scholarly journals Longitudinal Associations of Adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Lifestyle Recommendations with Quality of Life and Symptoms in Colorectal Cancer Survivors up to 24 Months Post-Treatment

Cancers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 417
Author(s):  
Marlou-Floor Kenkhuis ◽  
Floortje Mols ◽  
Eline H. van Roekel ◽  
José J. L. Breedveld-Peters ◽  
Stéphanie O. Breukink ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Cancer Research ◽  
Post Treatment ◽  
Research Fund ◽  
American Institute ◽  
The World ◽  
Lifestyle Recommendations ◽  
Longitudinal Associations

Post-treatment adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations were associated with health-related quality of life (HRQoL), fatigue, and chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer (CRC) survivors. In a prospective cohort among CRC survivors (n = 459), repeated home-visits were performed at 6 weeks, 6, 12, and 24 months post-treatment. Dietary intake, body composition, sedentary behaviour, and physical activity were assessed to construct a lifestyle score based on adherence to seven 2018 WCRF/AICR recommendations. Longitudinal associations of the lifestyle score with HRQoL, fatigue, and CIPN were analysed by confounder-adjusted linear mixed models. A higher lifestyle score was associated with better physical functioning and less activity-related fatigue, but not with CIPN. Adjustment for physical activity substantially attenuated observed associations, indicating its importance in the lifestyle score with regards to HRQoL. In contrast, adjustment for body composition and alcohol inflated observed associations, indicating that both recommendations had a counteractive influence within the lifestyle score. Our findings suggest that CRC survivors benefit from an overall adherence to the WCRF/AICR lifestyle recommendations in terms of HRQoL and fatigue, but not CIPN. Specific recommendations have a varying influence on these associations, complicating the interpretation and requiring further study.

Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and colorectal cancer risk

2017 ◽  
Vol 85 ◽  
pp. 86-94 ◽  
Author(s):  
Federica Turati ◽  
Francesca Bravi ◽  
Matteo Di Maso ◽  
Cristina Bosetti ◽  
Jerry Polesel ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Research ◽  
Cancer Risk ◽  
Colorectal Cancer Risk ◽  
Research Fund ◽  
American Institute ◽  
The World ◽  
Research Recommendations

scholarly journals Increases in adipose tissue and muscle function are longitudinally associated with better quality of life in colorectal cancer survivors

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marlou-Floor Kenkhuis ◽  
Eline H. van Roekel ◽  
Janna L. Koole ◽  
José J. L. Breedveld-Peters ◽  
Stéphanie O. Breukink ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Body Composition ◽  
Adipose Tissue ◽  
Mixed Models ◽  
Muscle Function ◽  
Post Treatment ◽  
Body Tissues ◽  
Longitudinal Associations

AbstractColorectal cancer (CRC) survivors need evidence-based guidelines pertaining to post-treatment body composition, which could benefit health-related quality of life (HRQoL). We aimed to describe the course of several body composition measures, and to assess longitudinal associations of these measures with HRQoL, fatigue and chemotherapy-induced peripheral neuropathy (CIPN). In a prospective cohort among stage I–III CRC survivors (n = 459), five repeated home visits from diagnosis up to 24 months post-treatment were executed. Body mass index (BMI), waist circumference and fat percentage were assessed as measures of adiposity, and muscle arm circumference and handgrip strength as measures of muscle mass and function. We applied linear mixed-models to describe changes in body composition over time and to analyze overall longitudinal associations. Of included participants, 44% was overweight and 31% was obese at diagnosis. All body composition measures followed similar trends, decreasing from diagnosis to 6 weeks and then increasing up to 24 months post-treatment. In confounder-adjusted mixed models, increases in adipose tissue and muscle function were longitudinally associated with better HRQoL and less fatigue, regardless of pre-treatment body composition. With regards to improving HRQoL, decreasing fatigue and CIPN, clinical practice should also focus on restoring body tissues after CRC treatment.Trial registration: NTR7099.

