Urinary N-terminal Pro-Brain Natriuretic Peptide in Newborn Infants with Cardiac and Pulmonary Diseases

2021 ◽  
Author(s):  
Marwa M. Elgendy ◽  
Rania Salah Elzayat ◽  
Mostafa Abdo ◽  
Hamed M. Elsharkawy ◽  
Maha Allam ◽  
...  
Keyword(s):  
Predictive Value ◽  
Congenital Heart ◽  
Screening Tool ◽  
Heart Diseases ◽  
Full Term ◽  
Congenital Heart Diseases ◽  
Control Groups ◽  
Term Neonates ◽  
And Control ◽  
Cardiac Group

Abstract Objectives The aim of this study was to assess the feasibility of urinary N-terminal pro-brain natriuretic peptide (NT-proBNP) as noninvasive screening tool for congenital heart diseases in full-term neonates with respiratory distress. Study Design A prospective cohort study was conducted on 90 full-term infants. Newborn were assigned into three groups: pulmonary, cardiac, and control groups. Urinary NT-proBNP were measured in all studied groups at day 1 (NT-proBNP1) and day 5 (NT-proBNP5). Results Urinary NT-proBNP1 was higher in cardiac group compared with pulmonary and control groups (488 ± 91, 321 ± 80, and 218 ± 41 ng/L, respectively; p ≤ 0.001). NT-proBNP5 was lower in pulmonary and control group than cardiac group (245 ± 84, 137 ± 39, and 546 ± 284 ng/L, respectively, with p ≤ 0.001). Receiver operating characteristic (ROC) analysis was performed to assess predictive value of NT-proBNP1 in cardiac and pulmonary populations. ROC showed area under curve of 0.97 and cutoff point of ≥386.5 ng/L referring to a cardiac etiology with sensitivity of 93.3%, specificity of 86.7%, negative predictive value of 93%, and positive predictive value of 88%. Conclusion Urinary NT-proBNP is feasible to be a noninvasive screening tool to predict congenital heart diseases in full-term neonates. Further studies are needed to assess the correlation between plasma and urinary levels of NT-proBNP in congenital heart diseases in full-term and preterm infants.

scholarly journals Defects in the interventricular and atrial septa: the contribution of the transcription factor GATA6 and the signal molecule NOTCH1

2020 ◽  
pp. 64-70
Author(s):  
А.В. Цепокина ◽  
А.В. Понасенко ◽  
Н.С. Деева ◽  
А.В. Шабалдин
Keyword(s):  
Congenital Heart ◽  
Heart Diseases ◽  
Modern Medicine ◽  
Gene Interactions ◽  
Congenital Heart Diseases ◽  
Control Groups ◽  
Signal Molecule ◽  
Exogenous Factors ◽  
And Control

Актуальность: Поиск биологических маркёров, вовлеченных в патогенез врожденных пороков сердца (ВПС), остается актуальным вопросом современной медицины и биологии. Врожденные пороки - мультифакторное заболевание, причинами развития которого является взаимовлияющее действие эндогенных и экзогенных факторов. В настоящее время показана роль генов семейства GATA и NOTCH1 в формировании предрасположенности к развитию врожденных пороков сердца. Материалы и методы: Группу исследования составили 58 детей с диагнозом дефекта межжелудочковой и межпредсердной перегородок, в контрольную группу включены 103 ребенка без данной патологии. Генотипирование проводили полимеразной цепной реакцией в режиме реального времени с использованием TaqMan-зондов. Результаты: Исследование встречаемости генотипов генов GATA6 и NOTCH1 в исследуемой и контрольной группах не показало статистически значимых различий. Однако, анализ межгенных взаимодействий при помощи программы MDR 3.0.2. позволил выделить ряд протективных и рисковых генотипов. Заключение: Несмотря на отсутствие статистически значимых различий по частоте встречаемости генотипов, полученные в ходе анализа межгенных связей сочетания генотипов могут быть связаны с предрасположенностью к развитию ВПС. Background: The search for biological markers involved in the congenital heart diseases pathogenesis remains a topical problem in modern medicine and biology. Congenital heart diseases are a multifactorial disease caused by the mutually affecting effects of endogenous and exogenous factors. Currently, the role of GATA and NOTCH1 gene family in the predisposition to development of congenital heart diseases is shown. Materials and methods: 58 children with a diagnosis of congenital heart diseases (defects in the interventricular and atrial septa) and 103 children without this pathology were included in the study and the control groups, respectively. Genotyping was performed by real-time polymerase chain reaction using TaqMan probes Results: A study of the frequencies of the genotypes in the GATA6 and NOTCH1 genes in the study and control groups showed no statistically significant differences. At the same time, the analysis of gene-gene interactions using MDR 3.0.2 software allows to determine a number of protective and risk genotypes. Conclusion: Despite the absence of significant differences in the frequency of genotypes, combinations of genotypes obtained during the analysis of gene-gene interactions may be associated with a predisposition to the development of congenital heart diseases.

