Radiotherapy in Cutaneous Squamous Cell and Basal Cell Carcinoma

AbstractRadiotherapy is a key component in the multidisciplinary treatment of skin cancers, used in definitive management of selected nonmelanomatous skin cancers and as an adjunct treatment in high-risk cases. Understanding the role of radiotherapy in nonmelanoma skin cancers is increasingly important as their incidence continues to rise. This article provides an overview of risk factors associated with nonmelanomatous skin cancers and the principles of both definitive and adjuvant radiotherapy.

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Mo1173 Risk Factors Associated With Rebleeding in Patients With High Risk Peptic Ulcer Bleeding: Focusing on the Role of Second Look Endoscopy

Gastroenterology ◽

10.1016/s0016-5085(15)32118-1 ◽

2015 ◽

Vol 148 (4) ◽

pp. S-629

Author(s):

Si Hyung Lee ◽

Sung Bum Kim ◽

Kook Hyun Kim ◽

Kyeong Ok Kim ◽

Byung Ik Jang ◽

...

Keyword(s):

Risk Factors ◽

Peptic Ulcer ◽

High Risk ◽

Ulcer Bleeding ◽

Peptic Ulcer Bleeding ◽

Factors Associated ◽

Second Look

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EP-1295: Role of postoperative adjuvant radiotherapy in early stage cervical cancer without high risk factors

Radiotherapy and Oncology ◽

10.1016/s0167-8140(17)31730-9 ◽

2017 ◽

Vol 123 ◽

pp. S695

Author(s):

W. Jung ◽

J. Kim ◽

Y.J. Kim ◽

J. Lee ◽

K. Kim ◽

...

Keyword(s):

Risk Factors ◽

Cervical Cancer ◽

High Risk ◽

Adjuvant Radiotherapy ◽

Early Stage ◽

High Risk Factors ◽

Early Stage Cervical Cancer

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Risk Factors Associated with Rebleeding in Patients with High Risk Peptic Ulcer Bleeding: Focusing on the Role of Second Look Endoscopy

Digestive Diseases and Sciences ◽

10.1007/s10620-015-3846-y ◽

2015 ◽

Vol 61 (2) ◽

pp. 517-522 ◽

Cited By ~ 12

Author(s):

Sung Bum Kim ◽

Si Hyung Lee ◽

Kyeong Ok Kim ◽

Byung Ik Jang ◽

Tae Nyeun Kim ◽

...

Keyword(s):

Risk Factors ◽

Peptic Ulcer ◽

High Risk ◽

Ulcer Bleeding ◽

Peptic Ulcer Bleeding ◽

Factors Associated ◽

Second Look

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Factors Associated with Skin Cancers in People with Albinism in Togo

Journal of Skin Cancer ◽

10.1155/2021/3433493 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Abas Mouhari-Toure ◽

Sefako Abla Akakpo ◽

Julienne Noude Teclessou ◽

Piham Gnossike ◽

Saliou Adam ◽

...

Keyword(s):

Risk Factors ◽

Skin Cancer ◽

Analytical Study ◽

Protective Factor ◽

Upper Limbs ◽

Actinic Keratoses ◽

Factors Associated ◽

Skin Cancers ◽

Basal Cell Carcinomas

Objective. The aim of this study was to identify the factors associated with skin cancers in people with albinism (PWA) in Togo. Method. This is a retrospective analytical study of the records of PWA examined during five dermatological consultation campaigns from 2019 to 2021. Results. During the study period, 517 PWA were seen. Sixty-four (12.3%) of these PWA had presented with 137 cases of skin cancer. The sex ratio (M/F) was 0.9. The average age of PWA with skin cancer was 39.69 ± 15.61 years and that of PWA without skin cancer was 19.17 ± 15.24 years ( p ≤ 0.001 ). The 137 cases of skin cancers were dominated by basal cell carcinomas (45.9%). These skin cancers were located preferentially in the cephalic region (77 cases; 56.2%), followed by the upper limbs (33 cases; 24.1%). In multivariate analysis, the risk factors for skin cancers in PWA were age over 39 years ( p ≤ 0.001 ) and the presence of actinic keratoses ( p ≤ 0.001 ). In contrast, the presence of ephelides ( p = 0.018 ) was a protective factor. Conclusion. This study confirms that advanced age and actinic keratoses are risk factors for skin cancer in PWA, in connection with the cumulative role of solar radiation. Its originality lies in the identification of ephelides as a protective factor. The knowledge and consideration of these risk factors will make it possible to optimise strategies for the prevention of skin cancers in PWA.

