Inter-Rater Reliability of Cyclotorsion Measurements Using Fundus Photography

2018 ◽  
Vol 235 (04) ◽  
pp. 420-423
Author(s):  
Muriel Dysli ◽  
Madeleine Kanku ◽  
Ghislaine Traber
Keyword(s):  
Healthy Subjects ◽  
Intraclass Correlation ◽  
Fundus Photography ◽  
Healthy Controls ◽  
Trochlear Nerve ◽  
Rater Reliability ◽  
Fundus Camera ◽  
The Mean ◽  
Fundus Photographs ◽  
Very High

Abstract Background The foveo-papillary angle (FPA) on fundus photographs is the accepted standard for the measurement of ocular cyclotorsion. We assessed the inter-rater reliability of this method in healthy subjects and in patients with trochlear nerve palsies. Patients and Methods In this methodological study, fundus photographs of healthy subjects and of patients with trochlear nerve palsies were made with a fundus camera (Zeiss Fundus Camera FF 450 plus, Jena, Germany). Three independent observers measured the FPA on the fundus photographs of all subjects in synedra View (synedra View 16, Version 16.0.0.11, Innsbruck, Austria). Results One hundred and four eyes of 52 subjects (26 healthy controls and 26 patients) were assessed. The mean FPA of the healthy controls was 5.80 degrees (°) [± 0.44 standard error of the mean (SEM)] compared to 11.55° (± 0.80 SEM) for patients with trochlear nerve palsies. The inter-rater reliability of all measured FPAs showed an intraclass correlation coefficient (ICC) of 0.98 (95% CI 0.97 – 0.98). Conclusions The inter-rater reliability of objective cyclotorsion measurements using fundus photographs was very high.

scholarly journals Retinal vascular findings in patients with COVID-19

2021 ◽  
Vol 13 ◽  
pp. 251584142110304
Author(s):  
Emre Aydemir ◽  
Alper Halil Bayat ◽  
Burak Ören ◽  
Halil Ibrahim Atesoglu ◽  
Yasin Şakir Göker ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Fundus Photography ◽  
Control Group ◽  
Fundus Fluorescein Angiography ◽  
University Of Wisconsin ◽  
Retinal Vascular Caliber ◽  
Retinal Artery ◽  
The Mean ◽  
And Gender ◽  
College Of Engineering

Purpose: The purpose of this study was to compare the retinal vascular caliber of COVID-19 patients with that of healthy subjects. Methods: This was a prospective case–control study. Forty-six patients who had COVID-19 were successfully treated, and 38 age- and gender-matched healthy subjects were enrolled in this study. Fundus photography was taken using fundus fluorescein angiography (FA; Visucam 500; Carl Zeiss Meditec, Jena, Germany). Retinal vascular caliber was analyzed with IVAN, a semi-automated retinal vascular analyzer (Nicole J. Ferrier, College of Engineering, Fundus Photography Reading Center, University of Wisconsin, Madison, WI, USA). Central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and artery–vein ratio (AVR) were compared between groups. Results: The mean age was 37.8 ± 9.5 years in the COVID-19 group ( n = 46) and 40 ± 8 years in the control group ( n = 38) ( p = 0.45). The mean CRAE was 181.56 ± 6.40 in the COVID-19 group and 171.29 ± 15.06 in the control group ( p = 0.006). The mean CRVE was 226.34 ± 23.83 in the COVID-19 group and 210.94 ± 22.22 in the control group ( p = 0.044). AVR was 0.81 ± 0.09 in the COVID-19 group and 0.82 ± 0.13 in the control group ( p = 0.712). Conclusion: Patients who had COVID-19 have vasodilation in the retinal vascular structure after recovery. As they may be at risk of retinal vascular disease, COVID-19 patients must be followed after recovery.

scholarly journals Detailed Morphological Changes of Foveoschisis in Patient with X-Linked Retinoschisis Detected by SD-OCT and Adaptive Optics Fundus Camera

2015 ◽  
Vol 2015 ◽  
pp. 1-8
Author(s):  
Keiichiro Akeo ◽  
Shuhei Kameya ◽  
Kiyoko Gocho ◽  
Daiki Kubota ◽  
Kunihiko Yamaki ◽  
...  
Keyword(s):  
Adaptive Optics ◽  
Morphological Changes ◽  
Fundus Photography ◽  
Foveal Thickness ◽  
Functional Changes ◽  
Fundus Camera ◽  
Fundus Photographs ◽  
Topical Dorzolamide ◽  
Retinal Folds ◽  
Sd Oct

