Matched-Pair Analysis of Magnetic Resonance Images for Location of the Common Peroneal Nerve in Valgus Knees: Comparison with the Varus Knees

2020 ◽  
Author(s):  
Kwang Am Jung ◽  
Oog-Jin Shon ◽  
Mohd Irfan Banday ◽  
Abhishek Patil ◽  
Gi Beom Kim
Keyword(s):  
Magnetic Resonance ◽  
Subgroup Analysis ◽  
Peroneal Nerve ◽  
Common Peroneal Nerve ◽  
Matched Pair ◽  
Soft Tissue Release ◽  
Control Group ◽  
Matched Pair Analysis ◽  
The Common ◽  
Pair Analysis

AbstractThis study aimed to assess the distance and angular location of the common peroneal nerve (CPN) on axial magnetic resonance imaging (MRI) in the valgus knees and compare the measurements with those obtained from the control group. We compared the location of the CPN according to the type of alignment by performing a subgroup analysis. From January 2009 to December 2019, we identified 41 knees with preoperative MRI in patients who underwent total knee arthroplasty (TKA) for valgus deformity (valgus group). We performed one-to-two matched-pair analysis to a cohort of patients who underwent MRI but were not candidates for TKA (control group), according to sex and age. The valgus group was classified according to the grading system reported by Ranawat et al, and the control group was also subdivided according to the hip-knee-ankle (HKA) angle obtained from lower extremity scanography: neutral (–3 to +3 degrees from the neutral mechanical axis), valgus (> +3 degrees), and varus alignment (< –3 degrees). Distance between the CPN and posterolateral cortex of the tibia at the knee joint (distance J) and tibial cut level (distance C) were measured. Angle of the CPN from the central anteroposterior axis of the tibia (angle α) was measured. We compared the measurements between the groups. Distance J was significantly closer in the valgus group (p < 0.001), whereas angle α was significantly smaller in the valgus group (p < 0.001). However, no significant differences were found in the subgroup analysis. Moreover, a significant correlation was found between distance J and the HKA angle (p < 0.001). The location of the CPN in the valgus knees was closer to the posterolateral cortex of the tibia at the joint level and showed a smaller angle than that in the other aligned knees. We recommend that lateral soft tissue release for valgus knees should not be performed at the joint line. The results of this study suggest that this would be less safe than a release performed at the level of the proximal tibial bone resection.

Efficacy and Safety of Colistin for the Treatment of Infections Caused by Multidrug-Resistant Isolates of Pseudomonas Aeruginosa Sensitive to Colistin in Patients with Haematological Malignancy; a Matched-Pair Analysis.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2283-2283
Author(s):  
Nadira Durakovic ◽  
Ana Boban ◽  
Mirando Mrsic ◽  
Dubravka Sertic ◽  
Ranka Serventi Seiwerth ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Renal Function ◽  
Haematological Malignancy ◽  
Multidrug Resistant ◽  
Matched Pair ◽  
Control Group ◽  
Efficacy And Safety ◽  
Matched Pair Analysis ◽  
Significant Difference ◽  
Pair Analysis