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Development of an Emergency Revisit Score for Patients With Drug-Related Problems

Journal of Pharmacy Technology ◽

10.1177/87551225211011731 ◽

2021 ◽

pp. 875512252110117

Author(s):

Jesus Ruiz Ramos ◽

Laura Gras-Martin ◽

Ana María Juanes Borrego ◽

Marta Blazquez-Andion ◽

Mireia Puig Campmany ◽

...

Keyword(s):

Risk Factors ◽

High Risk ◽

Receiver Operating Curve ◽

Drug Related Problems ◽

Derivation Cohort ◽

Factors Associated ◽

Final Score ◽

Anticholinergic Burden ◽

Risk Categories ◽

Frequent Reason

Background: Drug-related problems (DRPs) are a frequent reason for emergency departments (EDs) visits. However, data about the risk factors associated with EDs revisits are limited. Objective: To develop and validate a predictive model indicating the risk factors associated with EDs revisit within 30 days of the first visit. Methods: A retrospective cohort study was conducted involving patients who attended an ED for DRPs related to cardiovascular drugs. A 30-day prediction model was created in a derivation cohort by logistic regression. An integer score proportional to the regression coefficient was assigned to the variables with P < .100 in the multivariate analysis. Results: 581 patients (mean age: 80.0 [12.6] years) were included, 133 (22.9%) revisited the ED within 30 days from discharge. Six factors (chronic kidney disease, chronic heart failure, visit to an ED in the preceding 3 months, high anticholinergic burden, DRPs associated with heparin, and safety-related DRPs) were identified as risk factors and combined into a final score, termed the DREAMER score. The model reached an area under the receiver operating curve values of 0.72 (95% confidence interval [CI] = 0.67-0.77) in the referral cohort and 0.71 (95% CI = 0.65-0.74) in the validation cohort ( P = .273). Three risk categories were generated, with the following scores and estimated risks: low risk (0-8 points): 11.6%; intermediate risk (9-14 points): 21.3%; and high risk (>14 points): 41.2%. Conclusion and Relevance: The DREAMER score identifies patients at high risk for ED revisit within 30 days from the first visit for a DRPs, being a useful tool to prioritize interventions on discharge.

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Role of β-Adrenergic Receptors and Nitric Oxide Signaling in Exercise-Mediated Cardioprotection

Physiology ◽

10.1152/physiol.00011.2013 ◽

2013 ◽

Vol 28 (4) ◽

pp. 216-224 ◽

Cited By ~ 21

Author(s):

John W. Calvert ◽

David J. Lefer

Keyword(s):

Nitric Oxide ◽

Risk Factors ◽

Adrenergic Receptors ◽

Ischemia Reperfusion Injury ◽

Ischemia Reperfusion ◽

Nitric Oxide Signaling ◽

Factors Associated ◽

Cardioprotective Effects ◽

Β Adrenergic Receptors

Exercise promotes cardioprotection in both humans and animals not only by reducing risk factors associated with cardiovascular disease but by reducing myocardial infarction and improving survival following ischemia. This article will define the role that nitric oxide and β-adrenergic receptors play in mediating the cardioprotective effects of exercise in the setting of ischemia-reperfusion injury.

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Use of Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients

BioMed Research International ◽

10.1155/2013/349526 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 18

Author(s):

Christina Wlodek ◽

Faisal R. Ali ◽

John T. Lear

Keyword(s):

Photodynamic Therapy ◽

Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Actinic Keratoses ◽

Organ Transplant Recipients ◽

Skin Cancers ◽

Effective Treatment Modality ◽

Nonmelanoma Skin Cancers

Solid organ transplant recipients are predisposed to actinic keratoses (AK) and nonmelanoma skin cancers, owing to the lifelong immunosuppression required. Today, increasing numbers of organ transplants are being performed and organ transplant recipients (OTRs) are surviving much longer. Photodynamic therapy (PDT) is proving a highly effective treatment modality for AK amongst this susceptible group of patients. Following an overview of the pathogenesis of AK amongst OTRs, the authors review current safety and efficacy data and how this relates to the role of PDT for the treatment of AK in OTRs.

