Development of a Continuous Photochemical Benzyne-Forming Process
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AbstractA continuous-flow process is presented that enables the safe generation and derivatization of benzyne under photochemical conditions. This is facilitated by a new high-power LED lamp emitting light at 365 nm. The resulting flow process effectively controls the release of gaseous by-products based on an adjustable backpressure regulator and delivers a series of heterocyclic products in a short residence time of 3 minutes. The robustness of this methodology is demonstrated for the rapid generation of benzotriazoles, 2H-indazoles and various furan-derived adducts, facilitating the preparation of these important heterocyclic scaffolds via a simple and readily scalable flow protocol.
2017 ◽
Vol 2
(6)
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pp. 896-907
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2017 ◽
Vol 2
(2)
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pp. 149-158
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2016 ◽
Vol 20
(2)
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pp. 199-203
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Continuous Flow Process for Reductive Deoxygenation of ω-Chloroketone in the Synthesis of Vilazodone
2018 ◽
Vol 22
(8)
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pp. 1022-1028
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2018 ◽
Vol 190
(5)
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2019 ◽
Vol 23
(5)
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pp. 1069-1077
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