A Two-Stage Continuous-Flow Synthesis of Spirooxazine Photochromic Dyes
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A continuous-flow process for the synthesis of several known and previously unreported spirooxazine photochromic dyes is reported. The process proceeds via an initial copper catalysed addition of substituted anilines to naphthalene-1,2-dione. This is followed by reaction with 1,3,3-trimethyl-2-methyleneindoline in the presence of hydroxylamine hydrochloride to give the desired spirooxazine products. The photochromic dyes were then cast into lenses to allow a preliminary evaluation of their properties.
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2017 ◽
Vol 2
(2)
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pp. 149-158
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2016 ◽
Vol 20
(2)
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pp. 199-203
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Continuous Flow Process for Reductive Deoxygenation of ω-Chloroketone in the Synthesis of Vilazodone
2018 ◽
Vol 22
(8)
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pp. 1022-1028
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2018 ◽
Vol 190
(5)
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Keyword(s):
2019 ◽
Vol 23
(5)
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pp. 1069-1077
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