scholarly journals Pyrrolid-2-One-5-Carboxylic Acid as an N-Terminal Group of the Low-Sulphur Proteins of Wool

1968 ◽  
Vol 21 (6) ◽  
pp. 1327 ◽  
Author(s):  
IJ O'donnell
Keyword(s):  
Carboxylic Acid ◽  
Terminal Group ◽  
Enzymic Digestion

The detection of N-terminal pyrrolid-2-one-5-carboxylic acid (pyroglutamyl) residues in proteins is complicated by the ready formation of pyroglutamyl peptides from peptides with N-terminal glutaminyl residues which may be liberated during enzymic digestion of proteins. Recently, several methods for overcoming these problems have been described (Ikenaka et al. 1966; Wilkinson, Press, and Porter 1966; Doolittle and Armentrout 1968) and this communication describes the results obtained when two of these methods were applied to com~onent 8, one of the two major low-sulphur proteins extracted from reduced and carboxymethylated wool (Thompson and O'Donnell 1967)

Surface chemistry at the solid–solid interface: mechanically induced reaction pathways of C8 carboxylic acid monolayers on copper

2021 ◽  
Author(s):  
Resham Rana ◽  
Robert Bavisotto ◽  
Kaiming Hou ◽  
Wilfred T. Tysoe
Keyword(s):  
Carboxylic Acid ◽  
Surface Chemistry ◽  
Terminal Group ◽  
Reaction Pathways ◽  
Solid Interface ◽  
Induced Reaction

The rate of mechanochemical decomposition of C8-carboxylates on copper was found to be independent of the nature of the terminal group despite differences in the strength of binding to the moving counterface.

Influence of the Nature and Orientation of the Terminal Group on the Tribochemical Reaction Rates of Carboxylic Acid Monolayers on Copper

2021 ◽  
Vol 70 (1) ◽  
Author(s):  
Resham Rana ◽  
Robert Bavisotto ◽  
Kaiming Hou ◽  
Nicholas Hopper ◽  
Wilfred T. Tysoe
Keyword(s):  
Carboxylic Acid ◽  
Reaction Rates ◽  
Terminal Group ◽  
Tribochemical Reaction

Amino acid sequence of basic acrosin inhibitor from bull seminal plasma

1979 ◽  
Vol 44 (9) ◽  
pp. 2710-2721 ◽  
Author(s):  
Bedřich Meloun ◽  
Dana Čechová
Keyword(s):  
Molecular Weight ◽  
Amino Acid ◽  
Carboxylic Acid ◽  
Amino Acid Sequence ◽  
Seminal Plasma ◽  
Terminal Group ◽  
Sequential Data ◽  
Amino Acid Residues ◽  
Pyrrolidone Carboxylic Acid

The molecule of the inhibitor contains 57 amino acid residues whose sequence is the following: Pyr-Gly-Ala-Gln-Val-Asp-Cys-Ala-Glu-Phe-Lys-Asp-Pro-Lys-Val-Tyr-Cys-Thr-Arg-His-Ser-Asp-Pro-Gln-Cys-Gly-Ser-Asn-Gly-Glu-Thr-Tyr-Gly-Asn-Lys-Cys-Ala-Phe-Cys-Lys-Ala-Val-Met-Lys-Ser-Gly-Gly-Lys-Ile-Asn-Leu-Lys-His-Arg-Gly-Cys-Lys. The N-terminal group of the inhibitor is pyrrolidone carboxylic acid. The sequential data were obtained by analyses of peptides isolated from tryptic and chymotryptic digests of the oxidized or carboxymethylated inhibitor. The molecular weight of the inhibitor is 6 200.

Fibrinolytic Activity of Cerebro-Spinal Fluid and the Development of Artificial Cerebral Haematomas in Dogs

1969 ◽  
Vol 21 (02) ◽  
pp. 294-303 ◽  
Author(s):  
H Mihara ◽  
T Fujii ◽  
S Okamoto
Keyword(s):  
Cerebrospinal Fluid ◽  
Carboxylic Acid ◽  
Fibrinolytic Activity ◽  
Clinical Implications ◽  
Trans Form ◽  
Plate Method ◽  
Blood Samples ◽  
Fibrin Plate ◽  
The Brain

SummaryBlood was injected into the brains of dogs to produce artificial haematomas, and paraffin injected to produce intracerebral paraffin masses. Cerebrospinal fluid (CSF) and peripheral blood samples were withdrawn at regular intervals and their fibrinolytic activities estimated by the fibrin plate method. Trans-form aminomethylcyclohexane-carboxylic acid (t-AMCHA) was administered to some individuals. Genera] relationships were found between changes in CSF fibrinolytic activity, area of tissue damage and survival time. t-AMCHA was clearly beneficial to those animals given a programme of administration. Tissue activator was extracted from the brain tissue after death or sacrifice for haematoma examination. The possible role of tissue activator in relation to haematoma development, and clinical implications of the results, are discussed.

