scholarly journals Insulin Affects Glucose Uptake by Muscle and Mammary Tissues of Lactating Ewes

1988 ◽  
Vol 41 (4) ◽  
pp. 453 ◽  
Author(s):  
D Leenanuruksa ◽  
P Niumsup ◽  
GH McDowell
Keyword(s):  
Skeletal Muscle ◽  
Insulin Secretion ◽  
Continuous Infusion ◽  
Plasma Glucose ◽  
Intravenous Infusion ◽  
Mammary Tissue ◽  
Continuous Intravenous Infusion ◽  
Short Term ◽  
Exogenous Glucose ◽  
Frequent Monitoring

Effects of insulin on exchanges of glucose across skeletal muscle and mammary tissue were measured in short-term studies in lactating ewes. Insulin secretion was suppressed by a primed/continuous infusion of somatostatin, then insulin was administered by continuous intravenous infusion of doses that were increased, in a step-wise manner, from 0 to 2 U h -I. Plasma glucose was maintained essentially constant by frequent monitoring and intravenous administration of exogenous glucose.

PROLONGED INTRAVENOUS INFUSION OF LABELLED IODOCOMPOUNDS IN THE RAT: [125I]IODIDE METABOLISM AND EFFECTS OF MODERATE DIETARY IODINE DEFICIENCY

1979 ◽  
Vol 82 (2) ◽  
pp. 227-234 ◽  
Author(s):  
VIPA BOONNAMSIRI ◽  
J. C. KERMODE ◽  
B. D. THOMPSON
Keyword(s):  
Skeletal Muscle ◽  
Iodine Deficiency ◽  
Intravenous Infusion ◽  
Structure And Function ◽  
Continuous Intravenous Infusion ◽  
Close Approximation ◽  
Faecal Excretion ◽  
And Function ◽  
Layer Chromatography ◽  
Secretion Rates

SUMMARY Radio-iodide was administered by prolonged continuous intravenous infusion to rats maintained under iodine-replete conditions and in moderate iodine deficiency. A close approximation to equilibrium labelling was thereby achieved. Labelled iodocompounds extracted from various tissues were analysed by thin-layer chromatography. Moderate iodine deficiency resulted in a slight increase in the ratio of mono-iodotyrosine to di-iodotyrosine in the thyroid. No change in the ratio of tri-iodothyronine (T3) to thyroxine (T4) was found in thyroid, plasma or skeletal muscle. Faecal excretion of T3 declined appreciably relative to that of T4. Under iodine-replete conditions the ratio of thyroidal secretion rates of T3 and T4 was estimated to be more than three times higher than the ratio of these iodocompounds within the thyroid. Heterogeneity of thyroglobulin structure and function may explain these observations.

scholarly journals Prolonged Cefoxitin Infusion Using Mobile Elastomeric Infusors In Outpatients With Bone And Joint Infection

2018 ◽  
Vol 3 (4) ◽  
pp. 182-186 ◽  
Author(s):  
Zoé Cavalli ◽  
Agathe Becker ◽  
Alexie Bosch ◽  
Anne Conrad ◽  
Claire Triffault-Filit ◽  
...  
Keyword(s):  
Continuous Infusion ◽  
Intravenous Infusion ◽  
Joint Infection ◽  
Continuous Intravenous Infusion ◽  
Reference Center ◽  
Bone And Joint Infection ◽  
The Stability ◽  
Regional Reference

Abstract. We reviewed all outpatients with bone and joint infection treated with cefoxitin in continuous intravenous infusion using mobile elastomeric infusors in our regional reference center between 2014 and 2017. The stability of cefoxitin provides an interesting and well-tolerated alternative for continuous infusion in outpatients with polymicrobial bone and joint infection.

CONTINUOUS INTRAVENOUS INFUSION IN THE RAT, AND THE EFFECT ON THE ISLETS OF LANGERHANS OF THE CONTINUOUS INFUSION OF GLUCOSE

1954 ◽  
Vol 32 (4) ◽  
pp. 428-433 ◽  
Author(s):  
B. Kinash ◽  
R. E. Haist
Keyword(s):  
Body Weight ◽  
Continuous Infusion ◽  
Islets Of Langerhans ◽  
Intravenous Infusion ◽  
Continuous Intravenous Infusion ◽  
Islet Tissue ◽  
Pancreas Weight

A method is described for the continuous intravenous infusion of fluids in the unanesthetized rat. When rats were infused continuously with glucose solutions for 6–14 days the total amount of islet tissue was greatly increased, as compared to that of saline-infused controls. This increase was evident also when considered in relation to pancreas weight or body weight.

