scholarly journals Macular Vascular Geometry Changes With Sex and Age in Healthy Subjects: A Fundus Photography Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Ziqing Feng ◽  
Gengyuan Wang ◽  
Honghui Xia ◽  
Meng Li ◽  
Guoxia Liang ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Age Groups ◽  
Vessel Diameter ◽  
Cross Sectional Study ◽  
Fundus Photography ◽  
Cross Sectional ◽  
Age Related ◽  
Significant Difference ◽  
The Mean ◽  
Vascular Geometry

Purpose: To characterize the sex- and age-related alterations of the macular vascular geometry in a population of healthy eyes using fundus photography.Methods: A cross-sectional study was conducted with 610 eyes from 305 healthy subjects (136 men, 169 women) who underwent fundus photography examination and was divided into four age groups (G1 with age ≤ 25 years, G2 with age 26–35 years, G3 with age 36–45 years, and G4 with age ≥ 46 years). A self-developed automated retinal vasculature analysis system allowed segmentation and separate multiparametric quantification of the macular vascular network according to the Early Treatment Diabetic Retinopathy Study (ETDRS). Vessel fractal dimension (Df), vessel area rate (VAR), average vessel diameter (Dm), and vessel tortuosity (τn) were acquired and compared between sex and age groups.Results: There was no significant difference between the mean age of male and female subjects (32.706 ± 10.372 and 33.494 ± 10.620, respectively, p > 0.05) and the mean age of both sexes in each age group (p > 0.05). The Df, VAR, and Dm of the inner ring, the Df of the outer ring, and the Df and VAR of the whole macula were significantly greater in men than women (p < 0.001, p < 0.001, p < 0.05, respectively). There was no significant change of τn between males and females (p > 0.05). The Df, VAR, and Dm of the whole macula, the inner and outer rings associated negatively with age (p < 0.001), whereas the τn showed no significant association with age (p > 0.05). Comparison between age groups observed that Df started to decrease from G2 compared with G1 in the inner ring (p < 0.05) and Df, VAR, and Dm all decreased from G3 compared with the younger groups in the whole macula, inner and outer rings (p < 0.05).Conclusion: In the healthy subjects, macular vascular geometric parameters obtained from fundus photography showed that Df, VAR, and Dm are related to sex and age while τn is not. The baseline values of the macular vascular geometry were also acquired for both sexes and all age groups.

scholarly journals Evaluation of the Knowledge and Perceptions about Pharmacovigilance Activities among Pharmacy Students in Nigeria: A Cross-Sectional Study

2017 ◽  
Vol 20 (1) ◽  
pp. 1-13
Author(s):  
Osemene Kanayo Patrick ◽  
Afolabi Margaret Olubunmi
Keyword(s):  
Age Groups ◽  
Knowledge Score ◽  
Cross Sectional Study ◽  
Pharmacy Students ◽  
Sectional Study ◽  
Knowledge Domain ◽  
Cross Sectional ◽  
Mean Values ◽  
Significant Difference ◽  
The Mean

Studies on pharmacovigilance (PV) activities in Nigeria focused on perceptions of PV among professional healthcare workers are described here. There is paucity of information on pharmacy students’ knowledge about PV activities. Hence, this study, evaluated the knowledge and perceptions of final year pharmacy students about PV activities using descriptive and inferential statistics. A cross sectional study was undertaken in three Nigerian universities with a pretested questionnaire during the period of January and February, 2016. The questionnaire included closed-ended questions on demographic variables and questions designed to achieve the objectives of the study. Data was analyzed with IBM SPSS Statistics 20 and presented in percentages, means, standard deviations and median at 50% percentile. The mean knowledge score of pharmacovigilance and adverse drug reporting for the final year students was 4.25±0.18. There were significant differences in the mean scores of knowledge domain by age groups 21-24 years 4.8±0.70, 25-30 years 6.2 ± 0.84 and >30 years 4.6±0.72 at p=0.001; gender: male 4.1±1.20 and female 4.4±0.98 at (p=0.0001) as well as the current universities attended as follows University 1 with a scrore of 5.1±1.03, University 2 had a mean score of 6.3±0.99 at p=0.0120 and University 3 with a mean score of 4.3±1.01 at p=0.012. Furthermore, significant difference exist in the mean values of pharmacovigilance knowledge between those who had taking some courses in pharmacovigilance (7.3± 0.22) and those who did not (4.7 ± 0.13) at p=0.0001. Generally, the students had inadequate knowledge of PV activities. Therefore, emphasis on relevant PV courses in their curriculum is necessary.Bangladesh Pharmaceutical Journal 20(1): 1-13, 2017

