scholarly journals Changes of Fixed Anatomical Spinopelvic Parameter in Patients with Lumbosacral Transitional Vertebrae: A Matched Pair Analysis

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 59
Author(s):  
Henryk Haffer ◽  
Luis Becker ◽  
Michael Putzier ◽  
Mats Wiethölter ◽  
Katharina Ziegeler ◽  
...  
Keyword(s):  
Lumbar Vertebrae ◽  
Matched Pair ◽  
Control Group ◽  
Spinopelvic Parameters ◽  
Measuring Point ◽  
Matched Pair Analysis ◽  
Significant Difference ◽  
Spinopelvic Parameter ◽  
Lumbosacral Transitional Vertebrae ◽  
Pair Analysis

Functional spinopelvic parameters are crucial for describing spinal alignment (SA), but this is susceptible to variation. Anatomically fixed pelvic shape is defined by the parameters pelvic radius (PR), pelvic incidence (PI), and sacral table angle (STA). In patients with lumbosacral transitional vertebrae (LSTV), the spinopelvic alignment may be altered by changes of these parameters and influences of SA. There have been no reports studying the relation between LSTV, four (4 LV) and six (6 LV) lumbar vertebrae, and fixed anatomical spinopelvic parameters. A retrospective analysis of 819 abdomen–pelvis CT scans was performed, identifying 53 patients with LSTV. In a matched-pair analysis, we analyzed the influence of LSTV and the subgroups 4 LV (n = 9) and 6 LV (n = 11) on PR, PI, and STA. LSTV were classified according to Castellvi classification. In patients with 6 LV, measurement points at the superior endplates of S1 and S2 were compared. The prevalence of LSTV was 6.5% (53/819), 6 LV was 1.3% (11/819), and 4 LV was 1.1% (9/819) in our study population. PI significantly increased (p < 0.001), STA significantly decreased (p < 0.001), and PR (p = 0.051) did not differ significantly in the LSTV group (n = 53). Similar findings were observed in the 4 LV subgroup, with an increase in PI (p < 0.021), decrease in STA (p < 0.011), and no significant difference in PR (p < 0.678). The same results were obtained in the 6 LV subgroup at measuring point S2 (true S1) PI (p = 0.010), STA (p = 0.004), and PR (p = 0.859), but not at measuring point S1 (true L6). Patients with LSTV, 4 LV, and 6 LV showed significant differences in PI and STA compared to the matched control group. PR showed no significant differences. The altered spinopelvic anatomy in LSTV patients need to be reflected in preoperative planning rebalancing the sagittal SA.

Efficacy and Safety of Colistin for the Treatment of Infections Caused by Multidrug-Resistant Isolates of Pseudomonas Aeruginosa Sensitive to Colistin in Patients with Haematological Malignancy; a Matched-Pair Analysis.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2283-2283
Author(s):  
Nadira Durakovic ◽  
Ana Boban ◽  
Mirando Mrsic ◽  
Dubravka Sertic ◽  
Ranka Serventi Seiwerth ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Renal Function ◽  
Haematological Malignancy ◽  
Multidrug Resistant ◽  
Matched Pair ◽  
Control Group ◽  
Efficacy And Safety ◽  
Matched Pair Analysis ◽  
Significant Difference ◽  
Pair Analysis

