Corrigendum to: Multi-year fertility reduction in free-roaming feral horses with single-injection immunocontraceptive formulations

Context. Contraception is increasingly used as a management technique to reduce fertility in wildlife populations; however, the feasibility of contraceptive formulations has been limited until recently because they have required multiple treatments to achieve prolonged infertility. Aims. We tested the efficacy and evaluated potential side effects of two contraceptive formulations, a porcine zona pellucida (PZP) formulation, SpayVac� and a gonadotrophin-releasing hormone (GnRH) formulation GonaCon-B?, in a population of free-roaming feral horses (Equus caballus). Both formulations were developed to provide several years of infertility with one injection. Methods. Females were treated in June 2005 with either GonaCon-B (n�=�24), SpayVac (n�=�20), adjuvant only (n�=�22), or received no injection (n�=�18). Females were monitored for fertility status year round for 3 years after treatment. Key results. Both contraceptive treatments significantly reduced fertility for 3 years. Fertility rates for GonaCon-B mares were 39%, 42% and 31%, respectively, and 37%, 50% and 44% for SpayVac mares. During the same seasons, 61%, 67% and 76% of control females were fertile. We found no significant effects from contraceptive treatment on the sex ratio of foals, birthing season or foal survival. Conclusions. These results demonstrated that both vaccines are capable of significantly reducing fertility for several years without boosters. Implications. Contraceptive vaccines examined in the present study represent a useful tool for the management of feral horses, because of their being efficacious for 3 years in the absence of booster immunisations.

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Multi-year fertility reduction in free-roaming feral horses with single-injection immunocontraceptive formulations

Wildlife Research ◽

10.1071/wr09175 ◽

2010 ◽

Vol 37 (6) ◽

pp. 475 ◽

Cited By ~ 21

Author(s):

Meeghan E. Gray ◽

David S. Thain ◽

Elissa Z. Cameron ◽

Lowell A. Miller

Keyword(s):

Management Technique ◽

Feral Horses ◽

Fertility Status ◽

Fertility Reduction ◽

Injection Methods ◽

Gonadotrophin Releasing Hormone ◽

Wildlife Populations ◽

Contraceptive Vaccines ◽

Multiple Treatments ◽

Contraceptive Treatment

Context. Contraception is increasingly used as a management technique to reduce fertility in wildlife populations; however, the feasibility of contraceptive formulations has been limited until recently because they have required multiple treatments to achieve prolonged infertility. Aims. We tested the efficacy and evaluated potential side effects of two contraceptive formulations, a porcine zona pellucida (PZP) formulation, SpayVac® and a gonadotrophin-releasing hormone (GnRH) formulation GonaCon-B™, in a population of free-roaming feral horses (Equus caballus). Both formulations were developed to provide several years of infertility with one injection. Methods. Females were treated in June 2005 with either GonaCon-B (n = 24), SpayVac (n = 20), adjuvant only (n = 22), or received no injection (n = 18). Females were monitored for fertility status year round for 3 years after treatment. Key results. Both contraceptive treatments significantly reduced fertility for 3 years. Fertility rates for GonaCon-B mares were 39%, 42% and 31%, respectively, and 37%, 50% and 44% for SpayVac mares. During the same seasons, 61%, 67% and 76% of control females were fertile. We found no significant effects from contraceptive treatment on the sex ratio of foals, birthing season or foal survival. Conclusions. These results demonstrated that both vaccines are capable of significantly reducing fertility for several years without boosters. Implications. Contraceptive vaccines examined in the present study represent a useful tool for the management of feral horses, because of their being efficacious for 3 years in the absence of booster immunisations.

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THE ASSOCIATION BETWEEN HIV AND FERTILITY IN A COHORT STUDY IN RURAL TANZANIA

Journal of Biosocial Science ◽

10.1017/s0021932003001895 ◽

2003 ◽

Vol 35 (2) ◽

pp. 189-199 ◽

Cited By ~ 44

Author(s):

SUSAN-CATHERINE HUNTER ◽

RAPHAEL ISINGO ◽

J. TIES BOERMA ◽

MARK URASSA ◽

GABRIEL M. P. MWALUKO ◽

...

