Highly Chemoselective Solvent-Free Synthesis of 1,3,5-Triaryl-1,5-diketones: Crystallographic Investigation and Intramolecular Weak Bifurcated H Bonds Involving Aliphatic C–H Group

Synlett ◽  
2019 ◽  
Vol 30 (19) ◽  
pp. 2143-2147
Author(s):  
Zhongyou Yin ◽  
Changkun Xiong ◽  
Jianxin Guo ◽  
Xiaoyun Hu ◽  
Zixing Shan ◽  
...  
Keyword(s):  
Solid State ◽  
Decisive Role ◽  
Solvent Free ◽  
Dihedral Angles ◽  
Crystallographic Investigation ◽  
Structural Arrangement ◽  
Bond Lengths ◽  
Solvent Free Conditions ◽  
Solvent Free Synthesis

Several 1,3,5-triaryl-1,5-diketones have been chemoselectively synthesized under solvent-free conditions. It was found that intramolecular weak bifurcated H-bonds interaction of aliphatic C–H group plays a decisive role in the structural arrangement of 3-(2,6-dichlorophenyl)-1,5-diphenylpentane-1,5-dione in a solid state resulting in significant impact on the corresponding bond lengths and dihedral angles.

scholarly journals Solvent-free synthesis of symmetric methylene diesters via direct reaction of aromatic carboxylates with 1,n-dihaloalkanes

RSC Advances ◽  
2021 ◽  
Vol 11 (46) ◽  
pp. 28711-28715
Author(s):  
Lin Bai ◽  
Shenglong Ding ◽  
Xiaofang Ma
Keyword(s):  
Solvent Free ◽  
Direct Reaction ◽  
Highly Efficient ◽  
Solvent Free Conditions ◽  
Aromatic Carboxylates ◽  
Solvent Free Synthesis

This work provides a highly efficient and feasible strategy for the synthesis of symmetric methylene diesters, involving the direct diesterification of various carboxylates with 1,n-dihaloalkanes under solvent-free conditions.

Room Temperature Solvent-Free Synthesis of Monodisperse Magnetite Nanocrystals

2006 ◽  
Vol 6 (3) ◽  
pp. 852-856 ◽  
Author(s):  
X. R. Ye ◽  
C. Daraio ◽  
C. Wang ◽  
J. B. Talbot ◽  
S. Jin
Keyword(s):  
Oleic Acid ◽  
Solid State ◽  
Large Scale ◽  
Room Temperature ◽  
Solvent Free ◽  
Two Dimensional ◽  
New Process ◽  
High Boiling Point ◽  
Magnetite Nanocrystals ◽  
Solvent Free Synthesis

We have successfully demonstrated a facile, solvent-free synthesis of highly crystalline and monodisperse Fe3O4 nanocrystallites at ambient temperature avoiding any heating. Solid state reaction of inorganic Fe(II) and Fe(III) salts with NaOH was found to produce highly crystalline Fe3O4 nanoparticles. The reaction, if carried out in the presence of surfactant such as oleic acid–oleylamine adduct, generated monodisperse Fe3O4 nanocrystals extractable directly from the reaction mixture. The extracted nanoparticles were capable of forming self-assembled, two-dimensional and uniform periodic array. The new process utilizes inexpensive and nontoxic starting materials, and does not require a use of high boiling point and toxic solvents, thus is amenable to an environmentally desirable, large-scale synthesis of nanocrystals.

Solvent-free synthesis of novel vanillidene derivatives of Meldrum's acid: biological evaluation, DNA and BSA binding study

RSC Advances ◽  
2016 ◽  
Vol 6 (45) ◽  
pp. 39452-39459 ◽  
Author(s):  
Nenad Janković ◽  
Jovana Muškinja ◽  
Zoran Ratković ◽  
Zorica Bugarčić ◽  
Branislav Ranković ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Solvent Free ◽  
Binding Study ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
Bsa Binding ◽  
Solvent Free Conditions ◽  
Derivatives Of ◽  
Solvent Free Synthesis

A series of novel O-alkyl vanillidene derivatives containing Meldrum's acid scaffold under solvent-free conditions were synthesized.

Solid-state regioselective nitration of activated hydroxyaromatics and hydroxycoumarins with cerium (IV) ammonium nitrate

2005 ◽  
Vol 2005 (11) ◽  
pp. 733-735 ◽  
Author(s):  
Nemai C. Ganguly ◽  
Sanjoy Dutta ◽  
Mrityunjoy Datta ◽  
Prithwiraj De
Keyword(s):  
Solid State ◽  
Ammonium Nitrate ◽  
High Efficiency ◽  
Solvent Free ◽  
High Melting ◽  
Microwave Assisted ◽  
Solvent Free Conditions ◽  
High Yields ◽  
Regioselective Nitration ◽  
Cerium Iv Ammonium Nitrate

Predominant ortho-selective mononitration of low-melting and liquid phenols and hydroxycoumarins in moderate to high yields has been accomplished upon grinding with solid cerium (IV) ammonium nitrate (CAN). Microwave-assisted expeditious CAN-mediated nitration of relatively high melting phenols and hydroxycoumarins with high efficiency and selectively under solvent-free conditions has been also developed to address the problems of sluggishness and low yield for these reluctant substrates.

