scholarly journals The E3 Ubiquitin Ligase Neuregulin Receptor Degradation Protein 1 (Nrdp1) Promotes M2 Macrophage Polarization by Ubiquitinating and Activating Transcription Factor CCAAT/Enhancer-binding Protein β (C/EBPβ)

2012 ◽  
Vol 287 (32) ◽  
pp. 26740-26748 ◽  
Author(s):  
Shuo Ye ◽  
Hongmei Xu ◽  
Jing Jin ◽  
Mingjin Yang ◽  
Chunmei Wang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Ubiquitin Ligase ◽  
Binding Protein ◽  
Macrophage Polarization ◽  
E3 Ubiquitin Ligase ◽  
M2 Macrophage ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein ◽  
M2 Macrophage Polarization ◽  
Activating Transcription Factor

Impaired water-maze performance in mice lacking transcription factor CCAAT/enhancer-binding protein ?

2000 ◽  
Vol 26 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Kazunori Yukawa ◽  
Takashi Tanaka ◽  
Ayako Toyomi ◽  
Shigekatsu Tsuji ◽  
Shizuo Akira ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Water Maze ◽  
Binding Protein ◽  
Maze Performance ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein ◽  
Impaired Water

scholarly journals Transcription factor CCAAT/enhancer binding protein alpha up-regulates microRNA let-7a-1 in lung cancer cells by direct binding

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Yani Lin ◽  
Jian Zhao ◽  
Xiaoyan Hu ◽  
Lina Wang ◽  
Liming Liang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Binding Protein ◽  
Lung Cancer Cells ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein ◽  
Direct Binding

Role of transcription factor CCAAT/enhancer-binding protein alpha in human fetal liver cell typesin vitro

2014 ◽  
Vol 45 (8) ◽  
pp. 919-932 ◽  
Author(s):  
Jörg C. Gerlach ◽  
Patrick Over ◽  
Hubert G. Foka ◽  
Morris E. Turner ◽  
Robert L. Thompson ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Liver Cell ◽  
Fetal Liver ◽  
Binding Protein ◽  
Human Fetal Liver ◽  
Fetal Liver Cell ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein

scholarly journals A CCAAT/Enhancer Binding Protein β Isoform, Liver-Enriched Inhibitory Protein, Regulates Commitment of Osteoblasts and Adipocytes

2005 ◽  
Vol 25 (5) ◽  
pp. 1971-1979 ◽  
Author(s):  
Kenji Hata ◽  
Riko Nishimura ◽  
Mio Ueda ◽  
Fumiyo Ikeda ◽  
Takuma Matsubara ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Osteoblast Differentiation ◽  
Molecular Mechanisms ◽  
Binding Protein ◽  
Mesenchymal Cells ◽  
Dominant Negative ◽  
Inhibitory Protein ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein

ABSTRACT Although both osteoblasts and adipocytes have a common origin, i.e., mesenchymal cells, the molecular mechanisms that define the direction of two different lineages are presently unknown. In this study, we investigated the role of a transcription factor, CCAAT/enhancer binding protein β (C/EBPβ), and its isoform in the regulation of balance between osteoblast and adipocyte differentiation. We found that C/EBPβ, which is induced along with osteoblast differentiation, promotes the differentiation of mesenchymal cells into an osteoblast lineage in cooperation with Runx2, an essential transcription factor for osteogenesis. Surprisingly, an isoform of C/EBPβ, liver-enriched inhibitory protein (LIP), which lacks the transcriptional activation domain, stimulates transcriptional activity and the osteogenic action of Runx2, although LIP inhibits adipogenesis in a dominant-negative fashion. Furthermore, LIP physically associates with Runx2 and binds to the C/EBP binding element present in the osteocalcin gene promoter. These data indicate that LIP functions as a coactivator for Runx2 and preferentially promotes the osteoblast differentiation of mesenchymal cells. Thus, identification of a novel role of the C/EBPβ isoform provides insight into the molecular basis of the regulation of osteoblast and adipocyte commitment.

Sign in / Sign up

Export Citation Format

Share Document