scholarly journals A Facile Solvent Free Synthesis of 3-arylidenechroman-4-ones Using Grinding Technique

2012 ◽  
Vol 9 (3) ◽  
pp. 1251-1256 ◽  
Author(s):  
Suresh Kumar ◽  
Jagdish K. Makrandi
Keyword(s):  
Polyphosphoric Acid ◽  
Cold Water ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Environmentally Benign ◽  
High Yield ◽  
Solvent Free Conditions ◽  
Microwave Irradiations ◽  
Grinding Technique ◽  
Solvent Free Synthesis

An efficient method for the synthesis of 3-arylidenechroman-4-ones has been developed under solvent free conditions using grinding technique. Grinding of variously substituted chroman-4-ones with aromatic aldehydes in presence of anhydrous barium hydroxide at room temperature give 3-arylidenechroman-4-ones in high yield (75-92%). Products are obtained by just acidification of the reaction mixture in ice cold water. Reaction in solid state, with enhanced rate, high selectivity and manipulative simplicity are the attractive features of this environmentally benign protocol. The chroman-4-one derivatives required for the reaction have been obtained by polyphosphoric acid (PPA) catalysed cyclisation of phenoxypropanoic acids under microwave irradiations.

Solvent-free synthesis of pyrrolo [2,1-α]isoquinolines via one-pot four-component reaction

2021 ◽  
Vol 18 ◽  
Author(s):  
Ali Aminkhani ◽  
Sina Sharifi
Keyword(s):  
Cycloaddition Reaction ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Solvent Free Synthesis

: An efficient four-component reaction to synthesize pyrrolo[2,1-a]isoquinolines from malononitrile, aromatic aldehydes, isoquinoline, and cyclohexyl isocyanide under solvent-free conditions is described. In a convenient, simple, and efficient one-pot procedure, the domino Knoevenagel-nucleophilic cycloaddition reaction affords excellent yields of products in less than 1 h.

2,4,6-Trichloro-1,3,5-Triazine-Promoted Synthesis of 1,8-Dioxo-Octahydroxanthenes under Solvent-Free Conditions

2008 ◽  
Vol 61 (2) ◽  
pp. 77 ◽  
Author(s):  
Zhan-Hui Zhang ◽  
Xu-Ye Tao
Keyword(s):  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Cyanuric Chloride ◽  
Environmentally Benign ◽  
Solvent Free Conditions ◽  
High Yields

A practical protocol has been developed for the synthesis of 1,8-dioxo-octahydroxanthenes from aromatic aldehydes and 5,5-dimethylcyclohexane-1,3-dione under solvent-free conditions in the presence of wet 2,4,6-trichloro-1,3,5-triazine (TCT, cyanuric chloride). The desired products were obtained in high yields with a simple and environmentally benign procedure.

scholarly journals Facile Condensation of Aromatic Aldehydes with Chroman-4-ones and 1-Thiochroman-4-ones Catalysed by Amberlyst-15 under Microwave Irradiation Condition

2011 ◽  
Vol 8 (2) ◽  
pp. 863-869 ◽  
Author(s):  
Tapas K. Mandal ◽  
Rammohan Pal ◽  
Rina Mondal ◽  
Asok K. Mallik
Keyword(s):  
Microwave Irradiation ◽  
Aldol Condensation ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Environmentally Benign ◽  
High Yield ◽  
Irradiation Condition ◽  
Free Condition ◽  
Amberlyst 15 ◽  
Solvent Free Condition

Different aromatic aldehydes and cinnamaldehyde undergo cross-aldol condensation with chroman-4-ones and1-thiochroman-4-ones in the presence of amberlyst-15 under microwave irradiation in solvent free condition to afford rapidly the correspondingE-3-arylidene andE-3-cinnamylidene derivatives, respectively, in high yield. This process is simple, efficient and environmentally benign.

scholarly journals Microwave Assisted Solvent-Free Synthesis of Some Imine Derivatives

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Yunus Bekdemir ◽  
Kürşat Efil
Keyword(s):  
Microwave Heating ◽  
Aromatic Amines ◽  
Environmentally Friendly ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Molar Ratio ◽  
Microwave Assisted ◽  
Solvent Free Conditions ◽  
Solvent Free Synthesis ◽  
Environmentally Friendly Method

Some imine derivatives (1a–7d) were synthesized using a rapid and an environmentally friendly method with reaction of aromatic aldehydes (a–d) and aromatic amines (1–7) (in 1 : 1 molar ratio) in the presence of β-ethoxyethanol as a wetting reagent (2 drops) under solvent-free conditions using microwave heating.

scholarly journals Efficient and solvent-free synthesis of 1-amidoalkyl-2-naphthols using N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide

