Serologic Markers of Hepatitis Viruses in Hemophiliacs

1979 ◽  
Author(s):  
R.J. Gerety ◽  
E. Tabor ◽  
M.E. Eyster ◽  
J.A. Drunker
Keyword(s):  
Hepatitis B ◽  
Replacement Therapy ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Hepatitis B Surface Antigen ◽  
Core Antigen ◽  
Past Infection ◽  
Patients Âgés ◽  
Immune Adherence ◽  
Hepatitis B Core Antigen

To determine and compare the risks of exposure to hepatitis A and B viruses in patients with hemophilia A receiving intravenous replacement therapy, sera from 138 patients, ages 9 months to 67 years, were studied. Sera from all 138, exposed to either cryoprecipitate (Cryo) or antihemophilic factor (AHF) concentrates for periods ranging from a few months to 15 years were tested for hepatitis B surface antigen and antibody by radioimmunoassay, for antibody to the hepatitis B core antigen by complement fixation and radioimmunoassay, and for antibody to hepatitis A virus by immune adherence hemagglutination. Serologic evidence of past or present hepatitis B was detected in 88.4 percent, while 29.7 percent had evidence of past infection by the hepatitis A virus. The former prevalence is consistent with the known high frequency of exposure to hepatitis B in hemophiliacs as a result of replacement therapy. The latter prevalence, similar to prevalences of antibody to hepatitis A virus seen in populations lacking parenteral exposure to blood products or plasma derivatives, was unrelated to the degree of exposure to Cryo or AHF concentrate. These findings confirm that hepatitis A unlike hepatitis B, is infrequently transmitted by Cryo or AHF concentrate.

Serological markers of hepatitis B in long-stay patients in a psychiatric hospital

1990 ◽  
Vol 7 (1) ◽  
pp. 18-21
Author(s):  
Miriam A. Gannon ◽  
Denis J. Murphy ◽  
John F. Corish
Keyword(s):  
Hepatitis B ◽  
Hospital Stay ◽  
Psychiatric Patients ◽  
Hepatitis B Surface Antigen ◽  
Positive Association ◽  
Core Antigen ◽  
Past Infection ◽  
Duration Of Hospital Stay ◽  
Significant Difference ◽  
Hepatitis B Core Antigen

AbstractHepatitis B surface antigen and antibody to hepatitis B core antigen were measured in 232 long-term psychiatric patients. The aims of the study were to determine the prevalence of infection and to relate it to factors such as age, sex, duration of hospital stay and diagnosis.There was both an increased rate and increased evidence of past infection amongst the patients tested relative to the general population. There was no statistical significant difference between the antibody positive group compared to the antibody negative group for age, sex and duration of hospital stay, unlike that found in studies of mentally handicapped patients. There was a positive association between the presence of antibody and patient diagnosis. Patients with mental handicap appear to have a predilection for hepatitis B.Further work needs to be done to elucidate the epidemiology of hepatitis B in psychiatric patients and evaluate the reservoir of infection present.

Negative Serology for Hepatitis A and B Viruses in 18 Cases of Neonatal Cholestasis

PEDIATRICS ◽  
1980 ◽  
Vol 66 (2) ◽  
pp. 269-271
Author(s):  
William F. Balistreri ◽  
Edward Tabor ◽  
Robert J. Gerety
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Maternal Serum ◽  
Hbv Infection ◽  
Core Antigen ◽  
Neonatal Cholestasis ◽  
Immune Adherence ◽  
B Virus ◽  
Serologic Evidence

Serologic evidence of hepatitis A virus (HAV) or hepatitis B virus (HBV) infection was sought in 14 patients with biliary atresia and in four patients with neonatal hepatitis; maternal serum was also analyzed. Specific sensitive radioimmunoassays were used to detect HBV surface antigen (HBsAg) and antibody (anti-HBs); complement fixation was used to detect antibody to HBV core antigen (anti-HBc). Antibody to HAV (anti-HAV) was assayed by radioimmunoassay, as well as by immune adherence hemagglutination. There was no evidence of active or past HBV infection in any infant or mother studied. All three infants with detectable anti-HAV were born to mothers similarly anti-HAV positive; serial testing of sera from two of these infants documented disappearance of detectable anti-HAV by 9 months of age. It is unlikely, therefore, that either HAV or HBV had an etiologic role in neonatal cholestasis in these patients. The role of other (non-A, non-B) hepatitis viruses or nonviral etiologies must be investigated.

scholarly journals Viral Superinfection in Previously Unrecognized Chronic Carriers of Hepatitis B Virus with Superimposed Acute Fulminant versus Nonfulminant Hepatitis

1999 ◽  
Vol 37 (1) ◽  
pp. 235-237 ◽  
Author(s):  
Chia-Ming Chu ◽  
Chau-Ting Yeh ◽  
Yun-Fan Liaw
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Hepatitis B Surface Antigen ◽  
Significant Difference ◽  
B Virus ◽  
Hdv Infection

The role of viral superinfection in hepatitis B surface antigen carriers with superimposed fulminant (n = 60) versus nonfulminant (n = 90) acute hepatitis was studied. The frequency of hepatitis A virus (HAV) (0 versus 2.2%), HCV (18.3 versus 21.1%), HDV (15.0 versus 7.8%), and HEV (1.7 versus 4.4%) infection showed no significant difference, while simultaneous HCV and HDV infection was significantly more prevalent in the former (8.3 versus 0%). Only 3.6% of fulminant cases and 3.3% of nonfulminant controls were HGV RNA positive.

Serologic Evidence for Hepatitis B Virus Infection in Patients with Hemophilia B

1975 ◽  
Vol 33 (03) ◽  
pp. 606-609 ◽  
Author(s):  
Jay H Hoofnagle ◽  
David Aronson ◽  
Harold Roberts
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatitis B Surface Antigen ◽  
Factor Ix ◽  
Hemophilia B ◽  
Core Antigen ◽  
B Virus ◽  
Serologic Evidence ◽  
Hepatitis B Core Antigen ◽  
North And South America

SummaryAmong sera from 160 patients with hemophilia B from 9 centers in Europe and North and South America, 2.5% were positive for hepatitis B surface antigen (HBsAg), 60% for antibody to HBsAg, and 31% for antibody to the hepatitis B core antigen. Evidence of exposure to the hepatitis B virus appeared to be related to severity of disease and age rather than the source and method of manufacturer of factor IX concentrate.

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