Fabrication and characterization of nickel oxide nanoparticles/silicon NiO NPS/Si

A freshwater microalga strain ofChlorella vulgariswas used to investigate toxic effects induced by nickel oxide nanoparticles (NiO-NPs) in suspension. Algal cells were exposed during 96 h to 0–100 mg L−1of NiO-NPs and analyzed by flow cytometry. Physicochemical characterization of nanoparticles in tested media showed a soluble fraction (free Ni2+) of only 6.42% for 100 mg L−1of NiO-NPs, indicating the low solubility capacity of these NPs. Toxicity analysis showed cellular alterations which were related to NiO-NPs concentration, such as inhibition in cell division (relative cell size and granularity), deterioration of the photosynthetic apparatus (chlorophyll synthesis and photochemical reactions of photosynthesis), and oxidative stress (ROS production). The change in cellular viability demonstrated to be a very sensitive biomarker of NiO-NPs toxicity with EC50of 13.7 mg L−1. Analysis by TEM and X-ray confirmed that NiO-NPs were able to cross biological membranes and to accumulate inside algal cells. Therefore, this study provides a characterization of both physicochemical and toxicological properties of NiO-NPs suspensions in tested media. The use of the freshwater strain ofC. vulgarisdemonstrated to be a sensitive bioindicator of NiO-NPs toxicity on the viability of green algae.

Download Full-text

Preparation and characterization of ferromagnetic nickel oxide nanoparticles from three different precursors: application in drug delivery

RSC Advances ◽

10.1039/c5ra00642b ◽

2015 ◽

Vol 5 (45) ◽

pp. 35917-35928 ◽

Cited By ~ 25

Author(s):

Jaydeep Adhikary ◽

Prateeti Chakraborty ◽

Balaram Das ◽

Arnab Datta ◽

Sandeep Kumar Dash ◽

...

Keyword(s):

Drug Delivery ◽

Nickel Oxide ◽

Drug Uptake ◽

Oxide Nanoparticles ◽

Nickel Oxide Nanoparticles ◽

E Coli ◽

Nio Nps

Erythromycin conjugated NiO-NPs successfully deliver erythromycin toE. coliandS. aureusevidenced from MIC, MBC, DAD and drug uptake.

Download Full-text

TOXIC EFFECTS ASSESSMENT OF NICKEL OXIDE NANOPARTICLES BY INHALATION

ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT ◽

10.35627/2219-5238/2018-309-12-24-30 ◽

2018 ◽

pp. 24-29 ◽

Cited By ~ 2

Author(s):

B.A. Katsnelson ◽

M.P. Sutunkova ◽

L.I. Privalova ◽

S.N. Solovjeva ◽

V.B. Gurvich ◽

...

Keyword(s):

Nickel Oxide ◽

Redox Balance ◽

Systemic Toxicity ◽

Laboratory Animals ◽

Oxide Nanoparticles ◽

Nickel Oxide Nanoparticles ◽

White Rats ◽

Liver And Kidney ◽

Stimulation Of Erythropoiesis ◽

Nio Nps

The article presents in an experiment obtained principal results based on repeated low-level inhalation exposures of laboratory animals (white rats, outbred) to nickel oxide nanoparticles with a diameter of (23 ± 5) nm, 4 hours a day, 5 times a week for up to 10 months in a «nose only» installation. It was shown that non-specific body reactions to the action of NiO NPs include: diverse manifestations of systemic toxicity with a particularly pronounced influence on liver and kidney function, redox balance, damage to some areas of brain tissue, associated with proven movement of the nanoparticles themselves from the nasal mucosa along the olfactory tract; some cytological signs of probable development for allergic syndrome; paradoxically low severity of pulmonary pathology by pneumoconiotic type explained by a small chronic delay of nanoparticles in the lungs; the genotoxic effect of the organismal level, even at those low levels of chronic exposure, at which systemic toxicity is rather poorly. Along with that, NiO NPs also induce phase-stimulation of erythropoiesis, which is relatively specific for the toxic nickel effects.

Download Full-text

The inhibitory role of synthesized Nickel oxide nanoparticles against Hep-G2, MCF-7, and HT-29 cell lines: the inhibitory role of NiO NPs against Hep-G2, MCF-7, and HT-29 cell lines

Green Chemistry Letters and Reviews ◽

10.1080/17518253.2021.1939435 ◽

2021 ◽

Vol 14 (3) ◽

pp. 443-453

Author(s):

Mohammad Amin Jadidi Kouhbanani ◽

Yasin Sadeghipour ◽

Mina Sarani ◽

Erfan Sefidgar ◽

Saba Ilkhani ◽

...