Continuous infusion anaesthesia in baboons with alphaxolone-alphadolone

1983 ◽  
Vol 17 (3) ◽  
pp. 196-197 ◽  
Author(s):  
J. H. Cookson ◽  
F. J. Mills
Keyword(s):  
Continuous Infusion ◽  
Intravenous Infusion ◽  
Cumulative Effect ◽  
Uneventful Recovery ◽  
Continuous Intravenous Infusion ◽  
Rapid Induction

39 experiments were carried out in baboons using continuous intravenous infusion of alphaxalone-alphadolone as an anaesthetic for periods of up to 6 h. This steroid anaesthetic was found to be safe and reliable, with smooth, rapid induction, uneventful recovery, and no evidence of cumulative effect.

scholarly journals A simple technique for continuous intravenous infusion under neuroleptic tranquillization

1976 ◽  
Vol 10 (1) ◽  
pp. 69-72 ◽  
Author(s):  
H. Saarni ◽  
J. Viikari
Keyword(s):  
Continuous Infusion ◽  
Intravenous Infusion ◽  
Simple Technique ◽  
Continuous Intravenous Infusion ◽  
Tail Vein

A lateral tail vein of the rat is used as the route for continuous infusion. The animal is kept under neuroleptic tranquilisation during the infusion.

scholarly journals Effect of short-term GH and testosterone administration on body composition and glucose homoeostasis in men receiving chronic glucocorticoid therapy

2013 ◽  
Vol 168 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Oskar Ragnarsson ◽  
Morton G Burt ◽  
Ken K Y Ho ◽  
Gudmundur Johannsson
Keyword(s):  
Skeletal Muscle ◽  
Plasma Glucose ◽  
Combined Treatment ◽  
Cell Mass ◽  
Postprandial Glucose ◽  
Skeletal Muscle Atrophy ◽  
Short Term ◽  
Open Label ◽  
Short Term Treatment ◽  
Glucose Homoeostasis

ObjectiveLong-term pharmacological glucocorticoid (GC) therapy leads to skeletal muscle atrophy and weakness. The objective of this study was to investigate whether short-term treatment with GH and testosterone (T) can increase lean mass without major impairment of glucose homoeostasis in patients on GC therapy.Design, materials and methodsThis was a prospective, open-label, randomised, crossover study. Twelve men (age 74±6 years) on chronic GC treatment participated. The effects of 2 weeks' treatment with GH, testosterone and the combination of both on lean body mass (LBM), appendicular skeletal muscle mass (ASMM), extracellular water (ECW), body cell mass (BCM) and plasma glucose concentrations were investigated.ResultsLBM increased significantly after GH (Δ1.7±1.4 kg;P=0.007) and GH+testosterone (Δ2.4±1.1 kg;P=0.003), but not testosterone alone. ASMM increased after all three treatment periods; by 1.0±0.8 kg after GH (P=0.005), 1.7±0.4 kg after GH+testosterone (P=0.002) and 0.8±1.0 kg after testosterone (P=0.018). The increase in ASMM was larger with combined treatment than either GH or testosterone alone (P<0.05). ECW increased significantly after GH+testosterone by 1.5±2.6 l (P=0.038) but not after GH or testosterone alone. BCM increased slightly after single and combined treatments, but the changes were not significant. Fasting glucose increased significantly after GH (Δ0.4±0.4 mmol/l,P=0.006) while both fasting (Δ0.2±0.3 mmol/l,P=0.045) and post glucose-load (Δ1.8±2.3 mmol/l,P=0.023) plasma glucose concentrations increased after GH+testosterone.ConclusionsGH and testosterone induce favourable and additive body compositional changes in men on chronic, low-dose GC treatment. In the doses used, combination therapy increases fasting and postprandial glucose concentration.

scholarly journals Gastro-intestinal Tract Function in Sheep Infused with Somatostatin

1985 ◽  
Vol 38 (4) ◽  
pp. 393 ◽  
Author(s):  
TN Barry ◽  
GJ Faichney ◽  
Carolyn Redekopp
Keyword(s):  
Continuous Infusion ◽  
Intravenous Infusion ◽  
Dry Matter ◽  
Intestinal Tract ◽  
Sampling Procedure ◽  
Continuous Intravenous Infusion ◽  
Tract Function ◽  
Pelleted Diet ◽  
Gastro Intestinal Tract

The effect of a 5-day continuous intravenous infusion of somatostatin (4�6 ng min- I kg-I) was studied, using anoestrous ewes given 791 g dry matter per day of a 60: 40 lucerne hay: oat grain pelleted diet from a continuously moving belt. 5ICr-EDTA, I03Ru-phenanthroline and lignin were used as markers to determine digesta mean retention times (MRT) by a continuous infusion-total sampling procedure.