scholarly journals Myocardial Injury in Children with Unoperated Congenital Heart Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Mohamed O. Hafez ◽  
Saed M. Morsy ◽  
Ragab A. Mahfoz ◽  
Ahmed R. Ali
Keyword(s):  
Congenital Heart ◽  
Myocardial Injury ◽  
Heart Diseases ◽  
Pressure Overload ◽  
Systemic Arterial Pressure ◽  
Control Group ◽  
Congenital Heart Diseases ◽  
Healthy Children ◽  
Early Management ◽  
And Control

Background.Children with congenital heart diseases (CHDs) may have a risk of developing myocardial injury caused by volume and pressure overload.Objective.To evaluate the incidence of myocardial injury in children with cyanotic and acyanotic CHDs using cTnI assay and to correlate it with different hemodynamic parameters.Methods.This study included 80 children with CHDs (40 acyanotic and 40 cyanotic) as well as 40 healthy children (control group). Serum cTnI levels were measured for patients and control. Pulmonary to systemic blood flow (Qp/Qs) and pulmonary to systemic arterial pressure (Pp/Ps) ratios were measured for children with CHDs during cardiac catheterization.Results.Sixty-four out of 80 patients with CHDs had myocardial injury as evidenced by increased cTnI. Serum cTnI was significantly higher in both cyanotic and acyanotic groups compared to control group (p<0.05). Serum cTnI level significantly correlated with oxygen saturation (SpO2), ejection fraction (EF), Qp/Qs, and Pp/Ps ratios.Conclusion.The incidence of myocardial injury was high in children with CHDs. The use of cTnI for follow-up of children with CHDs may help early detection of myocardial injury and help early management of these cases.

scholarly journals Early corrective surgery may prevent Baroreflex impairment in congenital heart diseases

2014 ◽  
Vol 1 (1) ◽  
pp. 20-27
Author(s):  
Domonkos Cseh ◽  
Adrienn Sárközi ◽  
Alexandra Pintér
Keyword(s):  
Congenital Heart ◽  
Baroreflex Sensitivity ◽  
Heart Diseases ◽  
Surgical Correction ◽  
Congenital Heart Diseases ◽  
Corrective Surgery ◽  
Timing Of Operation ◽  
Control Subjects ◽  
The Difference ◽  
And Control

Arrhythmias in tetralogy of Fallot (ToF) and transposition of the great arteries (TGA) could be the consequence of reduced baroreflex-sensitivity (BRS). Hypoxia until the first surgical correction in these patients may impair BRS. We aimed to compare the BRS of ToF, TGA and control subjects and test the effect of the timing of operation on BRS. 19 patients with ToF, 22 patients with TGA and 19 healthy controls were enrolled. Carotid pulse pressure (PPc) was similar in ToF and TGA patients but lower in controls. BRS was lower in the ToF group compared to the control or to the TGA groups. The first operation was performed later in patients with ToF than in patients with TGA. Adjustment for PPc attenuated the difference in BRS between ToF and control subjects. Adjustment for age at corrective surgery abolished the difference in BRS between the ToF and the TGA groups. In ToF patients, reduced BRS could be explained by the stiffening of central arteries and the later corrective surgery. Earlier surgical correction may prevent irreversible deterioration of baroreflex-function and arrhythmia development in ToF patients.

scholarly journals White matter injury in term neonates with congenital heart diseases: Topology & comparison with preterm newborns

