scholarly journals Effectiveness of ultrasound-guided percutaneus neuromodulation on peripheal neuropathies induced by chemotherapy: a pilot study

2019 ◽  
Vol 02 (02) ◽  
pp. 084-085
Author(s):  
López-Garzón MC ◽  
Lozano-Lozano M. ◽  
Álvarez-Salvago F. ◽  
Galiano-Castillo N.
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Colorectal Cancer ◽  
Pilot Study ◽  
Treatment Protocol ◽  
University Hospital ◽  
Quality Of Sleep ◽  
Post Intervention ◽  
Eortc Qlq

Abstract Background and Aims Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most invalidating secondary effects (60%) both of colorectal cancer as well as breast cancer and is a reason for abandoning medical treatment. The symptoms are based on pain, tingling, numbness, and can affect quality of sleep. It is known that analgesia induced by TENS is multifactorial and probably comprises peripheral, spinal and supraspinal mechanisms. Besides, these effects could be greater if the application is performed percutaneously. Therefore, the principal aim of this study was to evaluate the effectiveness of ultrasound-guide percutaneous neuromodulation on the quality of life of patients who suffer CIPN. Material and Methods Three patients (n = 2 breast cancer and n = 1 colorectal cancer) were recruited from the University Hospital Virgen de las Nieves (Granada, Spain). This study received ethics committee approval (0110-N-18) The radial, cubital and median nerves were treated in the upper limb, and the tibial, peroneal, sural and saphenous nerves were treated for the lower limb. In total, eight treatment sessions were performed per affected limb, using the treatment protocol of NMP® (20 seconds of TENS 10Hz 2mA and 10 minutes of TENS 2Hz 1-10mA and in the sural nerve. Besides, 5 minutes of TENS was applied TENS 50Hz 1-10mA) in a weekly session during two months. Before and after treatment, the following variables were evaluated: 1) neuropathy specific quality of life (EORTC QLQ-CIPN20) consisting of three subscales (0-100): sensory, autonomic, motor (greater conduction); 2) intensity of symptoms (numbness, pain and tingling) using the visual analog scale (VAS) (0-10); and 3) sleep according to the Pittsburgh Sleep Quality Index (0-21) using its total component. For the analyses, the normality of the population was assumed due to the nature of the study (N = 3) and therefore the Student's t-test was used to analyze the differences in the baseline and post-intervention means using the IBM SPSS Statistics 21 software (IBM Corporation, Armonk, NY). Results Regarding the autonomic subscale (baseline mean, SD 38.89 ± 5.56) of the EORTC QLQ-CIPN20 the difference of means was statistically significant (-38.89 ± 9.62) (t = -6.99; P = 0.020). The remaining subscales were not significant (P > 0.05) despite the fact that the results also improved: sensory (-2.47 + -16.7); motor (-26.89 ± 19.25); and conduction (-11.11 ± 19.25). The VAS for pain (baseline mean, SD: 5 ± 2.52) obtained a difference in means of −1.67 ± 2.08, although it was not significant (P > 0.05) it did reach a clinically relevant difference (1.1 points). For the remaining VAS scales, numbing and tingling, no statistically significant differences were obtained −1.17 ± 2.021 and −1.5 ± 1.80, respectively (P > 0.05). Lastly, the Pittsburgh questionnaire (baseline mean: 10) decreased by −3.67 ± 1.53 showing a trend towards significance (t = -4.19; P= 0,053). Conclusion Despite this being a pilot study, percutaneous neuromodulation is shown to improve the symptoms of neuropathy induced by chemotherapy, specifically autonomic symptoms and quality of sleep. Our results may represent a change of paradigm in physical therapy treatment.

Quality of life of tunisian women after the treatment of breast cancer

2011 ◽  
Vol 26 (S2) ◽  
pp. 987-987
Author(s):  
L. Mnif ◽  
J. Masmoudi ◽  
N. Charfi ◽  
R. Damak ◽  
M. Guermazi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
General Population ◽  
Breast Cancer Survivors ◽  
University Hospital ◽  
Significant Deterioration ◽  
European Organization ◽  
Global Quality Of Life ◽  
Eortc Qlq

