scholarly journals Involvement of p130Casand p105HEF1, a Novel Cas-like Docking Protein, in a Cytoskeleton-dependent Signaling Pathway Initiated by Ligation of Integrin or Antigen Receptor on Human B Cells

1997 ◽  
Vol 272 (7) ◽  
pp. 4230-4236 ◽  
Author(s):  
Serge N. Manié ◽  
Andreas R.P. Beck ◽  
Anne Astier ◽  
Susan F. Law ◽  
Tim Canty ◽  
...  
Keyword(s):  
B Cells ◽  
Signaling Pathway ◽  
Antigen Receptor ◽  
Human B Cells ◽  
Docking Protein ◽  
Dependent Signaling Pathway

Down-modulation of the antigen receptor by a superantigen for human B cells

2004 ◽  
Vol 92 (1-2) ◽  
pp. 91-96 ◽  
Author(s):  
Muriel Viau ◽  
Béatrice Cholley ◽  
Lars Björck ◽  
Moncef Zouali
Keyword(s):  
B Cells ◽  
Antigen Receptor ◽  
Human B Cells

OP0199 Amplification of IL-21 Signaling Pathway Through Bruton’s Tyrosine Kinase (BTK) in Human B Cells

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A119.4-A120
Author(s):  
S.-P. Wang ◽  
S. Iwata ◽  
K. Yamaoka ◽  
H. Niiro ◽  
S. Nakayamada ◽  
...  
Keyword(s):  
B Cells ◽  
Tyrosine Kinase ◽  
Signaling Pathway ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase ◽  
Human B Cells

scholarly journals Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Kanika Vanshylla ◽  
Caren Bartsch ◽  
Christoffer Hitzing ◽  
Laura Krümpelmann ◽  
Jürgen Wienands ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Map Kinase ◽  
Antigen Receptor ◽  
B Cell Antigen Receptor ◽  
Kinase Activation ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Human B Cells

scholarly journals Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis.

1996 ◽  
Vol 183 (4) ◽  
pp. 1377-1388 ◽  
Author(s):  
C Lagresle ◽  
P Mondière ◽  
C Bella ◽  
P H Krammer ◽  
T Defrance
Keyword(s):  
B Cells ◽  
B Cell ◽  
Cell Survival ◽  
Antigen Receptor ◽  
Cell Types ◽  
Memory B Cells ◽  
Apoptotic Pathway ◽  
Cell Responses ◽  
Human B Cells ◽  
B Cell Survival

Naive and memory B cells were isolated from human tonsils and examined for expression of APO-1/Fas and for their sensitivity to the APO-1-dependent apoptosis. APO-1 was found to be constitutively expressed on memory but not on naive B cells. The susceptibility of both cell types to the APO-1 apoptotic pathway was acquired upon CD40 triggering and was correlated with increased expression of the APO-1 receptor. Both naive and memory B cells were protected from the APO-1-mediated death signal after dual ligation of the Ag receptor adn CD40. Our findings suggest that the APO-1 pathway controls the specificity of B cell responses to T-dependent Ags and that occupancy of the Ag receptor dictates the outcome of APO-1-ligation on B cell survival.

Antigen receptor triggered upregulation of CD86 and CD80 in human B cells: augmenting role of the CD21/CD19 co-stimulatory complex and IL-4

2002 ◽  
Vol 216 (1-2) ◽  
pp. 50-64 ◽  
Author(s):  
Patricia K.A Mongini ◽  
Sonia Tolani ◽  
Rasem J Fattah ◽  
John K Inman
Keyword(s):  
B Cells ◽  
Antigen Receptor ◽  
Human B Cells

scholarly journals Cross-linking of antigen receptor via Ig-β (B29, CD79b) can induce both positive and negative signals in CD40-activated human B cells

1997 ◽  
Vol 110 (3) ◽  
pp. 509-515 ◽  
Author(s):  
C. VAN KOOTEN ◽  
L. GALIBERT ◽  
B. K. SEON ◽  
P. GARRONE ◽  
Y.-J. LIU ◽  
...  
Keyword(s):  
B Cells ◽  
Antigen Receptor ◽  
Cross Linking ◽  
Human B Cells

scholarly journals An ATM/Chk2-Mediated DNA Damage-Responsive Signaling Pathway Suppresses Epstein-Barr Virus Transformation of Primary Human B Cells

2010 ◽  
Vol 8 (6) ◽  
pp. 510-522 ◽  
Author(s):  
Pavel A. Nikitin ◽  
Christopher M. Yan ◽  
Eleonora Forte ◽  
Alessio Bocedi ◽  
Jason P. Tourigny ◽  
...  
Keyword(s):  
Dna Damage ◽  
B Cells ◽  
Signaling Pathway ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Human B Cells ◽  
Virus Transformation ◽  
Epstein Barr
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