Purpose. To report the morphological and functional changes associated with a regression of foveoschisis in a patient with X-linked retinoschisis (XLRS).Methods. A 42-year-old man with XLRS underwent genetic analysis and detailed ophthalmic examinations. Functional assessments included best-corrected visual acuity (BCVA), full-field electroretinograms (ERGs), and multifocal ERGs (mfERGs). Morphological assessments included fundus photography, spectral-domain optical coherence tomography (SD-OCT), and adaptive optics (AO) fundus imaging. After the baseline clinical data were obtained, topical dorzolamide was applied to the patient. The patient was followed for 24 months.Results. A reportedRS1gene mutation was found (P203L) in the patient. At the baseline, his decimal BCVA was 0.15 in the right and 0.3 in the left eye. Fundus photographs showed bilateral spoke wheel-appearing maculopathy. SD-OCT confirmed the foveoschisis in the left eye. The AO images of the left eye showed spoke wheel retinal folds, and the folds were thinner than those in fundus photographs. During the follow-up period, the foveal thickness in the SD-OCT images and the number of retinal folds in the AO images were reduced.Conclusions. We have presented the detailed morphological changes of foveoschisis in a patient with XLRS detected by SD-OCT and AO fundus camera. However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

scholarly journals Diurnal Corrected QT Interval and QT Dispersion Variation in Non-Alcoholic Cirrhotic Patients and Healthy Control: A Case-Control Study, Iran

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Taghi Amiriani ◽  
Vahid Khori ◽  
Ali Davarian ◽  
Niloofar Rajabli ◽  
Mahsa Niknam ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Diurnal Variation ◽  
Healthy Subjects ◽  
Alcoholic Cirrhosis ◽  
Qt Dispersion ◽  
Qtc Interval ◽  
Healthy Controls ◽  
Cirrhotic Patients ◽  
The Mean

Background: Cirrhosis could lead to a long corrected QT (QTc) interval in a subgroup of patients, but there are spare data on its diurnal variation. Objectives: The present study aimed to determine the diurnal variation of QTc interval and its relationship to heart rate and blood pressure variation during 24-hour Holter-monitoring in non-alcoholic cirrhosis in comparison with the healthy controls. Methods: The study population comprised 15 patients with non-alcoholic cirrhosis and 15 healthy subjects, undergoing 24-hour electrocardiogram (ECG), heart rate, and blood pressure monitoring. The mean QT interval, mean QTc, maximum and minimum QT, QT dispersion (QT disp), heart rate, and mean arterial blood pressure were measured for each person for 24 hours. Liver stiffness measurement (LSM) was performed by FibroScan® 502 machine (EchoSense, Paris, France, 5 MHz). The results were demonstrated as percentages and mean ± SD. P value ≤ 0.05 was considered significant. Results: Mean QTc was significantly higher in cirrhosis (438 ms) than healthy controls (401.7 ms) (P = 0.03). The mean heart rate was significantly different in cirrhotic patients (79.6 ± 2.9/bpm) compared to healthy controls (72.47 ± 2.0/bpm) (P = 0.05). Conclusions: In this study, QTc was prolonged and increased with the severity of cirrhosis, and its diurnal variation in cirrhosis was different from healthy subjects.

Is the location of the signal intensity weighted centroid a reliable measurement of fluid displacement within the disc?

2018 ◽  
Vol 63 (4) ◽  
pp. 453-460 ◽  
Author(s):  
Vahid Abdollah ◽  
Eric C. Parent ◽  
Michele C. Battié
Keyword(s):  
Signal Intensity ◽  
Water Distribution ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Region Of Interest ◽  
Rater Reliability ◽  
Fluid Displacement ◽  
Intraclass Correlation Coefficients ◽  
The Mean ◽  
Standard Error Of Measurement