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AB0407 CARDIOVASCULAR BURDEN IN SYSTEMIC SCLEROSIS: QRISK3 VERSUS FRAMINGHAM FOR RISK ESTIMATION

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.327 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 1232.1-1232

Author(s):

M. Di Battista ◽

S. Barsotti ◽

A. Della Rossa ◽

M. Mosca

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Systemic Sclerosis ◽

High Risk ◽

General Population ◽

Risk Score ◽

Predictive Accuracy ◽

Risk Estimation ◽

Cross Sectional

Background:Cardiovascular (CV) diseases, namely myocardial infarction and stroke, are not among the most known and frequent complications of systemic sclerosis (SSc), but there is growing evidence that SSc patients have a higher prevalence of CV diseases than the general population [1].Objectives:To compare two algorithms for CV risk estimation in a cohort of patients with SSc, finding any correlation with clinical characteristics of the disease.Methods:SSc patients without previous myocardial infarction or stroke were enrolled. Traditional CV risk factors, SSc-specific characteristics and ongoing therapies were assessed. Framingham and QRISK3 algorithms were then used to estimate the risk of develop a CV disease over the next 10 years.Results:Fifty-six SSc patients were enrolled. Framingham reported a median risk score of 9.6% (IQR 8.5), classifying 24 (42.9%) subjects at high risk, with a two-fold increase of the mean relative risk in comparison to general population. QRISK3 showed a median risk score of 15.8% (IQR 19.4), with 36 (64.3%) patients considered at high-risk. Both algorithms revealed a significant role of some traditional risk factors and a noteworthy potential protective role of endothelin receptor antagonists (p=0.003). QRISK3 was also significantly influenced by some SSc-specific characteristics, as limited cutaneous subset (p=0.01), interstitial lung disease (p=0.04) and non-ischemic heart involvement (p=0.03), with the first two that maintain statistically significance in the multivariate analysis (p=0.02 for both).Conclusion:QRISK3 classifies more SSc patients at high-risk to develop CV diseases than Framingham, and it seems to be influenced by some SSc-specific characteristics. If its predictive accuracy were prospectively verified, the use of QRISK3 as a tool in the early detection of SSc patients at high CV risk should be recommended.References:[1]Ngian GS, Sahhar J, Proudman SM, Stevens W, Wicks IP, Van Doornum S. Prevalence of coronary heart disease and cardiovascular risk factors in a national cross-sectional cohort study of systemic sclerosis. Ann Rheum Dis. 2012;71:1980-3.Disclosure of Interests:None declared

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Role of Colour Doppler in High Risk Pregnancy

International Journal of Science and Healthcare Research ◽

10.52403/ijshr.20210434 ◽

2021 ◽

Vol 6 (2) ◽

pp. 185-191

Author(s):

Hiral Parekh ◽

Sneha Chaudhari

Keyword(s):

Risk Factors ◽

High Risk ◽

Perinatal Outcome ◽

Umbilical Artery ◽

High Risk Pregnancy ◽

Colour Doppler ◽

High Risk Factors ◽

Risk Pregnancy ◽

A Prospective Study

This was a prospective study conducted in pregnant patients with high risk factors who got admitted in the Department of Obstetrics and Gynaecology at Care Hospital, Jamnagar during the period from May 2018 to September 2020. Background: High-risk pregnancies causes many adverse perinatal outcomes. Doppler ultrasound is a non-invasive technique to study the feto-maternal circulation to guide the clinical management. Objective: This study aims at evaluating the role of colour Doppler in high-risk pregnancies and their perinatal outcome. Materials and Methods: This was a prospective study carried out for 29 months in the Department of Radiology with antenatal women in the age group of 18-35 years with singleton pregnancy of gestational age of <28 weeks to >35 weeks having high-risk factors considered in study. The risk factors considered were pregnancy induced hypertension (PIH), gestational diabetes, anemia, oligohydramnios, polyhydramnios and IUGR. Doppler study of umbilical artery and fetal middle cerebral artery (MCA) arteries was done and amniotic fluid index (AFI) was measured. Parameters in the form of resistive index, pulsatility index, and systolic/diastolic ratio were taken. obstetric history was taken with regular interval follow up. Results: The study was carried out with 50 patients. High-risk pregnancy was more common in the age group of 21-25 years. The most common high-risk factor in pregnancy was oligohydramnios which accounted for 30% of cases. Out of 50 high-risk pregnancies, 5 (10 %) of cases resulted in intrauterine growth restriction (IUGR). Out of 50 high-risk cases, in 36 cases, umbilical artery findings were abnormal. 3 patients had intrauterine death (IUD) and 27 patients had poor perinatal outcome. Umbilical artery abnormality showed significant sensitivity and negative predictive value for adverse (poor + IUD) perinatal. Correlation was seen between high risk pregnancy and need of emergency caesarean section and induction and associated adverse perinatal outcome. Conclusion: Combination of different arterial waveform study enhance the diagnostic accuracy in identifying those intrauterine growth restricted foetuses that were at risk. Keywords: Colour Doppler, high risk pregnancy, perinatal outcome.

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