scholarly journals The Effect of Oral Contraceptive Pills on The Gene Mutation of Factor V Leiden among Sudanese Women

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Kawthar Abdelgaleil Mohammed Salih ◽  
Hiba Abdelmalik ◽  
Hiba Babiker ◽  
Ahmed Bakheet Abd Alla
Keyword(s):  
Oral Contraceptive ◽  
Gene Mutation ◽  
Oral Contraceptive Pill ◽  
Factor V Leiden ◽  
Factor V ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pill ◽  
Contraceptive Pills ◽  
Significant Difference ◽  
The Impact

Oral contraceptive pills are problems for women, often have many effects, and may cause several diseases. The purpose of this research was to determine the impact of oral contraceptive pills on factor V sufferers. This case-control study conducted in Khartoum Sudan during the period from April to November 2018. The study included 50 women who used oral contraceptive as a case and 50 women who did not use oral contraceptive pills as a control, all of whom were verbally informed of the study and approved for participation. The PCR do for each sample. The results obtained from cases show that the mean age is 30±5.5 and divided into three groups less than 20 with a lower frequency of 4 % (2/50), (20-35) with a higher incidence of 80 % (40/50) and a higher rate of 16 % (8/50) for more than 35 years. Most cases use the oral contraceptive pill for more than one year at a frequency of 60% (30/50) with a mean of 2±0.8. The most frequent oral contraceptive pill use was levonorgestrel 88% (44/50), followed by desogestrel 12% (6/50). The study concludes that there is no significant difference in gene mutation between case and control. There was also an insignificant association between the mutation and demographic data.

scholarly journals Knowledge, Attitude and Practice of Women in Jeddah Towards the Use of Oral Contraceptive Pills

2017 ◽  
Vol 7 (2) ◽  
pp. 5-10
Author(s):  
Hanan M. Shamrani ◽  
Arwa F. Shamrani ◽  
Abdulrahman E. Alsaggaf ◽  
Mohammad I. Khojah ◽  
Maram M. Alafif ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Oral Contraceptive ◽  
Oral Contraceptive Pill ◽  
P Value ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pill ◽  
Jeddah City ◽  
Attitude And Practice ◽  
Contraceptive Pills ◽  
Knowledge Attitude And Practice

Objective (Background): The use of oral contraceptive pill is considered an acceptable practice worldwide. Socio-demographic patterns in Saudi Arabia are rapidly changing with time. This study aims to evaluate the knowledge, attitude and practice among women in Jeddah towards the use of oral contraceptive pills. Methodology: A cross-sectional study was conducted using a self-administered questionnaire as a tool for data collection. Results: The study was conducted in Jeddah city in the Western region of Saudi Arabia between 2014-2015, 913 women were approached and 40 refused to participate (4.378% refusal rate). Out of those 873 who agreed to participate, 713 responded correctly and were included (78.09% response rate). Participants were grouped into six categories based on their age. The majority of the women polled were Saudis (71.4%). There was a positive correlation between the attitude of women towards the use of oral contraceptive pill and age (P-value < 0.001). Similar correlation was true also in the case of knowledge and the level of education towards the use of oral contraceptive pills. There was a significant correlation between marital status towards oral contraceptive pill use (P-value <0.001). Conclusions: This study should be extended to other regions of the kingdom. The results emphasize the need for women in Jeddah city as well as the rest of Saudi Arabia to be better educated, aware and informed about the different contraceptive methods available in order for them to make the right decision regarding the method they like to choose for birth control.

scholarly journals Massive Pulmonary Embolism Associated With Factor V Leiden, Prothrombin, and Methylenetetrahydrofolate Reductase Gene Mutations in a Young Patient on Oral Contraceptive Pills: A Case Report

2009 ◽  
Vol 16 (5) ◽  
pp. 594-598 ◽  
Author(s):  
Khalil M. Charafeddine ◽  
Rami A. Mahfouz ◽  
Georges Y. Ibrahim ◽  
Ali T. Taher ◽  
Jamal J. Hoballah ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Oral Contraceptive ◽  
Methylenetetrahydrofolate Reductase ◽  
Oral Anticoagulants ◽  
Gene Mutations ◽  
Factor V Leiden ◽  
Massive Pulmonary Embolism ◽  
Factor V ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills

Factor V Leiden (Factor V G1691A), prothrombin gene mutation G20210A, and homozygous C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene are known to predispose venous thromboembolism (VTE). We present herein a rare case of a young woman heterozygous for these mutations and taking oral contraceptive pills for less than 2 months, diagnosed to have massive deep venous thrombosis and bilateral pulmonary embolism. The patient was managed for 10 days in the hospital and discharged home on oral anticoagulants. This case suggests that screening for these factors in people with family history of thrombosis and in relatives of patients with these mutations is highly recommended to prevent fatal consequences. In addition, a new guideline for treatment and prophylaxis with anticoagulant for these patients and others who are at risk of developing VTE (American College of Chest Physicians [ACCP] guidelines-Chest 2008) has been published recently. Our recommendation is to promote for the internationally published algorithms through their application, where necessary, to prevent any future thrombotic morbidity or mortality incidents.