Stereospecific, Palladium-catalyzed C(sp3)–H Alkenylation and Alkynylation of a Proline Derivative Enabled by 8-Aminoquinoline as a Directing Group

2020 ◽  
Author(s):  
Aleksandra Balliu ◽  
Aaltje Roelofje Femmigje Strijker ◽  
Michael Oschmann ◽  
Monireh Pourghasemi Lati ◽  
Oscar Verho
Keyword(s):  
Carboxylic Acid ◽  
Building Blocks ◽  
Wide Range ◽  
Palladium Catalyzed ◽  
Directing Group ◽  
High Yields ◽  
Vinyl Iodides ◽  
Initial Results

<p>In this preprint, we present our initial results concerning a stereospecific Pd-catalyzed protocol for the C3 alkenylation and alkynylation of a proline derivative carrying the well utilized 8‑aminoquinoline directing group. Efficient C–H alkenylation was achieved with a wide range of vinyl iodides bearing different aliphatic, aromatic and heteroaromatic substituents, to furnish the corresponding C3 alkenylated products in good to high yields. In addition, we were able show that this protocol can also be used to install an alkynyl group into the pyrrolidine scaffold, when a TIPS-protected alkynyl bromide was used as the reaction partner. Furthermore, two different methods for the removal of the 8-aminoquinoline auxiliary are reported, which can enable access to both <i>cis</i>- and <i>trans</i>-configured carboxylic acid building blocks from the C–H alkenylation products.</p>

Ketones from Nickel-Catalyzed Decarboxylative, Non-Symmetric Cross-Electrophile Coupling of Carboxylic Acid Esters

2019 ◽  
Author(s):  
Jiang Wang ◽  
Brian P. Cary ◽  
Peyton Beyer ◽  
Samuel H. Gellman ◽  
Daniel Weix
Keyword(s):  
Carboxylic Acid ◽  
Solid Support ◽  
Reaction Conditions ◽  
Decarboxylative Coupling ◽  
New Strategy ◽  
The Cross ◽  
Acyl Donors ◽  
Acid Esters

A new strategy for the synthesis of ketones is presented based upon the decarboxylative coupling of N-hydroxyphthalimide (NHP) esters with S-2-pyridyl thioesters. The reactions are selective for the cross-coupled product because NHP esters act as radical donors and the thioesters act as acyl donors. The reaction conditions are general and mild, with over 40 examples presented, including larger fragments and the 20-mer peptide Exendin(9-39) on solid support.

Harnessing Applied Potential: The Anti-Markovnikov Hydrocarboxylation of Substituted Olefins

2019 ◽  
Author(s):  
Anas Alkayal ◽  
Volodymyr Tabas ◽  
Andrei V. Malkov ◽  
Benjamin Buckley
Keyword(s):  
Carboxylic Acid ◽  
Applied Potential ◽  
Markovnikov Addition

<div>The construction of carboxylic acid compounds in a selective fashion, from low value materials such as alkenes remains a long-standing challenge to synthetic chemists. In particular, anti-Markovnikov addition to styrenes are underdeveloped. Herein we report a new electrosynthetic approach to the selective hydrocarboxylation of substituted alkenes.</div>

Harnessing Applied Potential: The Anti-Markovnikov Hydrocarboxylation of Substituted Olefins

2019 ◽  
Author(s):  
Anas Alkayal ◽  
Volodymyr Tabas ◽  
Andrei V. Malkov ◽  
Benjamin Buckley
Keyword(s):  
Carboxylic Acid ◽  
Applied Potential ◽  
Markovnikov Addition

<div>The construction of carboxylic acid compounds in a selective fashion, from low value materials such as alkenes remains a long-standing challenge to synthetic chemists. In particular, anti-Markovnikov addition to styrenes are underdeveloped. Herein we report a new electrosynthetic approach to the selective hydrocarboxylation of substituted alkenes.</div>

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