scholarly journals Increases in Adipose Tissue and Muscle Function are Longitudinally Associated with Better Quality of Life in Colorectal Cancer Survivors

2021 ◽  
Author(s):  
Marlou-Floor Kenkhuis ◽  
Eline H. Van Roekel ◽  
Janna L. Koole ◽  
José J.L. Breedveld-Peters ◽  
Stephanie O. Breukink ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Body Composition ◽  
Adipose Tissue ◽  
Mixed Models ◽  
Muscle Function ◽  
Post Treatment ◽  
Body Tissues ◽  
Longitudinal Associations

Abstract Background: Colorectal cancer (CRC) survivors need evidence-based guidelines pertaining to post-treatment body composition, which could benefit health-related quality of life (HRQoL). We aimed to describe the course of several body composition measures, and to assess longitudinal associations of these measures with HRQoL, fatigue and chemotherapy-induced peripheral neuropathy (CIPN). Methods: In a prospective cohort among stage I-III CRC survivors (n=459), five repeated home visits from diagnosis up to 24 months post-treatment were executed. Body mass index (BMI), waist circumference and fat percentage were assessed as measures of adiposity, and muscle arm circumference and handgrip strength as measures of muscle mass and function. We applied linear mixed-models to describe changes in body composition over time and to analyze overall longitudinal associations.Results: Of included participants, 44% was overweight and 31% was obese at diagnosis. All body composition measures followed similar trends, decreasing from diagnosis to 6 weeks and then increasing up to 24 months post-treatment. In confounder-adjusted mixed models, increases in adipose tissue and muscle function were longitudinally associated with better HRQoL and less fatigue, regardless of pre-treatment body composition.Discussion: With regards to improving HRQoL, decreasing fatigue and CIPN, clinical practice should also focus on restoring body tissues after CRC treatment.

scholarly journals Does adherence to the World Cancer Research Fund/American Institute of Cancer Research cancer prevention guidelines reduce risk of colorectal cancer in the UK Women’s Cohort Study?

2018 ◽  
Vol 119 (3) ◽  
pp. 340-348 ◽  
Author(s):  
Petra Jones ◽  
Janet E. Cade ◽  
Charlotte E. L. Evans ◽  
Neil Hancock ◽  
Darren C. Greenwood
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Cancer Research ◽  
Cohort Study ◽  
Research Fund ◽  
American Institute ◽  
The World ◽  
Prevention Guidelines ◽  
The Uk ◽  
Adjusted Model

AbstractEvidence on adherence to diet-related cancer prevention guidelines and associations with colorectal cancer (CRC) risk is limited and conflicting. The aim of this cohort analysis is to evaluate associations between adherence to the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) 2007 recommendations and incident CRC. The UK Women’s Cohort Study comprises over 35 372 women who filled in a FFQ at baseline in 1995. They were followed up for CRC incidence for a median of 17·4 years, an individual score linking adherence to eight of the WCRF/AICR recommendations was constructed. Cox proportional hazards regression provided hazard ratios (HR) and 95 % CI for the estimation of CRC risk, adjusting for confounders. Following exclusions, 444 CRC cases were identified. In the multivariate-adjusted model, women within the second and third (highest) categories of the WRCF/AICR score had HR of 0·79 (95 % CI 0·62, 1·00) and 0·73 (95 % CI 0·48, 1·10), respectively, for CRC compared with those in the lowest, reference category. The overall linear trend across the categories was not significant (P=0·17). No significant associations were observed between the WCRF/AICR score and proximal colon, distal colon and rectal cancers separately. Of the individual score components, a BMI within the normal weight range was borderline significantly protective only for rectal cancer in the fully adjusted model. In view of the likely different causes of CRC subtypes, further research is needed to identify the optimal dietary patterns associated with reducing colon and rectal cancer risk, respectively.

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