Information design for bowel cancer detection

Abstract Colorectal cancer is one of the most commonly occurring cancers in the world, and colonoscopy is the most sensitive procedure to detect it. Colonoscopy success depends on the quality of bowel preparation, yet the way information is designed and communicated to patients does not meet their needs. By considering how information is conveyed through three different outputs (booklet, motion graphics and app), this study investigates the advantages of using visualised information when communicating bowel preparation instructions for colonoscopy screening. A user-centered multiple-methods approach was followed and results show how user performance benefits from the use of information visualisation. A set of guidelines is given to inform the development of bowel preparation instructions and other similar health related communications.

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Exploring the relationship among dispositional optimism, health-related quality of life, and CIPN severity among colorectal cancer patients with chronic peripheral neuropathy

Supportive Care in Cancer ◽

10.1007/s00520-021-06352-0 ◽

2021 ◽

Author(s):

Hester.R. Trompetter ◽

Cynthia S. Bonhof ◽

Lonneke V. van de Poll-Franse ◽

Gerard Vreugdenhil ◽

Floortje Mols

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Peripheral Neuropathy ◽

Cancer Patients ◽

Anxiety Symptoms ◽

Health Related Quality ◽

Related Quality ◽

Health Related

Abstract Purpose Chemotherapy-induced peripheral neuropathy ((CI)PN) becomes chronic in 30% of cancer patients. Knowledge of predictors of chronic (CI)PN and related impairments in health-related quality of life (HRQoL) is lacking. We examined the role of optimism in chronic (CI)PN severity and associated HRQoL in colorectal cancer (CRC) patients up to two years after diagnosis. Methods CRC patients from a prospective cohort study participated, with sensory peripheral neuropathy (SPN) 1 year after diagnosis (n = 142). Multivariable regression analyses examined the cross-sectional association between optimism (measured by the LOT-R) and SPN severity/HRQoL (measured by the EORTC QLQ-CIPN20 and QLQ-C30), as well as the prospective association in a subsample that completed measures 2 years after diagnosis and still experienced SPN (n = 86). Results At 1-year follow-up, higher optimism was associated with better global HRQoL, and better physical, role, emotional, cognitive, and social functioning (all p < .01). Optimism at year one was also prospectively associated with better global HRQoL (p < .05), and emotional and cognitive functioning at 2-year follow-up (both p < .01). Optimism was not related to self-reported SPN severity. Significant associations were retained when controlling for demographic/clinical variables, and became non-significant after controlling for depressive and anxiety symptoms. Conclusions Optimism and depressive and anxiety symptoms are associated with HRQoL in CRC patients with chronic (CI)PN. Future research may illuminate the mechanisms that these factors share, like the use of (non)adaptive coping styles such as avoidance and acceptance that may inform the design of targeted interventions to help patients to adapt to chronic (CI)PN.

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472 Addressing the Quality of Hospital Care of Colorectal Cancer Patients Undergoing Surgery: What Did We Learn from the National Bowel Cancer Audit?

British Journal of Surgery ◽

10.1093/bjs/znab134.558 ◽

2021 ◽

Vol 108 (Supplement_2) ◽

Author(s):

C Li ◽

S Z Y Ooi ◽

T Woo ◽

P H M Chan

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

External Validation ◽

Distant Metastases ◽

Management Plan ◽

Bowel Cancer ◽

Clinical Factors ◽

Quality Outcomes ◽

Colorectal Cancer Patients

Abstract Aim To identify the most relevant clinical factors in the National Bowel Cancer Audit (NBOCA) that contribute to the variation in the quality of care provided in different hospitals for colorectal cancer patients undergoing surgery. Method Data from 36,116 patients with colorectal cancer who had undergone surgery were retrospectively collected from the NBOCA and analysed from 145 and 146 hospitals over two years. A validated multiple linear regression was performed to compare the identified clinical factors with various quality outcomes. The quality outcomes defined in this study were the length of hospitalisation, 2-year mortality, readmission rate, 90-day mortality, and 18-month stoma rate. Results Four clinical factors (laparoscopy rate, abdominal-perineal-resection-of-rectum (APER), pre-operative radiotherapy and patients with distant metastases) were shown to have a significant (p < 0.05) impact on the length of hospitalisation and 18-month stoma rate. 18-month stoma rate was also significantly associated with 2-year mortality. External validation of the regression model demonstrated the Root-Mean-Square-Error of 0.811 and 4.62 for 18-month stoma rate and 2-year mortality respectively. Conclusions Hospitals should monitor the four clinical factors for patients with colorectal cancer during perioperative care. Clinicians should consider these factors along with the individual patients’ history when formulating a management plan for patients with colorectal cancer.

