: After the recent introduction of GnRH antagonists in ovarian stimulation, OCP has been used for cycle scheduling purposes. Cycle programming has become more difficult with the use of GnRH antagonists, as stimulation initiation is dependent on the occurrence of menstruation. To overcome this limitation in the GnRH antagonist protocol, patients can be offered the use of pretreatment with oral contraceptive pills (OCP). Objective: To evaluate the effect of oral contraceptive pills (OCP) pretreatment on pregnancy rate in GnRH antagonist cycles. Design: Observational cohort study. Setting: Observational study performed at Sri Ramachandra institute of higher education & research Chennai. Patients: Total 115 patients included in the study from January 2019 to December 2019. All patients divided into two groups, oral contraceptives pretreated group (n-64) and oral contraceptives non treated group (n-51). Results: All oral contraceptives pretreated patients required significantly higher dose of gonadotropins (4745±1476 versus 3659±1230;P <0.0005) and significantly longer days of stimulations (12.2±1.2 versus 10.5±0.8;P <0.0005) in comparison to non-oral contraceptives treated group. There were no difference in total oocytes retrieved and fertilization rate. There were no other differences in cycle characteristics between groups. Implantation and pregnancy rates were not affected by OCP pretreatment. Conclusions: OCP pretreatment use for synchronization of follicles and cycle scheduling in GnRH-antagonist protocol, though it may be associated with longer stimulation and higher gonadotropin consumption but similar pregnancy rates.

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