Abstract Infections due to multidrug-resistant (MDR) Gram-negative bacteria have been increasing and they are an important cause of nosocomial morbidity and mortality, especially in immunocompromised patients. In order to determine efficacy and safety of colistin (colistimethate sodium) use in the treatment of MDR Pseudomonas aeruginosa sensitive to colistin, a comparison of renal function, other toxicities, and outcome of therapy was done between a group of patients treated with colistin and patients treated with other antipseudomonas drugs as control group. A group of 26 patients that was hospitalized in our institution between February 2002 and December 2006 and treated with intravenous colistin for an infection caused by MDR P.aeruginosa was compared in a matched-pair analysis to a group of 26 patients treated with other antipseudomonas drugs. Patients were 52% male and 48% female; mean age was 37 years (range 17–63). All of the patients were treated for haematological malignancy, most received intensive chemotherapy regimens (44%), 19% received allogeneic and 31% autologous transplants. Groups of patients did not differ in age, sex, disease, or kind of treatment received. All of the patients in both groups had clinical signs of sepsis; in 69% of patients from colistin group and 84% from control group P.aeruginosa was isolated from blood, and in 27% and 12% it was isolated from skin lesions that had clinical presentation of echtyma gangrenosum, respectively. Patients treated with colistin received 3 MU of colistin every 8 hours for a mean (± SD) duration of 12.5 (± 5.4) days. Due to nature of their disease, and severity of infections, all of the patients received more than two other possibly nephrotoxic drugs; in colistin group 4 other concomitant drugs, on control group 3; most frequently vancomycin, cefepime, amikacine, garamycine and amphotericine B deoxycholate was used. Of 26 patients receiving colistin, 76.9% of patients had the drug discontinued after successful clearance of infection, while in control group 65.4% of patients had the drug discontinued due to same reason. Only one patient had displayed neurological toxicity (Jacksons attack with secondary generalisation), but the drug was not discontinued, dose was modified, patient had no further attacks. There was no statistically significant difference in the level of serum creatinine, creatinine clearance (calculated), or potassium levels between prior to therapy and after treatment discontinuation between groups. One patient treated with colistin developed renal failure and was subjected to continuous venovenous hemodiafiltration; of note is that at the time colistin introduction patient already had impaired renal function. In one patient drug was discontinued due to suspected allergic reaction. No other adverse events of colistin therapy were noted. Colistin is an effective antimicrobial drug for the treatment of severe infections caused by MDR P.aeruginosa in haematological patients. The safety profile observed is acceptable in these severe life-threatening infections, in matched-pair analysis it did not display greater toxicity than other antipseudomonas drugs. Further studies are needed to better address the treatment of MDR P. aeruginosa, naimely the optimal dose and schedule, also route of administration of colistin, as well as drug-to-drug interactions.

Comparison of bioactive coils and bare platinum coils for treatment of intracranial aneurysms: a matched-pair analysis

2010 ◽  
Vol 112 (4) ◽  
pp. 709-713 ◽  
Author(s):  
Serdar Geyik ◽  
Ozgur Ertugrul ◽  
Kivilcim Yavuz ◽  
Pinar Geyik ◽  
Isil Saatci ◽  
...  
Keyword(s):  
Class I ◽  
Matched Pair ◽  
Control Group ◽  
Treatment Results ◽  
Matched Pair Analysis ◽  
Significant Difference ◽  
Bare Platinum Coils ◽  
Pair Analysis ◽  
Platinum Coils

Object The primary goal of this matched-pair analysis was to evaluate the durability of the treatment results with Cerecyte coils in comparison with that of bare platinum coils in terms of angiographic occlusion rates at follow-up. Methods Eighty aneurysms treated with Cerecyte coils were included in this study to carry out a matched-pair analysis. Every aneurysm treated with Cerecyte coils was matched with an aneurysm treated with bare platinum coils. Matching of the aneurysms was done according to the aneurysm size, location, neck size, initial occlusion grade, and clinical presentation. Results The initial treatment results were similar in both groups as part of a matching protocol. Subgroup analysis revealed a significant difference in the durability of occlusion in aneurysms that showed Raymond Class I obliteration on follow-up angiograms (69 [86.2%] in the Cerecyte group vs 51 [63.8%] in the control group, p = 0.002). Further thrombosis to Raymond Class I occlusions was higher in the Cerecyte group (17 [77.3%] of 22 vs 8 [36.4%] of 22 aneurysms). Conclusions Cerecyte coils provide further thrombosis and more durable results than bare platinum coils following coil embolization of cerebral aneurysms.