Keyword(s):

Substantial Reduction ◽

Antenatal Clinic ◽

Sub Saharan Africa ◽

Hiv Status ◽

Fertility Status ◽

Fertility Reduction ◽

Rural Tanzania ◽

Duration Of Infection ◽

Sub Saharan ◽

Demographic Impact

Recent studies in sub-Saharan Africa have shown that fertility is reduced among HIV-infected women compared with uninfected women. The size and pattern of this fertility reduction has important implications for antenatal clinic-based surveillance of the epidemic and also for estimates and projections of the demographic impact of the epidemic. This paper examines the association between HIV and fertility in Kisesa, a rural area in Tanzania, where HIV prevalence among adults is about 6% and gradually increasing. The analysis is based on data obtained through a demographic surveillance system in Kisesa during 1994–98 and two large sero-surveys of all residents in 1994–95 and 1996–97. The HIV-associated fertility reduction among women was investigated by estimating fertility rates by HIV status and prevalence rates by fertility status. A substantial reduction (29%) was observed in fertility among HIV-infected women compared with HIV-uninfected women. The fertility reduction was most pronounced during the terminal stages of infection, but no clear association with duration of infection was observed. Use of modern contraception was higher among HIV-infected women. However, both among contracepting and noncontracepting women, a substantial reduction in fertility was seen among HIV-infected women.

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Field testing of single-administration porcine zona pellucida contraceptive vaccines in white-tailed deer (Odocoileus virginianus)

Wildlife Research ◽

10.1071/wr12117 ◽

2013 ◽

Vol 40 (4) ◽

pp. 281 ◽

Cited By ~ 10

Author(s):

Allen T. Rutberg ◽

Ricky E. Naugle ◽

John W. Turner ◽

Mark A. Fraker ◽

Douglas R. Flanagan

Keyword(s):

Odocoileus Virginianus ◽

Zona Pellucida ◽

Field Testing ◽

Specific Protein ◽

First Year ◽

Single Administration ◽

Contraceptive Agents ◽

Efficient Delivery ◽

Wildlife Populations ◽

Contraceptive Vaccines

Context Many contraceptive agents have demonstrated effectiveness in wild species, most notably immunocontraceptives such as GnRH conjugates and porcine zona pellucida (PZP). The major challenge in using these agents to control deer and other wildlife populations in the field now lies with safe, effective and efficient delivery to a large-enough proportion of the population to suppress growth. Aims Because deer and other wildlife are typically difficult to access for treatment, contraceptives that require multiple or repeated treatments will be of limited management value. To address this constraint, we conducted a field study of white-tailed deer (Odocoileus virginianus) on Fripp Island, SC, USA, to test two different technologies for achieving single-administration, multi-year efficacy in PZP vaccines. Methods Between 2005 and 2010, we captured, ear-tagged and blood-sampled a total of 245 individual adult and yearling female deer. Deer were hand-injected at capture with one of two preparations of SpayVac or a combination native PZP–adjuvant emulsion plus PZP–adjuvant incorporated into lactide–glycolide polymer pellets engineered to release at 1, 3 and 12 months post-treatment. Pregnancy was determined from serum assays of pregnancy-specific protein B sampled from captured deer. Key results Aqueous SpayVac, and the PZP–adjuvant-containing polymer pellets manufactured through a heat extrusion (H/X) method administered simultaneously with PZP–AdjuVac or modified Freund’s complete adjuvant emulsions reduced pregnancy rates from control levels by 95–100% in the first year after treatment, and by 65–70% in the second year after treatment. Conclusions A single, hand-injected vaccination with SpayVac or PZP–adjuvant emulsion combined with H/X PZP pellets reduced fertility for multiple years. Implications Single-treatment, multi-year immunocontraceptive vaccines bring contraceptive management of wildlife populations one step closer. Future efforts should focus on improving handling and storage, developing technologies for remote delivery, and addressing remaining regulatory and management concerns.

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Endocrinology: Sequential gonadotrophin-releasing hormone agonist/ low-dose oral contraceptive treatment for leiomyomata uteri

Human Reproduction ◽

10.1093/oxfordjournals.humrep.a135983 ◽

1995 ◽

Vol 10 (3) ◽

pp. 529-532 ◽

Cited By ~ 1

Author(s):

Juan Balasch ◽

Dolores Manau ◽

Jaime Mimó ◽

Magda Durán ◽

Bienvenido Puerto ◽

...

Keyword(s):

Oral Contraceptive ◽

Low Dose ◽

Releasing Hormone ◽

Dose Oral ◽

Gonadotrophin Releasing Hormone ◽

Dose Oral Contraceptive ◽

Contraceptive Treatment

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Percutaneous sclerotherapy for spongiform venous malformations – analysis of patient-evaluated outcome and satisfaction

VASA ◽

10.1024/0301-1526/a000650 ◽

2017 ◽

Vol 46 (6) ◽

pp. 477-483

Author(s):

Robert Karl Clemens ◽

Frederic Baumann ◽

Marc Husmann ◽

Thomas Oleg Meier ◽

Christoph Thalhammer ◽

...