Age Related Change of Inner Diameter of Ampulla of Fallopian Tube in Bangladeshi Female Cadaver

2018 ◽  
Vol 4 (2) ◽  
pp. 137-140
Author(s):  
Hasna Hena ◽  
Shamim Ara ◽  
Rubina Qasim ◽  
Dilruba Siddiqua ◽  
Fatema Johora ◽  
...  
Keyword(s):  
Fallopian Tube ◽  
Age Groups ◽  
Uterine Cavity ◽  
Fallopian Tubes ◽  
Cross Sectional ◽  
Age Related ◽  
Significant Difference ◽  
Inner Diameter ◽  
The Mean ◽  
The Right

Background: The fallopian tubes act as conduit for spermatozoa to reach the oocyte and to convey the fertilized (egg) to enter the uterine cavity following fertilization. Problems with the fallopian tubes can lead to infertility. Detailed morphological and histological knowledge is essential for the diagnosis and management of fallopian tube disease.Objective: The purpose of the present study was to identify the inner diameter of ampulla of the fallopian tube and its changes with advancing age.Methodology: This descriptive cross-sectional study was conducted in the Department of Anatomy at Dhaka Medical College, Dhaka, Bangladesh from July 2008 to June 2009 for a period of one (01) year. This present study was performed on post mortem fallopian tubes of Bangladeshi female. Among them lowest age was 12 years and highest age was 50 years. Samples were divided into three differential age groups named asgroup A (10 to 13 years), group B (14 to 45 years), and group C (46 to 50 years). All samples were studied morphologically and histologically.Results: The mean inner diameter of the ampulla of the right and left fallopian tubes ranged from 1.99±0.08 to 3.24±0.27 mm. The difference between all the groups were statistically significant (p < 0.001).Conclusion: The mean difference of the inner diameter of the ampulla of the right and left fallopian tubesbetween groupA and groupB and groupB and groupC were statistically significant; however, there was no significant difference between right and left fallopian tube.Journal of National Institute of Neurosciences Bangladesh, 2018;4(2): 137-140

scholarly journals Retinal vascular metrics difference by comparison of two image acquisition modes using a novel OCT angiography prototype

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243074
Author(s):  
Luca Di Antonio ◽  
Pasquale Viggiano ◽  
Giada Ferro ◽  
Lisa Toto ◽  
Rossella D’Aloisio ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Image Acquisition ◽  
Vessel Diameter ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
En Face ◽  
Capillary Plexus ◽  
Perfusion Density ◽  
Superficial Capillary Plexus

Purpose To assess the different impact of two enface OCTA image simultaneously acquired by means of a new prototype of Spectral-Domain Optical Coherence Tomography Angiography (SD-OCTA) on quantitative retinal vascular metrics. Methods In this prospective observational cross-sectional study 28 healthy subjects were enrolled. Macular (3x3 mm) OCTA images were acquired for all participants using Solix Fullrange OCT (Optovue Inc, Freemont CA, USA). The main outcome measurements were: Perfusion density (PD), vessel length density (VLD), and vessel diameter index (VDI) of both superficial capillary plexus (SCP) and deep capillary plexus (DCP), and choriocapillaris (CC) total flow-deficits area. Quantitative retinal vascular metrics were measured on binarized and skeletonized OCTA images by comparing not averaged and fast automated multiple averaged en face OCTA images. Results In both SCP and DCP, PD significantly increased (p = 0,005 and p = 0,030, respectively), and VLD significantly decreased (p<0,001 and p = 0,004, respectively), and VDI increased (p<0,001 and p = 0,068, respectively), and total CC flow deficits area significantly decreased (p<0,001) by averaging multiple OCTA images. Conclusions In this study, we found a significant difference of quantitative retinal metrics by comparing two different image acquisition modes using a novel and fully automated averaging OCTA system in young healthy subjects.

scholarly journals Age-Related Haematological Variations in Patients with Asymptomatic Malaria in Akure, Ondo State, Nigeria

