scholarly journals Continuous Flow Synthesis of Propofol

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7183
Author(s):  
Romain Mougeot ◽  
Philippe Jubault ◽  
Julien Legros ◽  
Thomas Poisson
Keyword(s):  
Intensive Care ◽  
Intensive Care Medicine ◽  
Continuous Flow ◽  
Intravenous Anesthesia ◽  
Flow Process ◽  
Short Acting ◽  
Flow Synthesis ◽  
Step Procedure ◽  
Continuous Flow Process

Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol—also known as Propofol—a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel–Crafts alkylation followed by a decarboxylation step, both under continuous flow.

Continuous flow synthesis of amine oxides by oxidation of tertiary amines

2019 ◽  
Vol 4 (7) ◽  
pp. 1270-1276
Author(s):  
Tobias Baumeister ◽  
Stefan Zikeli ◽  
Hannes Kitzler ◽  
Paul Aigner ◽  
Piotr P. Wieczorek ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Continuous Flow ◽  
Tertiary Amines ◽  
Flow Process ◽  
Flow Synthesis ◽  
Amine Oxides ◽  
Continuous Flow Process

An efficient, safe and scalable continuous flow process for the synthesis of amine oxides with hydrogen peroxide is described.

Continuous-Flow Synthesis of (–)-Oseltamivir Phosphate (Tamiflu)

Synlett ◽  
2020 ◽  
Vol 31 (19) ◽  
pp. 1925-1929 ◽  
Author(s):  
Paul Watts ◽  
Cloudius R. Sagandira
Keyword(s):  
Residence Time ◽  
Continuous Flow ◽  
Shikimic Acid ◽  
Flow Process ◽  
Flow Synthesis ◽  
Continuous Flow Process ◽  
The Individual ◽  
Total Residence Time ◽  
Oseltamivir Phosphate

Herein the anti-influenza drug (–)-oseltamivir phosphate is prepared in continuous flow from ethyl shikimate with 54% overall yield over nine steps and total residence time of 3.5 min from the individual steps. Although the procedure involved intermediate isolation, the dangerous azide chemistry and intermediates involved were elegantly handled in situ. It is the first continuous-flow process for (–)-oseltamivir phosphate involving azide chemistry and (–)-shikimic acid as precursor.

A Two-Stage Continuous-Flow Synthesis of Spirooxazine Photochromic Dyes

2013 ◽  
Vol 66 (2) ◽  
pp. 172 ◽  
Author(s):  
Mark York ◽  
Adriana Edenharter
Keyword(s):  
Continuous Flow ◽  
Hydroxylamine Hydrochloride ◽  
Preliminary Evaluation ◽  
Substituted Anilines ◽  
Two Stage ◽  
Flow Process ◽  
Flow Synthesis ◽  
Continuous Flow Process

A continuous-flow process for the synthesis of several known and previously unreported spirooxazine photochromic dyes is reported. The process proceeds via an initial copper catalysed addition of substituted anilines to naphthalene-1,2-dione. This is followed by reaction with 1,3,3-trimethyl-2-methyleneindoline in the presence of hydroxylamine hydrochloride to give the desired spirooxazine products. The photochromic dyes were then cast into lenses to allow a preliminary evaluation of their properties.

A Continuous Flow Process for LSN647712 via Double Organometallic Additions to Dimethylcarbamyl Chloride

2021 ◽  
Author(s):  
Hui Li ◽  
Jillian W. Sheeran ◽  
David Kouvchinov ◽  
Andrew M. Clausen ◽  
Ian T. Crouch ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process

Assessing inter- and intramolecular continuous-flow strategies towards methylphenidate (Ritalin) hydrochloride

2017 ◽  
Vol 2 (2) ◽  
pp. 149-158 ◽  
Author(s):  
Romaric Gérardy ◽  
Marc Winter ◽  
Alessandra Vizza ◽  
Jean-Christophe M. Monbaliu
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process

Development of a scalable continuous-flow process towards enriched threo-methylphenidate (Ritalin) hydrochloride.

Continuous-Flow Process for Selective Mononitration of 1-Methyl-4-(methylsulfonyl)benzene

2016 ◽  
Vol 20 (2) ◽  
pp. 199-203 ◽  
Author(s):  
Zhiqun Yu ◽  
Pengcheng Zhou ◽  
Jiming Liu ◽  
Wenzuo Wang ◽  
Chuanming Yu ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process

Continuous Flow Process for Reductive Deoxygenation of ω-Chloroketone in the Synthesis of Vilazodone

2018 ◽  
Vol 22 (8) ◽  
pp. 1022-1028 ◽  
Author(s):  
Avedis Karadeolian ◽  
Dineshkumar Patel ◽  
Prabhudas Bodhuri ◽  
Gamini Weeratunga ◽  
Boris Gorin
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process

Development of a Continuous Flow Process for a Matteson Reaction: From Lab Scale to Full-Scale Production of a Pharmaceutical Intermediate

2019 ◽  
Vol 23 (5) ◽  
pp. 1069-1077 ◽  
Author(s):  
Clemens Stueckler ◽  
Peter Hermsen ◽  
Bas Ritzen ◽  
Maria Vasiloiu ◽  
Peter Poechlauer ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Full Scale ◽  
Scale Production ◽  
Flow Process ◽  
Continuous Flow Process

Design of a microfluidic device for the measurement of the elastic modulus of deformable particles

Soft Matter ◽  
2019 ◽  
Vol 15 (5) ◽  
pp. 880-889 ◽  
Author(s):  
Massimiliano M. Villone ◽  
Janine K. Nunes ◽  
Yankai Li ◽  
Howard A. Stone ◽  
Pier Luca Maffettone
Keyword(s):  
Elastic Modulus ◽  
Interfacial Tension ◽  
Continuous Flow ◽  
Liquid Droplet ◽  
Flow Process ◽  
Deformable Particles ◽  
Soft Particles ◽  
Continuous Flow Process ◽  
Microfluidic Technique

A microfluidic technique recently proposed in the literature to measure the interfacial tension between a liquid droplet and an immiscible suspending liquid [Hudson et al., Appl. Phys. Lett., 2005, 87, 081905], [Cabral and Hudson, Lab Chip, 2006, 6, 427] is suitably adapted to the characterization of the elastic modulus of soft particles in a continuous-flow process.

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