Keyword(s):

Retrospective Study ◽

Medical Records ◽

Venous Malformation ◽

Primary Treatment ◽

Venous Malformations ◽

Treated Area ◽

Item Questionnaire ◽

Percutaneous Sclerotherapy ◽

Multiple Treatments ◽

Pain Improvement

Abstract. Background: Congenital venous malformations are frequently treated with sclerotherapy. Primary treatment goal is to control the often size-related symptoms. Functional impairment and aesthetical aspects as well as satisfaction have rarely been evaluated. Patients and methods: Medical records of patients who underwent sclerotherapy of spongiform venous malformations were reviewed and included in this retrospective study. The outcome of sclerotherapy as self-reported by patients was assessed in a 21 item questionnaire. Results: Questionnaires were sent to 166 patients with a total of 327 procedures. Seventy-seven patients (48 %) with a total of 159 procedures (50 %) responded to the survey. Fifty-seven percent of patients were male. The age ranged from 1 to 38.1 years with a median age of 16.4 years. The lower extremities were the most common treated area. Limitations caused by the venous malformation improved in the majority of patients (e.g. pain improvement 87 %, improvement of swelling 83 %) but also worsening of symptoms occurred in a minority of cases. Seventy-seven per cent would undergo sclerotherapy again. Conclusions: Sclerotherapy for treatment of venous malformations results in significant reduction of symptoms. Multiple treatments are often needed, but patients are willing to undergo them.

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Undesirable Effects of Goal Setting on Perceived Fairness, Commitment, and Unethical Behavior

Zeitschrift für Arbeits- und Organisationspsychologie A&O ◽

10.1026/0932-4089/a000267 ◽

2018 ◽

Vol 62 (2) ◽

pp. 97-107 ◽

Cited By ~ 2

Author(s):

Nina Keith

Keyword(s):

Goal Setting ◽

Unethical Behavior ◽

The United States ◽

Goal Commitment ◽

Management Technique ◽

Long Term Effects ◽

Perceived Fairness ◽

Negative Effects ◽

Positive Effects ◽

And Performance

Abstract. The positive effects of goal setting on motivation and performance are among the most established findings of industrial–organizational psychology. Accordingly, goal setting is a common management technique. Lately, however, potential negative effects of goal-setting, for example, on unethical behavior, are increasingly being discussed. This research replicates and extends a laboratory experiment conducted in the United States. In one of three goal conditions (do-your-best goals, consistently high goals, increasingly high goals), 101 participants worked on a search task in five rounds. Half of them (transparency yes/no) were informed at the outset about goal development. We did not find the expected effects on unethical behavior but medium-to-large effects on subjective variables: Perceived fairness of goals and goal commitment were least favorable in the increasing-goal condition, particularly in later goal rounds. Results indicate that when designing goal-setting interventions, organizations may consider potential undesirable long-term effects.

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Discussion on “Production management technique”, by G. Still, at the Birmingham Section of the Institution

Journal of the Institution of Production Engineers ◽

10.1049/jipe.1935.0040 ◽

1935 ◽

Vol 14 (7) ◽

pp. 410

Author(s):

F. Allen ◽

F. Pearson ◽

George Still ◽

R.H. Youngash ◽

E.T. Cooke ◽

...

Keyword(s):

Production Management ◽

Management Technique

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Radiographic Prevalence of Osteochondrosis in Yearling Feral Horses

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.1055/s-0038-1632481 ◽

1999 ◽

Vol 12 (03) ◽

pp. 151-155 ◽

Cited By ~ 19

Author(s):

L. W. Valentino ◽

E. M. Gaughan ◽

D. R. Biller ◽

R. H. Raub ◽

J. D. Lillich

Keyword(s):

Subchondral Bone ◽

Management Practices ◽

Articular Surface ◽

Radiographic Images ◽

Feral Horses ◽

Metacarpophalangeal Joints ◽

Genetic Base ◽

Domestic Horses ◽

The Difference ◽

Metatarsophalangeal Joints

The purpose of the study is to document the prevalence of articular surface osteochondrosis lesions in feral horses. Eighty yearling feral horses were used. Radiographic images of the left stifle, both tarsocrural, metatarsophalangeal, metacarpophalangeal joints were taken. Radiographs were examined for the presence of osteochondral fragmentation and abnormal outline of subchondral bone suggestive of osteochondrosis. The prevalence of each lesion was calculated for each joint as well as for overall prevalence within the group, the latter being 6.25%. Typical osteochondrosis lesions were found within the tarsocrural and metatarsophalangeal joints. Based on the difference in prevalence of osteochondrosis between feral and certain domestic horses, management practices and perhaps genetic base may have a greater influence on the development of the disease in horses than trauma alone.

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