Factors Associated with Skin Cancers in People with Albinism in Togo

Objective. The aim of this study was to identify the factors associated with skin cancers in people with albinism (PWA) in Togo. Method. This is a retrospective analytical study of the records of PWA examined during five dermatological consultation campaigns from 2019 to 2021. Results. During the study period, 517 PWA were seen. Sixty-four (12.3%) of these PWA had presented with 137 cases of skin cancer. The sex ratio (M/F) was 0.9. The average age of PWA with skin cancer was 39.69 ± 15.61 years and that of PWA without skin cancer was 19.17 ± 15.24 years ( p ≤ 0.001 ). The 137 cases of skin cancers were dominated by basal cell carcinomas (45.9%). These skin cancers were located preferentially in the cephalic region (77 cases; 56.2%), followed by the upper limbs (33 cases; 24.1%). In multivariate analysis, the risk factors for skin cancers in PWA were age over 39 years ( p ≤ 0.001 ) and the presence of actinic keratoses ( p ≤ 0.001 ). In contrast, the presence of ephelides ( p = 0.018 ) was a protective factor. Conclusion. This study confirms that advanced age and actinic keratoses are risk factors for skin cancer in PWA, in connection with the cumulative role of solar radiation. Its originality lies in the identification of ephelides as a protective factor. The knowledge and consideration of these risk factors will make it possible to optimise strategies for the prevention of skin cancers in PWA.

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Skin cancer risk factors among black South Africans — the Johannesburg Cancer Study, 1995–2016

10.21203/rs.3.rs-32648/v1 ◽

2020 ◽

Author(s):

Babongile Confidence Ndlovu ◽

Mazvita Sengayi-Muchengeti ◽

Caradee Y Wright ◽

Wenlong C Chen ◽

Lazarus Kuonza ◽

...

Keyword(s):

Risk Factors ◽

Skin Cancer ◽

Rural Areas ◽

Reference Group ◽

Lower Limbs ◽

Anatomical Site ◽

Hiv Status ◽

Factors Associated ◽

Awareness Campaigns ◽

Skin Cancers

Abstract Background The Black population is known to have lower risk for skin cancers due to melanin content of the skin. Regardless, skin cancers still occur in Black populations. The aim of this study was to identify risk factors associated with skin cancer among Blacks presenting at selected tertiary hospitals in Johannesburg, South Africa. Methods A case-control study was conducted; cases were patients with keratinocyte cancers (KCs) and/or melanoma skin cancer (MSC) and controls were cardiovascular patients. Socio-demographic exposures (sex and residency), environmental exposures (heating and cooking fuels), smoking, and HIV status were assessed. The proportions of cases by skin cancer major subtype, demographics, histological spectrum and anatomical site of distribution were determined. A stepwise (backward elimination) logistic regression was done to identify risk factors associated with KC and MSC. Results More KCs (n = 160) were found compared to MSCs (n = 101). The majority of both KCs and MSCs were reported in ages 51-60-years (27%). The median age at KC and MSC diagnosis was similar in both sexes; 50-years (IQR:38–57) and 56-years (IQR:48–68), respectively. The KC histological spectrum showed that there were more squamous cell carcinomas (SCCs) (78/160 in females, and 72/160 in males) than basal cell carcinoma (BCC). The SCC lesions were mostly found on the skin of the head and neck in males (51%, 38/72) and on the trunk in females (46%, 36/78). MSC was shown to affect the skin of the lower limbs in both males (68%, 27/40) and females (59%, 36/61). Using females as the reference group, when age, current place of residency, type of cooking fuel used currently, smoking, and HIV status were adjusted for, males had an odds ratio (OR) of 2.04 for developing KC (CI:1.08–3.84, p = 0.028). Similarly, when age, current place of residency, place of cooking (indoors or outdoors) were adjusted for, males had an OR of 2.26 for developing MSC (CI:1.19–4.29, p = 0.012). Conclusions Differences in anatomical distribution of KCs by sex suggest different risk factors between sexes. Rural dwelling was a newly found association to skin cancer and warrants further investigation. This study highlights the importance of skin cancer awareness campaigns and interventions especially in rural areas.

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Radiotherapy in Cutaneous Squamous Cell and Basal Cell Carcinoma

Facial Plastic Surgery ◽

10.1055/s-0040-1709119 ◽

2020 ◽

Vol 36 (02) ◽

pp. 180-185

Author(s):

Laila A. Gharzai ◽

Michelle L. Mierzwa

Keyword(s):

Risk Factors ◽

High Risk ◽

Adjuvant Radiotherapy ◽

Multidisciplinary Treatment ◽

Adjunct Treatment ◽

Factors Associated ◽

Skin Cancers ◽

Nonmelanoma Skin Cancers ◽

Definitive Management

AbstractRadiotherapy is a key component in the multidisciplinary treatment of skin cancers, used in definitive management of selected nonmelanomatous skin cancers and as an adjunct treatment in high-risk cases. Understanding the role of radiotherapy in nonmelanoma skin cancers is increasingly important as their incidence continues to rise. This article provides an overview of risk factors associated with nonmelanomatous skin cancers and the principles of both definitive and adjuvant radiotherapy.