IntroductionIn Tunisia, the breast cancer is the most frequently diagnosed neoplasm in women.Objectives were to- Highlight the health-related QOL of Tunisian women after the treatment of breast cancer compared with the general population.- assess the functional scales that predict the global quality of life (GQOL) scale of the QLQ - C30.MethodsWe recruited 50 patients who were in remission for at least 3 months after initial treatment of breast cancer, and 50 women with no history of cancer.Those patients were previously referred to the Department of Gynecology in Sfax University Hospital for breast surgery, and then they had all received adjuvant therapy.QOL was evaluated using the Arabic version of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire.ResultsThe mean scores for QLQ - C30 indicated that the patients had poor to average functioning (GQOL, 56.7; and five functional scales, 55.6%–67.3%).Those scores showed a significant deterioration in the sample of breast cancer survivors relative to general population.Among the symptoms scales, only the financial difficulties were significantly greater in patients (p = 9.10-7).Deterioration of the GQOL was induced by the worsening of the emotional (p = 0.005) and social (p = 0.008) functioning but it was independent of symptoms scales.ConclusionThe findings indicated that, despite many treatment advances, Tunisian women had significantly poorer GQOL and functional scales scores in comparison with the general population. It seems also that improving the emotional and social functioning contribute to a better GQOL.

scholarly journals Evaluation of a Post-Operative Rehabilitation Program in Patients Undergoing Laparoscopic Colorectal Cancer Surgery: A Pilot Study

2021 ◽  
Vol 18 (11) ◽  
pp. 5632
Author(s):  
Sveva Maria Nusca ◽  
Attilio Parisi ◽  
Paolo Mercantini ◽  
Marcello Gasparrini ◽  
Francesco Antonio Pitasi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Pilot Study ◽  
Exercise Program ◽  
Cancer Surgery ◽  
Colorectal Cancer Surgery ◽  
End Of Treatment ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

This pilot study explores the effects of a post-operative physical exercise program on the quality of life (QoL) and functional and nutritional parameters of patients that underwent laparoscopic colorectal cancer surgery, compared to usual care alone. The intervention group (IG) attended a 2-month-long supervised and combined exercise–training program during the post-operative period. Both IG and control group (CG) participated in the QoL, functional, and nutritional assessments before exercise training (T0), 2 months after the beginning of the exercise (end of treatment) (T1), and 2 (T2) and 4 (T3) months from the end of treatment. Eleven patients with colorectal cancer that underwent laparoscopic surgery were enrolled (six intervention; five control). The IG showed significant improvements compared to the CG in “Physical functioning” (PF2) (p = 0.030), “Cognitive functioning” (CF) (p = 0.018), and “Fatigue” (FA) (p = 0.017) of the European Organization for Research and Treatment of Cancer Quality of Life-C30 Questionnaire (EORTC QLQ-C30) at T1; in SMWT (p = 0.022) at T1; in PF2 (p = 0.018) and FA (p = 0.045) of EORTC QLQ-C30 at T2, in phase angle (PhA) of bioelectrical impedance analysis (p = 0.022) at T3. This pilot study shows that a post-operative, combined, and supervised physical exercise program may have positive effects in improving the QoL, functional capacity, and nutritional status in patients that undergo laparoscopic colorectal cancer surgery.

scholarly journals Psychometric validation of the Moroccan version of the EORTC QLQ-C30 in colorectal Cancer patients: cross-sectional study and systematic literature review

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yacir El Alami ◽  
Hajar Essangri ◽  
Mohammed Anass Majbar ◽  
Saber Boutayeb ◽  
Said Benamr ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Discriminant Validity ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Related Quality ◽  
Eortc Qlq C30 ◽  
Eortc Qlq ◽  
Colorectal Cancer Patients

Abstract Background Health-related quality of life is mainly impacted by colorectal cancer which justified the major importance addressed to the development and validation of assessment questionnaires. We aimed to assess the validity and reliability of the Moroccan Arabic Dialectal version of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (QLQ-C30) in patients with colorectal cancer. Methods We conducted a cross-sectional study using the Moroccan version of the EORTC QLQ-C30 on colorectal cancer patients from the National Oncology Institute of Rabat, in the period from February 2015 to June 2017. The QLQ-C30 was administered to 120 patients. Statistical analysis included reliability, convergent, and discriminant validity as well as known-groups comparisons. Results In total, 120 patients with colorectal cancer were included in the study with 38 (32%) patients diagnosed with colon cancers. Eighty-two patients (68%) had rectal cancer, among which 29 (24%) patients with a stoma. The mean age of diagnosis was 54 years (+/− 13.3). The reliability and validity of the Arabic dialectal Moroccan version of the EORTC QLQ-C30 were satisfactory. [Cronbach’s alpha (α =0.74)]. All items accomplished the criteria for convergent and discriminant validity except for question number 5, which did not complete the minimum required correlation with its own scale (physical functioning). Patients with rectal cancer presented with bad Global health status and quality of life (GHS/QOL), emotional functioning as well as higher fatigue symptoms compared to patients with colon cancer. The difference between patients with and without stoma was significant for diarrhea and financial difficulty. Conclusions The Moroccan Arabic Dialectal version of the QLQ-C30 is a valid and reliable measure of health-related quality of life (HRQOL) in patients with colorectal cancer.

scholarly journals The course of peripheral neuropathy and its association with health-related quality of life among colorectal cancer patients

