scholarly journals Should We Perform Laboratory and Radiographic Evaluations for All Children with COVID-19?: A Single-Center Experience

2021 ◽  
Vol 11 (01) ◽  
pp. e93-e99
Author(s):  
Mehmet Karaci ◽  
Şirin Güven ◽  
Aysun Boğa ◽  
Fatih Varol ◽  
Sümeyra Çalışkan ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Treatment Strategies ◽  
Information Management System ◽  
Single Center ◽  
Neutrophil Lymphocyte Ratio ◽  
Number Of Children ◽  
Single Center Experience ◽  
Radiologic Findings ◽  
Single Center Study ◽  
Hospital Information Management System

Abstract Background The diagnostic and treatment strategies for children are limited because of the small number of children with COVID-19. A large proportion of infected children are asymptomatic or have mild symptoms. We report our experience regarding clinical characteristics, laboratory, radiologic findings, and outcomes of children with COVID-19. Materials and Methods This retrospective single-center study was conducted on children with COVID-19. The data on epidemiologic characteristics, clinical features, laboratory, and radiologic findings of patients were extracted from the hospital information management system records, and patients' forms filled upon admission. Results The median age of children was 121 months, 46.8% of the patients were females and 53.2% were males. Of the 581 children assessed, a total of 222 (38.2%) had positive test results; 69 of them (31.1%) were asymptomatic. The median absolute lymphocyte and eosinophil counts were statistically significantly lower in symptomatic children (p = 0.001; p = 0.02). Neutrophil lymphocyte ratio was statistically significantly higher in the symptomatic children (p = 0.001). Of 72 computed tomography scans, 35 (48.6%) were normal, and only 29 (40%) were consistent with classic/probable/indeterminate COVID-19 predominant pattern. Conclusion Our results showed a few laboratory abnormalities in asymptomatic polymerase chain reaction positive children; therefore, unnecessary investigation might be avoided and clinicians should consider clinical symptoms.

P93 BELSEY MARK IV: STILL A VALID OPTION. SINGLE CENTER EXPERIENCE OF 100 CONSECUTIVE CASES

2019 ◽  
Vol 32 (Supplement_2) ◽  
Author(s):  
Ovaere Sander ◽  
Depypere Lieven ◽  
Van Veer Hans ◽  
Nafteux Philippe ◽  
Coosemans Willy
Keyword(s):  
Recurrence Rate ◽  
Antireflux Surgery ◽  
Clinical Symptoms ◽  
Antireflux Procedure ◽  
Barium Swallow ◽  
Type I ◽  
Single Center ◽  
Respiratory Complications ◽  
Single Center Experience ◽  
Belsey Mark Iv

Abstract Aim To share the single-center experience of a tertiary referral center using the Belsey Mark IV operation in the treatment of large primary hiatal hernias (PHH) and recurrent hernias after failed antireflux surgery. Background & Methods We conducted a retrospective analysis of all patients with PHH or recurrent hernia after antireflux surgery operated between May 1, 2012 and December 31, 2016 who received a Belsey-Mark IV antireflux procedure. Data on patient demographics, surgical history, pre-operative work-up, indication, short- and long-term complications graded by the Clavien-Dindo classification (CDC) and recurrence rate, defined as clinical symptoms confirmed with barium swallow test, were collected and analyzed. Results A total of 100 consecutive cases were included in this analysis. Median age at time of surgery was 67 years (range 0 - 86). Seventy-two were female. Indications were: PHH Type I (n = 2), Type II (n = 1); Type III (n = 55), Type IV (n = 3), redo after previous antireflux surgery (n = 39). Median follow-up was 23 months (range 4-80). Major peri-operative short-term morbidity (defined as CDC 3-4) was present in 14 cases, with respiratory complications being the most prevalent. Fundoplication leakage was present in five cases and managed conservatively in three of those. Hernia recurrence rate was 31% in the redo group (12/39) and 10% in the PHH group (6/61). Median time-to-recurrence was 22 months (range 2-78). Post thoracotomy pain syndrome requiring treatment (CDC 2) was present in 12 cases. One patient deceased due to respiratory complications after emergency Belsey Mark IV repair following early recurrence after laparoscopic Nissen fundoplication and two reinterventions. Conclusion The Belsey Mark IV repair is a safe and effective procedure in experienced hands, with well-defined risks and an acceptable recurrence rate, given the nature of the condition and patient’s comorbidities.