Solvent-free synthesis of pyrrolo [2,1-α]isoquinolines via one-pot four-component reaction

2021 ◽  
Vol 18 ◽  
Author(s):  
Ali Aminkhani ◽  
Sina Sharifi
Keyword(s):  
Cycloaddition Reaction ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Solvent Free Synthesis

: An efficient four-component reaction to synthesize pyrrolo[2,1-a]isoquinolines from malononitrile, aromatic aldehydes, isoquinoline, and cyclohexyl isocyanide under solvent-free conditions is described. In a convenient, simple, and efficient one-pot procedure, the domino Knoevenagel-nucleophilic cycloaddition reaction affords excellent yields of products in less than 1 h.

Solvent-free synthesis and properties of carboxymethyl starch fatty acid ester derivatives

2009 ◽  
Vol 63 (1) ◽  
Author(s):  
Viera Mazíková ◽  
Iva Sroková ◽  
Anna Ebringerová
Keyword(s):  
Fatty Acid ◽  
Methyl Esters ◽  
Solvent Free ◽  
Water Soluble ◽  
Polymeric Surfactants ◽  
Acid Complex ◽  
Carboxymethyl Starch ◽  
Solvent Free Conditions ◽  
Structural Surface ◽  
Solvent Free Synthesis

AbstractWater-soluble, partially hydrophobized polysaccharides have become attractive due to their potential to act as polymeric surfactants. From carboxymethyl starch (CMS), water-soluble polymeric surfactants were prepared by esterification using two unconvential methods based on (A) a reaction with mixed anhydrides and (B) with methyl laureate (MELA) and methyl esters of the fatty acid complex of rape seed oil (MERO) under ‘solvent-free’ conditions. The obtained CMS derivatives were characterized by structural, surface-active and surfactant performance properties. Esterification using method B was successful in contrast to method A which yielded derivatives with a very low extent of esterification. Although the derivatives reduced the surface tension moderately, they exhibited remarkable emulsifying properties. The performance tests indicated good washing power and antiredeposition efficiency. The results suggest that suitable polymeric surfactants can be prepared by the unconventional esterification method B using both acylation agents. The preparations might substitute the expensive and invasive industrially applied conventional methods.

Seed-assisted, solvent-free synthesis of a CHA-type aluminophosphate molecular sieve

RSC Advances ◽  
2015 ◽  
Vol 5 (116) ◽  
pp. 95690-95694 ◽  
Author(s):  
Xinhong Zhao ◽  
Jiangbo Zhao ◽  
Xiangping Gao ◽  
Yu Zhao
Keyword(s):  
Molecular Sieve ◽  
Solvent Free ◽  
Solvent Free Conditions ◽  
Solvent Free Synthesis

Triclinic AlPO4-34 with CHA topology has been successfully synthesized under seed-assisted, solvent-free conditions.

A One-Pot, Three-Component, Solvent-Free Synthesis of Novel 6H-Chromeno[3’,4’:5,6]Pyrido[2,3-d]Pyrimidine-Triones under Microwave Irradiation

2018 ◽  
Vol 42 (12) ◽  
pp. 604-607
Author(s):  
Loghman Firoozpour ◽  
Hoda Yahyavi ◽  
Ramona Ejtemaei ◽  
Setareh Moghimi ◽  
Alireza Foroumadi
Keyword(s):  
Microwave Irradiation ◽  
Efficient Method ◽  
Barbituric Acid ◽  
Reaction Times ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Substituted Benzaldehydes ◽  
High Yields ◽  
Solvent Free Synthesis

A green and efficient method for preparing novel heterocyclic systems is established through the reaction of differently substituted benzaldehydes, barbituric acid and 4-amino-2H-chromene-2-one under solvent-free conditions. This method affords 6H-chromeno[3’,4’:5,6] pyrido[2,3-d]pyrimidine-trione derivatives in high yields and short reaction times.

scholarly journals A Facile Solvent Free Synthesis of 3-arylidenechroman-4-ones Using Grinding Technique

2012 ◽  
Vol 9 (3) ◽  
pp. 1251-1256 ◽  
Author(s):  
Suresh Kumar ◽  
Jagdish K. Makrandi
Keyword(s):  
Polyphosphoric Acid ◽  
Cold Water ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Environmentally Benign ◽  
High Yield ◽  
Solvent Free Conditions ◽  
Microwave Irradiations ◽  
Grinding Technique ◽  
Solvent Free Synthesis

An efficient method for the synthesis of 3-arylidenechroman-4-ones has been developed under solvent free conditions using grinding technique. Grinding of variously substituted chroman-4-ones with aromatic aldehydes in presence of anhydrous barium hydroxide at room temperature give 3-arylidenechroman-4-ones in high yield (75-92%). Products are obtained by just acidification of the reaction mixture in ice cold water. Reaction in solid state, with enhanced rate, high selectivity and manipulative simplicity are the attractive features of this environmentally benign protocol. The chroman-4-one derivatives required for the reaction have been obtained by polyphosphoric acid (PPA) catalysed cyclisation of phenoxypropanoic acids under microwave irradiations.

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