Keyword(s):

Nickel Oxide ◽

Cell Lines ◽

Oxide Nanoparticles ◽

Hep G2 ◽

Nickel Oxide Nanoparticles ◽

Inhibitory Role ◽

Nio Nps ◽

Ht 29 ◽

Mcf 7

Download Full-text

Nickel oxide nanoparticles induce genotoxicity and cellular alterations in the ground beetle Blaps polycresta (Coleoptera: Tenebrionidae)

Toxicology and Industrial Health ◽

10.1177/07482337211000988 ◽

2021 ◽

pp. 074823372110009

Author(s):

Dalia Abdel Moneim Kheirallah ◽

Awatef Mohamed Ali ◽

Salah Eldein Osman ◽

Amal Mohamed Shouman

Keyword(s):

Nickel Oxide ◽

Structural Changes ◽

Ground Beetle ◽

Biological Tissues ◽

Treated Group ◽

Sublethal Dose ◽

Oxide Nanoparticles ◽

Nickel Oxide Nanoparticles ◽

Nio Nps ◽

The Impact

Nickel nanoparticles (Ni-NPs) have advantageous applications in the industry; however, little is known of their adverse effects on biological tissues. In the present study, the ground beetle Blaps polycresta was employed as a sensitive indicator for nickel oxide nanoparticles (NiO-NPs) toxicity. Adult male beetles were injected with six dose levels of NiO-NPs (0.01, 0.02, 0.03, 0.04, 0.05, and 0.06 mg/g body weight). Mortality was reported daily over 30 days under laboratory conditions to establish an LD50. Nickel was detected in the testicular tissues of the beetles using X-ray analysis and transmission electronic microscopy. Beetles treated with the sublethal dose of 0.02 mg/g were selected to observe molecular, cellular, and subcellular changes. Gene transcripts of HSP70, HSP90, and MT1 were found to be increased >2.5-, 1.5-, and 2-fold, respectively, in the treated group compared with the controls. Decreased gene expression of AcPC01, AcPC02, and AcPC04 (≤1.5-, ≤2-, and < 2.5-fold, respectively, vs. controls) also were reported in the treated group. Under light microscopy, various structural changes were observed in the testicular tissues of the treated beetles. Ultrastructure observations using scanning and transmission electron microscopy showed severe damage to the subcellular organelles as well as deformities of the heads and flagella of the spermatozoa. Therefore, the present study postulated the impact of NiO-NPs in an ecological model.

Download Full-text

Evaluation of the Biological Activity of Nickel Oxide Nanoparticles as Antibacterial and Anticancer Agents

Iraqi Journal of Science ◽

10.24996/ijs.2020.61.11.12 ◽

2020 ◽

pp. 2888-2896

Author(s):

Maha Fakhry Altaee ◽

Laith A. Yaaqoob ◽

Zaid K. Kamona

Keyword(s):

Antibacterial Activity ◽

Nickel Oxide ◽

Cell Lines ◽

Cancer Cell ◽

Anticancer Agents ◽

Cancer Cell Lines ◽

Oxide Nanoparticles ◽

Caspase 9 ◽

Nickel Oxide Nanoparticles ◽

Nio Nps

In the present study, nickel oxide nanoparticles (NiO NPs) were evaluated as an antibacterial and anticancer agent. The nanoparticles of nikel oxide were synthesized using aloe vera leaves extract and characterized with AFM (showing an average diameter of 45.11 nm), XRD and FE-SEM analyses. Three different concentrations (125, 250 and 500 µg/ml) were prepared from the synthesized NiO NPs and investigated for their potential antibacterial activity against both Enterococcus faecalis (Gram-positive bacteria) and Acinobacter baumannii (Gram-negative bacteria). While cytotoxicity and apoptotic activity were measured on both MCF-7 and AMJ13 cancer cell lines by MTT and caspase-9 luminescence assays. The results showed that NiO NPs inhibit bacterial growth, as indicated by large inhibition zones against both tested bacteria, with all studied concentrations. Moreover, the results of cytotoxicity and caspase-9 activity assays were in concordance with those of antibacterial activity, showing high cytotoxicity and apoptotic effects against both of the studied cancer cell lines and with all the tested concentrations of NiO NPs. Both the antibacterial and anticancer activities of NiO NPs were dose-dependent.

Download Full-text

Spectroscopic, Structural, and Morphology of Nickel Oxide Nanoparticles Prepared Using Physalis angulata Leaf Extract

Materials Science Forum ◽

10.4028/www.scientific.net/msf.917.167 ◽

2018 ◽

Vol 917 ◽

pp. 167-171 ◽

Cited By ~ 9

Author(s):

Najmawati Sulaiman ◽

Yoki Yulizar

Keyword(s):

Electron Microscopy ◽

Particle Size ◽

Nickel Oxide ◽

Band Gap ◽

Leaf Extract ◽

Optical Band Gap ◽

Oxide Nanoparticles ◽

Nickel Oxide Nanoparticles ◽

Microscopic Studies ◽

Nio Nps

Green synthesis of nickel oxide nanoparticles (NiO NPs) usingPhysalisangulataleaf extract (PALE) as weak base sources and stabilizing agents has been reported. Chemical bonding and vibration spectroscopy, crystallographic structure, optical band gap, particle size and microscopic studies of NiO NPs were also investigated. Ni-O vibration modes of NiO NPs were analyzed by FTIR and Raman instrument at ~400 and ~900 cm-1wavenumber. XRD pattern of NiO NPs confirmed cubic crystal structure with space groupFm-3m.Optical band gap of NiO NPs determined by using Tauc plot method was about 3.42 eV. Particle size analyzer showed size distribution of NiO NPs was 64.13 nm which confirm NiO formed in nanoscale. Electron microscopic studies of NiO NPs were observed by using scanning electron microscopy and transmission electron microscopy.

Download Full-text