The Preterm Prediction Study: The value of serum alkaline phosphatase, α-fetoprotein, plasma corticotropin-releasing hormone, and other serum markers for the prediction of spontaneous preterm birth

2002 ◽  
Vol 186 (5) ◽  
pp. 990-996 ◽  
Author(s):  
Atef H. Moawad ◽  
Robert L. Goldenberg ◽  
Brian Mercer ◽  
Paul J. Meis ◽  
Jay D. Iams ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Preterm Birth ◽  
Serum Alkaline Phosphatase ◽  
Serum Markers ◽  
Corticotropin Releasing Hormone ◽  
Spontaneous Preterm Birth ◽  
Releasing Hormone

Lack of association between two polymorphisms in the corticotropin-releasing hormone gene promoter and preterm birth in a Hispanic population

2012 ◽  
Vol 118 (2) ◽  
pp. 173-174
Author(s):  
Laura Diaz-Cueto ◽  
Pablo Dominguez-Lopez ◽  
Claudia Cordoba-Zavala ◽  
Patricia Casas-Gonzalez ◽  
Fabian Arechavaleta-Velasco
Keyword(s):  
Preterm Birth ◽  
Gene Promoter ◽  
Hispanic Population ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Predicting Risk of Preterm Birth: The Roles of Stress, Clinical Risk Factors, and Corticotropin-Releasing Hormone

2002 ◽  
Vol 4 (1) ◽  
pp. 54-64 ◽  
Author(s):  
R. Jeanne Ruiz ◽  
Judith Fullerton ◽  
Charles E. L. Brown ◽  
Donald J. Dudley
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Perceived Stress ◽  
Gestational Age ◽  
Maternal Plasma ◽  
Clinical Risk Factors ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Clinical Risk ◽  
Prospective Longitudinal

The relationships and predictive abilities of perceived stress, selected clinical risk factors, and corticotropin-releasing hormone (CRH) levels in maternal plasma were investigated for their association with preterm labor (PTL), preterm birth, and gestational age at delivery. An exploratory, prospective, longitudinal research design was used to measure CRH 4 times over pregnancy, perceived stress at 24 and 32 weeks of pregnancy, clinical risk factors, and genitourinary infections in low-income women. Multiple regression analyses revealed that a model of measurement of perceived stress at 24 or 32 weeks, CRH at 24 or 32 weeks, and PTL (indicated by a diagnosis by the physicians on the medical record and greater than 5 contractions per hour on the fetal monitor) was predictive of as much as 0.23 to 0.27 of the variance in gestational age at birth. Entering ethnicity as a variable into a model did not improve the predictive value. An analysis of variance between Caucasian and Hispanic ethnic groups revealed differences in CRH levels. However, simple regression analysis of ethnicity as a predictor showed a weak r 2 with no significance for prediction. There was some evidence of an association of smoking with stress and both PTL and preterm birth. The measurement of stress combined with the measurement of CRH from maternal plasma may improve the prediction of which pregnant women are at risk for preterm birth. The measurement of CRH has potential as an early biological marker of preterm birth.

The contemporary value of dedicated preterm birth clinics for high-risk singleton pregnancies: fifteen-year outcomes from a leading maternal centre

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Wallace Jin ◽  
Kelly Hughes ◽  
Shirlene Sim ◽  
Scott Shemer ◽  
Penelope Sheehan
Keyword(s):  
Preterm Birth ◽  
High Risk ◽  
Serum Alkaline Phosphatase ◽  
Conclusive Evidence ◽  
Primary Data ◽  
Spontaneous Preterm Birth ◽  
Short Cervix ◽  
Fetal Fibronectin ◽  
Retrospective Audit ◽  
Singleton Pregnancies

Abstract Objectives Preterm birth clinics provide dedicated obstetric care to women at high risk of spontaneous preterm birth (SPTB). There remains a lack of conclusive evidence to support the overall utility of such clinics, attributable to a paucity and heterogeneity of primary data. This study audits Australia’s largest and oldest dedicated preterm birth clinic with the aim to add primary data to the area and offer opportunities for similar clinics to align practice. Methods A retrospective audit of referrals to the Preterm Labour Clinic at the Royal Women’s Hospital, Melbourne, Australia, between 2004 and 2018 was conducted. 1,405 singleton pregnancies met inclusion criteria. The clinic’s key outcomes, demographics, predictive tests and interventions were analysed. The primary outcomes were SPTB before 37, 34 and 30 weeks’ gestation. Results The overall incidence of SPTB in the clinic was 21.2% (n=294). Linear regression showed reductions in the adjusted rates of overall SPTB and pre-viable SPTB (delivery <24 weeks) from 2014 (108%; 8%) to 2018 (65%; 2% respectively). Neonatal morbidity and post-delivery intensive care admission concurrently declined (p=0.02; 0.006 respectively). Rates of short cervix (cervical length <25 mm) increased over time (2018: 30.9%) with greater uptake of vaginal progesterone for treatment. Fetal fibronectin, mid-trimester short cervix, and serum alkaline phosphatase were associated with SPTB on logistic regression. Conclusions Dedicated preterm birth clinics can reduce rates of SPTB, particularly deliveries before 24 weeks’ gestation, and improve short-term neonatal outcomes in pregnant women at risk of preterm birth.

Vitamin D and corticotropin-releasing hormone in term and preterm birth: potential contributions to preterm labor and birth outcome

2017 ◽  
Vol 31 (21) ◽  
pp. 2911-2917 ◽  
Author(s):  
Sara A. Mohamed ◽  
Abdeljabar El Andaloussi ◽  
Ayman Al-Hendy ◽  
Ramkumar Menon ◽  
Faranak Behnia ◽  
...  
Keyword(s):  
Vitamin D ◽  
Preterm Birth ◽  
Preterm Labor ◽  
Birth Outcome ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

scholarly journals A Polymorphism of the Corticotropin-Releasing Hormone Receptor 2 (CRHR2) and Preterm Birth

2010 ◽  
Vol 28 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Maximilian Schmid ◽  
Christoph Grimm ◽  
Heinz Leipold ◽  
Martin Knöfler ◽  
Peter Haslinger ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Hormone Receptor ◽  
Case Group ◽  
Genotype Distribution ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Significant Difference ◽  
Gestational Age At Delivery ◽  
Caucasian Women ◽  
Dose Dependent

Our aim was to investigate whether a genetic variation in the corticotropin-releasing hormone receptor 2 gene might be associated with preterm birth. In this case-control study we evaluated the G/A polymorphism (rs2267717) in intron 2 of the corticotropin-releasing hormone receptor 2 gene in one hundred women with preterm birth and one hundred healthy women with at least one uncomplicated full term pregnancy and no history of preterm birth. No significant correlation was found between the presence of the investigated polymorphism and preterm birth (p= 0.9, odds ratio 0.9 [Confidence interval 0.5–1.7]). A dose dependent association of the investigated polymorphism, in women with preterm birth, with gestational age at delivery (p= 0.003) and birth weight was observed (p= 0.0001). However, no association between IUGR (n=10) with either one of the investigated genotypes (p= 0.3) was found. Stratified analysis within case group (i.e. PPROM vs. non-PPROM) revealed no significant difference in genotype distribution (p= 0.6). In conclusion, the investigated polymorphism does not increase the risk for preterm birth overall but might modulate the length of pregnancy in a dose dependent fashion in a series of Caucasian women.

Sign in / Sign up

Export Citation Format

Share Document