2021 ◽  
pp. 218-224
Author(s):  
Emmanuel Ifeanyi Obeagu ◽  
Ayomiposi Ibironke Busari ◽  
Immaculata Ogochukwu Uduchi ◽  
I. A. Ogomaka ◽  
Adaobi Maryann Ibekwe ◽  
...  
Keyword(s):  
Communicable Disease ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Asymptomatic Malaria ◽  
Age Group ◽  
Cross Sectional ◽  
Age Related ◽  
Parametric Data ◽  
Significant Difference ◽  
Ondo State

Background: Malaria is a life-threatening infectious disease of widespread burden. Malaria remains a leading communicable disease in the developing countries of the world. It occurs mostly in the tropical and subtropical regions and accounts for considerable morbidity and death. Malaria which is liable for a major amount of mortalities in endemic countries has been revealed to have both direct and indirect impacts on the haematologicalparameters.The study was done to compare the levels of haematological parameters of asymptomatic malaria patients based on age groups. Methods: The study is a cross-sectional study among asymptomatic malaria patients based on age groups. This study was conducted in Oda Road area of Akure, Ondo State. Two hundred (200) subjects were recruited for this study with each group comprising of 100 subjects for patients with asymptomatic malaria for the 2 age groups (16-30 years and 31-65 years). The data were presented in tables and as mean ± standard deviation and analyzed using student-test for parametric data and chi-square for non parametric data by statistical packages for social sciences (SPSS, Version 20.0) and level of significance set at as p≤ 0.05. Results: The results showed that subjects on age group 16-30 years were 100(50%) comprising of 50 males (25%) and 50 females (25). Also age group 31-65 years has 100 subjects (50%) comprising of 50 males (25%) and 50 females (25).The results showed significant difference in MCV (p=0.008), MCH (p=0.024) and no significant difference in PCV (p=0.675), WBC (p= 0.224), LYM (p=0.109), GRAN (p=0.061), MID (p=0.066), RBC (p=0.119), Hb (p=0.546), MCHC (p=0.262), PLT (p=0.783), when compared between age groups in years (16-30 and 31-65). Conclusion: The study showed increase in MCV and MCH of asymptomatic malaria patients within the age group of 31-65 years compared to asymptomatic malaria patients on 16-30 years age group. This shows that microcytic hypochromic anaemia may be experienced in asymptomatic malaria patients within the age group of 16-30 years more than in 31-65 years age group.

scholarly journals DERMAL PAPILLAE;

2019 ◽  
Vol 26 (02) ◽  
Author(s):  
Ayesha Baqar
Keyword(s):  
Age Groups ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Dermal Papillae

Introduction: To study and compare the changes in the height of dermal papillae in the skin of different age groups in a segment of Pakistani population. Study Design: Cross sectional study. Period: Five months, from July 2010 to November 2010. Setting: Anatomy Department, Army Medical College, Rawalpindi. Materials & Method: Sixty volunteers of both sexes, after fulfilling the inclusion criteria, participated in this cross sectional study. They all gave written informed consent. They were divided into three equal groups according to their ages, Group A ranged in age from 18 – 29 years, Group B from 30 – 49 years, and Group C > 50 years. Punch biopsies were taken from the sun protected upper arm skin, from all volunteers, after giving local anaesthesia. Samples were stained with Hematoxylin and Eosin. They were observed under light microscope. Height of dermal papillae was measured at three random sites in each sample and mean was taken.The mean of all three groups was compared with each other and data was analyzed. Results: The mean of each sample was taken and then final mean of each group was calculated. They were then compared with each other. The mean height of dermal papillae of group A was 98.667µm, that of group B was 83.333µm and the mean height of dermal papillae in group C was 47.33µm. There was significant difference between the three groups and ‘p’-value was less than 0.5. Conclusion: At the end of this study, it was concluded that, the height of dermal papillae reduces significantly with age.

scholarly journals Age-Related Value of Anti-Mullerian Hormone

2020 ◽  
pp. 111-116
Author(s):  
Doaa Noor ◽  
Rasmiyah Al-Midhachi ◽  
Ghufran jaafar ◽  
Maysoon Sharief
Keyword(s):  
Age Groups ◽  
Negative Relationship ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Infertile Women ◽  
Age Related ◽  
Treatment Objective ◽  
The Mean ◽  
Child Hospital