Matched-Pair Analysis of Open versus Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Cell Carcinoma

2014 ◽  
Vol 94 (2) ◽  
pp. 156-162 ◽  
Author(s):  
James P. Blackmur ◽  
Grant D. Stewart ◽  
Eric A. Egong ◽  
Mark L. Cutress ◽  
David A. Tolley ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Cell Carcinoma ◽  
Upper Urinary Tract ◽  
Matched Pair ◽  
Urothelial Cell Carcinoma ◽  
Free Survival ◽  
Matched Pair Analysis ◽  
Significant Difference ◽  
Pair Analysis ◽  
Laparoscopic Nephroureterectomy

Objective: Laparoscopic nephroureterectomy (LNU) offers a superior morbidity profile compared with open nephroureterectomy (ONU) in treating upper urinary tract urothelial cell carcinoma. Evidence of oncological equivalence between LNU and ONU is limited. We compare operative and oncological outcomes for LNU and ONU using matched-pair analysis. Methods: Of 159 patients who underwent a nephroureterectomy at a single institution between April 1992 and April 2010, 13 pairs of ONU and LNU patients were matched for gender, age, tumour location, tumour grade and stage. Operative details, post-operative characteristics and recurrences were collated and survival rates analysed using the Kaplan-Meier method. Results: There was no significant difference in mean operation time between LNU (191 min) and ONU (194 min, p = 0.92). There was no significant difference in the 5-year survival rate between LNU and ONU (overall survival 59.1% vs. 73.5%, p = 0.18; progression-free survival 24.0% vs. 56.0%, p = 0.14; cancer-specific survival 60.9% vs. 73.5%, p = 0.56; bladder cancer recurrence-free survival 8.7% vs. 0.0%, p = 0.09). Conclusion: Amidst limited RCT and comparative studies, this study presents further evidence of oncological equivalence between LNU and ONU. There was a trend towards poorer outcomes following LNU though, which merits further study.

The Outcomes Of Allogeneic Stem Cell Transplantation In Patients With Mixed Phenotype Acute Leukemia (MPAL) Are Comparable To Those In Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL): Results Of a Matched-Pair Analysis

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 3403-3403
Author(s):  
Hiroaki Shimizu ◽  
Takayuki Saitoh ◽  
Shinichiro Machida ◽  
Shinichi Kako ◽  
Noriko Doki ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Acute Leukemia ◽  
Allogeneic Stem Cell Transplantation ◽  
Matched Pair ◽  
Matched Pair Analysis ◽  
Donor Bone Marrow ◽  
Significant Difference ◽  
Pair Analysis