Abstract Infections due to multidrug-resistant (MDR) Gram-negative bacteria have been increasing and they are an important cause of nosocomial morbidity and mortality, especially in immunocompromised patients. In order to determine efficacy and safety of colistin (colistimethate sodium) use in the treatment of MDR Pseudomonas aeruginosa sensitive to colistin, a comparison of renal function, other toxicities, and outcome of therapy was done between a group of patients treated with colistin and patients treated with other antipseudomonas drugs as control group. A group of 26 patients that was hospitalized in our institution between February 2002 and December 2006 and treated with intravenous colistin for an infection caused by MDR P.aeruginosa was compared in a matched-pair analysis to a group of 26 patients treated with other antipseudomonas drugs. Patients were 52% male and 48% female; mean age was 37 years (range 17–63). All of the patients were treated for haematological malignancy, most received intensive chemotherapy regimens (44%), 19% received allogeneic and 31% autologous transplants. Groups of patients did not differ in age, sex, disease, or kind of treatment received. All of the patients in both groups had clinical signs of sepsis; in 69% of patients from colistin group and 84% from control group P.aeruginosa was isolated from blood, and in 27% and 12% it was isolated from skin lesions that had clinical presentation of echtyma gangrenosum, respectively. Patients treated with colistin received 3 MU of colistin every 8 hours for a mean (± SD) duration of 12.5 (± 5.4) days. Due to nature of their disease, and severity of infections, all of the patients received more than two other possibly nephrotoxic drugs; in colistin group 4 other concomitant drugs, on control group 3; most frequently vancomycin, cefepime, amikacine, garamycine and amphotericine B deoxycholate was used. Of 26 patients receiving colistin, 76.9% of patients had the drug discontinued after successful clearance of infection, while in control group 65.4% of patients had the drug discontinued due to same reason. Only one patient had displayed neurological toxicity (Jacksons attack with secondary generalisation), but the drug was not discontinued, dose was modified, patient had no further attacks. There was no statistically significant difference in the level of serum creatinine, creatinine clearance (calculated), or potassium levels between prior to therapy and after treatment discontinuation between groups. One patient treated with colistin developed renal failure and was subjected to continuous venovenous hemodiafiltration; of note is that at the time colistin introduction patient already had impaired renal function. In one patient drug was discontinued due to suspected allergic reaction. No other adverse events of colistin therapy were noted. Colistin is an effective antimicrobial drug for the treatment of severe infections caused by MDR P.aeruginosa in haematological patients. The safety profile observed is acceptable in these severe life-threatening infections, in matched-pair analysis it did not display greater toxicity than other antipseudomonas drugs. Further studies are needed to better address the treatment of MDR P. aeruginosa, naimely the optimal dose and schedule, also route of administration of colistin, as well as drug-to-drug interactions.

scholarly journals Chronic Expanding Hematoma in the Extremities: A Clinical Problem of Adhesion to the Surrounding Tissues

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Akio Sakamoto ◽  
Takeshi Okamoto ◽  
Shuichi Matsuda
Keyword(s):  
Magnetic Resonance ◽  
Lower Extremity ◽  
Peroneal Nerve ◽  
Subcutaneous Tissue ◽  
Common Peroneal Nerve ◽  
Clinical Problem ◽  
Blood Collection ◽  
Continuous Growth ◽  
Chronic Expanding Hematoma ◽  
The Common

Chronic expanding hematoma is characterized by continuous growth of a blood collection. We analyzed the clinical features of 7 patients with chronic expanding hematomas in the extremities, with an average age of 65.6 years. All lesions occurred in the lower extremities, with 4 seen in the thigh and 3 in the knee region. Six patients had subcutaneous hematomas, while 1 was deep-seated in the thigh. The magnetic resonance features of the lesion were compatible with those of a standard hematoma. A low signal intensity on T1- and T2-weighted imaging at the pseudocapsule was also characteristic. Cystic features were seen in 5 of 7 patients. All lesions were resected together with their pseudocapsule. In the subcutaneous lesions, it was necessary to resect adherent fascia, with or without involved skin. In the deep-seated thigh lesion, the common peroneal nerve was completely adherent to the pseudocapsule, a phenomenon from absence of the common peroneal nerve which appeared after resection. Chronic expanding hematomas of the extremities are predominantly located in the subcutaneous tissue of the lower extremity. The surrounding pseudocapsule is adherent to the adjacent tissues, and clinicians must be aware of this, especially when resecting a deep-seated lesion.

scholarly journals Changes of Fixed Anatomical Spinopelvic Parameter in Patients with Lumbosacral Transitional Vertebrae: A Matched Pair Analysis

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 59
Author(s):  
Henryk Haffer ◽  
Luis Becker ◽  
Michael Putzier ◽  
Mats Wiethölter ◽  
Katharina Ziegeler ◽  
...  
Keyword(s):  
Lumbar Vertebrae ◽  
Matched Pair ◽  
Control Group ◽  
Spinopelvic Parameters ◽  
Measuring Point ◽  
Matched Pair Analysis ◽  
Significant Difference ◽  
Spinopelvic Parameter ◽  
Lumbosacral Transitional Vertebrae ◽  
Pair Analysis

