Quality of life in women using the vaginal contraceptive ring Ornibel®: Data of an observational study.

Multiple myeloma (MM) is a bone marrow neoplasia that causes bone pain in 70% patients. While preclinical models of MM have suggested that both nerve sprouting and nerve injury may be causative for the pain, there is a lack of clinical data. Thus, the primary aims of this clinical study are: (1) to provide a deep characterization of the subjective experience of pain and quality of life in MM patients; (2) to investigate disturbances in the bone innervation of MM patients. Secondary aims include exploring correlations between pain and serum inflammatory and bone turnover biomarkers. In a prospective, observational study (clinicaltrials.gov: NCT04273425), patients with suspected MM requiring a diagnostic iliac crest biopsy at Sheffield Teaching Hospital (UK) are invited to participate. Consenting patients answer seven standardized questionnaires assessing pain, quality of life and catastrophizing. Bone turnover biomarkers and inflammatory cytokines are measured in fasting serum samples, and bone innervation is evaluated in diagnostic biopsies. MM patients are invited to a follow-up upon completion of first line treatment. This will be the first deep characterization of pain in MM patients and its correlation with disturbances in bone innervation. Understanding how bone turnover and inflammation correlate to pain in MM is crucial to identify novel analgesic targets for this condition.

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Food‐related quality of life in adults with inflammatory bowel disease is associated with restrictive eating behaviour, disease activity and surgery: a prospective multi‐centre observational study

Journal of Human Nutrition and Dietetics ◽

10.1111/jhn.12920 ◽

2021 ◽

Author(s):

Alice S. Day ◽

Chu K. Yao ◽

Samuel P. Costello ◽

Jane M. Andrews ◽

Robert V. Bryant

Keyword(s):

Quality Of Life ◽

Inflammatory Bowel Disease ◽

Observational Study ◽

Disease Activity ◽

Bowel Disease ◽

Eating Behaviour ◽

Restrictive Eating ◽

Related Quality ◽

Inflammatory Bowel

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Quality of Life in Patients with Nasal Obstruction after Septoplasty: A Single Institution Prospective Observational Study

International Archives of Otorhinolaryngology ◽

10.1055/s-0040-1722162 ◽

2021 ◽

Author(s):

Justyna Dąbrowska-Bień ◽

Henryk Skarżyński ◽

Sebastian Filip Górski ◽

Piotr Henryk Skarżyński

Keyword(s):

Quality Of Life ◽

Observational Study ◽

Nasal Obstruction ◽

Prospective Observational Study ◽

Common Symptom ◽

Single Institution ◽

High Satisfaction ◽

Symptom Evaluation ◽

The Individual

Abstract Introduction Nasal obstruction is a common symptom in otorhinolaryngological practice. It can impact significantly on the quality of life of the individual. Objective The primary goal of the present study was to evaluate quality of life after septoplasty in adults with nasal obstruction. A secondary goal was to assess the effectiveness of septoplasty. Methods This was a single institution prospective observational study. Patients had experienced septal deviation and symptomatic nasal obstruction with no benefit from medical treatment. There were 51 patients who completed the Nasal Obstruction Symptom Evaluation (NOSE-POL) scale as well as theVisual Analogue Scale (VAS) before undergoing septoplasty, 3 months later, and finally 7 months after surgery. Patients evaluated changes in their nasal obstruction and changes in their quality of life using the Clinical Global Impression Scale (CGI-S). Results There was a significant improvement in nasal obstruction after septoplasty. Before septoplasty, the mean score on NOSE was 60.3 ± 20.4; 3 months after surgery, it was 32.9 ± 16.8; and 7 months after surgery it was 39.6 ± 33.2. The VAS results also proved a significant enhancement in nasal obstruction after septoplasty. Patients reported an improvement in nasal obstruction as well as a positive change in quality of life, confirming the effectiveness of septoplasty. Conclusions In patients with deformed septum, septoplasty contributes to high satisfaction of the patient and a compelling improvement in disease-specific quality of life. The NOSE-POL questionnaire is a useful tool for measuring the outcomes of this procedure.

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The Scandinavian Solutions for Wellness Study - an Observational Study on the Effectiveness of the Lifestyle Program Solutions for Wellness

European Psychiatry ◽

10.1016/s0924-9338(09)71191-5 ◽

2009 ◽

Vol 24 (S1) ◽

pp. 1-1

Author(s):

V. Porsdal ◽

O.K. Kleivenes ◽

C. Beal ◽

P. Svanborg

Keyword(s):

Quality Of Life ◽

Waist Circumference ◽

Observational Study ◽

Psychiatric Patients ◽

Control Group ◽

Life Styles ◽

Lifestyle Program ◽

Life Style Changes ◽

Treatment Data

Aims:It is known that psychiatric disorders often lead to unhealthy life styles and reduced quality of life, which can lead to weight gain, possibly enhanced by psychotropic treatment.Solutions for Wellness (SfW) is an educational program for life style changes for psychiatric patients. This observational study evaluated the effectiveness of SfW.Method:30 psychiatric clinics collected data for the study. Quality of life was measured by the Subjective Wellbeing under Neuroleptics scale (SWN), at baseline and at the end of SfW participation at 3 months. Demographic, disease and treatment data were also collected. A control group consisted of patients from centers that did not offer the SfW program.Results:314 patients were enrolled in SfW group, 59 in the control group. 54% of the total group had schizophrenia, 67% received atypical antipsychotics. The baseline mean BMI in the SfW group was 31.7 kg/m2.SWN scores for the SfW group improved significantly from baseline to the end of the program (mean increase 3.3 ± 12.2), but not significantly more than for the control group (mean difference 1.4, p = 0.4158 (t-test)). The SfW group demonstrated a significant decrease in BMI, weight and waist circumference from baseline. The decreases were significantly larger compared to the control group for BMI (p = 0.0018) and weight (p = 0.0027) (t-tests).Conclusion:Patients in the SfW program improved in BMI, weight, waist circumference and SWN total score. Changes in weight and BMI were significantly larger in the SfW group compared to the control group.

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