The Association between Current Low-Dose Oral Contraceptive Pills and Periodontal Health: A Matched-Case-Control Study

2010 ◽  
Vol 11 (3) ◽  
pp. 33-40 ◽  
Author(s):  
Amir Moeintaghavi ◽  
Ahmad Haerian-ardakani ◽  
Mahammadreza Reza Talebi-Ardakani ◽  
Keyvan Sohrabi ◽  
Shahin Bahmani ◽  
...  
Keyword(s):  
Oral Contraceptive ◽  
Birth Control ◽  
Oral Contraceptives ◽  
Oral Contraceptive Pill ◽  
Plaque Index ◽  
Periodontal Health ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pill ◽  
Young Females ◽  
Contraceptive Pills

Abstract Aim This study assessed the influence of current oral contraceptive pills on periodontal health in young females. Methods and Materials Seventy women ranging in age from 17 to 35 years (mean 24 years) had a comprehensive periodontal examination. Their current and previous oral contraceptive pill use was assessed by a questionnaire. A periodontal assessment was performed that included recording the following: plaque index, gingival index, probing depth, and attachment level at six sites per tooth. The periodontal health of women taking birth control pills for at least two years was compared to that of women not taking an oral contraceptive. The control and test groups were matched for socioeconomic status, age, oral habits, occupation, and educational levels. Results Although there was no difference in plaque index levels between the two groups, current oral contraceptive pill users had higher levels of gingival inflammation and bleeding on probing. However, no significant differences were found regarding mean probing depths and attachment loss between the two groups. Conclusion Women who were on oral contraceptive pills had more extensive gingivitis and gingival bleeding than their matched controls not taking them. Clinical Significance As birth control policies are advocated by most countries, and because oral contraceptives are the most widely used method for birth control, a need exists to assess the effects of oral contraceptives on the periodontal health of young women. Although additional studies are needed to better understand the mechanism of OC-induced gingivitis, female patients should be informed of the oral and periodontal side effects of OCs and the need for meticulous home care and compliance with periodontal maintenance.

Effect of short-term use of oral contraceptive pills on intraocular pressure

2020 ◽  
Vol 35 (3) ◽  
Author(s):  
Tayyaba Gul Malik ◽  
Hina Nadeem ◽  
Eiman Ayesha ◽  
Rabail Alam
Keyword(s):  
Oral Contraceptive ◽  
Childbearing Age ◽  
Short Term ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
Time Period ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Short Time

Objective: To study the effect of short-term use of oral contraceptive pills on intra-ocular pressures of women of childbearing age.   Methods: It was a comparative observational study, conducted at Arif memorial teaching hospital and Allied hospital Faisalabad for a period of six months. Hundred female subjects were divided into two groups of 50 each. Group A, included females, who had been taking oral contraceptive pills (OCP) for more than 6 months and less than 36 months. Group B, included 50 age-matched controls, who had never used OCP. Ophthalmic and systemic history was taken. Careful Slit lamp examination was performed and intraocular pressures (IOP) were measured using Goldman Applanation tonometer. Fundus examination was done to rule out any posterior segment disease. After collection of data, we analyzed and compared the intra ocular pressures between the two groups by using ANOVA in SPSS version 21.   Results: Average duration of using OCP was 14.9 months. There was no significant difference of Cup to Disc ratios between the two groups (p= 0.109). However, significant difference was noted between the IOP of OCP group and controls. (p=0.000). Conclusion: OCP significantly increase IOP even when used for short time period.

scholarly journals Effect of Oral Contraceptives on Factor VIII Clotting Activity and Factor VIII Related Antigen in Known Haemophilia Carriers

1977 ◽  
Author(s):  
Penelope Stableforth ◽  
Katharine M. Dormandy ◽  
Roger M. Hardisty
Keyword(s):  
Statistical Analysis ◽  
Oral Contraceptive ◽  
Factor Viii ◽  
Oral Contraceptives ◽  
Matched Control ◽  
Carrier Detection ◽  
Oral Contraceptive Pills ◽  
Factor Viii Related Antigen ◽  
Contraceptive Pills ◽  
Significant Difference

The factor VIII clotting activity (VIII:C) and factor VIII related antigen (VIIIR:AG) were determined on 3 occasions in 14 known haemophilia carriers, each paired with an age-matched control, both groups being on oral contraceptives (O.C.), and 18 known carriers each paired with an age-matched control, neither group on O.C. The VIII:C/VIIIR:AG ratio was less than 0.7 in 14 out of 14 carriers on O.C. and greater than 0.7 in 13 out of 14 controls on O.C. 16 out of 18 carriers not on O.C. had a ratio less than 0.7 while 16 out of 18 controls not on O.C. had a ratio greater than 0.7. Statistical analysis showed that there was no significant difference in the accuracy of carrier detection in this group of known carriers, whether or not they were on oral contraceptive pills.