Abstract Background MPAL is a rare subtype of acute leukemia that accounts for 2-5% of all acute leukemia cases. It has been reported that patients with MPAL tend to have worse prognosis compared with those with AML or ALL. However, the efficacy and safety of allogeneic stem cell transplantation (allo-SCT) for adult MPAL patients has yet to be elucidated. Objective The aim of this retrospective study was to assess the outcomes of allo-SCT for adult MPAL and compared with those for AML/ALL using a matched pair analysis method. Patients and Methods This study included patients over 15 years of age who were diagnosed with MPAL according to the WHO classification and underwent allo-SCT for the first time between January 2001 and December 2010. Their clinical data were collected from the database of the Kanto Study Group for Cell Therapy. The clinical features and transplant outcomes of MPAL patients were then compared with those of adult patients with AML, ALL, and Philadelphia chromosome-positive acute leukemia (Ph+AL). We selected control cohorts at the rate of one to five using an optimal matching method with the following seven matching factors: age, sex, disease status at the time of transplant, the intensity of conditioning, human leukocyte antigen disparity between donor and recipient, donor type (related or not), and time of transplant (2001-2005 or 2006-2010). Overall survival (OS) and relapse-free survival (RFS) rates was estimated by the Kaplan-Meier method and compared using the log-rank test. Cumulative incidences (CI) of relapse and non-relapse mortality (NRM) were compared using the stratified Gray test. P <0.05 was considered to represent statistical significance. Results Eighteen MPAL patients (9 men, 9 women) with a median age of 40 years (range, 16–61 years) were identified. Immunophenotypic analysis showed B+M phenotype in 12 patients, B+T phenotype in five, and B+T+M phenotype in one. Seven patients possessed Ph. Fourteen patients were in remission at the time of transplant. Sixteen patients were conditioned with myeloablative regimens. Stem cell sources were related donor bone marrow in four patients, unrelated donor bone marrow in 13, and cord blood in one. Among 18 MPAL patients, 5-year OS and RFS rates were 48.1% and 39.7%, respectively, and 5-year CI of relapse and NRM were 43.3% and 17.1%, respectively. Patients in remission at the time of transplant showed significantly better outcomes than those not in remission (5-year OS: 71.8% vs. 0%, p = 0.001; 5-year RFS: 58.7% vs. 0%, p = 0.004). By contrast, no significant difference was seen in OS and RFS when stratifying patients according to immunophenotype and cytogenetic abnormalities. In matched pair analysis, 90 AML, 90 ALL, and 35 Ph+AL patients were extracted from the database as control. The 5-year OS rate of MPAL patients was similar to those of AML patients (48.1% vs. 48.1%; p = 0.855) and ALL patients (48.1% vs. 37.8%; p = 0.426). Similarly, the 5-year OS rate of Ph+MPAL patients was not significantly different from that of Ph+AL patients (68.6% vs. 39.9%; p = 0.234). No significant difference was observed in RFS, CI of relapse, and CI of NRM when comparing MPAL patients with AML and ALL patients, and Ph+MPAL patients with Ph+AL patients. Conclusion Transplant outcomes of adult MPAL patients were comparable to those of both AML and ALL patients, although the statistical power was possibly insufficient due to the relatively small cohort. The existing transplant procedures were not satisfactory for MPAL patients who were not in remission at the time of transplant. On the other hand, MPAL patients who underwent allo-SCT while in remission showed excellent outcomes. Therefore, transplant early in the disease course may lead to improved outcomes for patients with this serious disease. Disclosures: No relevant conflicts of interest to declare.

Efficacy of intraperitoneal treatment with the trifunctional antibody catumaxomab in patients with GI-tract cancer and peritoneal carcinomatosis: A matched-pair analysis

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 2544-2544 ◽  
Author(s):  
M. A. Stroehlein ◽  
K. U. Gruetzner ◽  
A. Tarabichi ◽  
K. W. Jauch ◽  
K. Bartelheim ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Tumor Cells ◽  
Matched Pair ◽  
Control Group ◽  
Advanced Tumor Stage ◽  
Gi Tract ◽  
Tract Cancer ◽  
Matched Pair Analysis ◽  
Intraperitoneal Treatment ◽  
Pair Analysis

2544 Background: Peritoneal carcinomatosis (PC) due to GI-tract cancer is an advanced tumor stage with poor survival. At present, no standard therapy has been recommended, as chemotherapy and surgery showed only limited efficacy in affected patients. When applied intraperitoneally (i.p.), the trifunctional antibody catumaxomab could be shown to destroy intraperitoneal tumor cells in patients with malignant ascites due to ovarian cancer. While binding simultaneously to EpCAM (on tumor cells), CD3 (T cells) and, via the Fc region, to Fc gamma receptor 1 and 3 on accessory cells, it induces a complex immunoreaction against epithelial tumor cells. The aim of this study was to investigate clinical efficacy of i.p. catumaxomab therapy in patients with PC compared to a matched control group. Methods: Between 2003 and 2005, 22 patients with PC due to cancer of colon (n=10), stomach (8), pancreas (3) and CUP (1) received treatment with catumaxomab within a phase I study. Treatment consisted of 3 to 4 i.p. applications (10–200 μg) of escalating catumaxomab doses. The survival was compared with patients receiving conventional therapies in a matched-pair analysis regarding sex, age, tumor surgery, chemotherapy, and extent of PC. Patients with existing ileus and clinically significant ascites were not included. Results: Follow up of patients receiving catumaxomab showed a median survival of 12.2 months (range 2–34) after first diagnosis of peritoneal carcinomatosis vs. 9.7 months (range 1–40) in patients with conventional treatment (p=0.005; log-rank). These data will be updated at presentation. Conclusion: Intraperitoneal treatment with the trifunctional antibody catumaxomab may be an attractive option for treatment of patients with peritoneal carcinomatosis due to GI-tract cancer. The convincing results have to be further investigated in clinical phase II/III trials. [Table: see text]