Abstract Degenerated discs have shorter T2-relaxation time and lower MR signal. The location of the signal-intensity-weighted-centroid reflects the water distribution within a region-of-interest (ROI). This study compared the reliability of the location of the signal-intensity-weighted-centroid to mean signal intensity and area measurements. L4-L5 and L5-S1 discs were measured on 43 mid-sagittal T2-weighted 3T MRI images in adults with back pain. One rater analysed images twice and another once, blinded to measurements. Discs were semi-automatically segmented into a whole disc, nucleus, anterior and posterior annulus. The coordinates of the signal-intensity-weighted-centroid for all regions demonstrated excellent intraclass-correlation-coefficients for intra- (0.99–1.00) and inter-rater reliability (0.97–1.00). The standard error of measurement for the Y-coordinates of the signal-intensity-weighted-centroid for all ROIs were 0 at both levels and 0 to 2.7 mm for X-coordinates. The mean signal intensity and area for the whole disc and nucleus presented excellent intra-rater reliability with intraclass-correlation-coefficients from 0.93 to 1.00, and 0.92 to 1.00 for inter-rater reliability. The mean signal intensity and area had lower reliability for annulus ROIs, with intra-rater intraclass-correlation-coefficient from 0.5 to 0.76 and inter-rater from 0.33 to 0.58. The location of the signal-intensity-weighted-centroid is a reliable biomarker for investigating the effects of disc interventions.

INTRA-RATER AND INTER-RATER RELIABILITY STUDY OF A MEASUREMENT METHOD FOR THE PATHWAY OF THE SUPRASPINATUS INTRAMUSCULAR TENDON BY 3.0 TESLA MRI IMAGES: THE SHEAR FORCE ANGLE ANTERIOR POSTERIOR

2018 ◽  
Vol 21 (02) ◽  
pp. 1850009
Author(s):  
Yohei Kanno ◽  
Hajime Toda ◽  
Tsutomu Horiuchi ◽  
Masaki Katayose
Keyword(s):  
Shear Force ◽  
Measurement Method ◽  
Intraclass Correlation ◽  
Three Dimensional ◽  
3D Models ◽  
Minimal Detectable Change ◽  
3.0 Tesla ◽  
Rater Reliability ◽  
The Mean ◽  
Anterior Posterior

Objective: The aim of this study was to establish intra-rater and inter-rater reliability of a measurement method for the pathway of the supraspinatus intramuscular tendon by 3.0 tesla MRI images. Methods: The scapula and intramuscular tendon extraction DICOM data was made to extract only a scapula domain and intramuscular tendon domain. The shear force angle anterior posterior (SFA-AP) was measured as the pathway of supraspinatus intramuscular tendon with respect to the glenoid plane on three-dimensional (3D) models of the bone and intramuscular tendon. SFA-AP of supraspinatus was measured on 3D models of the bone and intramuscular tendon. The mean and standard deviation of SFA-AP of supraspinatus was calculated. Intra-rater reliability and inter-rater reliability were evaluated by the intraclass correlation coefficient (ICC), the standard error of the mean (SEM) and the minimal detectable change (MDC). Inter-rater reliability was evaluated by three raters. Results: As for intra-rater reliability, SFA-AP of supraspinatus measured averaged [Formula: see text], with ICC (1,1) of 0.978, with ICC (1,3) of 0.993, with SEM of 0.53, with MDC of 1.46[Formula: see text]. As for inter-rater reliability, SFA-AP of supraspinatus measured averaged [Formula: see text] (rater1), SFA-AP measured averaged [Formula: see text] (rater2), SFA-AP measured averaged [Formula: see text] (rater3), with ICC (2,1) of 0.896, with ICC (2,3) of 0.963, with SEM of 1.11, with MDC of 3.09[Formula: see text]. Conclusions: 3D models of the bone and intramuscular tendon were evaluated as intra-rater and inter-rater reliabilities. SFA-AP of supraspinatus is guaranteed by one measurement.

Deep learning-assisted (automatic) diagnosis of glaucoma using a smartphone

2021 ◽  
pp. bjophthalmol-2020-318107
Author(s):  
Kenichi Nakahara ◽  
Ryo Asaoka ◽  
Masaki Tanito ◽  
Naoto Shibata ◽  
Keita Mitsuhashi ◽  
...  
Keyword(s):  
Deep Learning ◽  
Learning Algorithm ◽  
Fundus Photography ◽  
Training Dataset ◽  
Mean Deviation ◽  
Fundus Camera ◽  
Deep Learning Algorithm ◽  
Testing Dataset ◽  
Advanced Glaucoma ◽  
Fundus Photographs

