scholarly journals Induction of urokinase-type plasminogen activator, interleukin-8 and early growth response-1 by STI571 through activating mitogen activated protein kinase in human small cell lung cancer cells

2007 ◽  
Vol 18 (5) ◽  
pp. 425-433 ◽  
Author(s):  
Chikamasa Yoshida ◽  
Kenji Niiya ◽  
Masami Niiya ◽  
Misako Shibakura ◽  
Noboru Asaumi ◽  
...  
Keyword(s):  
Growth Response ◽  
Early Growth ◽  
Small Cell ◽  
Mitogen Activated Protein Kinase ◽  
Small Cell Lung ◽  
Early Growth Response ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Mitogen Activated Protein ◽  
Early Growth Response 1

scholarly journals Enteropathogenic Escherichia coli Infection Induces Expression of the Early Growth Response Factor by Activating Mitogen-Activated Protein Kinase Cascades in Epithelial Cells

2001 ◽  
Vol 69 (10) ◽  
pp. 6217-6224 ◽  
Author(s):  
Myriam de Grado ◽  
Carrie M. Rosenberger ◽  
Annick Gauthier ◽  
Bruce A. Vallance ◽  
B. Brett Finlay
Keyword(s):  
Signal Transduction ◽  
Type Iii Secretion ◽  
Growth Response ◽  
Signal Transduction Pathway ◽  
Early Growth ◽  
Secretion System ◽  
Mitogen Activated Protein Kinase ◽  
Transduction Pathway ◽  
Early Growth Response ◽  
Mitogen Activated Protein

ABSTRACT Enteropathogenic Escherichia coli (EPEC) is an extracellular bacterial pathogen that infects the human intestinal epithelium and is a major cause of infantile diarrhea in developing countries. EPEC belongs to the group of attaching and effacing (A/E) pathogens. It uses a type III secretion system to deliver proteins into the host cell that mediate signal transduction events in host cells. We used gene array technology to study epithelial cell responses to EPEC infection at the level of gene expression. We found that EPEC induces the expression of several genes in infected HeLa cells by a lipopolysaccharide (LPS)-independent mechanism, including cytokines and early growth response factor 1 (Egr-1). The transcription factor Egr-1 is an immediate-early-induced gene that is activated in most cell types in response to stress. EPEC-induced upregulation ofegr-1 is mediated by the activation of the MEK/extracellular signal-regulated kinase signal transduction pathway and is dependent on the type III secretion system. egr-1 is also induced during infection of mice by the A/E pathogenCitrobacter rodentium, suggesting that both Egr-1 and the activation of this mitogen-activated protein kinase signal transduction pathway may play a role in disease.

scholarly journals Early Growth Response 4 Is Involved in Cell Proliferation of Small Cell Lung Cancer through Transcriptional Activation of Its Downstream Genes

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e113606 ◽  
Author(s):  
Taisuke Matsuo ◽  
Le Tan Dat ◽  
Masato Komatsu ◽  
Tetsuro Yoshimaru ◽  
Kei Daizumoto ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Transcriptional Activation ◽  
Growth Response ◽  
Early Growth ◽  
Small Cell ◽  
Small Cell Lung ◽  
Early Growth Response
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