Matched-Pair Analysis of Magnetic Resonance Images for Location of the Common Peroneal Nerve in Valgus Knees: Comparison with the Varus Knees

2020 ◽  
Author(s):  
Kwang Am Jung ◽  
Oog-Jin Shon ◽  
Mohd Irfan Banday ◽  
Abhishek Patil ◽  
Gi Beom Kim
Keyword(s):  
Magnetic Resonance ◽  
Subgroup Analysis ◽  
Peroneal Nerve ◽  
Common Peroneal Nerve ◽  
Matched Pair ◽  
Soft Tissue Release ◽  
Control Group ◽  
Matched Pair Analysis ◽  
The Common ◽  
Pair Analysis

AbstractThis study aimed to assess the distance and angular location of the common peroneal nerve (CPN) on axial magnetic resonance imaging (MRI) in the valgus knees and compare the measurements with those obtained from the control group. We compared the location of the CPN according to the type of alignment by performing a subgroup analysis. From January 2009 to December 2019, we identified 41 knees with preoperative MRI in patients who underwent total knee arthroplasty (TKA) for valgus deformity (valgus group). We performed one-to-two matched-pair analysis to a cohort of patients who underwent MRI but were not candidates for TKA (control group), according to sex and age. The valgus group was classified according to the grading system reported by Ranawat et al, and the control group was also subdivided according to the hip-knee-ankle (HKA) angle obtained from lower extremity scanography: neutral (–3 to +3 degrees from the neutral mechanical axis), valgus (> +3 degrees), and varus alignment (< –3 degrees). Distance between the CPN and posterolateral cortex of the tibia at the knee joint (distance J) and tibial cut level (distance C) were measured. Angle of the CPN from the central anteroposterior axis of the tibia (angle α) was measured. We compared the measurements between the groups. Distance J was significantly closer in the valgus group (p < 0.001), whereas angle α was significantly smaller in the valgus group (p < 0.001). However, no significant differences were found in the subgroup analysis. Moreover, a significant correlation was found between distance J and the HKA angle (p < 0.001). The location of the CPN in the valgus knees was closer to the posterolateral cortex of the tibia at the joint level and showed a smaller angle than that in the other aligned knees. We recommend that lateral soft tissue release for valgus knees should not be performed at the joint line. The results of this study suggest that this would be less safe than a release performed at the level of the proximal tibial bone resection.

scholarly journals Safe Zones for Spinopelvic Screws in Patients With Lumbosacral Transitional Vertebra

2021 ◽  
pp. 219256822110193
Author(s):  
Luis Becker ◽  
Friederike Schömig ◽  
Henryk Haffer ◽  
Katharina Ziegeler ◽  
Torsten Diekhoff ◽  
...  
Keyword(s):  
Adult Spinal Deformity ◽  
Screw Placement ◽  
Matched Pair ◽  
Major Influence ◽  
Control Group ◽  
Matched Pair Analysis ◽  
Spinal Deformity Surgery ◽  
Iliac Screw ◽  
Lumbosacral Transitional Vertebrae ◽  
Safe Zones