NeuroImage ◽  
2019 ◽  
Vol 185 ◽  
pp. 742-749 ◽  
Author(s):  
Ting Guo ◽  
Vann Chau ◽  
Shabnam Peyvandi ◽  
Beatrice Latal ◽  
Patrick S. McQuillen ◽  
...  
Keyword(s):  
White Matter ◽  
Congenital Heart ◽  
Heart Diseases ◽  
White Matter Injury ◽  
Congenital Heart Diseases ◽  
Term Neonates ◽  
Preterm Newborns

scholarly journals Use of computed radiology as a screening test for the identification of congenital heart disease in dogs

2020 ◽  
Vol 41 (4) ◽  
pp. 1213
Author(s):  
Stephany Buba Lucina ◽  
Marco Antonio Ferreira da Silva ◽  
Amália Turner Giannico ◽  
Marlos Gonçalves Sousa ◽  
Tilde Rodrigues Froes
Keyword(s):  
Heart Disease ◽  
Predictive Value ◽  
Screening Test ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Screening Method ◽  
Congenital Heart Diseases ◽  
Cardiac Silhouette ◽  
Sensitivity Specificity

The objectives of this study were to evaluate the accuracy of thoracic radiology as a screening test for congenital heart diseases in dogs, to identify the main contributions and limitations of this modality, and to verify the reproducibility of the evaluations by three observers with different levels of training. An interobserver, observational, retrospective and prospective study was carried out, including ninety dogs: thirty healthy animals, thirty with acquired heart diseases and thirty with congenital heart diseases, which all had thoracic radiographs and a confirmed echocardiographic diagnosis. The cases were separated and randomized by a mediator who did not participate in the reading of the radiographic examinations, and no evaluator had access to the patients' data. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of each observer were calculated in relation to the correct classification of dogs to groups of normal or acquired and congenital heart diseases, as well as identification of enlargement of the cardiac silhouette and large vessels of dogs with congenital heart diseases. Finally, the Kappa coefficient was obtained between the observers to verify the reproducibility of the radiological evaluations performed. In general, sensitivity, PPV and accuracy were unsatisfactory ( 70%), and the agreement ranged from poor to reasonable (between 0 and 0.39). Although greater accuracy was achieved in the differentiation of healthy dogs from those with acquired and congenital heart diseases by thoracic radiography, when compared to the other studies, the modality was able only to identify healthy patients, and could not differentiate the individuals with different forms of heart disease or define the cardiac malformations. In addition, there was low reproducibility between observers, therefore, this technique should not be used as a sole screening method in dogs with suspected congenital heart diseases.

scholarly journals Assessment of Dental Status and Oral Health Status in Children with Congenital Heart Diseases

2019 ◽  
pp. 42-58
Author(s):  
Sreenita Chowdhury ◽  
Binita Srivastava ◽  
Siddhartha Pujari ◽  
Nidhi Gupta ◽  
Rashi Singh ◽  
...  
Keyword(s):  
Rural Areas ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Dental Health ◽  
Oral Health Status ◽  
Permanent Dentition ◽  
Control Group ◽  
Congenital Heart Diseases ◽  
Healthy Children ◽  
Cardiac Group

Purpose: This study aims to identify the dental caries, decayed, missing, and filled teeth index (dmft/DMFT) scores amongst children with cyanotic, and acyanotic congenital heart diseases (CHD), compare with healthy controls and identify the risk factors for poor dental health. Methods: Between January 2016 and June 2017, 236 children aged 2 to 15 years (mean±SD=7.61±3.88 yrs, median 7 yrs) with CHD and 951 healthy children aged 2 to 15 years (mean±SD=8.83±7.34 yrs, median 9 yrs) were evaluated. Results: Children with CHD had more caries in their primary and permanent dentition (mean dmft: 2.42±3.82, cardiac group vs. 2.32±6.68, control group; p<0·05; mean DMFT: 2.15±3.38, cardiac group vs. 1.27±1.89, control group; p=0.002). The DMFT scores for children with CHD were higher in the rural areas. Children frequently consuming biscuits, confectionary and sugared milk had higher dmft±SD scores. The possibility of caries in permanent dentition was more in children with cyanotic CHD compared to acyanotic. Caries in primary dentition showed positive correlation with age. Conclusions: CHD is associated with poorer dental health in children. Close cooperation between pediatric cardiologists and pediatric dentists is warranted to raise awareness, prevent and institute early treatment for dental ailments.

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