Background/aimsTo validate a deep learning algorithm to diagnose glaucoma from fundus photography obtained with a smartphone.MethodsA training dataset consisting of 1364 colour fundus photographs with glaucomatous indications and 1768 colour fundus photographs without glaucomatous features was obtained using an ordinary fundus camera. The testing dataset consisted of 73 eyes of 73 patients with glaucoma and 89 eyes of 89 normative subjects. In the testing dataset, fundus photographs were acquired using an ordinary fundus camera and a smartphone. A deep learning algorithm was developed to diagnose glaucoma using a training dataset. The trained neural network was evaluated by prediction result of the diagnostic of glaucoma or normal over the test datasets, using images from both an ordinary fundus camera and a smartphone. Diagnostic accuracy was assessed using the area under the receiver operating characteristic curve (AROC).ResultsThe AROC with a fundus camera was 98.9% and 84.2% with a smartphone. When validated only in eyes with advanced glaucoma (mean deviation value < −12 dB, N=26), the AROC with a fundus camera was 99.3% and 90.0% with a smartphone. There were significant differences between these AROC values using different cameras.ConclusionThe usefulness of a deep learning algorithm to automatically screen for glaucoma from smartphone-based fundus photographs was validated. The algorithm had a considerable high diagnostic ability, particularly in eyes with advanced glaucoma.

Haemostasis Change in Intensive Care Patients with Severe Sepsis and Patients with Organ Failure without Sepsis

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 1233-1233
Author(s):  
Patrick Van Dreden ◽  
Barry John Woodhams ◽  
Bernard Lenormand ◽  
Marc Vasse
Keyword(s):  
Severe Sepsis ◽  
Intensive Care ◽  
Organ Failure ◽  
Healthy Subjects ◽  
Protein C ◽  
Thrombin Generation ◽  
Protein S ◽  
Healthy Controls ◽  
Coagulation Abnormalities ◽  
The Mean

Abstract Abstract 1233 Introduction: Despite recent advances in understanding the pathophysiology of sepsis, multiple organ failure remains one of the leading causes of death in intensive care units (ICUs). A wide range of coagulation abnormalities have been observed in patients diagnosed with severe sepsis (SS). Its magnitude in relationship to organ failure without sepsis is less well documented. In this study, we examined and compared the results of plasma levels of coagulation tests and thrombin generation (calibrated automated thrombography (CAT) in patients with sepsis, patients with organ failure (OF) without sepsis and controls. We investigated whether the CAT and procoagulant phospholipids would be good prognostic markers and whether these markers would show a significant correlation with coagulation disorders. Patients and Methods: 21 patients with severe sepsis, 24 non-sepsis patients with organ failure were compared with 30 healthy subjects as controls. The delay between the onset of SS or OF and blood sampling was less than 12 hours. Analytical determinations of prothrombin time, activated partial thromboplastin time, and the levels of factors V,VII,VIII,X antithrombin, fibrinogen, protein C, protein S, D-Dimers were analysed using the STA-R analyser (Diagnostica Stago, France), Tissue factor activity (TFa) and thrombomodulin activity (TMa) were measured with two home-test. Free tissue factor pathway inhibitor (fTFPI), Soluble endothelial protein C receptor (sEPCR), and soluble thrombomodulin antigen were measured by ELISA assays (Diagnostica Stago, France). CAT was performed on PPP using PPP-reagent 5pM (Thrombinoscope, The Netherlands). Procoagulant phospholipids (PPL) were evaluated using the STA Procoag PPL assay (Diagnostica Stago, France). Results: The mean levels of factors V, VII, X, antithrombin, protein S, protein C, sEPCR were decreased in both SS and OF (p<0.001) compared with controls. Protein S, factor VII and X were significantly lower in the SS group than in the OF group (p<0.05). Factor VIII, D-Di, and fibrinogen level were increased in SS and OF groups (p<0.001). Activity and antigen thrombomodulin were significantly higher in SS and OF groups (p<0.01) than in healthy subjects, with no difference between patients groups. TFa was strongly increased in SS and OF (p<0.001) and not compensated by any increase in TFPI. We also observed that TF/fTFPI ratio were significantly increased in the SS and OF groups (p<0.001). Elevated thrombin generation was observed in patients with SS and OF. In particular lag-time and time to peak were prolonged (p<0.05), peak thrombin was significantly decreased only in SS group. However the mean total amount of thrombin generated in the groups of patients by endogenous Thrombin Potential (ETP) was equivalent to healthy controls. Procoagulant phospholipids were significantly higher in SS and OF groups than controls (p<0.001 and p<0.05 respectively). Non-surviving patients showed higher ETP, D-Di, TFa, PPL than survivors in both groups (p<0.05). No difference in fTFPI levels were observed between patients with negative outcome and survivors in the two groups of patients. IL-6 levels as inflammatory status were higher in SS and OF than in healthy controls, with a more pronounced increase in SS group. The levels of IL-6 were more important in non-survivors compared with survivors (p<0.05). Conclusion: This study suggests that severe septic and non septic patients with organ failure have similar coagulation abnormalities independently of the triggering event. Marked TFa generation was not adequately balanced by TFPI and inflammation may synergistically play a role in the pathogenesis of OF and death. Thrombin generation results showed that while the total amount of thrombin generated (ETP) was unchanged the initiation of thrombin generation was delayed and peak thrombin was reduced. This could be explained by the decreased levels of FVII, X, II causing a delay in the generation of thrombin. PPL and TGT may be useful in determining clinical outcome in patients and perhaps as a predictive parameter for an increased risk of bleeding or thrombotic complications in these patients. Their role to develop useful new markers in the management of patients remains to be defined. Disclosures: Van Dreden: Diagnostica Stago: Employment. Woodhams:Diagnostica Stago: Employment. Lenormand:Hospital: Employment. Vasse:hospital: Employment.