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Role of β-Adrenergic Receptors and Nitric Oxide Signaling in Exercise-Mediated Cardioprotection

Physiology ◽

10.1152/physiol.00011.2013 ◽

2013 ◽

Vol 28 (4) ◽

pp. 216-224 ◽

Cited By ~ 21

Author(s):

John W. Calvert ◽

David J. Lefer

Keyword(s):

Nitric Oxide ◽

Risk Factors ◽

Adrenergic Receptors ◽

Ischemia Reperfusion Injury ◽

Ischemia Reperfusion ◽

Nitric Oxide Signaling ◽

Factors Associated ◽

Cardioprotective Effects ◽

Β Adrenergic Receptors

Exercise promotes cardioprotection in both humans and animals not only by reducing risk factors associated with cardiovascular disease but by reducing myocardial infarction and improving survival following ischemia. This article will define the role that nitric oxide and β-adrenergic receptors play in mediating the cardioprotective effects of exercise in the setting of ischemia-reperfusion injury.

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Use of Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients

BioMed Research International ◽

10.1155/2013/349526 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 18

Author(s):

Christina Wlodek ◽

Faisal R. Ali ◽

John T. Lear

Keyword(s):

Photodynamic Therapy ◽

Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Actinic Keratoses ◽

Organ Transplant Recipients ◽

Skin Cancers ◽

Effective Treatment Modality ◽

Nonmelanoma Skin Cancers

Solid organ transplant recipients are predisposed to actinic keratoses (AK) and nonmelanoma skin cancers, owing to the lifelong immunosuppression required. Today, increasing numbers of organ transplants are being performed and organ transplant recipients (OTRs) are surviving much longer. Photodynamic therapy (PDT) is proving a highly effective treatment modality for AK amongst this susceptible group of patients. Following an overview of the pathogenesis of AK amongst OTRs, the authors review current safety and efficacy data and how this relates to the role of PDT for the treatment of AK in OTRs.

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Risk factors associated with delirium in a general ICU: role of S-100 protein

Critical Care ◽

10.1186/cc6734 ◽

2008 ◽

Vol 12 (Suppl 2) ◽

pp. P513

Author(s):

A Rubino ◽

F Forfori ◽

G Licitra ◽

P Cosimini ◽

F Foltran ◽

...

Keyword(s):

Risk Factors ◽

Factors Associated ◽

S 100

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ROLE OF VARIOUS RISK FACTORS ASSOCIATED WITH CARDIOVASCULAR DISEASES

International Research Journal of Pharmacy ◽

10.7897/2230-8407.04511 ◽

2013 ◽

Vol 4 (5) ◽

pp. 44-50

Author(s):

Pranay Wal ◽

Ankita Wal ◽

Nikita Saraswat ◽

Shalini Singh ◽

Shikha Bajpai

Keyword(s):

Risk Factors ◽

Cardiovascular Diseases ◽

Factors Associated

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Risk factors for bad obstetric history in Kirkuk women, Iraq

International Journal of Infection and Microbiology ◽

10.3126/ijim.v2i3.8121 ◽

2013 ◽

Vol 2 (3) ◽

pp. 70-77 ◽

Cited By ~ 5

Author(s):

ZKM Aljumaily ◽

AM Alsamarai

Keyword(s):

Risk Factors ◽

Protective Factor ◽

Inverse Correlation ◽

Normal Pregnancy ◽

Obstetric History ◽

Iraqi Women ◽

Mother Education ◽

Animal Exposure ◽

Microbial Agents

INTRODUCTION: Microbial agents such as Toxoplasma, rubella, CMV and HSV are important cause of infections during pregnancy, which mainly are asymptomatic. However, the infection during pregnancy may result in serious foetal side effects. Objective was to determine the risk factors that enhance the development of bad obstetric history (BOH) due to TORCH infections in Iraqi women. MATERIALS AND METHODS: A 538 women were included in the study, of them 293 (54.5%) were with BOH, and 245 (45.5%) were with normal pregnancy history. In the BOH group, 144 (49.1%) women were pregnant, while in the normal pregnancy group, 117 (47.7%) were pregnant. Logistic regression analysis was used to determine the risk factors that may play a role in development of BOH. RESULTS: Multifactorial analysis indicated that Toxoplasma gondi IgM, rubella IgM, rubella IgG, CMV IgM, HSV -2 IgG and animal exposure were risk factors that lead to BOH development. However, Toxoplasma IgG seropositivity had inverse correlation to BOH development. Mother education was a significant protective (OR=0.614, P=0.000) factor that reduce development of BOH. Residence, education, occupation and family size influenced the role of TORCH in induction of BOH. CONCLUSIONS: This study indicated that Toxoplasma gondi IgM, rubella IgM, rubella IgG, CMV IgM, HSV-2 IgG and animal exposure were risk factors that lead to BOH development. Mother education was a significant protective factor that reduce development of BOH. DOI: http://dx.doi.org/10.3126/ijim.v2i3.8121 Int J Infect Microbiol 2013;2(3):70-77

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Covid-19 and ex-smokers: an underestimated prognostic factor?

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2020.1463 ◽

2020 ◽

Vol 90 (3) ◽

Author(s):

Pierluigi Carratù ◽

Roberto Boffi ◽

Silvano Dragonieri ◽

Elena Munarini ◽

Chiara Veronese ◽

...

Keyword(s):

Risk Factors ◽

Prognostic Factors ◽

Prognostic Factor ◽

Protective Factor

Dear Editor, The recent and explosive worldwide outbreak of Covid-19 leads many scientists and clinicians to identify the most responsible triggering risk factors in individuals without comorbidities, as well as potential prognostic factors. A notable field of research has been conducted on the role of smoking, which has been initially hypothesized as being a protective factor for Covid-19....

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