Background: There is a correlation between anti-mullerian hormone (AMH) and the age when it becomes undetectable during menopause. The AMH immunoassay has been widely estimated in clinical practice to assist in reproduction and infertility treatment. Objective: To investigate the normal level of serum anti-mullerian hormone (AMH) in relation to women’s age in Basra. Patients and Methods: Cross-sectional study was carried out in Basra Maternity and Child Hospital from January 2018 to September 2019. Serum AMH levels were estimated for 975 women aged 15–50 years. They were classified into 7 age groups:15–20, 20–25, 25–30, 30–35, 35–40, 40–45 and 45–50 years. Serum AMH and FSH levels were determined by commercial enzyme-linked immunoassay. Results: Negative relationship was noticed between AMH concentration and age. The mean AMH levels for the age groups 1, 2, 3, 4, 5, 6 and 7 were 4.9 ng/ml, 4.25ng/ml, 3.27 ng/ml, 2.43ng/ml, 2.17ng/ml, 1.95ng/ml and 0.9ng/ml respectively. Conclusions: This study recorded normal levels of AMH in women in Basra. These levels can be considered for the medical treatment of infertile women. Keywords: age, anti-mullerian hormone, FSH.

Age-related changes of the corneal endothelium in a Hispanic elderly population.

2020 ◽  
Author(s):  
J Valdez-Garcia ◽  
Gustavo Ortiz-Morales ◽  
Nallely Morales-Mancillas ◽  
Jorge Luis Domene-Hickman ◽  
Julio Hernandez-Camarena ◽  
...  
Keyword(s):  
Corneal Endothelium ◽  
Corneal Thickness ◽  
Age Groups ◽  
The Elderly ◽  
Specular Microscopy ◽  
Cross Sectional ◽  
Healthy Elderly ◽  
Age Related ◽  
Significant Difference ◽  
The Mean

Abstract Purpose: To assess the corneal endothelial morphometry in healthy elderly Hispanic eyes.Methods: A retrospective, cross-sectional, observational, descriptive, and analytical study was designed to assess by specular microscopy the central region of the corneal endothelium. In a 4-year period, a total of 75 eyes from 42 patients were studied. All eyes included were from patients 65 or older (mean: 73.87±6.86), without ocular disease or surgeries.Results: The mean cell density (MCD) was 2268±597.0 cells/mm2. 44% of patients had polymegethism, with an average coefficient of variation (CV) of 42.04 ± 10.1%. 76% of patients had low pleomorphism, with an average of 42.3 ± 8.9% hexagonal cells. The mean corneal thickness was 537±38.2 μm. There was no statistically significant difference between age groups for MCD, CV, hexagonality and pachymetry (p=>.05). 27% of patients had corneal guttata.Conclusion: This study suggests that the elderly Hispanic population has a high prevalence of polymegethism, pleomorphism and guttata. Surprisingly, the oldest age group (>85) had an above average MCD, low polymegethism and good pleomorphism.

Pediatric Laryngeal Diadochokinetic Rates

2011 ◽  
Vol 146 (2) ◽  
pp. 302-306 ◽  
Author(s):  
Steve Maturo ◽  
Courtney Hill ◽  
Glenn Bunting ◽  
Cathy Ballif ◽  
Rie Maurer ◽  
...  
Keyword(s):  
English Literature ◽  
Statistical Significance ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Mean ◽  
And Gender ◽  
The Voice ◽  
Diadochokinetic Rates

Objective. Laryngeal diadochokinetic (L-DDK) rate is a measure of laryngeal neural integrity. The objectives for this study included the following: (1) establish the first comprehensive pediatric normative database for L-DDK rates (DDK) using the Voice Evaluation Suite, a computerized voice analysis program; and (2) analyze normal L-DDK rates for age and gender differences. Study Design. Cross-sectional study with planned data collection. Setting. Outpatient pediatric otolaryngology clinic. Subjects and Methods. Three hundred seven children aged 4 to 18 with normal voices. L-DDK rates were collected during a 6-month period. Main outcome measures included age, gender, and L-DDK rates. Results. Three hundred seven children (151 girls and 156 boys) were evaluated. There was no statistically significant difference between the overall mean L-DDK rate of boys (2.69 syllables/s) compared to girls (2.55 syllables/s; P > .05). Further analysis of all individual age groups did not reveal any statistical significance between boys and girls. There was a statistically significant difference among children aged 4 to 11 compared to those 12 to 18 years old. Among boys aged 4 to 11, the mean rate was 2.49 syllables per second, whereas among 12- to 18-year-olds, the rate was 2.95 syllables per second ( P < .01). The mean rate was 2.40 syllables per second among girls aged 4 to 11 and 2.74 syllables per second for those aged 12 to 18 ( P < .01). Conclusion. This is the largest normative pediatric L-DDK analysis in the English literature. The findings suggest that neurolaryngeal development approaches adult maturation at the beginning of the teenage years. These data have the potential application for objective measurement of neurolaryngeal coordination in children with neurologic impairment and also in children who have undergone nerve reinnervation procedures.