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The course of peripheral neuropathy and its association with health-related quality of life among colorectal cancer patients

Journal of Cancer Survivorship ◽

10.1007/s11764-020-00923-6 ◽

2020 ◽

Author(s):

Cynthia S. Bonhof ◽

Lonneke V. van de Poll-Franse ◽

Dareczka K. Wasowicz ◽

Laurens V. Beerepoot ◽

Gerard Vreugdenhil ◽

...

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Peripheral Neuropathy ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Eortc Qlq ◽

The Impact

Abstract Purpose To gain more insight into the course of chemotherapy-induced peripheral neuropathy (CIPN) and its impact on health-related quality of life (HRQoL) in a population-based sample of colorectal cancer (CRC) patients up to 2 years after diagnosis. Methods All newly diagnosed CRC patients from four hospitals in the Netherlands were eligible for participation in an ongoing prospective cohort study. Patients (n = 340) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30) before initial treatment (baseline) and 1 and 2 years after diagnosis. Results Among chemotherapy-treated patients (n = 105), a high sensory peripheral neuropathy (SPN) level was reported by 57% of patients at 1 year, and 47% at 2-year follow-up, whereas a high motor peripheral neuropathy (MPN) level was reported by 47% and 28%, at years 1 and 2, respectively. Linear mixed model analyses showed that SPN and MPN symptoms significantly increased from baseline to 1-year follow-up and did not return to baseline level after 2 years. Patients with a high SPN or MPN level reported a worse global quality of life and a worse physical, role, emotional, cognitive, and social functioning compared with those with a low SPN or MPN level. Conclusions Future studies should focus on understanding the mechanisms underlying CIPN so targeted interventions can be developed to reduce the impact of CIPN on patient’s lives. Implications for cancer survivors Patients need to be informed of both CIPN and the impact on HRQoL.

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Associations of sedentary time and patterns of sedentary time accumulation with health-related quality of life in colorectal cancer survivors

Preventive Medicine Reports ◽

10.1016/j.pmedr.2016.06.022 ◽

2016 ◽

Vol 4 ◽

pp. 262-269 ◽

Cited By ~ 31

Author(s):

Eline H. van Roekel ◽

Elisabeth A.H. Winkler ◽

Martijn J.L. Bours ◽

Brigid M. Lynch ◽

Paul J.B. Willems ◽

...

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Cancer Survivors ◽

Sedentary Time ◽

Health Related Quality ◽

Colorectal Cancer Survivors ◽

Related Quality ◽

Health Related ◽

Time Accumulation

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Health-related quality of life and oncologic outcomes after surgery in older adults with colorectal cancer

Supportive Care in Cancer ◽

10.1007/s00520-019-05087-3 ◽

2019 ◽

Vol 28 (6) ◽

pp. 2857-2865

Author(s):

Andrew M. Blakely ◽

Dayana Chanson ◽

F. Lennie Wong ◽

Oliver S. Eng ◽

Stephen M. Sentovich ◽

...

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Older Adults ◽

Oncologic Outcomes ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Longitudinal Associations of Adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Lifestyle Recommendations with Quality of Life and Symptoms in Colorectal Cancer Survivors up to 24 Months Post-Treatment

Cancers ◽

10.3390/cancers14020417 ◽

2022 ◽

Vol 14 (2) ◽

pp. 417

Author(s):

Marlou-Floor Kenkhuis ◽

Floortje Mols ◽

Eline H. van Roekel ◽

José J. L. Breedveld-Peters ◽

Stéphanie O. Breukink ◽

...

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Cancer Research ◽

Post Treatment ◽

Research Fund ◽

American Institute ◽

The World ◽

Lifestyle Recommendations ◽

Longitudinal Associations

Post-treatment adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations were associated with health-related quality of life (HRQoL), fatigue, and chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer (CRC) survivors. In a prospective cohort among CRC survivors (n = 459), repeated home-visits were performed at 6 weeks, 6, 12, and 24 months post-treatment. Dietary intake, body composition, sedentary behaviour, and physical activity were assessed to construct a lifestyle score based on adherence to seven 2018 WCRF/AICR recommendations. Longitudinal associations of the lifestyle score with HRQoL, fatigue, and CIPN were analysed by confounder-adjusted linear mixed models. A higher lifestyle score was associated with better physical functioning and less activity-related fatigue, but not with CIPN. Adjustment for physical activity substantially attenuated observed associations, indicating its importance in the lifestyle score with regards to HRQoL. In contrast, adjustment for body composition and alcohol inflated observed associations, indicating that both recommendations had a counteractive influence within the lifestyle score. Our findings suggest that CRC survivors benefit from an overall adherence to the WCRF/AICR lifestyle recommendations in terms of HRQoL and fatigue, but not CIPN. Specific recommendations have a varying influence on these associations, complicating the interpretation and requiring further study.

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