scholarly journals Peptide G, Containing the Binding Site of the 67-kDa Laminin Receptor, Increases and Stabilizes Laminin Binding to Cancer Cells

1996 ◽  
Vol 271 (49) ◽  
pp. 31179-31184 ◽  
Author(s):  
Alessandra Magnifico ◽  
Elda Tagliabue ◽  
Simona Butó ◽  
Elena Ardini ◽  
Vincent Castronovo ◽  
...  
Keyword(s):  
Binding Site ◽  
Cancer Cells ◽  
Laminin Receptor ◽  
Laminin Binding ◽  
Peptide G

scholarly journals Structure-Guided Identification of a Laminin Binding Site on the Laminin Receptor Precursor

2011 ◽  
Vol 405 (1) ◽  
pp. 24-32 ◽  
Author(s):  
Kelly V. Jamieson ◽  
Stevan R. Hubbard ◽  
Daniel Meruelo
Keyword(s):  
Binding Site ◽  
Laminin Receptor ◽  
Laminin Binding

scholarly journals Bioinformatic Analysis of the Nicotinamide Binding Site in Poly(ADP-Ribose) Polymerase Family Proteins

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1201
Author(s):  
Garri Manasaryan ◽  
Dmitry Suplatov ◽  
Sergey Pushkarev ◽  
Viktor Drobot ◽  
Alexander Kuimov ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Binding Site ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Bioinformatic Analysis ◽  
Parp Inhibitors ◽  
Functional Region ◽  
D Loop

The PARP family consists of 17 members with diverse functions, including those related to cancer cells’ viability. Several PARP inhibitors are of great interest as innovative anticancer drugs, but they have low selectivity towards distinct PARP family members and exert serious adverse effects. We describe a family-wide study of the nicotinamide (NA) binding site, an important functional region in the PARP structure, using comparative bioinformatic analysis and molecular modeling. Mutations in the NA site and D-loop mobility around the NA site were identified as factors that can guide the design of selective PARP inhibitors. Our findings are of particular importance for the development of novel tankyrase (PARPs 5a and 5b) inhibitors for cancer therapy.

scholarly journals 37-kDa Laminin Receptor Precursor Mediates GnRH-II–Induced MMP-2 Expression and Invasiveness in Ovarian Cancer Cells

2011 ◽  
Vol 32 (1) ◽  
pp. 153-154
Author(s):  
Song Ling Poon ◽  
Christian Klausen ◽  
Geoffrey L. Hammond ◽  
Peter C. K. Leung
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Laminin Receptor ◽  
Ovarian Cancer Cells

scholarly journals miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Peng Zou ◽  
Menghai Zhu ◽  
Chong Lian ◽  
Jiaqiang Wang ◽  
Zhiquan Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Bone Metastasis ◽  
Binding Site ◽  
Cancer Cells ◽  
Significant Role ◽  
Research Group ◽  
Luciferase Activity ◽  
Migration And Invasion

AbstractLung cancer is the leading cause of cancer-related deaths worldwide, with 50–70% of patients suffering from bone metastasis. Accumulating evidence has demonstrated that miRNAs are involved in cell proliferation, migration, and invasion in malignancy, such as lung cancer bone metastasis. In the present study, we demonstrated that reduced miR-192-5p and increased TRIM44 levels were associated with the proliferation, migration and invasion of lung cancer. Furthermore, the potential functions of miR-192-5p were explored in A549 and NCI-H1299 cells. We found that miR-192-5p upregulation suppressed tumour behaviours in lung cancer cells. To further investigate whether miR-192-5p is associated with TRIM44, we used TargetScan software to predict the binding site between miR-192-5p and TRIM44. Luciferase activity assays were performed to verify this prediction. In addition, the significant role of miR-192-5p in negatively regulating TRIM44 expression was manifested by our research group. our results suggest that miR-192-5p inhibited the proliferation, migration and invasion of lung cancer through TRIM44.

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