scholarly journals Effect of Short-term Use of Oral Contraceptive Pills on Intraocular Pressure

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Tayyaba Gul Malik, Hina Nadeem Eiman Ayesha Rabail Alam
Keyword(s):  
Oral Contraceptive ◽  
Childbearing Age ◽  
Short Term ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
Time Period ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Short Time

Purpose: To study the effect of short-term use of oral contraceptive pills on intra-ocular pressures of women of childbearing age. Study Design: Observational case control study. Place and Duration of Study: The study was conducted at Arif memorial teaching hospital and Allied hospital Faisalabad from October 2017 to March 2018. Material and Methods: There were 100 female subjects, who were divided into two groups of 50 each. Group A, included females, who had been taking oral contraceptive pills (OCP) for more than 6 months and less than 36 months. Group B, included 50 age-matched controls, who had never used OCP. Ophthalmic and systemic history was taken. Careful Slit lamp examination was performed and intraocular pressures (IOP) were measured using Goldman Applanation tonometer. Fundus examination was done to rule out any posterior segment disease. We compared the intra ocular pressures between the two groups by using Student t test. Results: Average age was 29.16 in group A and 27.74 years in group B. Average duration of using OCP was 14.9 months. Mean IOP in right eye was 13.08 � 1.41 mm of Hg and 13.34 � 1.27 mm of Hg in left eye in Group A. While, mean IOP in right eye was 11.72 � 1.35 mm of Hg and in left eye was 11.92 � 1.3 mm of Hg in controls. Significant difference was noted between the IOP of OCP group and controls. (p = 0.000). Conclusion: OCP significantly increases IOP even when used for short time period. Key words: Oral contraceptive pills, Intra-ocular pressure, Glaucoma.

The Impact of Ethinyl Estradiol on Metformin Action on Prolactin Levels in Women with Hyperprolactinemia

2019 ◽  
Vol 129 (01) ◽  
pp. 22-28
Author(s):  
Robert Krysiak ◽  
Witold Szkróbka ◽  
Bogusław Okopień
Keyword(s):  
Oral Contraceptive ◽  
Insulin Sensitivity ◽  
Growth Factor ◽  
Adrenocorticotropic Hormone ◽  
Hormonal Contraception ◽  
Plasma Prolactin ◽  
Insulin Like Growth Factor ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
The Impact

Abstract Background Metformin reduced prolactin levels only in women with hyperprolactinemia. Objective The purpose of this case-control study was to compare metformin action on lactoctrope function between women receiving oral contraceptive pills and women not using hormonal contraception. Methods The study included two groups of matched women with elevated prolactin levels and new-onset prediabetes or diabetes. The first group consisted of 20 women using oral contraceptive pills for at least 12 months before entering the study, while the second group included 20 patients not using any hormonal contraception. Over the whole study period, all women were treated with metformin (1.7–3 g daily). Circulating levels of glucose, insulin, prolactin, thyrotropin, free thyroid hormones, adrenocorticotropic hormone, gonadotropins and insulin-like growth factor-1 were measured at the beginning and at the end of the study (16 weeks later). Results Thirty-eight patients completed the study. Metformin reduced plasma glucose levels and improved insulin sensitivity but the latter effect was stronger in women receiving oral contraceptive pills than in women not using any contraception. Although metformin treatment decreased plasma prolactin levels in both study groups, this effect was stronger in women taking oral contraceptive pills. Only in this group of women, metformin increased plasma luteinizing hormone levels. The changes in plasma prolactin correlated with their baseline insulin sensitivity and the effect of metformin on insulin sensitivity. Metformin did not affect plasma levels of thyrotropin, free thyroxine, free triiodothyronine, follicle-stimulating hormone, adrenocorticotropic hormone and insulin-like growth factor-1. Conclusions The obtained results suggest that the effect of metformin on overactive lactotropes depends on estrogen levels.

scholarly journals Inflammatory Bowel Disease, the Oral Contraceptive Pill and Pregnancy

1994 ◽  
Vol 8 (7) ◽  
pp. 430-432 ◽  
Author(s):  
Robert N Allan
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Oral Contraceptive ◽  
Crohn's Disease ◽  
Bowel Disease ◽  
Oral Contraceptive Pill ◽  
Contraceptive Pill ◽  
Inflammatory Bowel ◽  
The Impact

This paper summarizes our current knowledge of the role of the oral contraceptive pill in the pathogenesis of inflammatory bowel disease (IBO), followed by a review of fertility in women and men. IBD and pregnancy, including the impact on the fetus and the mother with ulcerative colitis or Crohn’s disease, is considered. The safety of drug treatment during pregnancy, the outcome of surgical treatment during pregnancy and the problems that may be encountered during pregnancy in patients with an ileostomy or ileo-anal pouch are discussed, followed by a review of the short and long term prognosis of ulcerative colitis and Crohn’s disease partition.

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