Study Design: Retrospective matched-pair analysis. Objectives: Lumbosacral transitional vertebrae (LSTV) have a reported prevalence of 4-36% in the population. The safe zones for screw placement for spinopelvic fusion in adult spinal deformity surgery for patients with LSTV have not been described in the literature. Our study aimed to assess the safety of S1-pedicle screw (S1PS), S2-alar screw (S2AS), S2-alar-iliac screw (S2AIS), and iliac screw (IS) placement in patients with LSTV. Methods: Out of the 819 examined patients, 49 patients with LSTV were included in our retrospective analysis with a matched pair control group. We used the 3-dimensional planning tool mediCAD for screw placement of S1PS, S2AS, S2AIS, IS with different angles, length and diameters. Results: We evaluated a total of 10 192 screw trajectories. No serious complications occurred due to the trajectories used for S1PS. LSTV increased the risk of vessel injury for S2AS trajectories ( P = .001) but not for S2AIS ( P = .526). Besides the presence of an LSTV, the screw trajectory had a major influence on the frequency of serious complications. Conclusions: Sacral anchoring of long spinal constructions using S1PS, S2AS, S2AIS and IS is also possible in the presence of LSTV. For S2AS the trajectory with 30° lateral and caudal angulation of 10° showed the least vascular injuries and the least sacro-iliac-joint violations in patients with LSTV. S2AIS trajectories with 40° lateral and 0° sagittal angulation reduced the risk of serious complications in our patients collective with LSTV.

scholarly journals An Age- and Sex-Controlled Matched Pair Analysis of T Scores in Ethnic Indians with Hip Fractures

2003 ◽  
Vol 11 (1) ◽  
pp. 22-27 ◽  
Author(s):  
SV Vaidya ◽  
D Dholakia ◽  
S Yadav
Keyword(s):  
Fracture Risk ◽  
Indian Population ◽  
Matched Pair ◽  
Control Group ◽  
Fracture Group ◽  
T Score ◽  
Matched Pair Analysis ◽  
Patients At Risk ◽  
The Mean ◽  
Pair Analysis

Objective. The first study to predict peritrochanteric fractures by the use of T scores amongst the Indian population was performed. This study aimed to assess the risk of fracture around the hip in peri-menopausal and postmenopausal women, and in men over the age of 35 years using dual energy X-ray absorptiometry, and to analyse whether the result, i.e. the T score, can predict an impending hip fracture. Methods. T scores of the unaffected hip in 30 patients with peritrochanteric fractures were determined, and matched pair analysis was done using a control group without fracture. All patients were from a single centre and were evaluated using the same scanner. Results. The mean T score of the 30 patients in the fracture group was −3.34 (range, −1.2 to −5.1; standard deviation [SD], 1.032), compared with the mean T score of the 30 control subjects which was −2.41 (range, 0.6 to −5.0; SD, 1.378). T scores of patients from the fracture group were significantly lower than those in the control group. Conclusion. We infer that T scores are the best predictors for fracture risk. A score of −2.5 or lower effectively defines patients at risk and is useful for predicting fracture risk in the Indian population. In patients with osteoporosis, whether a fall precedes the fracture or the fracture precedes a fall may not be an issue of debate, but can serve as a basis for prevention of additional fractures by instituting appropriate measures in patients at risk.

A matched pair analysis of intra- and postoperative catumaxomab in patients with ovarian cancer from a multicenter, single-arm phase II trial versus a consecutive single-center collective of ovarian cancer patients without immunotherapy.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 5080-5080 ◽  
Author(s):  
Klaus Pietzner ◽  
Radoslav Chekerov ◽  
Alexander Reinthaller ◽  
Daniel Reimer ◽  
Toralf Reimer ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Cytoreductive Surgery ◽  
Matched Pair ◽  
Control Group ◽  
Matched Pair Analysis ◽  
Matching Criteria ◽  
Pair Analysis

