Clinical Effect of Encephabol (Pyritinol) in the Treatment of Cerebrovascular Disorders

1980 ◽  
Vol 8 (2) ◽  
pp. 118-126 ◽  
Author(s):  
Yoshiaki Tazaki ◽  
Teruo Omae ◽  
Shoshiro Kuromaru ◽  
Eiichi Ohtomo ◽  
Kazuo Hasegawa ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Clinical Effect ◽  
Cerebrovascular Disorders ◽  
Double Blind ◽  
Blind Trials

The results of a series of multicentre, controlled, double-blind trials of the clinical efficacy of Encephabol compared with placebo in patients with a variety of cerebrovascular disorders are reported.

Clinical efficacy of specific immunotherapy to cat dander: a double-blind placebo-controlled trial

1997 ◽  
Vol 27 (8) ◽  
pp. 860-867 ◽  
Author(s):  
V.A. VARNEY ◽  
J. EDWARDS ◽  
K. TABBAH ◽  
H. BREWSTER ◽  
G. MAVROLEON ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Specific Immunotherapy ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo

Placebo response in antidepressant drug trials

1994 ◽  
Vol 9 (3) ◽  
pp. 115-118 ◽  
Author(s):  
M Beneke ◽  
W Rasmus ◽  
J Fritze
Keyword(s):  
Frequency Analysis ◽  
Low Dose ◽  
Antidepressant Drug ◽  
Placebo Response ◽  
Response Patterns ◽  
Relative Efficacy ◽  
Drug Trials ◽  
Double Blind ◽  
Pooled Data ◽  
Blind Trials

SummaryResponse patterns derived from dichotomized (0/1) weekly CGI ratings conducted in antidepressant drug trials (Quitkin et al, 1984) were compared with those found in the pooled data from several randomized double-blind trials comparing the relative efficacy and tolerability low-dose flupenthixol im with that of three trieyclics (amitriptyline sr, imipramine, doxepine). Using the configurational frequency analysis (Krauth and Lienert, 1973), the postulated patterns could be rediscovered in our data apart from “early onset persistent patterns” which were less frequent in Quitkin et al's (1984) drug data. However, apart from this finding no “typical” patterns in terms of drug- or placebo-dependent response patterns could be detected in either the flupenthixol or Quitkin et al's (1984) data. It is concluded that there is little empirical evidence for the assumption of placebo- or drug related change- or response patterns. Moreover, theoretical aspects do not support the usefulness of such concepts.

scholarly journals Sex differences in prevalence of anaemia and iron deficiency in infancy in a large multi-country trial in South-East Asia

2007 ◽  
Vol 98 (5) ◽  
pp. 1070-1076 ◽  
Author(s):  
Frank T. Wieringa ◽  
Jacques Berger ◽  
Marjoleine A. Dijkhuizen ◽  
Adi Hidayat ◽  
Nguyen X. Ninh ◽  
...  
Keyword(s):  
Sex Differences ◽  
Relative Risk ◽  
East Asia ◽  
Fe Deficiency ◽  
South East Asia ◽  
Infant Feeding Practices ◽  
Lower Serum ◽  
Double Blind ◽  
Deficiency Anaemia ◽  
Blind Trials

To evaluate effects of Fe supplementation and sex on the prevalence of anaemia and Fe status in infants in South-East Asia, biochemical data from four parallel, randomized, double-blind trials with Fe and/or Zn supplementation in infants (n 2452) in Indonesia, Thailand and Vietnam was pooled. At recruitment (5 months of age), Hb concentrations were slightly but significantly lower in boy infants compared with girl infants (108·7 g/l v. 111.4 g/l, P = 0·04). At 11 months of age, boy infants not receiving Fe had significantly lower Hb (106·2 g/l v. 111.0 g/l, P < 0·001) and lower serum ferritin concentrations (14·3 μg/l v. 21.1 g/l, P < 0·001) than girl infants not receiving Fe. Consequently, boy infants had a relative risk of 1·6 (95 % CI 1·3, 2·1) to be anaemic, and of 3·3 (95 % CI 2·1, 5·0) for having Fe deficiency anaemia compared with girl infants. Fe supplementation significantly increased Hb concentrations in both boys and girls. There was no sex difference in Fe status in infants receiving Fe for 6 months. This study shows that the markedly higher risk for anaemia and Fe deficiency indicates higher Fe requirements in boy than in girl infants. In South-East Asia, standard infant feeding practices do not provide sufficient Fe to meet requirements of infants, especially boys. Current daily recommended intake for Fe in infancy is the same for boy and girl infants however. Our findings suggest that in especially the second half of infancy, Fe requirements for boy infants are approximately 0·9 mg/d higher than for girl infants.

QUESTION FOR META-ANALYSTS: CAN YOU MAKE A SILKEN PURSE OUT OF A SOW'S EAR?

PEDIATRICS ◽  
1989 ◽  
Vol 84 (4) ◽  
pp. A108-A108
Author(s):  
Student
Keyword(s):  
Rheumatoid Arthritis ◽  
Meta Analysis ◽  
Multiple Comparisons ◽  
Measurement Scales ◽  
Double Blind ◽  
New Drug ◽  
Baseline Difference ◽  
Blind Trials

Choice of dose [in 196 double-blind trials of treatments for rheumatoid arthritis], multiple comparisons, wrong calculation, sub-group and within-group analyses, wrong sampling units. . . , change in measurement scales before analyses, baseline difference, and selecting reporting of significant results were some of the verified or possible causes for the large proportion of results that favored the [newly proposed] drug. Doubtful or invalid statements were found in 76% of the conclusions or abstracts. Bias consistently favored the new drug in 81 trials, and the control in only one trial. It is not obvious how a reliable meta-analysis could be done [reliably] in these trials.

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