scholarly journals MRI KNEE BONE AGE: A NOVEL SHORTHAND APPROACH TO REDUCE BONE AGE RADIOGRAPHS IN CHILDREN

2020 ◽  
Vol 8 (4_suppl3) ◽  
pp. 2325967120S0018
Author(s):  
Blake C. Meza ◽  
Scott M. LaValva ◽  
Christopher J. DeFrancesco ◽  
Brendan M. Striano ◽  
Julien T. Aoyama ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Medical Training ◽  
Skeletal Maturity ◽  
Intraclass Correlation ◽  
Age Determination ◽  
Bone Age ◽  
Observer Agreement ◽  
Rater Reliability ◽  
Knee Mri ◽  
The Mean

Background: Determining bone age in skeletally immature patients is critical for proper management and surgical planning. Pennock et al. recently created and validated a bone age atlas using the ossification pattern of the knee on MRI in pediatric patients, obfuscating the need for a hand radiograph and its associated cost, radiation exposure, and clinical inefficiency. Hypothesis/Purpose: We sought to validate and demonstrate reliability of a novel shorthand method of bone age determination using knee MRI across multiple levels of medical training. Methods: We identified patients who underwent knee MRI and hand bone age radiograph within a ninety-day period. In collaboration with a pediatric musculoskeletal radiologist, stepwise algorithms for predicting bone age on knee MRI were developed- one for males and one for females. Six raters at varying levels of training used the algorithm to assign a bone age for each patient. Intraclass correlation coefficient (ICC) was used to compare each rater’s predicted knee bone age to the Greulich and Pyle (G&P) hand bone age and validate the shorthand algorithm. Inter-rater reliability was also calculated using ICC. Results: Thirty-eight patients (44.7% female) underwent a knee MRI at a mean age of 12.8 years (range 9.3-15.7). The mean time between hand bone age x-ray and knee MRI was 20.2 days (range 0-88). The inter-rater reliability for the application of our shorthand algorithm was 0.81 (95% CI: 0.72 – 0.88), indicating good inter-observer agreement. The shorthand methos was shown to be a good predictor of G&P hand bone age, both for each individual rater (ICC range: 0.73 – 0.80) and the mean knee MRI bone age across all raters (ICC 0.81; 95% CI 0.65 – 0.90). It was also shown to be a consistent predictor of hand bone age across level of training, as medical students (ICC 0.77, 95% CI 0.60-0.88), residents (ICC 0.80, 95% CI 0.65-0.89), and attending physicians (ICC 0.80, 95% CI 0.63-0.89) all achieved strong correlation between predicted knee MRI bone age and G&P hand bone age. Conclusions: This novel shorthand algorithm is a reliable and valid way to determine skeletal maturity using knee MRI. It can be utilized clinically across different levels of radiographic and orthopaedic expertise and reduces the need for hand bone age radiographs and consequential radiation exposure in children. [Figure: see text][Figure: see text][Table: see text]

scholarly journals Macular Vascular Geometry Changes With Sex and Age in Healthy Subjects: A Fundus Photography Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Ziqing Feng ◽  
Gengyuan Wang ◽  
Honghui Xia ◽  
Meng Li ◽  
Guoxia Liang ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Age Groups ◽  
Vessel Diameter ◽  
Cross Sectional Study ◽  
Fundus Photography ◽  
Cross Sectional ◽  
Age Related ◽  
Significant Difference ◽  
The Mean ◽  
Vascular Geometry