Age related volume of cadaver-prostates in Bangladesh

1970 ◽  
Vol 4 (2) ◽  
pp. 74-77
Author(s):  
Rukshana Ahmed ◽  
Shamim Ara
Keyword(s):  
Prostate Gland ◽  
Age Groups ◽  
Clinical Settings ◽  
Cross Sectional ◽  
Medical College ◽  
Age Related ◽  
Group A ◽  
Key Words Prostate ◽  
The Mean ◽  
Group B

Pathological changes in the prostate gland occur commonly with advancing age including inflammation, atrophy, hyperplasia and carcinoma and a change in volume is also evident. Estimation of volume of prostate may be useful in a variety of clinical settings. A cross-sectional descriptive study was designed to see the changes in volume of the prostate with advancing age and done in the Department of Anatomy, Dhaka Medical College, Dhaka from August 2006 to June 2007. The study was performed on 70 post-mortem human prostates collected from the unclaimed dead bodies that were under examination in the Department of Forensic Medicine, Dhaka Medical College, Dhaka. The samples were divided into three age groups; group A (10-20 years), group B (21-40 years) and group C (41-70 years). Volume of the sample was measured by using the ellipsoid formula. The mean ± SD volume of prostate was 7.68 ± 3.64 cm3 in group A, 10.61 ± 3.99 cm3 in group B and 15.40 ± 6.31 cm3 in group C. Mean difference in volume between group A and group C, group B and group C were statistically significant (p<0.001). Statistically significant positive correlation was found between age and volume of prostate (r = + 0.579, p < 0.001). Key Words: Prostate; volume; Bangladeshi. DOI: 10.3329/imcj.v4i2.6501Ibrahim Med. Coll. J. 2010; 4(2): 74-77

scholarly journals Interleukin-37 as an anti-inflammatory cytokine: does its relation to disease activity suggest its potential role in rheumatoid arthritis therapy?

2021 ◽  
Vol 48 (1) ◽  
Author(s):  
Eman A. Baraka ◽  
Mona G. Balata ◽  
Shereen H. Ahmed ◽  
Afaf F. Khamis ◽  
Enas A. Elattar
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Tender Joint ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
The Mean ◽  
Anti Inflammatory

Abstract Background This study aimed to measure the serum and synovial interleukin (IL)-37 levels in rheumatoid arthritis (RA) patients compared to patients with primary knee osteoarthritis (PKOA) and healthy controls and to detect its relation to RA disease activity. Results This cross-sectional study included 50 RA patients with a mean age of 40.24 ± 8.62 years, 50 patients with PKOA with a mean age of 56.69 ± 4.21, and 40 healthy controls with a mean age of 41.75 ± 7.38 years. The mean serum IL-37 level in the RA patients (382.6 ± 73.97 pg/ml) was statistically significantly (P < 0.001) the highest among the studied groups; however, it showed a non-significant difference between the PKOA patients (70.38 ± 27.49 pg/ml) and the healthy controls (69.97 ± 25.12 pg/ml) (P > 0.94). Both serum and synovial IL-37 levels were significantly positively correlated with disease activity scores (r = 0.92, P< 0.001 and r = 0.85, P < 0.001), tender joint counts (r = 0.83, P < 0.001 and r = 0.82, P < 0.001 ), swollen joint counts (r = 0.72, P < 0.001 and r = 0.60, P < 0.001), visual analog scale (r = 0.82, P < 0.001 and r = 0.82, P < 0.001), erythrocyte sedimentation rate (r = 0.75, P < 0.001 and r = 0.65, P < 0.001), and C-reactive protein (r = 0.93, P < 0.001 and r = 0.79, P < 0.001), respectively. Conclusion Serum and synovial IL-37 were significantly elevated in the RA patients, and they were closely correlated. Being less invasive, the serum IL-37 could be a marker of disease activity and could reflect the effective disease control by drugs. Having an anti-inflammatory effect could not suggest IL-37 as the key player to control inflammation alone, but its combination with other anti-proinflammatory cytokines could be investigated.

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