5080 Background: Advanced ovarian cancer is still connected to high mortality rates due to intraperitoneal tumor cells that survive radical cytoreductive surgery as well as adjuvant chemotherapy. These persistent tumor cells need to be targeted in order to improve survival. Catumaxomab has demonstrated the ability to kill EpCAM-positive intraperitoneal tumor cells of ovarian cancer patients in studies aiming to controll malignant ascites in the recurrent setting. This analysis was conducted to investigate the efficacy of intraperitoneal catumaxomab at the timepoint of primary cytoreductive surgery and postoperative period, prior to standard adjuvant chemotherapy. Methods: Ovarian cancer patients undergoing radical surgery received one intraoperative (10 μg) followed by four subsequent intraperitoneal (i.p.) dosages (10, 20, 50 and 150 μg) of catumaxomab on days 7, 10, 13, and 16, respectively. Because of the single arm design of the study, the patients treated with catumaxomab were compared in a matched pair analysis to consecutive patients with primary ovarian cancer who received standard treatment without catumaxomab in a large center, in order to compare survival. The two main prognostic factors of stage and level of tumorreduction were chosen as matching criteria. Results: Of 58 patients screened, 41 were treated with catumaxomab and available for survival evaluation. Median age was 57 years in the catumaxomab group and 59 years in the matched-pair control group. The most comon histology was the serous subtype with 70.7 % in the catumaxomab and 80.5 % of the patients in the control group. The median for overall survival was reached for the historical consecutive matched-pair control collective, but is not yet reached for the catumaxomab group. However, 3-year survival data were available for both groups and showed survival of 85.4% (35) in the catumaxomab group and 63.4% (26) in the matched-pair control group (p-value: 0.041; HR 2.073) Conclusions: There seems to be a trend to beneficial 3-year survival in the catumaxomab group, suggesting that a phase III trial is warranted.

scholarly journals Intraoperative blood loss as indicated by haemoglobin trend is a predictor for the development of postoperative spinal implant infection—a matched-pair analysis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Friederike Schömig ◽  
Justus Bürger ◽  
Zhouyang Hu ◽  
Axel Pruß ◽  
Edda Klotz ◽  
...  
Keyword(s):  
Blood Loss ◽  
Spine Surgery ◽  
Matched Pair ◽  
Complication Rates ◽  
Intraoperative Blood Loss ◽  
Implant Infection ◽  
Spinal Implant ◽  
Matched Pair Analysis ◽  
Significant Difference ◽  
Pair Analysis

Abstract Background With a reported rate of 0.7–20%, postoperative spinal implant infection (PSII) is one of the most common complications after spine surgery. While in arthroplasty both haematoma formation and perioperative blood loss have been identified as risk factors for developing periprosthetic joint infections and preoperative anaemia has been associated with increased complication rates, literature on the aetiology of PSII remains limited. Methods We performed a matched-pair analysis of perioperative haemoglobin (Hb) and haematocrit (Hct) levels in aseptic and septic spine revision surgeries. 317 patients were included, 94 of which were classified as septic according to previously defined criteria. Patients were matched according to age, body mass index, diabetes, American Society of Anesthesiologists score and smoking habits. Descriptive summaries for septic and aseptic groups were analysed using Pearson chi-squared for categorical or Student t test for continuous variables. Results Fifty patients were matched and did not differ significantly in their reason for revision, mean length of hospital stay, blood transfusion, operating time, or number of levels operated on. While there was no significant difference in preoperative Hb or Hct levels, the mean difference between pre- and postoperative Hb was higher in the septic group (3.45 ± 1.25 vs. 2.82 ± 1.48 g/dL, p = 0.034). Conclusions We therefore show that the intraoperative Hb-trend is a predictor for the development of PSII independent of the amount of blood transfusions, operation time, number of spinal levels operated on and hospital length of stay, which is why strategies to reduce intraoperative blood loss in spine surgery need to be further studied.

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