2020 ◽  
Author(s):  
Cynthia S. Bonhof ◽  
Lonneke V. van de Poll-Franse ◽  
Dareczka K. Wasowicz ◽  
Laurens V. Beerepoot ◽  
Gerard Vreugdenhil ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Peripheral Neuropathy ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Eortc Qlq ◽  
The Impact

Abstract Purpose To gain more insight into the course of chemotherapy-induced peripheral neuropathy (CIPN) and its impact on health-related quality of life (HRQoL) in a population-based sample of colorectal cancer (CRC) patients up to 2 years after diagnosis. Methods All newly diagnosed CRC patients from four hospitals in the Netherlands were eligible for participation in an ongoing prospective cohort study. Patients (n = 340) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30) before initial treatment (baseline) and 1 and 2 years after diagnosis. Results Among chemotherapy-treated patients (n = 105), a high sensory peripheral neuropathy (SPN) level was reported by 57% of patients at 1 year, and 47% at 2-year follow-up, whereas a high motor peripheral neuropathy (MPN) level was reported by 47% and 28%, at years 1 and 2, respectively. Linear mixed model analyses showed that SPN and MPN symptoms significantly increased from baseline to 1-year follow-up and did not return to baseline level after 2 years. Patients with a high SPN or MPN level reported a worse global quality of life and a worse physical, role, emotional, cognitive, and social functioning compared with those with a low SPN or MPN level. Conclusions Future studies should focus on understanding the mechanisms underlying CIPN so targeted interventions can be developed to reduce the impact of CIPN on patient’s lives. Implications for cancer survivors Patients need to be informed of both CIPN and the impact on HRQoL.

scholarly journals An international update of the EORTC questionnaire for assessing quality of life in breast cancer patients (EORTC QLQ-BC23) - EORTC QLQ-BR45

2018 ◽  
Vol 29 ◽  
pp. viii59-viii60 ◽  
Author(s):  
V. Bjelic-Radisic ◽  
A. Bottomley ◽  
F. Cardoso ◽  
D. Cameron ◽  
E. Brain ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Eortc Qlq

scholarly journals Factors associated with depression and the relationship to quality of life among Saudi women with breast cancer

2020 ◽  
Vol 11 (4) ◽  
pp. 43
Author(s):  
Monefah Al-Shammari ◽  
Amani Khalil
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Life Questionnaire ◽  
Primary Therapy ◽  
Convenience Sample ◽  
Saudi Women ◽  
Patient Reported ◽  
Eortc Qlq ◽  
The Relationship

Background and objective: Breast cancer is the most common malignancy among women worldwide, diagnosis and treatment and the months following primary therapy associated with different psychological symptoms that affect quality of life (QoL) in most women with breast cancer. The aim of this study was to identify the relationship between depression and quality of life QoL among Saudi women with breast cancer.Methods: Design: This is a descriptive, cross-sectional study. Methods: A convenience sample of 370 women with breast cancer was recruited from the out-clinic in King Faisal Specialist Hospital \& Research Center (KFSH&RC). Data were collected using self-report tools derived from the Patient-Reported Outcomes Measurement Information System (PROMIS) Emotional Distress-Depression-Short Form; the EORTC quality of life questionnaire (QLQ) (EORTC QLQ-C30, v.3.0 and EORTC QLQ-BR23); and from the Demographic and Clinical Data Sheet.Results: The correlation between depression and global health status with functioning subscales for the women was negative (Pearson’s r = -.357, p < .001; r = -.368, p < .001); whereas a positive correlation was found between depression and symptom subscales, together with its items.Conclusions: This study shows that depression is associated with QoL among Saudi women diagnosed with breast cancer. Therefore, depression affects upon QoL among the breast cancer population. However, enhancement of mental health statuses and psychological interventions helps to reduce the severity of depression and improves health related QoL among this population.

scholarly journals Qualidade de Vida Relacionada à Saúde de Pacientes com Câncer de Mama: Revisão Integrativa da Literatura

