scholarly journals Functional Role of the Third Cytoplasmic Loop in Muscarinic Receptor Dimerization

1996 ◽  
Vol 271 (49) ◽  
pp. 31055-31060 ◽  
Author(s):  
Roberto Maggio ◽  
Pascaline Barbier ◽  
Francesco Fornai ◽  
Giovanni U. Corsini
Author(s):  
Jacob Ross

The morally wrong actions, it seems, are the actions that are worthy of moral disapproval. Hence, one way to approach normative ethics is to ask the following question: Toward what kinds of action is moral disapproval fitting or correct? Chapter 13 argues that we can answer this question by adopting a teleosemantic framework. The chapter proceeds in three stages. It begins by proposing and defending a teleological theory of the contents of attitudes in general. The account proposed implies that the content of an attitude depends on its functional role. Accordingly, the second part of the paper defends an account of the functional role of moral disapproval. Then the third part combines the results of the first two parts in order to determine the content, and hence the correctness conditions, of moral disapproval. The chapter concludes with some remarks about the normative implications of the resulting view. In particular, it argues for a form of moral relativism.


FEBS Letters ◽  
1997 ◽  
Vol 415 (2) ◽  
pp. 200-205 ◽  
Author(s):  
Régine Capeyrou ◽  
Joëlle Riond ◽  
Maité Corbani ◽  
Jean-François Lepage ◽  
Brigitte Bertin ◽  
...  

1997 ◽  
Vol 25 (3) ◽  
pp. 1036-1039 ◽  
Author(s):  
K. Saar ◽  
A. Valkna ◽  
U. Soomets ◽  
K. Rezaei ◽  
M. Zorko ◽  
...  

Blood ◽  
2006 ◽  
Vol 109 (2) ◽  
pp. 802-810 ◽  
Author(s):  
Eveliina Ihanus ◽  
Liisa M. Uotila ◽  
Anne Toivanen ◽  
Minna Varis ◽  
Carl G. Gahmberg

Abstract Intercellular adhesion molecule 4 (ICAM-4) is a unique member of the ICAM family because of its specific expression on erythroid cells and ability to interact with several types of integrins expressed on blood and endothelial cells. The first reported receptors for ICAM-4 were CD11a/CD18 and CD11b/CD18. In contrast to these 2, the cellular ligands and the functional role of the third β2 integrin, CD11c/CD18, have not been well defined. Here, we show that ICAM-4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM-4 demonstrated that both its domains contain binding sites for CD11c/CD18. Analysis of a panel of ICAM-4 point mutants identified residues that affected binding to the integrin. By molecular modeling the important residues were predicted to cluster in 2 distinct but spatially close regions of the first domain with an extension to the second domain spatially distant from the other residues. We also identified 2 peptides derived from sequences of ICAM-4 that are capable of modulating the binding to CD11c/CD18. CD11c/CD18 is expressed on macrophages in spleen and bone marrow. Inhibition of erythrophagocytosis by anti–ICAM-4 and anti-integrin antibodies suggests a role for these interactions in removal of senescent red cells.


2018 ◽  
Vol 26 (3) ◽  
pp. 1-17
Author(s):  
Muhammad Amin Muhammad Amin

Islamic institutions are intended to contribute to the implementation of some Islamic programs in the community through the mosque and endowments and charitable work and advocacy. This research is an attempt to demonstrate the two pillars of Islam in the clear message of peace in its supreme objectives and then the role of these institutions in achieving and establishing peace in society through its functional role and dealing with three models, namely, mosque, endowments and the third sector. They need to be monitored because of their significant impact in achieving peace on society and the nation and to achieve the purposes of the law.


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