Purpose: To characterize the sex- and age-related alterations of the macular vascular geometry in a population of healthy eyes using fundus photography.Methods: A cross-sectional study was conducted with 610 eyes from 305 healthy subjects (136 men, 169 women) who underwent fundus photography examination and was divided into four age groups (G1 with age ≤ 25 years, G2 with age 26–35 years, G3 with age 36–45 years, and G4 with age ≥ 46 years). A self-developed automated retinal vasculature analysis system allowed segmentation and separate multiparametric quantification of the macular vascular network according to the Early Treatment Diabetic Retinopathy Study (ETDRS). Vessel fractal dimension (Df), vessel area rate (VAR), average vessel diameter (Dm), and vessel tortuosity (τn) were acquired and compared between sex and age groups.Results: There was no significant difference between the mean age of male and female subjects (32.706 ± 10.372 and 33.494 ± 10.620, respectively, p &gt; 0.05) and the mean age of both sexes in each age group (p &gt; 0.05). The Df, VAR, and Dm of the inner ring, the Df of the outer ring, and the Df and VAR of the whole macula were significantly greater in men than women (p &lt; 0.001, p &lt; 0.001, p &lt; 0.05, respectively). There was no significant change of τn between males and females (p &gt; 0.05). The Df, VAR, and Dm of the whole macula, the inner and outer rings associated negatively with age (p &lt; 0.001), whereas the τn showed no significant association with age (p &gt; 0.05). Comparison between age groups observed that Df started to decrease from G2 compared with G1 in the inner ring (p &lt; 0.05) and Df, VAR, and Dm all decreased from G3 compared with the younger groups in the whole macula, inner and outer rings (p &lt; 0.05).Conclusion: In the healthy subjects, macular vascular geometric parameters obtained from fundus photography showed that Df, VAR, and Dm are related to sex and age while τn is not. The baseline values of the macular vascular geometry were also acquired for both sexes and all age groups.

scholarly journals Precision of Corneal Thickness Measurements Obtained Using the Scheimpflug-Placido Imaging and Agreement with Ultrasound Pachymetry

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Jinhai Huang ◽  
Giacomo Savini ◽  
Chengfang Wang ◽  
Weicong Lu ◽  
Rongrong Gao ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Corneal Thickness ◽  
Intraclass Correlation ◽  
Normal Subjects ◽  
Limits Of Agreement ◽  
Ultrasound Pachymetry ◽  
Good Repeatability ◽  
Repeatability And Reproducibility ◽  
The Mean ◽  
Thickness Measurements

Purpose.To assess the reliability and comparability of measuring central corneal thickness (CCT) and thinnest corneal thickness (TCT) using a new Scheimpflug-Placido analyzer (TMS-5, Japan) and ultrasound (US) pachymetry.Methods.Seventy-six healthy subjects were prospectively measured 3 times by 1 operator using the TMS-5, 3 additional consecutive scans were performed by a second operator, and ultrasound (US) pachymetry measurements were taken. The test-retest repeatability (TRT), coefficient of variation (CoV), and intraclass correlation coefficient (ICC) were calculated to evaluate intraoperator repeatability and interoperator reproducibility. Agreement among the devices was assessed using Bland-Altman plots and 95% limits of agreement (LoA).Results.The intraoperators TRT and CoV were <19 μm and 2.0%, respectively. The interoperators TRT and CoV were <12 μm and 1.0%, respectively, and ICC was >0.90. The mean CCT and TCT measurements using the TMS-5 were 15.97 μm (95% LoA from −26.42 to −5.52 μm) and 20.32 μm (95% LoA from −30.67 to −9.97 μm) smaller, respectively, than those using US pachymetry.Conclusions.The TMS-5 shows good repeatability and reproducibility for measuring CCT and TCT in normal subjects but only moderate agreement with US pachymetry results. Caution is warranted before using these techniques interchangeably.

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