2020 ◽  
Vol 66 (1) ◽  
Author(s):  
Monique Binotto ◽  
Gilberto Schwartsmann
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cáncer De Mama ◽  
Life Questionnaire ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
Cancer Breast ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Introdução: O câncer de mama pode alterar a qualidade de vida relacionada à saúde das pacientes. Objetivo: Compreender o impacto da quimioterapia para câncer de mama na qualidade de vida relacionada à saúde de pacientes. Método: Trata-se de uma revisão integrativa da literatura, compreendendo artigos publicados entre 2007 e 2019, disponíveis nas bases de dados PubMed, LILACS e SciELO. Analisaram-se 25 artigos na íntegra. Resultados: Os questionários mais frequentemente utilizados nos estudos foram o European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) e o módulo complementar European Organization for Research and Treatment of Cancer Breast Cancer-specific Quality of Life Questionnaire (EORTC QLQ-BR23). Em relação às alterações da qualidade de vida, a saúde global diminui durante a quimioterapia, mas pode melhorar após o término do tratamento. O aumento dos sintomas é relatado em diversos estudos e prejudicou a qualidade de vida relacionada à saúde das pacientes. Entretanto, os sintomas diminuem após o término da quimioterapia, exceto para algumas escalas. As escalas de imagem corporal, função sexual e funcionamento físico pioram ao longo do tratamento. A qualidade de vida mental/psicológica tem oscilações durante o tratamento, assim como a escala sobre as relações sociais. Conclusão: A qualidade de vida relacionada à saúde de mulheres com câncer de mama é afetada negativamente pelo tratamento quimioterápico, expressando maior impacto nas escalas de sintomas.

scholarly journals Key Factors Contributing to Quality of Life for Breast Cancer Patients in Latvia: Supplementing Quantitative Surveys with Qualitative Interviews

2012 ◽  
Vol 12 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Agnese Dzērvīte ◽  
Maruta Pranka ◽  
Tana Lace ◽  
Ritma Rungule ◽  
Edvins Miklasevics ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Qualitative Interviews ◽  
Treatment Strategies ◽  
Well Being ◽  
University Hospital ◽  
Breast Cancer Patients ◽  
Key Factors

Summary Introduction. Health related quality of life is a much debated topic in medicine with much quantitative and qualitative research contributing to the understanding of how to improve the lives of patients, yet little has been published in relation to the quality of life of Latvian breast cancer patients. Aim of the Study. To gather base measurements of subjective and objective quality of life factors for breast cancer patients in Latvia and discover which key factors contribute most to quality of life of Latvian breast cancer patients at the start of treatment. Materials and Methods. This paper presents data collected from April 2010 to June 2011 at the Pauls Stradins Clinical University hospital on key factors influencing quality of life for breast cancer patients: health and physical well-being; state of surroundings and environment; social support and functionality; financial state, employment and leisure. Quantitative survey material has been supplemented with insight from qualitative in-depth interviews to better explain the objective and subjective implications for breast cancer patients’ quality of life. Results. Interviewed breast cancer patients rated their quality of life as being average or good at the beginning of treatment. Negative factors contributing to lowered quality of life were mainly linked to patient financial, social and emotional state at the first weeks of treatment and correspond to previous research done in Latvia on quality of life issues. Conclusions. Further follow-up surveys will contribute to the evaluation of breast cancer patients’ needs while undergoing treatment to further improve treatment strategies, especially if validated quality of life measurement surveys were to be implemented in Latvian hospitals.

scholarly journals Painful and non-painful chemotherapy-induced peripheral neuropathy and quality of life in colorectal cancer survivors: results from the population-based PROFILES registry

2020 ◽  
Vol 28 (12) ◽  
pp. 5933-5941 ◽  
Author(s):  
C. S. Bonhof ◽  
H. R. Trompetter ◽  
G. Vreugdenhil ◽  
L. V. van de Poll-Franse ◽  
F. Mols
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Peripheral Neuropathy ◽  
Population Based ◽  
Disease Stage ◽  
Netherlands Cancer Registry ◽  
Global Quality Of Life ◽  
Eortc Qlq ◽  
Time Since Diagnosis

Abstract Purpose This study aims to (1) examine the prevalence of painful versus non-painful chemotherapy-induced peripheral neuropathy (CIPN) among long-term colorectal cancer (CRC) survivors, (2) identify sociodemographic, clinical, and psychological factors associated with painful and non-painful CIPN, and (3) examine the associations of painful CIPN with health-related quality of life (HRQoL) in comparison with non-painful CIPN, i.e., numbness/tingling. Methods All CRC survivors diagnosed between 2000 and 2009 as registered by the population-based Netherlands Cancer Registry (Eindhoven region) were eligible for participation. Chemotherapy-treated survivors (n = 477) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30). Results Painful CIPN was reported by 9% (n = 45) of survivors and non-painful CIPN was reported by 22% (n = 103). Time since diagnosis was related to painful CIPN, and time since diagnosis, a higher disease stage, osteoarthritis, and more anxiety symptoms were related to non-painful CIPN. Finally, survivors with painful CIPN reported a worse global quality of life and worse physical, role, cognitive, and social functioning compared to survivors with non-painful CIPN and those without any sensory CIPN. No differences were found between survivors with non-painful CIPN and those without sensory CIPN. Conclusions It seems that painful CIPN must be distinguished from non-painful CIPN, as only painful CIPN was related to a worse HRQoL. Future research is needed to examine whether painful CIPN must be distinguished from non-painful CIPN regarding predictors, mechanisms, and treatment.

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