Functional spinopelvic parameters are crucial for describing spinal alignment (SA), but this is susceptible to variation. Anatomically fixed pelvic shape is defined by the parameters pelvic radius (PR), pelvic incidence (PI), and sacral table angle (STA). In patients with lumbosacral transitional vertebrae (LSTV), the spinopelvic alignment may be altered by changes of these parameters and influences of SA. There have been no reports studying the relation between LSTV, four (4 LV) and six (6 LV) lumbar vertebrae, and fixed anatomical spinopelvic parameters. A retrospective analysis of 819 abdomen–pelvis CT scans was performed, identifying 53 patients with LSTV. In a matched-pair analysis, we analyzed the influence of LSTV and the subgroups 4 LV (n = 9) and 6 LV (n = 11) on PR, PI, and STA. LSTV were classified according to Castellvi classification. In patients with 6 LV, measurement points at the superior endplates of S1 and S2 were compared. The prevalence of LSTV was 6.5% (53/819), 6 LV was 1.3% (11/819), and 4 LV was 1.1% (9/819) in our study population. PI significantly increased (p < 0.001), STA significantly decreased (p < 0.001), and PR (p = 0.051) did not differ significantly in the LSTV group (n = 53). Similar findings were observed in the 4 LV subgroup, with an increase in PI (p < 0.021), decrease in STA (p < 0.011), and no significant difference in PR (p < 0.678). The same results were obtained in the 6 LV subgroup at measuring point S2 (true S1) PI (p = 0.010), STA (p = 0.004), and PR (p = 0.859), but not at measuring point S1 (true L6). Patients with LSTV, 4 LV, and 6 LV showed significant differences in PI and STA compared to the matched control group. PR showed no significant differences. The altered spinopelvic anatomy in LSTV patients need to be reflected in preoperative planning rebalancing the sagittal SA.

Does Cholecystectomy Status Influence the Common Bile Duct Diameter? A Matched-Pair Analysis

2009 ◽  
Vol 55 (4) ◽  
pp. 1155-1160 ◽  
Author(s):  
Saurabh Chawla ◽  
William E. Trick ◽  
Susan Gilkey ◽  
Bashar M. Attar
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Matched Pair ◽  
Matched Pair Analysis ◽  
Duct Diameter ◽  
The Common ◽  
Common Bile Duct Diameter ◽  
Pair Analysis

Comparison of bioactive coils and bare platinum coils for treatment of intracranial aneurysms: a matched-pair analysis

2010 ◽  
Vol 112 (4) ◽  
pp. 709-713 ◽  
Author(s):  
Serdar Geyik ◽  
Ozgur Ertugrul ◽  
Kivilcim Yavuz ◽  
Pinar Geyik ◽  
Isil Saatci ◽  
...  
Keyword(s):  
Class I ◽  
Matched Pair ◽  
Control Group ◽  
Treatment Results ◽  
Matched Pair Analysis ◽  
Significant Difference ◽  
Bare Platinum Coils ◽  
Pair Analysis ◽  
Platinum Coils

Object The primary goal of this matched-pair analysis was to evaluate the durability of the treatment results with Cerecyte coils in comparison with that of bare platinum coils in terms of angiographic occlusion rates at follow-up. Methods Eighty aneurysms treated with Cerecyte coils were included in this study to carry out a matched-pair analysis. Every aneurysm treated with Cerecyte coils was matched with an aneurysm treated with bare platinum coils. Matching of the aneurysms was done according to the aneurysm size, location, neck size, initial occlusion grade, and clinical presentation. Results The initial treatment results were similar in both groups as part of a matching protocol. Subgroup analysis revealed a significant difference in the durability of occlusion in aneurysms that showed Raymond Class I obliteration on follow-up angiograms (69 [86.2%] in the Cerecyte group vs 51 [63.8%] in the control group, p = 0.002). Further thrombosis to Raymond Class I occlusions was higher in the Cerecyte group (17 [77.3%] of 22 vs 8 [36.4%] of 22 aneurysms). Conclusions Cerecyte coils provide further thrombosis and more durable results than bare platinum coils following coil embolization of cerebral aneurysms.