A new system for continuous intravenous infusion of pigs

1996 ◽  
Vol 30 (1) ◽  
pp. 75-78 ◽  
Author(s):  
D. J. van Kleef
Keyword(s):  
Continuous Infusion ◽  
Psychological Stress ◽  
Intravenous Infusion ◽  
Cost Effective ◽  
Continuous Intravenous Infusion ◽  
Restricted Movement ◽  
Physical Discomfort ◽  
Infusion Tube ◽  
New System

The swivel system described has been used by ILOB-TNO for prolonged periods of continuous infusion. It allows for less restricted movement of animals. The swivel prevents the infusion tube from twisting. The swivel system is simple, safe to operate and cost-effective. Animals have greater movement, can stretch and turn around. The physical discomfort and psychological stress of restricted movement are greatly reduced. The potentially complicating/confusing effects on the measurements taken during an experiment are reduced.

Effects of prolonged administration of a β-agonist drug, ritodrine, on cardiovascular, metabolic and endocrine responses to adrenaline in growing ram lambs

1993 ◽  
Vol 120 (1) ◽  
pp. 121-128 ◽  
Author(s):  
J. M. Bassett
Keyword(s):  
Heart Rate ◽  
Plasma Glucose ◽  
Plasma Concentrations ◽  
Continuous Intravenous Infusion ◽  
Plasma Growth Hormone ◽  
Prolonged Administration ◽  
Short Term ◽  
Endogenous Catecholamines ◽  
Ram Lambs ◽  
Β Receptor

SUMMARYFive Suffolk crossbred ram lambs were administered ritodrine, a β2-agonist drug, by continuous intravenous infusion at 0·5 μg/kg per min for 9 days to determine effects of prolonged β-agonist infusion on metabolism and on the responsiveness of the animals to short-term infusions of adrenaline. Consistent with other investigations, this study showed that initially the drug caused rapid increases in heart rate and plasma concentrations of free fatty acids (FFA), lactate and insulin, but decreased plasma growth hormone. There was no effect on plasma glucose or pancreatic glucagon concentrations. After 24 h of ritodrine infusion, these effects were attenuated as tachyphylaxis to the drug developed. On days 2–9 of the infusion, heart rate remained significantly higher than preinfusion values, but plasma glucose concentration was significantly lower than before infusion. Despite the rapid disappearance of these ‘side-effects’ of the drug and the apparent normality of most metabolic parameters, short-term infusion of adrenaline (50 ng/kg per min for 60 min then 500 ng/kg per min for a further 60 min) after 9 days of ritodrine infusion showed that the responses of lactate, FFA and heart rate to adrenaline were significantly attenuated in comparison with the responses determined before β-agonist infusion. This result, together with similar earlier observations on fetal lambs, implies that selective attenuation of β-receptor mediated cardiovascular, metabolic and endocrine responses to the endogenous catecholamines could play an important role in determining how β-agonist drugs act to modify carcass development.

Protein synthesis and RNA in tissues of the pig

1976 ◽  
Vol 230 (4) ◽  
pp. 1108-1112 ◽  
Author(s):  
PJ Garlick ◽  
TL Burk ◽  
RW Swick
Keyword(s):  
Skeletal Muscle ◽  
Protein Synthesis ◽  
Metabolic Rate ◽  
Protein Content ◽  
Intravenous Infusion ◽  
Whole Body ◽  
Continuous Intravenous Infusion ◽  
Visceral Organs ◽  
Fractional Rate ◽  
Rna Concentration

The rate of protein synthesis in 75-kg pigs was measured by continuous intravenous infusion of [14C]tyrosine. In the whole body, over 600 g of protein were synthesized each day. In pigs, rats, and man the rate of protein synthesis in the whole body was related to metabolic rate. The fractional rate of synthesis of protein in the tissues was also measured. The proteins of visceral organs (liver kidney, lung, and spleen) were renewed at rates close to 20% per day, those of brain at 8% per day, heart 7% per day, and skeletal muscle 4% per day. A significant correlation was observed between the fractional rate of protein synthesis in the tissue and RNA concentration. Calculation of the total amount of protein synthesized in skeletal muscle of the pig (fractional rate of synthesis X protein content) shows that muscle contributes 42% of whole-body synthesis. By contrast, in the rat only 19% of whole-body synthesis occurs in muscle.

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