The Degree of Overjet and Anterior Traumatic Dental Injury in the Mixed Dentition: A Single-Center Experience

2019 ◽  
Vol 43 (5) ◽  
pp. 360-363 ◽  
Author(s):  
Monica Munro ◽  
Marc B Ackerman
Keyword(s):  
Chart Review ◽  
Young Patients ◽  
Retrospective Chart Review ◽  
Mixed Dentition ◽  
Single Center ◽  
Dental Injury ◽  
Single Center Experience ◽  
Single Center Study ◽  
Review Study ◽  
Center Study

Objective. The objective of this retrospective chart review study was twofold. The first was to determine whether there is a correlation between the degree of overjet and the type of anterior traumatic dental injury (ATDI) in the mixed dentition. The second was to assess whether the decision to not treat young patients with prominent upper front teeth for trauma prevention resulted in a greater number of ATDI's in patients of record from a single-center. Study Design. The authors conducted a retrospective chart review of patients presenting to the Boston Children's Hospital (BCH) Emergency Department with an ATDI in the mixed dentition between October 2011 and March 2016. Results. Patients with an overjet less than or equal to 4 millimeters experienced all types of ATDI with greater frequency than those patients with an overjet greater than 4 mm. Conclusions. Our experience at BCH described in this study has led us to believe that a patient's risk of suffering an ATDI has more to do with the type of activities they participate in rather than the degree of their overjet.

Safety of subcutaneous daratumumab in the treatment of plasma-cell disorders: A single-center experience.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e20007-e20007
Author(s):  
Jung Kye ◽  
Magdalena Seyer ◽  
Samit Patel ◽  
Eun-Jeong Kim ◽  
Rhonda Hewitt ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Outpatient Setting ◽  
Single Center ◽  
Treatment Area ◽  
Single Center Experience ◽  
Frequent Use ◽  
Single Center Study ◽  
Plasma Cell Disorders ◽  
Delayed Reactions ◽  
Group 2

e20007 Background: Daratumumab (Dara) is a CD38-directed monoclonal antibody approved for the treatment of patients with multiple myeloma (MM) and light-chain amyloidosis (AL). Infusion-related reactions (IRRs) have been reported in 28-56% of individuals receiving the conventional intravenous (IV) formulation, necessitating slow infusions and frequent use of rescue medications to mitigate complications. Recently subcutaneous (SC) Dara received approval in MM, and randomized data suggests a lower rate of IRRs compared to IV Dara. Guidelines regarding post-injection monitoring with SC Dara are not well established. This retrospective study aims to evaluate the safety of SC Dara in patients with MM and AL, and to suggest guidelines for monitoring following SC Dara administration. Methods: This single-center retrospective study included patients treated with MM or AL receiving SC Dara between June 2020 and December 2020. The primary outcome of the study was incidence of IRRs. Secondary outcomes include timing and severity of IRRs based on CTCAE version 4.0. Results: A total of 82 patients received SC Dara during the study period. Of these 82, forty-nine (60%) had previously received Dara (Dara-exposed), and 33 patients (40%) were Dara-naïve. Eight of the 82 patients (9.8%) experienced an IRR. All were grade 1 (n=5, 63%) or grade 2 (n=3, 38%) in severity. Seven patients in the Dara-naïve group experienced an IRR (21%), and one patient in the Dara-exposed group (2%) experienced injection-site erythema with the second SC dose after transitioning from IV. Three patients experienced reactions immediately after SC Dara administration, and four patients experienced delayed reactions >4 hours after SC Dara administration (median 11.9 hours; range 5-24). Among those with delayed reactions, three experienced reactions after being discharged from the treatment area but symptoms resolved without any intervention. Conclusions: In this single-center study of patients receiving SC Dara, IRRs occurred in about 10% of patients, and were more likely with a patient’s first dose of SC Dara. All reactions were mild to moderate in severity and could be managed in the outpatient setting. We suggest that Dara-naïve patients receiving their 1st SC Dara dose be monitored for one hour after SC Dara administration. Monitoring does not appear necessary for patients transitioning from IV to SC Dara or receiving subsequent doses of SC Dara. [Table: see text]