Efficacy of intraperitoneal treatment with the trifunctional antibody catumaxomab in patients with GI-tract cancer and peritoneal carcinomatosis: A matched-pair analysis

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 2544-2544 ◽  
Author(s):  
M. A. Stroehlein ◽  
K. U. Gruetzner ◽  
A. Tarabichi ◽  
K. W. Jauch ◽  
K. Bartelheim ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Tumor Cells ◽  
Matched Pair ◽  
Control Group ◽  
Advanced Tumor Stage ◽  
Gi Tract ◽  
Tract Cancer ◽  
Matched Pair Analysis ◽  
Intraperitoneal Treatment ◽  
Pair Analysis

2544 Background: Peritoneal carcinomatosis (PC) due to GI-tract cancer is an advanced tumor stage with poor survival. At present, no standard therapy has been recommended, as chemotherapy and surgery showed only limited efficacy in affected patients. When applied intraperitoneally (i.p.), the trifunctional antibody catumaxomab could be shown to destroy intraperitoneal tumor cells in patients with malignant ascites due to ovarian cancer. While binding simultaneously to EpCAM (on tumor cells), CD3 (T cells) and, via the Fc region, to Fc gamma receptor 1 and 3 on accessory cells, it induces a complex immunoreaction against epithelial tumor cells. The aim of this study was to investigate clinical efficacy of i.p. catumaxomab therapy in patients with PC compared to a matched control group. Methods: Between 2003 and 2005, 22 patients with PC due to cancer of colon (n=10), stomach (8), pancreas (3) and CUP (1) received treatment with catumaxomab within a phase I study. Treatment consisted of 3 to 4 i.p. applications (10–200 μg) of escalating catumaxomab doses. The survival was compared with patients receiving conventional therapies in a matched-pair analysis regarding sex, age, tumor surgery, chemotherapy, and extent of PC. Patients with existing ileus and clinically significant ascites were not included. Results: Follow up of patients receiving catumaxomab showed a median survival of 12.2 months (range 2–34) after first diagnosis of peritoneal carcinomatosis vs. 9.7 months (range 1–40) in patients with conventional treatment (p=0.005; log-rank). These data will be updated at presentation. Conclusion: Intraperitoneal treatment with the trifunctional antibody catumaxomab may be an attractive option for treatment of patients with peritoneal carcinomatosis due to GI-tract cancer. The convincing results have to be further investigated in clinical phase II/III trials. [Table: see text]

scholarly journals A matched-pair analysis on survival and response rates between German and non-German cancer patients treated at a Comprehensive Cancer Center

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Marie K. Budde ◽  
Walther Kuhn ◽  
Mignon-Denise Keyver-Paik ◽  
Friedrich Bootz ◽  
Jörg C. Kalff ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Cancer Patients ◽  
Subgroup Analysis ◽  
Progression Free Survival ◽  
Response Rates ◽  
Response To Treatment ◽  
Matched Pair ◽  
Free Survival ◽  
Matched Pair Analysis ◽  
Pair Analysis

Abstract Background Research shows disparities in cancer outcomes by ethnicity or socio-economic status. Therefore, it is the aim of our study to perform a matched-pair analysis which compares the outcome of German and non-German (in the following described as ‘foreign’) cancer patients being treated at the Center for Integrated Oncology (CIO) Köln Bonn at the University Hospital of Bonn between January 2010 and June 2016. Methods During this time, 6314 well-documented patients received a diagnosis of cancer. Out of these patients, 219 patients with foreign nationality could be matched to German patients based on diagnostic and demographic criteria and were included in the study. All of these 438 patients were well characterized concerning survival data (Overall survival, Progression-free survival and Time to progression) and response to treatment. Results No significant differences regarding the patients’ survival and response rates were seen when all German and foreign patients were compared. A subgroup analysis of German and foreign patients with head and neck cancer revealed a significantly longer progression-free survival for the German patients. Differences in response to treatment could not be found in this subgroup analysis. Conclusions In summary, no major differences in survival and response rates of German and foreign cancer patients were revealed in this study. Nevertheless, the differences in progression-free survival, which could be found in the subgroup analysis of patients with head and neck cancer, should lead to further research, especially evaluating the role of infectious diseases like human papillomavirus (HPV) and Epstein-Barr virus (EBV) on carcinogenesis and disease progression.

