scholarly journals A Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK)-dependent Transcriptional Program Controls Activation of the Early Growth Response 1 (EGR1) Gene during Amino Acid Limitation

2014 ◽  
Vol 289 (35) ◽  
pp. 24665-24679 ◽  
Author(s):  
Jixiu Shan ◽  
Mukundh N. Balasubramanian ◽  
William Donelan ◽  
Lingchen Fu ◽  
Jaclyn Hayner ◽  
...  
Keyword(s):  
Amino Acid ◽  
Growth Response ◽  
Early Growth ◽  
Mitogen Activated Protein Kinase ◽  
Transcriptional Program ◽  
Extracellular Signal Regulated Kinase ◽  
Early Growth Response ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Early Growth Response 1

Extracellular signal-regulated kinase-1 phosphorylates early growth response-1 at serine 26

2019 ◽  
Vol 510 (3) ◽  
pp. 345-351
Author(s):  
Fernando S. Santiago ◽  
Estella Sanchez-Guerrero ◽  
Guishui Zhang ◽  
Ling Zhong ◽  
Mark J. Raftery ◽  
...  
Keyword(s):  
Growth Response ◽  
Early Growth ◽  
Extracellular Signal Regulated Kinase ◽  
Early Growth Response ◽  
Extracellular Signal ◽  
Early Growth Response 1

scholarly journals Enteropathogenic Escherichia coli Infection Induces Expression of the Early Growth Response Factor by Activating Mitogen-Activated Protein Kinase Cascades in Epithelial Cells

2001 ◽  
Vol 69 (10) ◽  
pp. 6217-6224 ◽  
Author(s):  
Myriam de Grado ◽  
Carrie M. Rosenberger ◽  
Annick Gauthier ◽  
Bruce A. Vallance ◽  
B. Brett Finlay
Keyword(s):  
Signal Transduction ◽  
Type Iii Secretion ◽  
Growth Response ◽  
Signal Transduction Pathway ◽  
Early Growth ◽  
Secretion System ◽  
Mitogen Activated Protein Kinase ◽  
Transduction Pathway ◽  
Early Growth Response ◽  
Mitogen Activated Protein

ABSTRACT Enteropathogenic Escherichia coli (EPEC) is an extracellular bacterial pathogen that infects the human intestinal epithelium and is a major cause of infantile diarrhea in developing countries. EPEC belongs to the group of attaching and effacing (A/E) pathogens. It uses a type III secretion system to deliver proteins into the host cell that mediate signal transduction events in host cells. We used gene array technology to study epithelial cell responses to EPEC infection at the level of gene expression. We found that EPEC induces the expression of several genes in infected HeLa cells by a lipopolysaccharide (LPS)-independent mechanism, including cytokines and early growth response factor 1 (Egr-1). The transcription factor Egr-1 is an immediate-early-induced gene that is activated in most cell types in response to stress. EPEC-induced upregulation ofegr-1 is mediated by the activation of the MEK/extracellular signal-regulated kinase signal transduction pathway and is dependent on the type III secretion system. egr-1 is also induced during infection of mice by the A/E pathogenCitrobacter rodentium, suggesting that both Egr-1 and the activation of this mitogen-activated protein kinase signal transduction pathway may play a role in disease.

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