2010 ◽  
Vol 8 (5) ◽  
pp. 1086-1089 ◽  
Author(s):  
Ramin Ghorbani-Vaghei ◽  
Seyedeh Malaekehpour
Keyword(s):  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Reusable Catalyst ◽  
Efficient Synthesis ◽  
Amidoalkyl Naphthols ◽  
Solvent Free Conditions ◽  
High Yields ◽  
Solvent Free Synthesis

AbstractN,N,N,’N’-Tetrabromobenzene-1,3-disulfonamide [TBBDA] is found to be a reusable catalyst for efficient synthesis of various amidoalkyl naphthols from β-naphthol, aromatic aldehydes and urea in good to high yields under solvent-free conditions.

An Efficient Solvent-Free Synthesis of Bis(2-Tetrahydrobenzofuranyl)Alkanes Catalyzed by H2SO4•SiO2

2014 ◽  
Vol 1033-1034 ◽  
pp. 49-52
Author(s):  
Fan Zhang ◽  
Lu Lu Xiao ◽  
Lei Jin ◽  
Wen Bin Wang ◽  
Nian Yu Huang
Keyword(s):  
Good Yield ◽  
Functional Group ◽  
Condensation Reaction ◽  
Reaction Times ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Simple Operation ◽  
Solvent Free Conditions ◽  
Benign Nature ◽  
Solvent Free Synthesis

A series of bis (2-tetrahydrobenzofuranyl) alkanes in good yield under solvent-free conditions from differently aromatic substituted aldehydes and 3-methyl-6,7-dihydrobenzofuran-4(5H)-one in the presence of H2SO4•SiO2 as catalyst at 90oC. Their structures were characterized by NMR, IR and ESI-MS. The proposed mechanism for the H2SO4•SiO2-catalyzed condensation reaction have been discussed in the work. This versatile approach has the advantages of broad functional group compatibility, short reaction times, simple operation and environmentally benign nature.

Morpholinium hydrogen sulfate (MHS) ionic liquid as an efficient catalyst for the synthesis of bio-active multi-substituted imidazoles (MSI) under solvent-free conditions

2017 ◽  
Vol 72 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Adel A. Marzouk ◽  
Antar A. Abdelhamid ◽  
Shaaban K. Mohamed ◽  
Jim Simpson
Keyword(s):  
Ionic Liquid ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Biologically Active ◽  
High Yield ◽  
Hydrogen Sulfate ◽  
Efficient Catalyst ◽  
Solvent Free Conditions ◽  
Very High

AbstractMorpholinium hydrogen sulfate as an ionic liquid was employed as a catalyst for the synthesis of a biologically active series of multi-substituted imidazoles by a four-component reaction involving the combination of benzil with different aromatic aldehydes, ammonium acetate, and 1-amino-2-propanol under solvent-free conditions. The key advantages of this method are shorter reaction times, very high yield, and ease of processing. Furthermore, the resulting products can be purified by a non-chromatographic method and the ionic liquid catalyst is reusable. All of these novel compounds have been fully characterized from spectral data. The X-ray crystal structures of two representative molecules are also detailed.

scholarly journals Direct Synthesis of Vinylene Carbonates from Aromatic Aldehydes

2021 ◽  
Author(s):  
Killian Onida ◽  
Leyli Ibrahimli ◽  
Nicolas Duguet
Keyword(s):  
Direct Synthesis ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
High Yield ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Benzoin Condensation

Substituted vinylene carbonates were directly prepared from aromatic aldehydes following a one-pot Benzoin condensation / transcarbonation sequence under solvent-free conditions. The combination of a N-phenyl substituted triazolium salt NHC precursor and 4-dimethylaminopyridine (DMAP) was found essential to reach high yield and selectivity. The reaction scope was investigated with a range of aromatic aldehydes and the corresponding vinylene carbonates were obtained with 32-86% isolated yields (14 examples).

Efficient solvent-free synthesis of bis(indolyl)methanes on SiO2 solid support under microwave irradiation

2015 ◽  
Vol 69 (3) ◽  
Author(s):  
Da-Wei Zhang ◽  
Yu-Min Zhang ◽  
Yi-Liang Zhang ◽  
Tian-Qi Zhao ◽  
Hong-Wei Liu ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Aromatic Aldehydes ◽  
Solid Support ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
Solvent Free Conditions ◽  
Solvent Free Synthesis

AbstractAn efficient synthesis of bis(indolyl)methanes was developed. Bis(indolyl)methanes were synthesized starting from various aromatic aldehydes with indole under microwave irradiation and solvent-free conditions (85-98 %). Solid support SiO

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