scholarly journals An Age- and Sex-Controlled Matched Pair Analysis of T Scores in Ethnic Indians with Hip Fractures

2003 ◽  
Vol 11 (1) ◽  
pp. 22-27 ◽  
Author(s):  
SV Vaidya ◽  
D Dholakia ◽  
S Yadav
Keyword(s):  
Fracture Risk ◽  
Indian Population ◽  
Matched Pair ◽  
Control Group ◽  
Fracture Group ◽  
T Score ◽  
Matched Pair Analysis ◽  
Patients At Risk ◽  
The Mean ◽  
Pair Analysis

Objective. The first study to predict peritrochanteric fractures by the use of T scores amongst the Indian population was performed. This study aimed to assess the risk of fracture around the hip in peri-menopausal and postmenopausal women, and in men over the age of 35 years using dual energy X-ray absorptiometry, and to analyse whether the result, i.e. the T score, can predict an impending hip fracture. Methods. T scores of the unaffected hip in 30 patients with peritrochanteric fractures were determined, and matched pair analysis was done using a control group without fracture. All patients were from a single centre and were evaluated using the same scanner. Results. The mean T score of the 30 patients in the fracture group was −3.34 (range, −1.2 to −5.1; standard deviation [SD], 1.032), compared with the mean T score of the 30 control subjects which was −2.41 (range, 0.6 to −5.0; SD, 1.378). T scores of patients from the fracture group were significantly lower than those in the control group. Conclusion. We infer that T scores are the best predictors for fracture risk. A score of −2.5 or lower effectively defines patients at risk and is useful for predicting fracture risk in the Indian population. In patients with osteoporosis, whether a fall precedes the fracture or the fracture precedes a fall may not be an issue of debate, but can serve as a basis for prevention of additional fractures by instituting appropriate measures in patients at risk.

A matched pair analysis of intra- and postoperative catumaxomab in patients with ovarian cancer from a multicenter, single-arm phase II trial versus a consecutive single-center collective of ovarian cancer patients without immunotherapy.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 5080-5080 ◽  
Author(s):  
Klaus Pietzner ◽  
Radoslav Chekerov ◽  
Alexander Reinthaller ◽  
Daniel Reimer ◽  
Toralf Reimer ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Cytoreductive Surgery ◽  
Matched Pair ◽  
Control Group ◽  
Matched Pair Analysis ◽  
Matching Criteria ◽  
Pair Analysis

5080 Background: Advanced ovarian cancer is still connected to high mortality rates due to intraperitoneal tumor cells that survive radical cytoreductive surgery as well as adjuvant chemotherapy. These persistent tumor cells need to be targeted in order to improve survival. Catumaxomab has demonstrated the ability to kill EpCAM-positive intraperitoneal tumor cells of ovarian cancer patients in studies aiming to controll malignant ascites in the recurrent setting. This analysis was conducted to investigate the efficacy of intraperitoneal catumaxomab at the timepoint of primary cytoreductive surgery and postoperative period, prior to standard adjuvant chemotherapy. Methods: Ovarian cancer patients undergoing radical surgery received one intraoperative (10 μg) followed by four subsequent intraperitoneal (i.p.) dosages (10, 20, 50 and 150 μg) of catumaxomab on days 7, 10, 13, and 16, respectively. Because of the single arm design of the study, the patients treated with catumaxomab were compared in a matched pair analysis to consecutive patients with primary ovarian cancer who received standard treatment without catumaxomab in a large center, in order to compare survival. The two main prognostic factors of stage and level of tumorreduction were chosen as matching criteria. Results: Of 58 patients screened, 41 were treated with catumaxomab and available for survival evaluation. Median age was 57 years in the catumaxomab group and 59 years in the matched-pair control group. The most comon histology was the serous subtype with 70.7 % in the catumaxomab and 80.5 % of the patients in the control group. The median for overall survival was reached for the historical consecutive matched-pair control collective, but is not yet reached for the catumaxomab group. However, 3-year survival data were available for both groups and showed survival of 85.4% (35) in the catumaxomab group and 63.4% (26) in the matched-pair control group (p-value: 0.041; HR 2.073) Conclusions: There seems to be a trend to beneficial 3-year survival in the catumaxomab group, suggesting that a phase III trial is warranted.

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