Surgical Procedure in the Treatment of Organized Chronic Subdural Hematoma: A Single-Center Experience

2021 ◽  
Author(s):  
Keng Chen ◽  
Kun Wang ◽  
Danzhi Chen ◽  
Huanjiang Niu ◽  
Shuxu Yang ◽  
...  
Keyword(s):  
Subdural Hematoma ◽  
Surgical Procedure ◽  
Clinical Symptoms ◽  
Chronic Subdural Hematoma ◽  
Acute Subdural Hematoma ◽  
Imaging Data ◽  
Single Center ◽  
Single Center Experience ◽  
Significant Difference ◽  
Better Than

Abstract Background Organized chronic subdural hematoma (CSDH) is a special type of CSDH. However, the optimal surgical procedure has not been established. We present our experience here to discuss the surgical procedure in treatment of organized CSDH. Methods Thirty-three patients with organized CSDH were admitted between January 1, 2008 and January 1, 2018. Age, gender, clinical symptoms, imaging data, type of surgical procedure, Barthel index (BI), and postoperative complications were collected and retrospectively analyzed. The BI was assessed both pre and postoperatively (1 week and 1 month after surgery). Results Overall, 14 patients underwent large craniotomy and 19 patients underwent small craniotomy. No significant differences in gender, age, initial clinical symptoms, and preoperative BI were found between the groups (p > 0.05). Among the 14 patients who underwent large craniotomy, 2 patients developed epilepsy after the operation, while 1 patient had postoperative aphasia. None of the patients had recurrence in 6 months postoperatively. Among the 19 patients who underwent small craniotomy, 1 patient developed an acute subdural hematoma and 1 patient developed aphasia. No obvious complications were found in the remaining 18 patients and none of the 19 patients had recurrence in 6 months postoperatively. BI scores of the small craniotomy group were significantly better than those of the large craniotomy group at 1 week postoperatively (p < 0.05). However, there was no significant difference in the 1-month results (p > 0.05). Conclusion According to our single-center experience, a small craniotomy for treating organized CSDH can be considered as an alternative to a larger craniotomy.

Compartment Surgery in Treatment Strategies for Retroperitoneal Sarcomas: A Single-center Experience

2010 ◽  
Vol 34 (11) ◽  
pp. 2773-2781 ◽  
Author(s):  
Carlos Eduardo Rodrigues Santos ◽  
Mauro Monteiro Correia ◽  
Luiz Claudio Santos Thuler ◽  
Bruno Rodrigues Rosa ◽  
Antonio Accetta ◽  
...  
Keyword(s):  
Treatment Strategies ◽  
Single Center ◽  
Single Center Experience ◽  
Retroperitoneal Sarcomas

scholarly journals Os Odontoideum: A Single-Center Experience with Controversies in Management and Evolution of Treatment Strategies

2021 ◽  
Author(s):  
Vamsi Krishna Yerramneni ◽  
Neeraj Sharma
Keyword(s):  
Treatment Strategies ◽  
Craniovertebral Junction ◽  
The Body ◽  
Os Odontoideum ◽  
Review Of Literature ◽  
Single Center ◽  
Variable Size ◽  
Size And Shape ◽  
Single Center Experience ◽  
Clinical Presentations

AbstractOs odontoideum is an independent ossicle of variable size and shape separated from the body of C2. There are various theories on the etiology. Different hypothesis on etiology include traumatic and congenital. Because of the laxity of the ligaments associated with the anomalous odontoid, there can be associated instability at the craniovertebral junction. The authors presented their experience of treating these anomalies, their clinical presentations, evolution of the treatment strategies over years, and a brief review of literature on etiopathogenesis.

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